检索结果-南通市图书馆

Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review and meta-analyses

World Journal of gastroenterology 2024年第38期30卷 4221-4231页

作者： Ashleigh Russell Shauna Mitchell Richard c Turkington Helen g coleman centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick g Johnston centre for cancer Research Queen's University BelfastBelfast BT71NNUnited Kingdom

BAcKgROUND The incidence of oesophageal adenocarcinoma(OAc)has been reported to be increasing in many *** this trend,an increase in incidence of early-onset OAc,defined as OAc in adults aged under 50 years,has been *** is unclear whether survival outcomes for early-onset OAc patients differ from older age *** To investigate survival outcomes in early-onset OAc *** Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAc and survival *** regarding the overall five-year survival and risk of death of younger and older patients with OAc were extracted and pooled using meta-analyses to produce pooled estimates and 95%cIs where *** Eleven studies which compared survival of early-onset OAc,defined as age at diagnosis ofcluded.A narrative review of median and mean survival demonstrated conflicting results,with studies showing early-onset OAc patients having both better and worse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,with 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAc patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%cI:0.85-1.47).INTRODUcTION There is concern that the incidence of oesophageal adenocarcinoma(OAc)in patients under 50,described as early-onset OAc,is ***,data regarding survival of younger patients with OAc is ***,while increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].This includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and he

关键词： Early-onset cancer Early-onset oesophageal adenocarcinoma Survival cancer epidemiology Systematic review Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring one material for dual applications:A red-emitting Mg_(2)geO_(4):Eu^(3+)nanophosphor for future generation energy efficient WLEDs and dosimetric applications

引用

Journal of Rare Earths 2024年第10期42卷 1835-1845页

作者： Akshay Arjun g.P.Darshan S.c.Sharma H.Nagabhushana D.V.Sunitha H.B.Premkumar Department of Physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied SciencesBengaluru560054India Honorary Professor of Law and Forensic Materials Jain UniversityBengaluru560069India c.N.R.Rao centre for Advanced Materials Tumkur UniversityTumkur572103India School of Applied Sciences(Physics) REVA UniversityBengaluru560064India

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured Mg_(2)geO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffraction patterns confirm the orthorhombic crystal system with a Puma space *** results clearly show irregularly shaped cluster-like structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the Mg_2geO_4:Eu^(3+)(1 mol%-9 mol%)nanophosphors was estimated and obtained to be~4.12-4.32 *** photoluminescence emission spectra exhibit intense peaks at~579,589,610,661,and 707 nm,which are due to characteristic~5D_(0)→~7F_(0),~5D_(0)→~7F_(1),~5Do→~7F_(2),~5D_(0)→~7F_(3)and~5D_(0)→~7F_(4)transitions of Eu^(3+)ions,*** commission International de L'Eclairage color coordinates are gradually tuned from pale red(0.5980,0.4012)to a pure red(0.6385,0.3611)*** glow peaks showcase excellent super-linear response at low doses ofγ-irradiations,indicating that the prepared phosphor can be used in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results demonstrate that the prepared Mg_2geO_4:Eu^(3+)(1 mol%-9 mol%)nanophosphors are considered an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes(WLEDs)and personal dosimetric applications.

关键词： Nanophosphors Photoluminescence Thermoluminescence Dosimetry Photometric properties Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of B4c and zrB2 reinforcements on microstructural,mechanical and wear behaviour of AA 2014 aluminium matrix hybrid composites

引用

Defence Technology（防务技术） 2024年第10期40卷 242-254页

作者： Ramesh Babu R Rajendran c Saiyathibrahim A Rajkumar Velu Department of Mechanical Engineering Karpagam Institute of TechnologyCoimbatore 641105India Department of Mechanical Engineering Sri Krishna College of Engineering and TechnologyCoimbatore 641008India Department of Mechanical Engineering Indian Institute of Technology JammuJammu and Kashmir 181221India

