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维多珠单抗治疗慢性肉芽肿相关炎症性肠病的疗效

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Gastroenterology Report 2020年第5期8卷 404-406,I0003页

作者： Natasha Kamal Beatriz Marciano Bryan Curtin anna strongin Suk See DeRavin Athos Bousvaros Christopher Koh Harry L.Malech Steven M.Holland Christa Zerbe Theo Heller Digestive Disease Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Laboratory of Host Defenses National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA Division of Gastroenterology Hepatology and NutritionBoston Children’s HospitalBostonMAUSA Liver Disease Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Laboratory of Clinical Immunology and Microbiology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA

Introduction Chronic granulomatous disease(CGD)is a rare immunodeficiency affecting approximately 1 in 200,000 people[1].Patients with CGD are unable to produce normal amounts of neutrophil superoxide and other phagocyte reactive oxygen species.As a result,phagocytes have decreased microbicidal activity and patients develop recurrent bacterial and fungal infections.

关键词：慢性肉芽肿单抗治疗炎症性肠病 immunodeficiency

Tissue inhibitors of metalloproteases strike a nerve

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Neural Regeneration Research 2018年第11期13卷 1890-1892页

作者： veronica i.shubayev alex y.strongin department of anesthesiology university of californiasan diego va san diego healthcare system la jollacausa sanford burnham prebys medical discovery institute la jollacausa

Signals of touch,pressure,pain,temperature,position,and vibration are transmitted from the peripheral nervous system（PNS）to the dorsal horn of the segmental spinal cord via pseudounipolar dorsal root ganglia（DRG）neurons.Sensory information gathering relies on functional integrity of DRG neurons and can be interrupted by PNS injury due to trauma,disease or exposure to drugs, toxins or viral pathogens. Despite the high regenerative capacity of DRG neurons, sensory recovery after PNS injury is often incomplete and severe neuropathic pain may last for years. Although numerous mechanisms of PNS injury have been established, neuropathic pain is refractory to therapy, contributing to the physical and emotional suffering of patients and the enormous economic burden to society.

关键词： TIMPs PNS In Tissue inhibitors of metalloproteases strike a nerve

Role of myelin auto-antigens in pain:a female connection

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Neural Regeneration Research 2016年第6期11卷 890-891页

作者： Veronica I.Shubayev Alex Y.strongin Tony L.Yaksh Department of Anesthesiology University of CaliforniaSan DiegoLa JollaCAUSA VA San Diego Healthcare System La JollaCAUSA Sanford-Burnham-Prebys Medical Discovery Institute La jollaCAUSA

Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation（mechanical allodynia）is commonly observed.Its origins are poorly understood and the pain is often refractory to common analgesic therapeutics.The past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain（pain arising from damage or disease of the somatosensory system）.

关键词： myelin understood stimulation poorly refractory analgesic microglia immunity signaling likely

Highly Dispersed RuOOH Nanoparticles on Silica Spheres:An Efficient Photothermal Catalyst for Selective Aerobic Oxidation of Benzyl Alcohol

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Nano-Micro Letters 2020年第3期12卷 169-178页

作者： Qilin Wei Kiersten G.Guzman Xinyan Dai Nuwan H.Attanayake Daniel R.strongin Yugang Sun Department of Chemistry Temple University

Photothermal catalysis represents a promising strategy to utilize the renewable energy source(e.g.,solar energy)to drive chemical reactions more efficiently.Successful and efficient photothermal catalysis relies on the availability of ideal photothermal catalysts,which can provide both large areas of catalytically active surface and strong light absorption power simultaneously.Such duplex requirements of a photothermal catalyst exhibit opposing dependence on the size of the catalyst nanoparticles,i.e.,smaller size is beneficial for achieving higher surface area and more active surface,whereas larger size favors the light absorption in the nanoparticles.In this article,we report the synthesis of ultrafine RuOOH nanoparticles with a size of 2–3 nm uniformly dispersed on the surfaces of silica(SiOx)nanospheres of hundreds of nanometers in size to tackle this challenge of forming an ideal photothermal catalyst.The ultrasmall RuOOH nanoparticles exhibit a large surface area as well as the ability to activate adsorbed molecular oxygen.The SiOx nanospheres exhibit strong surface light scattering resonances to enhance the light absorption power of the small RuOOH nanoparticles anchored on the SiOx surface.Therefore,the RuOOH/SiOx composite particles represent a new class of efficient photothermal catalysts with a photothermal energy conversion efficiency of 92.5%for selective aerobic oxidation of benzyl alcohol to benzylaldehyde under ambient conditions.

关键词： Ultrasmall RuOOH nanoparticles Photothermal catalyst Selective aerobic oxidation Light antenna effect Light scattering resonance

铯钠镱和其它金属与固体氨功函数的测量和研究

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中国科学技术大学学报 1990年第4期20卷 472-477页

作者：徐彭寿 S.L.Qiu M.strongin 国家同步辐射实验室美国布鲁克海文国家实验室

测量了80K 下氨吸附在金、钽、镱的表面引起的功函数的改变.结果表明,氨的吸附会引起功函数的减小.当铯(或钠)淀积在固体氨上时,其功函数变得此铯(或钠)本身还要低.更为有趣的是经过一层接一层的交替淀积可溶于氨的金属(如铯、钠、钝),... 详细信息

测量了80K 下氨吸附在金、钽、镱的表面引起的功函数的改变.结果表明,氨的吸附会引起功函数的减小.当铯(或钠)淀积在固体氨上时,其功函数变得此铯(或钠)本身还要低.更为有趣的是经过一层接一层的交替淀积可溶于氨的金属(如铯、钠、钝),可得到最小功函数0.9(±0.1)eV.其值与金属本身和所用的衬底无关.本文对上述实验现象连行了解释,并用“大极化子理论”,估算了极化频率和耦合常数.

关键词：测量铯钠镱固体氨功函数

镱和固体氨的光电发射谱研究及其功函数的测量

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中国科学技术大学学报 1989年第2期19卷 257-260页

作者：徐彭寿 S.L.Qiu M.strongin 中国科学技术大学同步辐射实验室美国布鲁克海文国家实验室

1 引言自从1946年Ogg报道钠—氨溶液具有超导性质以来,碱金属和氨溶液体系一直是人们极感兴趣的课题。这种体系的一个显著的特点首先是金属原子分解为溶解的阳离子和溶解的电子,其次是导电性由电解溶液向液体金属改变。某些稀土金属(如... 详细信息

1 引言自从1946年Ogg报道钠—氨溶液具有超导性质以来,碱金属和氨溶液体系一直是人们极感兴趣的课题。这种体系的一个显著的特点首先是金属原子分解为溶解的阳离子和溶解的电子,其次是导电性由电解溶液向液体金属改变。某些稀土金属(如镱、铕)具有和钠氨体系类似的性质。本文的目的是试图通过光电发射谱的研究和功函数的测量来研究镱—氨体系的电子结构。

关键词：镱固体氨光电发射谱功函数

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石油产业向非传统技术转变

新财富 2005年第10期 32-33页

作者： Jeffrey Currie Hussein Allidina David Greely Allison Nathan Steven strongin Ruifang Zhang 于欣（译）

只有当市场确信低成本传统供应商不足以满足未来需求时方具成本效率。

关键词：石油产业非传统技术成本效率油价风险防范机制