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意大利与中国“一带一路”倡议研究 ——以谅解备忘录为中心的考察

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意大利与中国“一带一路”倡议研究 —...

作者： russo anna 浙江大学

学位级别：硕士

“一带一路”倡议是一个由中国提出的宏大经济战略构想,推动欧亚非沿线各国开放合作,共同打造命运共同体。本文围绕中国“一带一路”倡议展开探究,重点分析了意大利在这个区域性战略合作中的作用。中意两国共同推进“一带一路”建设,于2... 详细信息

“一带一路”倡议是一个由中国提出的宏大经济战略构想,推动欧亚非沿线各国开放合作,共同打造命运共同体。本文围绕中国“一带一路”倡议展开探究,重点分析了意大利在这个区域性战略合作中的作用。中意两国共同推进“一带一路”建设,于2019年3月签署了双边谅解备忘录。本文第一部分主要概述中国发起倡议的动机,与之相关的利益和风险,以及欧洲各国对这一倡议的态度。第二章到第六章,阐述意大利和中国的关系,从古代丝绸之路到当代的政治经济文化交流。意大利是欧洲对华关系的先行者,谅解备忘录的签署,是意中关系日益密切的新开端。备忘录在意大利各界引起热烈反响,也引起美国与欧盟的忧虑,他们担心西方国家的敏感技术和关键基础设施将落入中国手中,论文探讨了意大利各界对签署备忘录的各种意见。对意大利而言,这份谅解备忘录意味着两种可能性:一是促进出口,为意大利企业和产品进入中国市场提供更多机会;二是促进更多中国企业在意大利投资。意大利支持共建“一带一路”,加强与中国的战略对接,深化在港口、物流和海运领域的合作,使意大利制造业面临着历史性的发展机遇,促进“意大利制造”品牌推广和摆脱困境。论文重点论述意大利在该项目中的地位与作用。意大利是七国集团（G7）中第一个正式加入“一带一路”倡议的西方发达国家,受到中国政府高度重视。作为欧洲大陆的重要国家和连接北非与中东地区的桥梁,将成为中国开展基础设施和物流领域、制造业和技术创新等领域的优先合作伙伴。意中构建全面战略伙伴关系不仅限于经济金融领域,还包括政治对话与文化合作。中国与意大利是东西方文明的杰出代表,两国对彼此历史文化传统高度认可和尊重。在“一带一路”框架下,双方重视人文交流,建立文化旅游教育等领域合作机制,推动两国关系长远发展。

关键词： “一带一路”倡议丝绸之路意中关系谅解备忘录

Nano-confinement of biomolecules： Hydrophilic confinement promotes structural order and enhances mobility of water molecules

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Nano Research 2016年第2期9卷 273-281页

作者： Bachir Aoun Daniela russo Argonne National Laboratory Chicago IL 60439 USA CNR-IOM c/o Institut Laue-Langevin 38400 Grenoble France Institut Lumiere Matiere Universite de Lyon 69622 Lyon France

Molecular dynamics simulations have been used to investigate the confinement packing characteristics of small hydrophilic （N-acetyl-glycine-methylamide, Nagma） and hydrophobic （N-acetyl-leucine-methylamide, Nalma） biomolecules in large diameter single-wall carbon nanotubes （SWCNTs）. We find that hydrophilic biomolecules easily fill the nanotube and self organize into a geometrical configuration which reminds the water structural organization under SWCNT confinement. The packing of hydrophilic biomolecules inside the cylinder confines all water molecules in its core, which enhances their mobility. Conversely, hydrophobic biomolecules accommodate into the nanotubes with a trend for homogeneous filling, which generate unstable small pockets of water and drive toward a state of dehydration. These results shed light on key parameters important for the encapsulation of biomolecules with direct relevance for long-term storage and prevention of degradation.