considering their affordability and high strength-to-weight ratio,lightweight aluminium alloys are the subject of intensive research aimed at improving their properties for use in the aerospace *** research effort aims to develop novel hybrid composites based on AA 2014 alloy through the use of liquid metallurgy stir casting to reinforce dual ceramic particles of zirconium Diboride(zrB_(2))and Boron carbide(B4c).The weight percentage(wt%)of zrB_(2) was varied(0,5,10,and 15),while a constant 5 wt%of B4c was maintained during this *** as-cast samples have been assessed using an Optical Microscope(OM)and a Scanning Electron Microscope(SEM)with Energy Dispersive Spectroscopy(EDS).The properties such as hardness,tensile strength,and wear characteristics of stir cast specimens were assessed to examine the impact of varying weight percentages of reinforcements in AA 2014 *** particular,dry sliding wear behaviour was evaluated considering varied loads using a pin-on-disc *** the weight%of zrB_(2) grew and B4c was incorporated,hybrid composites showed higher hardness,tensile strength,and wear ***,the incorporation of a cumulative reinforcement consisting of 15 wt%zrB_(2) and 5 wt%B4c resulted in a significant 31.86%increase in hardness and a 44.1%increase in tensile strength compared to AA 2014 *** addition,it has been detected that wear resistance of hybrid composite pin(containing 20 wt%cumulative reinforcement)is higher than that of other stir cast wear test pins during the whole range of applied *** surfaces of tensile specimens showed ductile fracture in the AA 2014 matrix and mixed mode for hybrid *** surfaces obtained employing higher applied load indicated abrasive wear with little plastic deformation for hybrid composites and dominant adhesive wear for matrix ***,the superior mechanical and tribological performance of hybrid composites can be attributed to dual reinforcement pa

关键词： AA 2014 alloy Stir casting Hybrid composite Hardness Tensile strength Specific wear rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

STcF conceptual design report (Volume 1): Physics & detector

引用

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.c.Ai L.P.An R.Aliberti Q.An X.z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko z.H.Bu F.M.cai H.cai J.J.cao Q.H.cao X.cao z.cao Q.chang K.T.chao D.Y.chen H.chen H.X.chen J.F.chen K.chen L.L.chen P.chen S.L.chen S.M.chen S.chen S.P.chen W.chen X.chen X.F.chen X.R.chen Y.chen Y.Q.chen H.Y.cheng J.cheng S.cheng T.g.cheng J.P.Dai L.Y.Dai X.c.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du z.g.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang z.J.Fang g.Fedotovich c.Q.Feng X.Feng Y.T.Feng J.L.Fu J.gao Y.N.gao P.S.ge c.Q.geng L.S.geng A.gilman L.gong T.gong B.gou W.gradl J.L.gu A.guevara L.c.gui A.Q.guo F.K.guo J.c.guo J.guo Y.P.guo z.H.guo A.guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.g.He Y.L.He z.B.He z.X.Heng B.L.Hou T.J.Hou Y.R.Hou c.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.c.Hu J.Hua g.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia z.K.Jia H.B.Jiang J.Jiang S.z.Jiang J.B.Jiao z.Jiao H.J.Jing X.L.Kang X.S.Kang B.c.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev c.H.Li c.Li D.Y.Li F.Li g.Li g.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li z.J.Li H.Liang J.H.Liang Y.T.Liang g.R.Liao L.z.Liao Y.Liao c.X.Lin D.X.Lin X.S.Lin B.J.Liu c.W.Liu D.Liu F.Liu g.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu z.Q.Liu z.Y.Liu z.W.Liu I.Logashenko Y.Long c.g.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov g.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian c.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker c.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia cAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom central china Normal University Wuhan 430079China central South University Changsha 410083China china University of geosciences Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China goethe University Frankfurt D-60325 Frankfurt am MainGermany guangxi Normal University Guilin 541004China guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STcF)is an electron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 geV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STcF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPcII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STcF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STcF,describes conceptual designs of the STcF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STcF detector conceptual design

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrocarbon indication in Rio Bonito Formation sandstone:Implication for cO_(2)storage in São Paulo,Brazil

引用

Energy geoscience 2024年第1期5卷 331-341页

作者： Richardson M.Abraham-A Haline V.Rocha Saulo B.de Oliveira colombo c.g.Tassinarri Orlando c.da Silva Institute of Energy and Environment University of São PauloSão PauloBrazil Research centre for greenhouse gas Innovation University of São PauloSão PauloBrazil

