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Profile of Extra-Pulmonary Tuberculosis in Internal Medicine

Open Journal of Internal Medicine 2024年第1期14卷 64-73页

作者： Mouhamed Dieng Djiby Sow Demba Diédhiou Michel Assane Ndour Boundia Djiba Mouhamed Almahy Niang Matar Ndiaye Oumar Boun Khattab Diouf Fatou Kiné Gadji anna Sar Maïmouna Ndour Mbaye Clinique Médicale II H&ocircpital Aristide Abass Ndao Université Cheikh Anta Diop Dakar Sénégal

Introduction: Tuberculosis is an infectious disease that mainly affects the lung. Extrapulmonary localizations are a reason for hospitalization in our health facilities. The objective of this study was to describe the epidemiological, clinical, paraclinical and evolutionary aspects of extra pulmonary tuberculosis (EPT) at the Abass Ndao Hospital Center. Patients and Methods: This was a descriptive cross-sectional study conducted over a period of 11 years (January 1, 2010 to December 30, 2021). All patients with extrapulmonary tuberculosis hospitalized in the department of internal medicine during the recruitment period were included. Results: Fifty-two (52) patients were collected. The year 2019 recorded the most cases 23.08% (n = 20). The mean age of the patients was 40.56 ± 18.24 years. The age group 20 - 34 years 42.31% (n = 22) was the most represented. Females were in the majority 61.54% (n = 32) with a sex ratio (M/F) was 0.63. Housewives were in the majority 40.38% (n = 21). 60.87% of the cases (n = 14) came from a health facility. 38.46% of the cases had been infected. 21.74% (n = 9) were smokers. The reasons for consultation were dominated by fever (67.44%), AEG (62.79%) and cough (41.86%). Eighteen patients (40.91%) had fever. The mean time to consultation was 77.37 ± 90.3 days with extremes of 3 and 365 days. The median was 45 days. More than half of the patients 61.90% (n = 26) had anemia. Positive retroviral serology was noted in 21.43% of cases. All patients had a CRP greater than 6. More than half of the patients 51.92% (n = 27) had multifocal tuberculosis. The peritoneum 44.23% (n = 23) was the main organ affected. The average hospital stay was 9.8 ± 4.9 days with extremes of 1 and 19 days. All patients had received the protocol in force at the national level. Death was noted in 4 patients (9.52%). Conclusion: EPT is characterized in our context by a notorious diagnostic difficulty due to the multiplicity of clinical presentations, the complexity of

关键词： Extrapulmonary Tuberculosis Epidemiology Diagnosis Senegal

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Novel Role and Regulation of the Interleukin-1 Receptor Associated Kinase(IRAK)Family Proteins

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Cellular & Molecular Immunology 2005年第1期2卷 36-39页

作者： anna Misior Department of Medicine Wake Forest University School of Medicine.Winston Salem.NC 27157USA.

The interleukin-1 receptor associated kinases(IRAKs)sit at the bottle neck for the Toll-like-receptor(TLR) mediated signal transduetion process controlling host innate immune ***,the exact role and regulation of IRAKs are still in the early stage and not fully *** review intends to summarize the recent advancement in this important topic and points out areas that need further intensive *** & Molecular Immunology.2005:2(1):36-39.

关键词： IRAK innate immunity signaling TLR

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Strategically designing layered two-dimensional SnS_(2)-based hybrid electrodes: A futuristic option for low-cost supercapacitors

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Journal of Energy Chemistry 2023年第10期85卷 394-417,I0011页

作者： Susmi anna Thomas Jayesh Cherusseri Centre for Advanced Functional Materials(CAFM) Department of PhysicsBishop Moore CollegeMavelikaraKerala 690110India Sunway Centre for Electrochemical Energy and Sustainable Technology(SCEEST) School of Engineering and TechnologySunway UniversityNo.5 Jalan UniversityBandar SunwayPetaling Jaya 47500Malaysia

Supercapacitors are promising energy storage devices in current century due to their high specific capacitance, cyclic stability, high power density, and high voltage rating. Due to their excellent electrochemical properties, supercapacitors are invariably used in a multitude of applications ranging from portable electronics to electric vehicles. The electrochemical performance of a supercapacitor mainly depends on the type of electrode-active material used in it. Thereby a careful selection is mandatory to achieve the excellency. Nanostructured electrode-active materials such as carbon nanomaterials, transition metal oxides,transition metal dichalcogenides(TMDs), electronically conducting polymers, etc. are invariably used for supercapacitor application. Among these, TMDs have received great interest, particularly transition metal disulfides such as molybdenum disulfide, tin disulfide(SnS_(2)), etc. Tin is abundant on the earth with excellent charge storage capabilities, attracted great scientific interest for application as electrode materials in supercapacitors. Good electronic conductivity, long cycling life and low-cost are its added ***, we discuss the recent trends in layered two-dimensional(2D) SnS_(2)-based electrodes to develop low-cost supercapacitors. Initially, their crystal structure, basic properties, synthesis methods are discussed. Further, strategically designing electrode nanostructures to achieve excellent electrochemical performance is reviewed then after. This includes material design in terms of morphology, pore-size,and shape as well as preparation of 2D SnS_(2)-based nanocomposite electrodes. Furthermore, the challenges and future perspectives of 2D SnS_(2)-based supercapacitors are included.