关键词： nano-confinement protein folding hydration water carbon nanotube drug delivery

The role of LRRK2 on PKA-NFκB pathway in microglia cells: implications for Parkinson’s disease

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Neural Regeneration Research 2019年第10期14卷 1713-1714页

作者： Isabella russo Biology and Genetic Unit Department of Molecular and Translational Medicine University of Brescia

Leucine-rich repeat kinase 2 (LRRK2), a gene linked to autosomal- dominantly inherited and sporadic Parkinson’s disease (PD) as a risk factor, encodes a large and complex protein with a dual enzymatic activity. LRRK2 contains several domains involved in protein-protein interactions, however, the presence of both a kinase and GTPase domain points to intracellular signaling functions (Marin, 2006). While LRRK2 has been linked to several molecular pathways important for neuronal activity (Martin et al., 2014), the observation that its expression is high in microglia has attracted the attention of different groups to understand whether LRRK2 dysfunctions in these cells may impact neuronal activity as secondary event.

关键词： cells NFκB Parkinson protein GTPase impact gene has

Therapeutic application of stem cells in gastroenterology:An up-date

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World Journal of Gastroenterology 2011年第34期17卷 3870-3880页

作者： Patrizia Burra Debora Bizzaro Rachele Ciccocioppo Fabio Marra anna Chiara Piscaglia Laura Porretti Antonio Gasbarrini Francesco Paolo russo Department of Surgical and Gastroenterological Sciences Gastroenterology Section University of Padua First Department of Internal Medicine IRCCS Policlinico San Matteo Foundation University of Pavia Department of Internal Medicine University of Florence Department of Internal Medicine Gemelli Hospital "Gastrointestinal and Liver Stem Cell Research Group" (GILSteR) Catholic University of Rome Center of Transfusion Medicine Cell Therapand Cryobiology IRCCS Fondazione Ospedale Maggiore Poli-clinico Mangiagalli e Regina Elena

Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastro-enterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immunemediated conditions,further studies are needed to fully understand the biology of stem cellsand carefully assess their put ativeonco- ***,there searchonstemcellsarousesferventethical,***llsheldinVeronaduringtheⅩⅥCongressoftheFederationofItalianSocietiesofDigestiveDiseases(March 6-9,2010).Here,we report on the issues discussed,including liver and intestinal diseases that may benefit from stemcell therapy,the biology of hepatic and intestinal tissue repair,and stem cell usage inclinical trials.

关键词： Stem cells Cell therapy Regenerative medicine Liver disease Inflammatory bowel disease

A mutation in the ZNF687 gene that is responsible for the severe form of Paget's disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model

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Bone Research 2023年第1期11卷 201-214页

作者： Sharon russo Federica Scotto di Carlo Antonio Maurizi Giorgio Fortunato anna Teti Danilo Licastro Carmine Settembre Tommaso Mello Fernando Gianfrancesco Institute of Genetics and Biophysics“Adriano Buzzati-Traverso” National Research Council of ItalyNaplesItaly Department of Environmental Biological and Pharmaceutical Sciences and Technologies(DiSTABiF)University of Campania Luigi VanvitelliCasertaItaly Department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’AquilaItaly AREA Science Park PadricianoTriesteItaly Telethon Institute of Genetics and Medicine(TIGEM) PozzuoliItaly Gastroenterology Unit Department of Experimental and Clinical Biochemical Sciences“Mario Serio”University of FlorenceFlorenceItaly IRCCS INM Neuromed PozzilliISItaly

