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Core needle biopsy for thyroid nodules assessment-a new horizon?

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World Journal of Clinical Oncology 2024年第5期15卷 580-586页

作者： David D Dolidze Serghei Covantsev Grigorii M Chechenin Natalia V Pichugina Anastasia V Bedina anna Bumbu Department of Clinical Research and Development Botkin HospitalMoscow 125284Russia Department of Surgery Russian Medical Academy of Continuous Professional EducationMoscow 125445Russia Emergency Surgery No.76 Botkin HospitalMoscow 125284Russia Department of Surgery Botkin HospitalMoscow 125284Russia Department of Medical Ultrasonography Botkin HospitalMoscow 125284Russia Medicine Moscow State Medical University I.M.SechenovMoscow 119048Russia Department of Oncology Botkin HospitalMoscow 125284Russia

Ultrasound-guided fine-needle aspiration is the standard for evaluating thyroid nodules with a high safety profile and a relatively low number of non-diagnostic cytological ***,this diagnostic method traditionally has its weak *** diagnostic categories such as BethesdaⅠ,ⅢandⅣare not reliable for thyroid carcinoma risk *** advancements in a core needle biopsy made it possible to use this tool as a new method for thyroid nodules *** main feature of this method is the use of thin needles(18-21G)and guns with an automatic trigger *** histological material collected with the use of a core needle biopsy is usually superior to ***,the core needle biopsy can be used as a complementary technique to a standard fine needle aspiration in difficult and dubious cases of thyroid neoplasia with uncertain malignant potential.

关键词： Core-needle biopsy Thyroid Follicular tumor Fine-needle aspiration Thyroid cancer

Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev anna V.Ruseikina Maxim S.Molokeev Vladimir A.Chernyshev Aleksandr S.Aleksandrovsky Alexander S.Krylov Svetlana N.Krylova Nikolai P.Shestakov Dmitriy A.Velikanov Alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and Educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of EuRECuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

Increasingβ-hexosaminidase A activity using genetically modified mesenchymal stem cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovуeva Shaza S.Issa Aysilu I.Mullagulova Angelina A.Titova Yana O.Mukhamedshina anna V.Timofeeva Alexander M.Aimaletdinov Islam R.Nigmetzyanov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 gangliosidoses are a group of autosomal-recessive lysosomal storage disorde *** diseases result from a deficiency of lysosomal enzymeβ-hexosaminidase A(HexA),which is responsible for GM2 ganglioside *** deficiency causes the accumulation of GM2-gangliosides mainly in the nervous system cells,leading to severe progressive neurodegeneration and *** date,there is no treatment for these ***-mediated gene therapy is considered a promising treatment for GM2 *** study aimed to evaluate the ability of genetically modified mesenchymal stem cells(MSCs-HEXA-HEXB)to restore HexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of MSCs in *** effectiveness of HexA deficiency cross-correction was shown in mutant MSCs upon intera ction with *** results also showed that the MSCs-HEXA-HEXB express the functionally active HexA enzyme,detectable in vivo,and intravenous injection of the cells does not cause an immune response in *** data suggest that genetically modified mesenchymal stem cells have the potentials to treat GM2 gangliosidoses.

关键词： adeno-associated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosaminidase

情境优化、结构重塑与行为纠偏:农村生态河道长效管护的路径突破

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西北农林科技大学学报（社会科学版） 2024年第1期24卷 32-40页

作者：杜春林涂安娜河海大学公共管理学院南京211100

加强农村河湖管理是实施乡村振兴战略的重要任务。在自上而下的政策引导下,各级政府全面推进农村生态河道建设工作。然而,农村生态河道管护是一项长期任务和系统工程。反思既有研究从单一维度分析农村生态河道管护的局限性,在对P镇生态... 详细信息

加强农村河湖管理是实施乡村振兴战略的重要任务。在自上而下的政策引导下,各级政府全面推进农村生态河道建设工作。然而,农村生态河道管护是一项长期任务和系统工程。反思既有研究从单一维度分析农村生态河道管护的局限性,在对P镇生态河道管护的运行逻辑及长效机制分析基础上发现农村生态河道要实现真正意义上的长效管护,必须构建集保障、组织、运行于一体的管护体系,并从情境优化、结构重塑、行动纠偏等三个层面提出相应的治理思路。