关键词： SnS_(2) Supercapacitor Transition metal dichalcogenides Electrochemical energy storage

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Faith and Belief in Autism in Cote d’Ivoire: About Judith, God’s Strange Gift

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Case Reports in Clinical Medicine（临床医学病理报告） 2024年第1期

作者： anna-Corinne Bissouma Lawrence Yapi

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香菇多糖内源性金属离子对其结构和活性的影响

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中国食品学报 2024年第9期24卷 60-68页

作者：董赵微王岸娜王慧朱俊友河南工业大学粮油食品学院郑州450001

香菇多糖是香菇中主要活性物质,其结构复杂,活性机制尚不明确,因此对香菇多糖的应用具有局限性。采用水提醇沉法制备香菇粗多糖,Sevage法脱蛋白得香菇多糖。利用EDTA-2Na脱除香菇多糖中金属离子,通过刚果红试验、傅里叶红外光谱、原子... 详细信息

香菇多糖是香菇中主要活性物质,其结构复杂,活性机制尚不明确,因此对香菇多糖的应用具有局限性。采用水提醇沉法制备香菇粗多糖,Sevage法脱蛋白得香菇多糖。利用EDTA-2Na脱除香菇多糖中金属离子,通过刚果红试验、傅里叶红外光谱、原子力显微镜试验和DPPH、ABTS、羟基自由基清除试验,以及抑菌试验,比较脱除金属离子前、后香菇多糖结构、抗氧化和抑菌活性的变化。结果表明,脱除金属离子后,香菇多糖三螺旋结构刚性减弱,厚度由1.2 nm降低至0.8 nm;ABTS和羟自由基清除能力下降,而DPPH自由基清除能力增强,当多糖质量浓度为1 mg/mL时,对DPPH、ABTS和羟自由基的清除率分别为94.94%,83.52%和26.52%。抑菌试验表明:脱除金属离子使香菇多糖抑菌作用降低,当多糖质量浓度为40mg/mL时,对大肠杆菌和金黄色葡萄球菌的抑菌圈范围分别由9.50 mm减小至8.30 mm、12.25 mm减小至11.33 mm。金属离子作为香菇多糖主要成分,参与其结构组成,并对香菇多糖活性有重要影响。

关键词：香菇多糖金属离子 AFM 抗氧化抑菌

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胃癌晚期患者CYP3A5^(*)3基因多态性与阿帕替尼单药治疗不良反应的相关性研究

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现代检验医学杂志 2024年第1期39卷 1-4,105页

作者：孟安娜李杨南京医科大学附属南京医院/南京市第一医院药学部南京210006

目的探讨胃癌晚期患者细胞色素P4503A5^(*)3(CYP3A5^(*)3)基因多态性与阿帕替尼单药治疗不良反应的关系。方法选取南京市第一医院2020年1月~2022年6月接受阿帕替尼单药治疗的胃癌晚期患者86例。采集患者2ml外周静脉血,采用限制性片段长... 详细信息

目的探讨胃癌晚期患者细胞色素P4503A5^(*)3(CYP3A5^(*)3)基因多态性与阿帕替尼单药治疗不良反应的关系。方法选取南京市第一医院2020年1月~2022年6月接受阿帕替尼单药治疗的胃癌晚期患者86例。采集患者2ml外周静脉血,采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)联合测序法鉴定患者CYP3A5^(*)3的基因型,分析其与阿帕替尼所致不良反应的相关性。结果86例患者中,突变杂合子型(AG型)29例,突变纯合子型(GG型)51例,突变型占比93.02%。携带CYP3A5^(*)3 GG基因型的患者高血压和白细胞减少的发生率明显高于AA+AG基因型患者(χ^(2)=6.154,6.947,P=0.043,0.027)。阿帕替尼治疗相关的其他不良反应未发现与CYP3A5^(*)3基因型的相关性(P>0.05)。此外,未发现CYP3A5^(*)3基因型与严重不良反应的相关性(P>0.05)。结论CYP3A5^(*)3 GG基因型明显增加阿帕替尼单药治疗所致的高血压和白细胞减少发生风险,未发现其与严重不良反应发生风险的相关性。

关键词：细胞色素P4503A5^(*)3 基因多态性胃癌阿帕替尼不良反应

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《黑骏马》(节选)

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疯狂英语（新读写） 2024年第1期 54-55,77页

