检索结果-南通市图书馆

World Journal of Gastroenterology 2014年第22期20卷 6774-6785页

作者： Marco Scarpa Ignazio Castagliuolo Carlo Castoro anna pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman Surgical Oncology Unit Veneto Institute of Oncology (IOV-IRCCS)35128 PadovaItaly Department of Molecular Medicine University of Padova35128 PadovaItaly Department of Surgery Gastroenterology and OncologyUniversity of Padova35128 PadovaItaly

Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic ***-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal *** fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite *** of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory ***,p53 is frequently mutated in the early stages of UC-associated *** is an independentrisk factor for forthcoming carcinogenesis in *** cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis.

关键词： Colorectal cancer Ulcerative colitis Carci-nogenes

Treatment Sequencing Strategies in Lung Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国肺癌杂志 2022年第5期25卷 323-336页

作者： Daniel Humberto pozza Ramon Bezerra Andrade de Mello Department of Biomedicine Faculty of Medicine and i3sUniversity of Porto4200-319 PortoPortugal Discipline of Medical Oncology Post-graduation Program in MedicineNine of July University(UNINOVE)São PauloBrazil./Nine of July HospitalSão PauloBrazi

Background and objective The advances in the lung cancer screening methods and therapeutics,together with awareness towards deleterious habits,such as smoking,is increasing the overall survival with better quality of life for the ***,lung cancer is still one of the most common and fatal neoplasm with a high incidence and consequently burden to public health ***,based on guidelines and recent phasesⅡandⅢclinical trials studies,this manuscript summarizes the current treatment sequencing strategies in lung *** A comprehensive search of related articles was performed focused on phasesⅡandⅢclinical trials *** The lung cancer management should take into consideration the tumor characteristics,histology,molecular pathology and be discussed in a multidisciplinary *** cancer treatment options comprises surgery whenever possible,radiotherapy associate with/or chemotherapy and immunotherapy as monotherapy,or combined with chemotherapy and best palliative *** The screening predictability in more patients,smoking reduction,early diagnosis,better disease understanding and individualized,more effective and tolerable therapeutics are related to an increasing in overall survival and quality of *** the near future improvement of personalized therapy in precision medicine is expected,enhancing new predictive biomarkers,optimal doses and optimal treatment sequencing as well as anti-cancer vaccines development.

关键词： Lung neoplasms Immunotherapy Clinical trials Targeted therapies Pembrolizumab Nivolumab Atezolizumab Necitumumab Brigatinib

Prevalence of Bicuspid Aortic Valve in Turner Syndrome Patients Receiving Cardiac MRI and CT: A Meta-Analysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Congenital Heart Disease 2022年第2期17卷 129-140页

作者： Pengzhu Li Martina Bacova Robert Dalla-pozza Nikolaus Alexander Haas Felix Sebastian Oberhoffer Department of Pediatric Cardiology and Intensive Care Medical Hospital of the University of MunichLudwig Maximilians University MunichMunichGermany

Turner syndrome(TS)is a rare disorder affecting 25–50 in 100000 female *** aortic valve(BAV)is assumed to be the most common congenital heart defect(CHD)in *** literature,reported BAV prevalence in TS ranges between 14%and 34%.The specific BAV prevalence in TS is still *** aim of this study was to give a more precise estimation of BAV prevalence in TS by conducting a meta-analysis of TS-studies,which detected BAV by either cardiac magnetic resonance imaging(MRI)or cardiac computed tomography(CT).We searched PubMed,Cochrane Library,and Web of Science databases to collect observational studies including the prevalence of BAV identified by cardiac MRI or cardiac CT in TS patients up to June 4th,*** screening for inclusion,data extraction,and quality assessment by two independent reviewers,the meta-analysis was performed with R 4.1.1 *** are shown as proportion and weighted mean difference with 95%confidence intervals(95%CI).In total,11 studies involving 1177 patients were *** data showed that the prevalence of BAV in TS patients was 23.7%(95%CI:21.3%to 26.1%).No high heterogeneity was found between the included *** current meta-analysis reveals that BAVcan be detected in 23.7%of TS patients receiving cardiac MRI or cardiac ***,BAV can be considered as the most common CHD in *** to TTE,cardiac MRI and cardiac CT might represent superior imaging modalities in BAV assessment of adult TS patients.