关键词：农村生态河道管护多重维度运作逻辑长效机制

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A Case Report of Kissing Molars Class II

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Open Journal of Stomatology 2024年第5期14卷 249-254页

作者： Toshiyuki Inou Keiichi Uchida Keiko Kaneko anna Fuji Nina Wakimoto Tatsuo Takaya Hiroyuki Kitamura Hiroshi Mori Yuji Kurihara Department of Oral Diagnostics and Comprehensive Dentistry Matsumoto Dental University Hospital Shiojiri Japan Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University Shiojiri Japan

Kissing molars (KMs) is a condition of occlusal molar surfaces in a single follicular space with roots extending in opposite directions. Here, we have reported a case of KMs in a 58-year-old woman. The patient complained of pain in the right mandibular molar region and was diagnosed with KMs consisting of the right mandibular second and third molars. Because of the patient’s pain having subsided at the time of the visit and her unwillingness to undergo tooth extraction, the patient was followed up. KMs is classified into three classes (I-III) and is either true-KMs or pseudo-KMs and presents with or without cystic variants of dental follicles. The presents as true-KMs class II without a cystic variant. With reference to the literature and based on our analysis, the mean age of patients affected by this specific case of KMs is 31.7 years and unilateral KMs is relatively more common (85.7%). Histopathological findings of dentigerous cysts are more often indicated (42.9%). The treatment policy for KMs should therefore be based on the classification of KMs. Importantly, the focus should be on preserving the first and second molars as much as possible. The treatment approach, such as the employment of surgical removal or orthodontics, should be determined by considering the associated factors such as the crowns, tissues, and age of the patient.

关键词： Kissing Molars Mandibular Second Molar Mandibular Third Molar Cone-Beam Computed Tomography

考虑投入产出的常规公交调度绩效回溯性动态评价

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同济大学学报（自然科学版） 2024年第5期52卷 778-787,821页

作者：吴娇蓉田子立刘安娜同济大学道路与交通工程教育部重点实验室上海201804 同济大学城市交通研究院上海201804 湖南省邵阳市邵阳县黄荆乡人民政府湖南邵阳422118

实时调度因其灵活性在公交运营组织中发挥着重要决策作用。现行调度(员)绩效评价虽然能够考核行车计划执行情况,却忽略了在乘客体验和企业投入产出层面对调度效果考查,也不支持回溯过往调度实施效果。为使调度员能够精准提升调度技能和... 详细信息

实时调度因其灵活性在公交运营组织中发挥着重要决策作用。现行调度(员)绩效评价虽然能够考核行车计划执行情况,却忽略了在乘客体验和企业投入产出层面对调度效果考查,也不支持回溯过往调度实施效果。为使调度员能够精准提升调度技能和绩效、解决调度决策滞后造成的运能浪费等问题并提高乘客满意度,从投入产出及回溯性动态评价2个维度提出基于三阶段Super-SBM(super-efficiency slack-based measurement)模型的常规公交调度绩效评价方法,考虑路况及客流对调度效果的影响,在现行指标基础上从乘客角度增加运营速度、候车时间变化率及满载率标准差3项产出指标,构建评价体系。对2条上海公交线路的实际调度进行回溯性评价,验证了本文评价方法能准确区分调度效果差异。结果表明,高峰时段灵活的调度策略比在平峰能产生更明显的效益,且调度策略在不同时空场景呈现差异化适用性。通过回溯分析历史调度记录的绩效,一方面可以针对各场景为调度员提供调度决策支持,另一方面可为基于机器学习的公交实时调度策略生成技术挑选合适的学习样本,从而提升常规公交运营组织效率。

关键词：交通工程公交调度回溯性动态评价投入产出三阶段Super-SBM模型

Evaluation of a complex couplet care intervention in a neonatal intensive care unit:A mixed methods study protocol

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Pediatric Investigation 2024年第2期8卷 139-148页