São Paulo State has witnessed cO_(2)storage-based investigations considering the availability of suitable geologic structures and proximity to primary cO_(2)source sinks related to bioenergy and carbon capture and storage(BEccS)*** current study presents the hydrocarbon viability evaluations and cO_(2)storage prospects,focusing on the sandstone units of the Rio Bonito *** objective is to apply petrophysical evaluations with geochemical inputs in predicting future hydrocarbon(gas)production to boost cO_(2)storage within the study *** study used data from eleven wells with associated wireline logs(gamma ray,resistivity,density,neutron,and sonic)to predict potential hydrocarbon accumulation and fluid mobility in the investigated *** samples(shale and carbonate)obtained from depths>200 m within the study location have shown bitumen *** geochemistry data of the Rio Bonito Formation shale beds suggest they are potential hydrocarbon source rocks and could have contributed to the gas accumulations within the sandstone *** drilled well data,e.g.,cB-1-SP and TI-1-SP,show hydrocarbon(gas)presence based on the typical resistivity and the combined neutron-density responses at depths up to 3400 m,indicating the possibility of other hydrocarbon members apart from the heavy oil(bitumen)observed from the near-surface rocks *** the three-dimensional(3-D)model,the free fluid indicator(FFI)is more significant towards the southwest and southeast of the area with deeper depths of occurrence,indicating portions with reasonable hydrocarbon recovery rates and good prospects for cO_(2)injection,circulation and permanent ***,future studies based on contemporary datasets are required to establish the hydrocarbon viability further,foster gas production events,and enhance cO_(2)storage possibilities within the region.

关键词： ParanáBasin Hydrocarbon indication Sandstone reservoirs Rio Bonito Formation cO_(2)storage Hydrocarbon recovery factor Fluid injection rate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Why Sustainable Porous carbon Should be Further Explored as Radar-Absorbing Material? A comparative Study with Different Nanostructured carbons

引用

Journal of Renewable Materials 2024年第10期12卷 1639-1659页

作者： Alan F.N.Boss Manuella g.c.Munhoz gisele Amaral-Labat rodrigo g.A.Lima Leonardo I.Medeiros Nila c.F.L.Medeiros Beatriz c.S.Fonseca Flavia L.Braghiroli guilherme F.B.Lenz e Silva Department of Metallurgical and Materials Engineering University of de São PauloAvenida Mello MoraesCidade UniversitáriaSão PauloSP 05508-030Brazil coordination of Applied Research and Technological Development National Institute for Space ResearchAvenida dos AstronautasJardim da GranjaSão Josédos CamposSP 12227-010Brazil Department of Exact and Technological Sciences Santa Cruz State UniversityRodovia Jorge Amadokm16IlhéusBA 45662900Brazil Institut de recherche sur les forêts Universitédu Québec en Abitibi-TémiscamingueRouyn-Noranda445 Bd de l’UniversitéRouyn-NorandaQC J9X 5E4Canada

Radar Absorbing Materials(RAM)are a class of composites that can attenuate incident electromagnetic waves to avoid radar *** carbon allotropes that have the potential to be used as RAM are either carbon nano-tubes(cNTs),graphene,carbon black(cB)and ultimately,sustainable porous carbon(SPc).Here,black wattle bark waste(following tannin extraction)was used as a sustainable source to produce SPc made from biomass *** was characterized and used as aﬁller for a silicone rubber matrix to produce aﬂexible *** elec-tromagnetic performance of this composite was compared with composites made with commercial cB and cNT through reﬂection loss(RL),where-10 dB is equivalent to 90%of *** composites were evaluated in single-layer,double-layer,and as radar absorbing structures(RAS)with the aim of improving their effective absorption bandwidth(EAB)performances and a reduction in *** cNT composite presented a RL of-26.85 dB at 10.89 gHz and an EAB of 2.6 gHz with a 1.9 mm thickness,while the double-layer structures using cNT and SPc provided a RL of-19.74 dB at 10.75 gHz and an EAB of 2.51 ***,the double-layer structures are~42%cheaper than the composite using only cNT since less material is ***,the largest EAB was achieved with a RAS using SPc,reaching~2.8 gHz and a RL of-49.09 dB at 10.4 ***,SPc made of black wattle bark waste can be a competitive,alternative material for use as RAM and RAS since it is cheaper,sustainable,and suitable for daily life uses such as absorbers for anechoic chambers,sensors,and elec-tromagnetic interference shields for electronics,wallets,vehicles,and others.