关键词： Turner syndrome bicuspid aortic valve magnetic resonance imaging(MRI) tomography X-ray computed(CT)

Pancreatic resection in very elderly patients:A critical analysis of existing evidence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2017年第1期9卷 30-36页

作者： Cosimo Sperti Lucia Moletta Gioia pozza Department of Surgery Oncology and Gastroenterology3~(rd)Surgical ClinicUniversity of Padua35128 PaduaItaly

The aging of the population results in a rise of number of elderly patients(aged 80 years and older) with pancreatic or periampullary cancer, and more pancreatectomies could eventually be performed in such complex patients. However, early and long-term results after pancreatic resection in octogenarians are still controversial, and may trouble the surgeon when approaching this type of population. Evaluation of reported experiences shows that for almost all Authors, pancreatectomy can be performed safely in elderly population, although overall morbidity and mortality rates were 34.9% and 13.2% respectively, with a mean length of hospital stay of 18 d. These features appear higher in older patients compared to the younger counterpart. Less than 50% of patients underwent adjuvant therapy after operation. Long-term survival is reported not significantly different in aged 80 years and older patients, with a median overall survival time of 17.6 mo. The quality of life after pancreatic resection is only sporadically evaluated but, when considered, it highlights the need of health facility service after operation for these "frail" patients. Prospective studies on the quality of life of pancreatectomized octogenarians are welcome. Proper selection of patients, geriatric assessment with multidisciplinary approach, centralization of pancreatic surgery in high-volume centres and rehabilitation programs after surgery appear to be crucial points in order to improve surgical treatments of pancreatic tumors in very elderly patients.

关键词：老八十至八十九岁 Pancreatectomy 胰腺的瘤幸存

Diagnosis of pervasive developmental disorders:when and how?An area-based study about health care providers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2015年第1期11卷 48-53页

作者： Silvia Manea Laura VisonàDalla pozza Monica Mazzucato Oliviana Gelasio Paola Facchin Veneto Region Child&Mother Health Observatory Epidemiology and Community Medicine UnitDepartment of PediatricsPadua University

Background:Pervasive developmental disorders(PDDs)can be very difficult to diagnose in children and to communicate such a diagnosis to their *** of children with PDD learn of their child's diagnosis long after the first symptoms are noted in the child's ***:An area-based survey was conducted to assess all social and health care providers taking care of patients with PDDs in the Veneto Region(North-East Italy).Results:Only 28%of health care providers arrived at a definite diagnosis when the child was in his/her first year of age,51%when the child was 2-3 years old and 21%from age of 4 years and *** average,the latency between the time of the diagnosis and its communication to the family was 6.9 ***,a number of families did not ever have a diagnosis communicated to ***,68%of the providers did not communicate a PDDs diagnosis to patient's families,and 4%of them quite ***:The well-known delay in making a diagnosis of PDDs has two distinct components:one relating to the difficulty of confirming a diagnosis of PDDs,the other,hitherto unrecognized,relating to the family being notified.

关键词： autism,pervasive development disorders classification system communication diagnosis

Hypercalcaemia after treatment with denosumab in children:bisphosphonates as an option for therapy and prevention?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2020年第5期16卷 520-527页

作者： Carmen Sydlik Hans Roland Dürr Susanne Bechtold-Dalla pozza Claudia Weiβenbacher Julia Roeb Heinrich Schmidt Department of Pediatric Endocrinology Dr.v.Haunersches Children's HospitalLudwig-Maximilian-University of MunichLindwurmstr.480337 MunichGermany Department of Orthopaedics Physical Medicine and RehabilitationUniversity HospitalLudwig-Maximilian-University of MunichMunichGermany

