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Oxytocin but Not Testosterone Modulates Behavioral Patterns in Autism Spectrum Disorders

Open Journal of Medical Psychology 2014年第1期3卷 48-53页

作者： Silvia Lakatosova Sheinberg Nurit pivovarciova anna Husarova Veronika Rozenfeld Irina Ostatnikova Daniela Castejon Ana Maria College of Osteopathic Medicine Nova Southeastern University Fort Lauderdale USA College of Pharmacy Nova Southeastern University Fort Lauderdale USA Institute of Physiology Comenius University in Bratislava Bratislava Slovakia Mailman Segal Center Nova Southeastern University Fort Lauderdale USA

Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown etiology. Social deficits represent one of the core symptoms of the diagnosis. The aim was to reveal possible correlations among peripheral levels of oxytocin and testosterone with behavioral and symptom characteristics in patients with ASD. 8 children with ASD were recruited and underwent psychological profiling. Blood oxytocin and testosterone levels were analyzed using ELISA method. Oxytocin levels positively correlated with Adaptation to change category of CARS-2 (P = 0.008, R = 0.848) and Vineland-II maladaptive behavior scores (P = 0.004, R = 0.884). No significant correlations were found among testosterone levels and behavioral parameters. Higher oxytocin levels were connected with more severe adaptive behavior in ASD patients. Increased oxytocin levels in children with more severe phenotype could be a result of compensatory mechanism of impaired oxytocin signaling. Oxytocin seems to employ distinct mechanisms in regulating social behavior in autism and healthy population.

关键词： Autism Oxytocin Testosterone Maladaptive Behavior

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Brief report: Plasma oxytocin is lower in children with Asperger syndrome and associated with autistic trait attention to detail

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Open Journal of Psychiatry 2013年第4期3卷 399-402页

作者： Veronika Husarova Silvia Lakatosova anna pivovarciova Jan Bakos Jaroslava Durdiakova Aneta Kubranska Daniela Ostatnikova 1Institute of Physiology Medical Faculty Comenius University Bratislava Slovakia Institute of Physiology Medical Faculty Comenius University Bratislava Slovakia

Aim: Autism spectrum disorders (ASD) are described as a continuum of severity gradient of autistic symptoms diffusing through particular ASD diagnoses, however the biological correlates among individuals with the different ASD diagnoses slightly or considerably differ. Oxytocin (OT) has been implicated to play an important role in autism etiology. Lower OT levels have been previously found in children with infantile autism, however in a group of high-functioning autistic subjects, no differences have been shown compared to controls. Moreover, whereas the opposite patterns of OT associations with social measures have been found in children with infantile autism compared to healthy children, no associations have been found in individuals with high-functioning autism. We aimed to find out the plasma OT differences between separate group of children with Asperger syndrome (AS) and healthy children and the associations of OT with particular autistic traits in a group of children with AS. Methods: We included 9 children (m = 6, f = 3) with AS at the age 9 to 12 years and 9 age- and gender-matched controls. OT levels were analyzed by ELISA method. Autistic traits in children with AS were evaluated by Autism Spectrum Quotient (AQ), child and adolescent versions. Results: Children with AS had significantly lower plasma OT levels compared to healthy children. We found the significant negative correlation of OT level and AQ Attention to detail area score. Conclusion: In spite of the lower OT level in children with AS, which is also previously found in children with infantile autism, the pattern of OT associations with autistic traits more resembles the pattern in non-autistic population. Our preliminary results support the hypothesis of continuum within the ASD particular diagnoses in the terms of biological correlates.

关键词： Oxytocin Asperger Syndrome Autism Spectrum Quotient

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