关键词： Microwave absorption material tannin waste dielectric constant carbon composite reﬂectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Floristic composition and edaphic relationships in ferruginous campo rupestre reference ecosystems

引用

Journal of Mountain Science 2024年第3期21卷 719-733页

作者： g.Wilson FERNANDES Letícia RAMOS Dario c.PAIVA Jéssica cUNHA-BLUM Vanessa Matos gOMES Daniel NEgREIROS Ecologia Evolutiva&Biodiversidade Departamento de GenéticaEcologia e Evolução/ICBUniversidade Federal de Minas Gerais31270-901Belo HorizonteMGBrazil Knowledge center for Biodiversity 31270-901Belo HorizonteMGBrazil Department of Biological Sciences Institute of EnvironmentFlorida International UniversityMiamiFL 33199USA Programa de Pós graduação em Biodiversidade e Uso dos Recursos Naturais Universidade Estadual de Montes ClarosMontes ClarosMGBrazil Laboratório de Estudo das Relações Solo-Planta Departamento de SolosUniversidade Federal Rural do Rio de JaneiroSeropédicaRGBrazil

Land use change and occupation have led to modifications in the environment causing loss of biodiversity and ecosystem services throughout the *** environments with high economic relevance,such as the ferruginous campo rupestre(rupestrian grassland known as canga in Brazil),are even more susceptible to severe impacts due to their extreme habitat conditions and low *** determination of reference ecosystems based on the intrinsic characteristics of the ecosystem is essential for conservation as well as to the implementation of ecological *** proposed the reference ecosystem of the three main types of habitats of the ferruginous campo rupestre based on their floristic *** described the floristic composition of each habitat and evaluated the physicochemical properties of the soils and the relationship between plants and *** three habitats showed high diversity of plant species and many endemic species,such as chamaecrista choriophylla,cuphea pseudovaccinium,Lychnophora pinaster,and Vellozia *** distribution of vegetation was strongly related with the edaphic characteristics,with a set of species more adapted to high concentration of base saturation,fine sand,organic carbon,and iron,while another set of species succeeded in more acidic soils with higher S and silt *** provide support for the contention that the ferruginous campo rupestre is a mosaic of different habitats shaped by intrinsic local *** to recognize the floristic composition of each particular habitat can lead to inappropriate restoration,increased habitat homogenization and increased loss of biodiversity and ecosystem *** study also advances the knowledge base for building the reference ecosystem for the different types of ferruginous campo rupestre habitats,as well as a key database for highlighting those species contribute most to community assembly in this diverse and threatened tropical mountain ecosystem.

关键词： canga Ecological restoration Extreme ecosystem Non-forest ecosystems Rupestrian grassland Taxon environment relationships

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

geochemical elements in suspended particulate matter of Ensenada de La Paz Lagoon,Baja california Peninsula,Mexico:Sources,distribution,mass balance and ecotoxicological risks

引用

Journal of Environmental Sciences 2024年第2期136卷 422-436页

作者： Sandra Soledad Morales-garcía Pilar de Acacia Pérez-Escamilla Suresh Babu Sujitha Pichaimani godwyn-Paulson Andrés Felipe zuniga-cabezas Muthuswamy Ponniah Jonathan Instituto Politécnico Nacional(IPN) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto Politécnico Nacional(IPN) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto Politécnico Nacional(IPN) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The present study aimed to evaluate multi-element concentrations(Al,As,ca,cd,co,cr,cu,Fe,Mg,Mn,Mo,Ni,Pb,Sr)in suspended particulate material(SPM)collected from Ensenada de La Paz(ELP)lagoon,Baja california Sur,Mexico in two different periods(September and May)to comprehend their origin,geochemical behavior,mass transfer and associated ecotoxicological *** 24 hr variation coefficient of volumetric SPM levels were found to be 51.7%in September and 40.5%in May,signifying the effects of oceanic *** calculated enrichment factor(EF)values for all the studied elements were of higher magnitude because of the high surface area and oxide nature of SPM,and in this study,Mo had the highest EF of 46.77 probably due to its origin from continental *** the ecotoxicological perspective,the integrated toxic risk index revealed low toxic risk to the benthic ***,the mean-ERM-Quotient calculated using the particulate concentrations of As,cd,cr,cu,Ni,Pb indicated 9%probability of toxicity to *** comprehensive geochemical and ecotoxicological assessment of particulate metal concentrations in the ELP lagoon signify low to moderate contamination.