Background Pharmacologic options for treatment of osteolytic diseases especially in children are *** not licensed for use,denosumab,a fully humanized antibody to RANKL,is used in children with good *** others,one possible indication are giant cell tumors and aneurysmatic bone ***,there are reports of severe hypercalcemia during weeks to months after termination of denosumab,that are rarely seen in *** We collected data of four patients,aged 6-17 years,who experienced severe hypercalcemia after completion of treatment with denosumab for unresectable giant cell tumors of bone or aneurysmal bone cysts and methods of their *** detailed case information were *** One patient was treated with long-term,high-dose steroid therapy,leading to typical Cushing's *** patient was restarted on denosumab repeatedly due to relapses of hypercalcemia after every ***,in two patients,hypercalcemia ceased definitely after treatment with ***,several applications were necessary to stabilize calcium *** There is a considerable risk of hypercalcemia as an adverse effect after denosumab treatment in *** and,preferably,preventive strategies are *** seem to be an option for both,but effective proceedings still remain to be established.

关键词： Aneurysmatic bone cyst Bisphosphonates Calcium homeostasis Denosumab Giant cell tumor of the bone

Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第24期23卷 4399-4406页

作者： Cosimo Sperti Mario Gruppo Stella Blandamura Michele Valmasoni Gioia pozza Nicola Passuello Valentina Beltrame Lucia Moletta Departments of Surgery Oncology and Gastroenterology3rd Surgical ClinicUniversity of Padua Departments of Medicine section of PathologyUniversity of Padua

AIM To analyze the importance of para-aortic node status in a series of patients who underwent pancreaticoduodenectomy(PD)in a single *** Between January 2000 and December 2012,151patients underwent PD with para-aortic node dissection for pancreatic adenocarcinoma in our *** were divided into two groups:patients with negative PALNs(PALNs-),and patients with metastatic PALNs(PALNs+).Pathologic factors,including stage,nodal status,number of positive nodes and lymph node ratio,invasion of para-aortic nodes,tumor’s grading,and radicality of resection were studied by univariate and multivariate *** curves were constructed with Kaplan-Meier method and compared with Log-rank test:significance was considered as P<*** A total of 107 patients(74%)had nodal *** number of pathologically assessed lymph nodes was 26(range 14-63).Twenty-five patients(16.5%) had para-aortic lymph node ***-three patients(23%)underwent R1 pancreatic *** forty-one patients recurred and died for tumor recurrence,one is alive with recurrence,and 9 are alive and free of *** survival was significantly influenced by grading(P=0.0001),radicality of resection(P=0.001),stage(P=0.03),lymph node status(P=0.04),para-aortic nodes metastases(P=0.02).Multivariate analysis showed that grading was an independent prognostic factor for overall survival(P=0.0001),while grading(P=0.0001)and radicality of resection(P=0.01)were prognostic parameters for disease-free *** of metastatic nodes,node ratio,and para-aortic nodes involvement were not independent predictors of disease-free and overall *** In this experience,lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis,but they were not independent prognostic factors.

关键词： Lymphadenectomy 胰胰腺的癌症 Pancreatectomy 淋巴节点转移帕拉大动脉的节点幸存

pregnane X receptor and constitutive androstane receptor modulate differently CYp3A-mediated metabolism in earlyand late-stage cholestasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第42期23卷 7519-7530页

作者： Daniela Gabbia Arianna Dalla pozza Laura Albertoni Roberta Lazzari Giorgia Zigiotto Maria Carrara Vincenzo Baldo Tatjana Baldovin annarosa Floreani Sara De Martin Department of Pharmaceutical and Pharmacological Sciences University of Padova Department of Medicine General Pathology and Cytopathology UnitUniversity of Padova Department of Cardiac Thoracicand Vascular SciencesHygiene and Public Health UnitUniversity of Padova Department of Surgery Oncology and GastroenterologyUniversity of Padova

AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive androstane receptor(CAR).METHODS Cholestasis was induced by bile duct ligation in 16 male Wistar rats; whereas 8 sham-operated rats were used as controls. Severity of cholestasis was assessed on histological examination of liver sections, and serum concentrations of albumin, AST, ALT, GGT, ALPK and bilirubin. Gene and protein expressions of PXR, CAR, CYP3 A1 and CYP3 A2 were assessed by means of q RT-PCR and Western blot, respectively. Alterations in CYP3 A activity were measured by calculating the kinetic parameters of 4-OH and 1'-OH-midazolam hydroxylation, marker reactions for CYP3 A *** The m RNA and protein expression of CYP3 A1 increased significantly in mild cholestasis(P < 0.01). At variance, m RNA and protein expression of CYP3 A2 didn't change in mild cholestasis, whereas the expression and activity of both CYP3 A1 and CYP3 A2 decreased dramatically when cholestasis became severe. Consistently with these observations, the nuclear expression of both PXR and CAR, which was measured because they both translocate into the cell nucleus after their activation, virtually disappeared in the late stage of cholestatic injury, after an initial increase. These results indicate that early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently, probably as consequence of the different activation of PXR and *** Early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently. PXR and CAR might be targeted therapeutically to promote CYP3 Amediated liver detoxification.

关键词： Cholestasis CYP3A Drug metabolism Pregnane X receptor Constitutive androstane receptor

Effects of percutaneous varicocele repair on testicular volume:results from a 12-month follow-up

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2019年第4期21卷 408-412页

作者： Andrea Sansone Danilo Alunni Fegatelli Carlotta pozza Giorgio Fattorini Rosa Lauretta Marianna Minnetti Francesco Romanelli Pierleone Lucatelli Mario Corona Mario Bezzi Francesco Lombardo Andrea Lenzi Daniele Gianfrilli Departme nt of Experime ntal Medici ne Sa pie nza Un iversity of Rome Rome 00161 Italy Department of Public Health and In fectious Diseases Sapienza University of Rome Rome 00161 Italy Unit of Endocrinology Regina Elena National Cancer Institute Rome 00144 Italy Vascular and Interventional Radiology Unit Department of Radiological Oncological and Anatomo-Pathological Sciences Sapienza-University of Rome Rome 00161 Italy

Varicocele is a comm on fin ding in men. Varicocele correcti on has bee n advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular "catch-up growth" in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml;P= 0.032). Repeated measures mixed models showed a sign ifica nt in teraction betwee n LTH and time posttreatme nt when correcting for baseli ne left testicular volume (β= 0.114, 95% confidence interval [Cl]: 0.018-0.210, P=0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% Cl: 0.221- 2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% Cl:-0.135--0.009;P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implicati ons of these findings n eed to be confirmed in Ion ger and larger prospective studies.

关键词： catch-up growth percutaneous treatment testicular hypotrophy testicular ultrasound testicular volume varicocele young adults

Mitochondrial uncoupling protein 2 and pancreatic cancer:A new potential target therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第11期21卷 3232-3238页

作者： Massimo Donadelli Ilaria Dando Elisa Dalla pozza Marta Palmieri Department of Life and Reproduction Sciences Biochemistry SectionUniversity of Verona

Overall 5-years survival of pancreatic cancer patients is nearly 5%,making this cancer type one of the most lethal ***,the incidence rate of pancreatic cancer has a growing trend that determines a constant increase in the number of deceases caused by this *** poor prognosis of pancreatic cancer is mainly caused by delayed diagnosis,early metastasis of tumor,and resistance to almost all tested cytotoxic *** this respect,the identification of novel potential targets for new and efficient therapies should be strongly encouraged in order to improve the clinical management of pancreatic *** studies have shown that the mitochondrial uncoupling protein 2(UCP2) is over-expressed in pancreatic cancer as compared to adjacent normal *** addition,recent discoveries established a key role of UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions and in the promotion of cancer cell metabolic reprogramming,including aerobic glycolysis stimulation,promotion of cancer *** observations together with the demonstration that UCP2 repression can synergize with standard chemotherapy to inhibit pancreatic cancer cell growth provide the molecular rationale to consider UCP2 as a potential therapeutic target for pancreatic *** this editorial,recent advances describing the relationship between cancer development and mitochondrial UCP2 activity are critically provided.

关键词： Uncoupling protein 2 Target therapy Reactive oxyge