作者：安娜·塞维尔不详

作品:本文节选自安娜·塞维尔的《黑骏马》,节选时有删改。小说的主人公黑骏马是一匹漂亮的优种黑马,从小生活在贵族人家,受过良好的训练,性格温顺、善良,而且聪明、机智,主人非常喜欢他。但是好景不长,主人家里有了变故,黑骏马不得不... 详细信息

作品:本文节选自安娜·塞维尔的《黑骏马》,节选时有删改。小说的主人公黑骏马是一匹漂亮的优种黑马,从小生活在贵族人家,受过良好的训练,性格温顺、善良,而且聪明、机智,主人非常喜欢他。但是好景不长,主人家里有了变故,黑骏马不得不被卖掉。

关键词：黑骏马《黑骏马》机智

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Interactions of naturally occurring compounds with antimicrobials

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1452-1470页

作者： Izabela Malczak anna Gajda Department of Pharmacology and Toxicology National Veterinary Research InstitutePartyzantów 5724-100Poland

Antibiotics are among the most often used medications in human healthcare and *** these substances can lead to complications such as increasing antibiotic resistance in bacteria or a toxic effect when administering large *** solve these problems,new solutions in antibacterial therapy are *** use of natural products in medicine has been known for *** of them have antibacterial activity,hence the idea to combine their activity with commercial antibiotics to reduce the latter's *** review presents collected information on natural compounds(terpenes,alkaloids,flavonoids,tannins,sulfoxides,and mycotoxins),of which various drug interactions have been *** of the indicated compounds show synergistic or additive interactions with antibiotics,which suggests their potential for use in antibacterial therapy,reducing the toxicity of the antibiotics used and the risk of further development of bacterial ***,there are also compounds which interact antagonistically,potentially hindering the therapy of bacterial *** on its mechanism of action,each compound can behave differently in combination with different antibiotics and when acting against various bacterial strains.

关键词： Interactions Antimicrobials Natural compounds Antibiotics

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The influence of time and temperature on molecular gut content analysis： Adalia bipunctata fed with Rhopalosiphum padi

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Insect Science 2007年第5期14卷 353-358页

作者： STUART MCMILLAN anna-KARIN KUUSK anna CASSELLUNDHAGEN BARBARA EKBOM Department of Ecology Swedish University of Agricultural Sciences Box 7044 750 07 Uppsala Sweden

Gut content analysis is a useful tool when studying arthropod predator-prey interactions. We used polymerase chain reaction （PCR） technique to examine how detection of prey DNA in the gut content of predators was influenced by digestion time and temperature. Such knowledge is critical before applying PCR-based gut content analysis to field collected predators. Larvae of the two-spotted ladybeetle （Adalia bipunctata L.） were fed with the bird cherry-oat aphid （Rhopalosiphum padi L.） at either 21℃ or 14℃. After consuming one aphid, the predators were allowed to digest the prey for a range of time periods up to 24 hours. The influence of temperature on A. bipunctata feeding behavior was also recorded. From the fed larvae, total DNA was extracted and PCR reactions with R. padi specific primers were run. The number ofA. bipunctata that tested positive for R. padi DNA was negatively related to the length of digestion time. Temperature influenced larval feeding behavior but did not have a significant effect on R. padi DNA detection. After pooling the data from both temperature treatments we estimated the time point when R. padi DNA could be amplified from 50% of the fed A. bipunctata by PCR to be 4.87 hours. With such a rapid decrease in prey DNA detection success, positive PCR reactions will most likely be the result of predation events occurring shortly before capture. If a defined digestion temperature range has proven not to influence prey detection, PCR data obtained from predators collected within that particular range can be interpreted in the same way.

关键词： Adalia bipunctata aphidophagous predator prey DNA detection success gut content analysis PCR Rhopalosiphum padi

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The effect of growth conditions on the relationship between fine root and foliage biomass

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Journal of Forestry Research 2022年第5期33卷 1585-1591页

作者： Yury Karpechko anna Karpechko Andrej Tuyunen Forest Research Institute of the Karelian Research Centre of the Russian Academy of Sciences 11 Pushkinskaya St.PetrozavodskKareliaRussia 185910

This article examines the physiological relationships between fine roots and foliage, and how their biomass ratio correlates with changes in stand quality class. The biomass of fine roots ≤ 3 mm in diameter of spruce stands in the Republic of Karelia (Northwest Russia) was determined by the soil monolith method. Foliage biomass was calculated using a previously designed technique from the standing stock, average height and quality class of the stand. A relation between fine-root: foliage biomass ratio and stand quality class (representing soil fertility) has been established. The closest correlation between fine-root: foliage biomass ratio and stand quality based on soil fertility was for the 1-2 mm root fraction. Analysis of the water flux balance in the trees revealed a correlation between fine-root: foliage ratio and the ratio of the specific volume of transpiration by the stand to the specific volume of water uptake from the soil by roots. Theoretical explanations for the decrease in fine-root: foliage biomass ratios with increasing stand quality class are offered.

关键词： Fine-root biomass Foliage biomass Stand quality class Soil fertility

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