关键词： Suspended particulate material Heavy metals Risk assessment Mass transfer Ensenada de La Paz

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Utilizing neural networks to supplant chemical kinetics tabulation through mass conservation and weighting of species depletion

引用

Energy and AI 2024年第2期16卷 101-110页

作者： Franz M.Rohrhofer Stefan Posch clemens gößnitzer JoséM.garcía-Oliver Bernhard c.geiger Know-center gmbH Sandgasse 36Graz8010StyriaAustria LEc gmbH Inffeldgasse 19Graz8010StyriaAustria Universitat Politècnica de València Camíde VeraValència46022ValènciaSpain

Artificial Neural Networks(ANNs)have emerged as a powerful tool in combustion simulations to replace memory-intensive tabulation of integrated chemical *** reaction mechanisms,however,present a challenge for standard ANN approaches as modeling multiple species typically suffers from inaccurate predictions on minor *** paper presents a novel ANN approach which can be applied on complex reaction mechanisms in tabular data form,and only involves training a single ANN for a complete reaction *** approach incorporates a network architecture that automatically conserves mass and employs a particular loss weighting based on species *** modifications are used to improve the overall ANN performance and individual prediction accuracies,especially for minor species mass *** validate its effectiveness,the approach is compared to standard ANNs in terms of performance and ANN *** distinct reaction mechanisms(H_(2),c_(7)H_(16),c_(12)H_(26),OME_(34))are used as a test cases,and results demonstrate that considerable improvements can be achieved by applying both modifications.

关键词： Neural network approach chemical kinetics Flamelet tabulation Mass conservation Species loss weighting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural basis for polyuridine tract recognition by SARS-coV-2 Nsp15

引用

Protein & cell 2024年第7期15卷 547-552页

作者： Fumiaki Ito Hanjing Yang z.Hong zhou Xiaojiang S.chen Molecular and computational Biology Department of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90089United States Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095United States california NanoSystems Institute University of CaliforniaLos AngelesCA90095United States genetic Molecular and Cellular Biology ProgramKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States Norris comprehensive cancer center University of Southern CaliforniaLos AngelesCA 90089United States center of Excellence in NanoBiophysics University of Southern CaliforniaLos AngelesCA 90089United States

Dear Editor,coronaviruses have evolved a wide array of tactics to evade host antiviral *** host cells detect invading foreign nucleic acids including viral genome and viral replication intermediates,they activate interferon(IFN)signaling via cytoplasmic pattern recognition receptors(Kang et al.,2002;Kato et al.,2006).Remarkable stealth activities exhibited by coronaviruses are facilitated by a series of non-structural proteins(Nsps),such as Nsp15(Deng and Baker,2018;Deng et al.,2019;Hackbart et al.,2020),which is a uridine-specific endoribonuclease that mediates evasion of host detection of viral double-stranded RNA(dsRNA)(Bhardwaj et al.,2004;Deng et al.,2017;Frazier et al.,2021;Ivanov et al.,2004).Nsp15 targets a polyuridine[poly(U)]tract on the coronavirus negative strand RNA(Hackbart et al.,2020).Nsp15 limits the abundance and length of poly(U)within the negative strand RNA 5ʹ-extension by trimming down the initially synthesized poly(U)lead sequence to the optimal length that can suppress dsRNA formation but still serves as a template for poly(A)tail of the positive strand genome of the coronaviruses(Hofmann and Brian,1991).

关键词： p15 interferon template

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：