作者： Michella Bjerregaard anna Axelin Emma Louise Malchau Carlsen Hans Okkels Birk Ingrid Poulsen Patrick Palisz Thomas Kallemose Anne Brødsgaard Department of Paediatric and Adolescent Medicine Copenhagen University Hospital Amager HvidovreHvidovreDenmark Department of Public Health Faculty of HealthResearch Unit for Nursing and HealthcareUniversity of AarhusAarhusDenmark Department of Nursing Science University of TurkuTurkuFinland Department of Clinical Medicine Faculty of Health and Medical ScienceUniversity of CopenhagenCopenhagenDenmark Department of Public Health Section of Health Service ResearchUniversity of CopenhagenCopenhagenDenmark Department of People and Technology Roskilde UniversityRoskildeDenmark Department of Clinical Research Copenhagen University Hospital Amager HvidovreHvidovreDenmark Department of Gynaecology and Obstetrics Copenhagen University Hospital Amager HvidovreHvidovreDenmark

Background:Families with an infant in need of intensive care most often experience a harmful separation after *** is due to a division of medical specialties into neonatal care and maternal ***,a couplet care intervention is implemented for mother-infant dyads in a neonatal intensive care *** study protocol provides a comprehensive evaluation of the *** aim is to evaluate the effect and implementation of a complex couplet care intervention to promote zero separation between mother and ***:The couplet care intervention is a family-centered model of care,where treatment-requiring mother-infant dyads will be admitted together and receive couplet care by neonatal *** study adheres to the framework of the Medical Research Council and will use a mixed methods embedded design comprising a quasi-experimental trial and a qualitative process ***,a health economic evaluation will be conducted to assess the cost-effectiveness of this complex couplet care ***:Separation of mother-infant dyads after birth has an adverse impact on family health and *** study protocol evaluates a complex couplet care *** this study,a first step is taken to help bridge the gap between current practices and a new care model to prevent the separation of mothers and their infants.

关键词： Complex interventions Couplet care Family-centered care Neonatology Zero separation

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木筏

世界建筑 2024年第1期 34-35页

作者：无 anna Katrine Tan(摄影) 母卓尔(译) Coquille工作室 Tan&Blixenkrone工作室不详

“木筏”是哥本哈根运河的一座浮动平台上的感官装置,旨在为游客提供直接、有趣的水上感官体验。“木筏”的设计受到海洋动物的启发,并结合了帆船的几何形式和技术,用彩色屋顶来体现水的运动,仿佛创造出一个河边的“动物”。港口生活定... 详细信息

“木筏”是哥本哈根运河的一座浮动平台上的感官装置,旨在为游客提供直接、有趣的水上感官体验。“木筏”的设计受到海洋动物的启发,并结合了帆船的几何形式和技术,用彩色屋顶来体现水的运动,仿佛创造出一个河边的“动物”。港口生活定义了哥本哈根这座城市的身份和传统。在这个运河上的装置中,参观者被邀请去耐心观察和感受周围的环境,并在此过程中了解海平面上升给沿海城市及居民带来的挑战,以及全球变暖导致的海洋生物多样性危机。

关键词：几何形式浮动平台海洋生物多样性哥本哈根海洋动物感官体验全球变暖海平面上升

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应对TikTok美国国会思路是否狭隘

商业周刊（中文版） 2024年第6期 14-16页

作者： anna Edgerton Alex Barinka 程玺(译) 不详

3月13日,美国众议院通过了一项可能会在美国封禁视频分享应用TikTok的法案,这是该国迄今在社交媒体时代采取的最激进的立法举措之一。许多持反对意见的议员希望拓宽思维。“我们需要通过有意义的保护言论自由的监管来解决所有社交网络... 详细信息

3月13日,美国众议院通过了一项可能会在美国封禁视频分享应用TikTok的法案,这是该国迄今在社交媒体时代采取的最激进的立法举措之一。许多持反对意见的议员希望拓宽思维。“我们需要通过有意义的保护言论自由的监管来解决所有社交网络的数据隐私问题,包括Meta和X等美国公司,”对该法案投下反对票的威斯康星州民主党众议员马克.波坎(Mark Pocan)在X上发帖表示,“而不只是针对一个平台。”

关键词：美国国会威斯康星州言论自由数据隐私美国众议院社交网络社交媒体时代视频分享