Paget’s disease(PDB)is a late-onset bone remodeling disorder with a broad spectrum of symptoms and *** of the most aggressive forms is caused by the P937R mutation in the ZNF687 *** the genetic involvement of ZNF687 in PDB has been extensively studied,the molecular mechanisms underlying this association remain ***,we describe the first Zfp687 knock-in mouse model and demonstrate that the mutation recapitulates the PDB phenotype,resulting in severely altered bone *** microcomputed tomography analysis,we observed that 8-month-old mutant mice showed a mainly osteolytic phase,with a significant decrease in the trabecular bone volume affecting the femurs and the ***,osteoblast activity was deregulated,producing disorganized ***,this phenotype became pervasive in 16-month-old mice,where osteoblast function overtook bone resorption,as highlighted by the presence of woven bone in histological analyses,consistent with the PDB ***,we detected osteophytes and intervertebral disc degeneration,outlining for the first time the link between osteoarthritis and PDB in a PDB mouse *** sequencing of wild-type and Zfp687 knockout RAW264.7 cells identified a set of genes involved in osteoclastogenesis potentially regulated by Zfp687,e.g.,Tspan7,Cpe,Vegfc,and Ggt1,confirming its role in this ***,in this mouse model,the mutation was also associated with a high penetrance of hepatocellular ***,this study established an essential role of Zfp687 in the regulation of bone remodeling,offering the potential to therapeutically treat PDB,and underlines the oncogenic potential of ZNF687.

关键词： RAW264.7 Paget remodeling

Exploiting European GNSS and Ethereum in location proof systems

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International Journal of Digital Earth 2022年第1期15卷 1018-1037页

作者： Gianluca Lax Antonia russo DIIES Dept. University Mediterranea of Reggio CalabriaReggio CalabriaItaly

Location-Based Services(LBSs)are essential in many application contexts like ride-sharing or navigation *** are cases where users could gain an advantage by submitting fake *** problem faced in this paper concerns the possibility that the geographic location declared by a user is not the actual location in which the user is *** solutions are based on centralized or distributed verification in the literature,and other solutions are based on witnesses or *** this paper,we highlight the limitations of such approaches and propose a new scheme that exploits signals coming from satellites to provide trustworthy location proofs,also respecting users'*** proposed approach is decentralized because location proofs are stored by users in a suitably-encrypted way,and a blockchain is adopted to guarantee data integrity and *** show that the proposed approach overcomes the state of the art through a detailed analysis.

关键词： Localization location privacy location-based services blockchain Galileo

Hierarchical control for generator and battery in the more electric aircraft

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Science China(Information Sciences) 2019年第9期62卷 168-181页

作者： Alberto CAVALLO Antonio russo Giacomo CANCIELLO Department of Engineering University of Campania

This paper addresses the problem of intelligent power management for the more electric aircraft framework. The main objective is to regulate the power flow between a low voltage and a high voltage busses through control of a Buck-Boost converter unit. This approach allows the battery to help the generator when an overload scenario occurs, keeping at the same time the battery state of charge above a prescribed threshold. Moreover, in case a continued severe overload causes the battery state of charge to drop below a prescribed threshold, partial shedding of(noncritical) loads occurs. The control objectives are achieved through the design of a hierarchical control strategy based on high gain control for the low level and a finite state automaton for the high level control. Rigorous mathematical proofs of stability are provided for both low level and high level control and a detailed simulator with accurate model of the battery is presented in order to demonstrate the correctness and effectiveness of the proposed approach.

关键词： supervisory control high gain control sliding mode control nonlinear control robust control more electric aircraft switched systems

CUBE, a Cable-driven Device for Limb Rehabilitation

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Journal of Bionic Engineering 2019年第3期16卷 492-502页

作者： Daniele Cafolla Matteo russo Giuseppe Carbone IRCCS Neuromed Via delFelettronica 86077 Pozzilli IS Italy University of Nottingham Advanced Manufacturing Building C47 Nottingham NG8 IBB UK DIMEG University of Calabria Via Bucci Cubo 46C 87036 Rende Italy CESTER Technical University of Cluj-Napoca MunciiAve. 103-105 400641 Cluj-Napoca Romania

In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises.

关键词： cable-driven robots medical robots parallel robots rehabilitation devices

Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino Cristina russo anna Longo Carmelina Daniela Anfuso Gabriella Lupo Debora Lo Furno Rosario Giuffrida Giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells Eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine