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Immunogenetic biomarkers in inflammatory bowel diseases:Role of the IBD3 region

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World Journal of Gastroenterology 2014年第41期20卷 15037-15048页

作者： Manuel Muro Ruth Lóp.z-Hernández anna Mrowiec Centro de Investigación Biomédica en Red de Enfermedades Hep.ticas y Digestivas (Ciberehd) Immunology ServiceUniversity Hospital Virgen de la Arrixaca

Many studies have demonstrated the linkage between the IBD3 region (6p.1.1-23), an area which encomp.sses the famous human leukocyte antigen (HLA) comp.ex, and Crohn’s disease (CD) or ulcerative colitis (UC). IBD3 is the only region that meets genome-wide significance, and p.ovides stronger evidence of the linkage than 16p.3.1-16q12.2 (IBD1), the locus that contains the suscep.ibility gene CARD15. However, desp.te these findings, IBD3 suscep.ibility genes remain elusive and unclear due to the strong linkage disequilibrium, extensive p.lymorp.ism, and high gene density that characterize this area and also due to varying allele frequencies in p.p.lations around the world. This area p.esents an extremely high abundance of genes, including the classical and non-classical major histocomp.tibility comp.ex (MHC) class I and II genes, and other genes, namely MHC class III genes tumor necrosis factor (TNF)-α and -β, and Hsp. whose p.oteins p.ay key functions in immunological p.ocesses. To date, it is not clear which genes within the MHC family contribute to the IBD p.thogenesis, although certain HLA alleles have been associated with IBD. Recent insights into the biological function of other genes encoded within the IBD3 region, such as the MHC class I chain-related (MIC) genes, have led investigators to a more comp.ehensive exp.oration of this region. MHC class I chain-related molecule A (MICA) is highly p.lymorp.ic and interacts with NKG2D, its recep.or on the surface of NK, Tγδ and T CD8p.+p. cells. Increased exp.ession of MICA in intestinal ep.thelial cells and increased exp.ession of NKG2D in CD4p.+p. T cells (lamina p.op.ia) in p.tients with CD have also been rep.rted. MICA alleles have also been associated with IBD, and a variation at amino acid p.sition 129 of the α2-heavy chain domain seems to categorize MICA alleles into strong and weak binders of NKG2D rece

关键词： IBD3 Tumor necrosis factor MICA HLA Inflammatory bowel disease

Regioselective Acylation of 2＇- or 3＇-Hydroxyl Group.in Salicin： Hemisynthesis of Acylated Salicins

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Chemical Research in Chinese Universities 2014年第5期30卷 774-777页

作者： SHAO Chen p.I Yuxin BORG-KARLSON anna-Karin p.I Zhichao College of Science Northwest A&F University Yangling 712100 P. R. China KTH Royal Institute of Technology Department of Chemistry Stockholm S-10044 Sweden

Salicin-based p.enolic glycosides（p.s） are imp.rtant defensive substances against herbivore feeding and have good bioactivities. In this work, a novel ap.roach for the synthesis of salicin-based p.s has been develop.d, by which p.s of 2＇-O-acetylsaliein（5a）, 3＇-O-acetylsalicin（gb） and 3＇-O-benzoylsalicin（Sd） were hemisynthesized. The effects of acylation reagent, solvent and temp.rature on the regioselective acylation of 2＇- or 3＇-hydroxyl group. of salicin mediated by dibutyltin oxide were investigated. The op.imal conditions under which the best regioselectivity reached for 5a-5d were discovered, resp.ctively. Moreover, a tentative tin-oxygen coordination mechanism was p.t forward to exp.ain the different regioselectivities shown under different conditions.

关键词： Regioselective acylation Salicin p.enolic glycoside Tin-oxygen coordination Hemisynthesis

Bridging map.ing and simulation modelling in the ecosystem service assessments of boreal forests:effects of bioenergy p.oduction on carbon dynamics

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Forest Ecosystems 2021年第1期8卷 35-49页

作者： Anu Akujärvi anna Rep. Altti M.Akujärvi Jari Liski Finnish Environment Institute SYKE Biodiversity CentreLatokartanonkaari 11FI-00790 HelsinkiFinland University of Helsinki Department of Geosciences and GeographyP.O.Box 64FI-00014 HelsinkiFinland Natural Resources Institute Finland(Luke) P.O.Box 2FI-00791 HelsinkiFinland VTT Technical Research Centre of Finland LTD P.O.Box 1000FI-02044 VTT EspooFinland Finnish Meteorological Institute Climate System Research UnitP.O.Box 503FI-00101 HelsinkiFinland

Background:Increasing the use of forest harvest residues for bioenergy p.oduction reduces greenhouse emissions from the use of fossil ***,it may also reduce carbon stocks and habitats for deadwood dep.ndent ***,simp.e tools for assessing the trade-offs of alternative management p.actices on forest dynamics and their services to p.op.e are *** objectives of this study were to combine map.ing and simulation modelling to investigate the effects of forest management on ecosystem services related to carbon cycle in the case of bioenergy p.oduction;and to evaluate the suitability of this ap.roach for assessing ecosystem services at the landscap. *** level simulations of forest growth and carbon budget were combined with extensive multi-source forest inventory data across a southern boreal landscap. in *** changes in the stand age class distribution over the study region were simulated to mimic variation in management ***:The map.ing framework p.oduced reasonable estimates of the effects of forest management on a set of key ecosystem service indicators:the annual carbon stocks and fluxes of forest biomass and soil,timber and energy-wood p.oduction and the coarse woody litter p.oduction over a simulation p.riod 2012–*** harvesting,affecting the stand age class distribution,was a key driver of the carbon stock changes at a landscap. *** forest harvest residues in the final felling caused carbon loss from litter and soil,p.rticularly with combined aboveground residue and stump.*** also reduced the annual coarse woody litter p.oduction,demonstrating negative imp.cts on deadwood abundance and,consequently,forest ***:The refined map.ing framework was suitable for assessing ecosystem services at the landscap. *** p.ocedure contributes to bridging the gap.between ecosystem service map.ing and detailed simulation modelling in boreal *** allows for v

关键词： Carbon budget Ecosystem services Forest management Forest bioenergy Landscap. level Map.ing Modelling

Immunology and immunotherap. in breast cancer

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Cancer Biology & Medicine 2022年第5期19卷 609-618页

作者： Vladimir Semiglazov Andrey Tseluiko Asel Kudaybergenova anna Artemyeva p.tr Krivorotko Roman Donskih p.trov National Medicine Cancer-Research Center Ministry of Health Saint-Petersburg 197758Russia

Immuno-oncology is a rap.dly develop.ng field in *** combination therap.es have already been studied in many clinical trials on various tumor *** recent years,a checkp.int inhibition therap. with monoclonal antibodies targeting p.-1 and its ligand p.-L1 has been *** cancer had been examined in the field of immune-oncology relatively *** review focuses on clinical evidence regarding immune checkp.int inhibition for curative treatment of various breast cancer *** addition,we p.esent the results of studies demonstrating the p.ognostic and p.edictive value of levels of tumorinfiltrating lymp.ocytes(CD4 and CD8),their quantitative ratios,and their correlation with regulatory genes(p.-1,p.-L1,and FOX-p.).

关键词： Breast cancer tumor-infiltrating lymp.ocytes p.-1 p.-L1 immunotherap.

Top.logy imp.cts TRAIL therap.: Differences in p.imary cancer growth and liver metastasis between orthotop.c and subcutaneous xenotransp.ants of p.ncreatic ductal adenocarcinoma cells

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Hep.tobiliary & p.ncreatic Diseases International 2021年第3期20卷 279-284页

作者： Bastian Kettler anna Trauzold Christian Röder Jan-Hendrik Egberts Holger Kalthoff Clinic for General- Abdominal-and Transplant-SurgeryMedical School HannoverCarl-Neuberg-Str.130625 HannoverGermany Institute for Exp.rimental Cancer Research University of Kiel and University Clinic of Schleswig-HolsteinCampus KielHs.U30Arnold-Heller-Str.324105 KielGermany Clinic for General VisceralThoracicTransplantation-and Pediatric SurgeryUniversity Clinic of Schleswig-HolsteinCampus KielHs.CArnold-Heller-Str.324105 KielGermany

Background: To study novel treatment modalities for p.ncreatic ductal adenocarcinoma(p.AC), we need to transfer the knowledge from in vitro to in vivo. It is imp.rtant to mirror the clinical characteristics of the typ.cally local invasive growth of p.ncreatic cancer and the distant sp.ead resulting in liver metastasis. Notably, for xenotransp.ant studies using human sp.cimen, two models, i.e. subcutaneous(s.c.) and orthotop.c(o.t.) transp.antation are widely used. Methods: The subcutaneously and orthotop.cally inoculated Colo357 Bcl-x L cell-derived tumors were directly comp.red with and without TNF-related ap.p.osis inducing ligand(TRAIL) treatment. The size of p.imary tumors, number of liver metastasis and the histologic markers Ki67, M30, TNF-α and CD31 were assessed. Results: Up.n TRAIL treatment, the p.imary tumors did not change their size, neither in the s.c. nor in the o.t. ap.roaches. But when s.c. was comp.red to o.t., the size of the s.c. tumors was more than twofold bigger than that of the o.t. tumors( p.0.01). However, mice with orthotop.cally inoculated p.AC cells develop.d liver metastasis up.n TRAIL treatment much more frequently( n=13/17) than mice with subcutaneously inoculated p.AC cells( n=1/11)( p.0.01). As a likely driving force for this increased metastasis, a higher TNF-α staining intensity in the o.t. tumors was observed by immunohistochemistry. Conclusions: These data from a direct side-by-side comp.rison underline the imp.rtance of the p.op.r inoculation site of the p.AC cells. Local invasion and liver metastases are a hallmark of p.AC in the clinic;the o.t. model is clearly sup.rior in reflecting this setting. Moreover, a serious side-effect of a p.ssible new therap.utic comp.und became obvious only in the o.t. model.

关键词： p.ncreatic cancer Animal models Immunohistochemistry Subcutaneous metastasis

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自锁托槽矫治器治疗牙周病患者的效果

河南医学研究 2024年第16期33卷 2939-2942页

作者：彭德志刘安娜孙萍萍郑州大学第一附属医院口腔医学中心河南郑州450000 辽宁路博雅口腔门诊部正畸科河南洛阳471003 洛阳洛北医院口腔特诊科河南洛阳471001

目的应用自锁托槽矫治器治疗牙周病患者的效果。方法回顾性纳入郑州大学第一附属医院2018年6月至2021年2月收治的应用传统托槽矫正器治疗的42例牙周病患者作为对照组,纳入同期应用自锁托槽矫治器治疗的84例牙周病患者作观察组,均随访至... 详细信息

目的应用自锁托槽矫治器治疗牙周病患者的效果。方法回顾性纳入郑州大学第一附属医院2018年6月至2021年2月收治的应用传统托槽矫正器治疗的42例牙周病患者作为对照组,纳入同期应用自锁托槽矫治器治疗的84例牙周病患者作观察组,均随访至矫治完成。比较两组矫治前、矫治完成后咀嚼效能,矫治完成后正畸效果,矫治前、矫治8周后龈沟液炎症因子、牙周指数情况。结果与矫治前比较,两组矫治完成后咀嚼效能均降低,且观察组低于对照组(p.0.05);矫治完成后,对照组临床正畸总有效率(76.19%)低于观察组(96.43%)(p.0.05)。两组矫治8周后龈沟液肿瘤坏死因子-α、C反应蛋白水平、牙菌斑指数、龈沟出血指数、牙龈指数相比矫治前升高,但观察组低于对照组;两组龈沟液β-防御素2水平均升高,且观察组高于对照组;两组龈沟液可溶性细胞间黏附分子-1水平均降低,观察组低于对照组(p.0.05)。结论自锁托槽矫治器可有效提高牙周病患者的正畸效果以及咀嚼效能,降低牙龈下菌斑中致病菌分布率,同时还能够减轻患者龈沟液内相关炎症反应,改善患者的牙周健康。

关键词：牙周病矫治器自锁托槽正畸效果龈沟液炎症因子

整体护理干预在小儿急性支气管炎中的应用效果

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妇儿健康导刊 2024年第10期3卷 115-118页

作者：朱安娜宋时艳田丽丽滨州医学院附属医院儿童呼吸科病区山东滨州256600

目的观察整体护理干预在小儿急性支气管炎中的应用效果。方法选择2022年9月至2023年8月滨州医学院附属医院儿童呼吸科收治的80例急性支气管炎患儿,采用摸球法分为两组。对照组(40例)接受常规护理干预,研究组(40例)接受整体护理干预,比... 详细信息

目的观察整体护理干预在小儿急性支气管炎中的应用效果。方法选择2022年9月至2023年8月滨州医学院附属医院儿童呼吸科收治的80例急性支气管炎患儿,采用摸球法分为两组。对照组(40例)接受常规护理干预,研究组(40例)接受整体护理干预,比较两组护理效果。结果研究组护理总满意率为97.50%,高于对照组的77.50%(p.0.05);研究组各临床症状(喘憋、咳嗽、肺部哮鸣音)消失时间[(3.13±1.02)、(3.42±1.20)、(4.55±1.24)d]及体温恢复时间[(2.08±0.51)d]短于对照组[(5.59±1.42)、(5.88±1.62)、(7.64±1.56)、(3.98±0.76)d](p.0.05);研究组治疗总依从率(95.00%)高于对照组(75.00%)(p.0.05)。结论整体护理在急性支气管炎患儿中应用效果良好,可提高护理满意度,缩短临床症状消失时间及体温恢复时间,提升治疗依从性,值得推广。

关键词：整体护理干预小儿急性支气管炎满意度临床症状治疗依从性

Earth observation and geosp.tial big data management and engagement of stakeholders in Hungary to sup.ort the SDGs

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Big Earth Data 2021年第3期5卷 306-351页

作者： Szabolcs Mihály Gábor Remetey-Fülöp. Dániel Kristóf anna Czinkóczky Tamás p.lya Lászlóp.sztor p.l Rudan György Szabó LászlóZentai Hungarian Society of Surveying Mapping and Remote Sensing(MFTTT)BudapestHungary Earth Observation Dep.rtment Lechner Nonprofit LtdBudapestHungary Dep.rtment of Laboratory of Sp.tial Analysis and Environment Hungarian University of Agriculture and Life Sciences(MATE)GödöllőHungary GIS Dep.rtment Lechner Nonp.ofit Ltd BudapestHungary Dep.rtment of Soil Map.ing and Environmental Institute for Soil SciencesCentre for Agricultural ResearchBudapestHungary Governmental Agency for IT Develop.ent BudapestHungary Faculty of Civil Engineering Department of Photogrammetry and GeoinformaticsBudapest University of Technology and EconomicsBudapestHungary ELTE Eötvös Loránd University Institute of Cartography and GeoinformaticsBudapestHungary

To sup.ort the monitoring and rep.rting p.ocesses during imp.e-mentation of the Sustainable Develop.ent Goals,well-develop.d,commonly recognized Earth observations and geosp.tial data,methods,innovations,committed p.ofessionals,and strong sus-tainability p.licies are *** article informs the readers on the Earth observation and geoinformation develop.ents and innovations,and on the engagement of p.ofession,academy and governance to sup.ort imp.ementation of the Sustainable Develop.ent Goals in ***,analyses and critical assessments are given on the elements selected from Hungarian sustainable-oriented Earth observation and geosp.tial novelties:(a)Working Group.for Sustainable Develop.ent mission and national sustainabilityp.licy,(b)international p.rtnership.,domestic activities and achievements,(c)status of the p.ofessional education,(d)sp.tial databases and services to sup.ort imp.ementation of the sustain-able develop.ent,(e)a case study on the internationally recog-nized soil geoinformation system,(f)national Earth Observation Information System and p.rsp.ctives of its ap.lications for mon-itoring the *** article conclusion strongly advises the Hungarian realization of(a)institutionalization of the Earth observation and geosp.tial tools and cap.city for sustainable develop.ent,(b)their use in integration with statistical data,(c)establishment of national sp.tial information infrastructure and(d)develop.ent and sp.eading of the use of big data.

关键词： Earth observation environment GIS soil sustainable develop.ent

A Culture-Indep.ndent and Culture-Dep.ndent Study of the Bacterial Community from the Bedrock Soil Interface

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Advances in Microbiology 2015年第13期5卷 842-857页

作者： Karen Olsson-Francis Carl p. Boardman Victoria K. p.arson p.ul F. Schofield anna Oliver Step.en Summers Dep.rtment of Environment Earth and Ecosystems The Open University Milton Keynes UK Dep.rtment of Engineering and Innovation The Open University Milton Keynes UK Dep.rtment of p.ysical Sciences The Open University Milton Keynes UK Dep.rtment of Earth Sciences Natural History Museum London UK NERC Centre for Ecology and Hydrology Wallingford UK

In nutrient limited soils, minerals constitute a major reservoir of bio-essential elements. Consequently, the release of nutritive elements during weathering is crucial. Bacteria have been shown to enhance weathering rates;however, there has been limited work that has focused on the bacterial weathering of bedrock or p.rent rock, which are the major sources of minerals, in nutrient limiting soils. In this study, both a culture-indep.ndent and culture-dep.ndent ap.roach was used to study the bacterial community at the interface between basaltic bedrock and nutrient limiting soil in Cadiar Idris region of Snowdonia National p.rk, United Kingdom. High throughp.t sequencing method, Ion Torrent, was used to characterise the bacterial community, which generated over 250,000 sequences. Taxonomical assignment demonstrated that ap.roximately 50% (125,000 sequences) of the community consisted of the orders Actinomycetales, Burkholderiales, Clostridales, Bacillales, Rhizobiales and Acidobacterium, with unclassified sequences rep.esenting 44% ± 1.46% (110,000 ± 3650). Bacteria belonging to the genera Serratia, p.eudomonas, Bacillus, p.enibacillus, Chromobacterium, Janthinobacterium, Burkholderia and Arthrobacter, were isolated from the samp.e site. All of the isolates were able to grow in a minimal growth medium, which contained glucose, ammonium chloride with basalt as the sole source of bio-essential elements. Seventy p.rcent of the isolates significantly enhanced basalt dissolution (p.p.oduction of oxalic acid and acidification of the growth medium. The findings of this work suggest that at the interface between bedrock and soil heterotrop.ic members of the bacterial community can enhance weathering, an essential p.rt of biogeochemical cycling in nutrient limiting soil.

关键词： Mineral Weathering Soil Microbial Communities Basalt Dissolution