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Laetmonice iocasica ***.,a new polychaete species(Annelida:Aphroditidae)from seamounts in the tropical Western Pacific,with remarks on *** Grube,1877

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Journal of Oceanology and Limnology 2021年第5期39卷 1805-1816页

作者： Xuwen WU Pat HUTCHINGS anna murray Kuidong XU Laboratory of Marine Organism Taxonomy and Phylogeny Shandong Province Key Laboratory of Experimental Marine BiologyInstitute of OceanologyCenter for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Australian Museum Australian Museum Research InstituteSydney NSW 2000Australia Biological Sciences Macquarie UniversityNorth Ryde 2109Australia University of Chinese Academy of Sciences Beijing 100049China

Laetmonice Kinberg,1856 is a remarkable genus characterized by having harpoon notochaetae in the polychaete family *** describe a new species of Laetmonice,Laetmonice iocasica ***.,found from seamounts on the Caroline Ridge in the tropical Western *** new species is readily distinguished from congeners,particularly those distributed in the Indo-Pacific Ocean by possessing45 segments with 18 pairs of elytra,and the tuberculated harpoon notochaetae in the elytrigerous segments,which are replaced by tuberculated notochaetae without recurved fangs on segments 4 and *** iocasica *** closely related to *** Grube,1877,but differs in both morphology and the genetic distance of the mitochondrial cytochrome oxidase subunit I(COI)*** producta Grube,1877 contained five varieties reported in various marine areas,which have been raised to species ***,the records of *** from the Sagami B ay and Suruga B ay in Japan and in the south-eastern Australia remain obscure and probably represent a different *** data indicate that ***,which was originally described from Kerguelen Islands in the Southern Ocean and later commonly found on the Antarctic shelf,is probably distributed only at high latitudes of the Southern Hemisphere.

关键词： Polychaeta taxonomy biodiversity deep-sea

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Expression profiling of putative type 2 diabetes susceptibility genes in human islets and in rat beta cell lines

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Journal of Diabetes Mellitus 2013年第1期3卷 27-32页

作者： Faer Morrison Jonathan Locke anna murray Lorna W. Harries Institute of Biomedical and Clinical Sciences University of Exeter Medical School Exeter UK

Over 50 single nucleotide polymorphisms (SNPs) have been identified by genome wide association studies (GWAS) to be associated with susceptibility to type 2 diabetes (T2D);however the causal gene in most cases is not known. In this study we sought to identify which may be the most likely causal genes at five T2D GWAS loci by measuring their expression in control and T2D islets, as well as observing their regulation by glucose. We measured the expression of ten genes at five loci (CDKN2A/2B, CDC123/CAMK-1D, HHEX/IDE, TSPAN8/LGR5, and DGKB/TMEM 195), in control and human pancreatic islets by real-time PCR. We then measured the expression of these genes in the rodent pancreatic beta cell line INS-1 exposed to 5.6 mmol/l, 11 mmol/l and 28 mmol/l glucose for 48 hours. We found differential expression of the longest isoform of CDKN2B specifically between control and T2D human islets, whereas the shortest isoform of this gene had no expression in islets. Tmem195 was the only gene to show differential expression in response to increasing glycemia in INS-1 cells under the conditions described. Our study is an example of how the differential expression of genes in loci spanning more than one gene can aid identification of the more likely causal gene.

关键词： Human Type 2 Diabetes Islet GWAS Gene Expression

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Management of monogenic diabetes in pregnancy:A narrative review

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World Journal of Diabetes 2024年第1期15卷 15-23页

作者： Mohammad Sadiq Jeeyavudeen Sarah R murray Mark W J Strachan Metabolic Unit Western General HospitalEdinburgh EH42XUUnited Kingdom MRC Centre for Reproductive Health University of Edinburgh Queen’s Medical Research InstituteEdinburgh EH164TJUnited Kingdom

Pregnancy in women with monogenic diabetes is potentially complex,with significant implications for both maternal and fetal *** these,maturity-onset diabetes of the young(MODY)stands out as a prevalent monogenic diabetes subtype frequently encountered in clinical *** subtype of MODY requires a distinct approach tailored to the pregnancy,diverging from management strategies in non-pregnant *** MODY(GCK-MODY)typically does not require treatment outside of pregnancy,but special considerations arise when a woman with GCK-MODY becomes *** glycemic targets in GCK-MODY pregnancies are not exclusively dictated by the maternal/paternal MODY genotype but are also influenced by the genotype of the developing *** pregnancy,the choice between sulfonylurea or insulin for treating hepatocyte nuclear factor 1-alpha(HNF1A)-MODY and HNF4A-MODY depends on the mother’s specific circumstances and the available *** of other rarer MODY subtypes is individu-alized,with decisions made on a case-by-case ***,a collaborative approach involving expert diabetes and obstetric teams is crucial for the compre-hensive management of MODY pregnancies.

关键词： Diabetes Pregnancy Maturity-onset diabetes of the young Insulin Sulphonylurea Glucokinase Hepatocyte nuclear factor 1-alpha,hepatocyte nuclear factor 1-beta,and hepatocyte nuclear factor 4-alpha

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Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post‑weaning period

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1241-1257页

作者： Kayla Law Eduardo Rosa Medina Garcia Chad Hastad Deborah murray Pedro E.Urriola Andres Gomez Department of Animal Science University of Minnesota1364 Eckles AvenueSaint PaulMN 55108USA New Fashion Pork 164 Industrial ParkwayJacksonMN 56143USA

Background Nursery pigs undergo stressors in the post-weaning period that result in production and welfare *** challenges disproportionately impact the offspring of primiparous sows compared to those of mul-tiparous *** is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig ***,the objective of this study was to investigate the effects of maternal parity on sow and offspring microbiomes and the influence of sow parity on pig fecal microbi-ome and performance in response to a prebiotic *** weaning,piglets were allotted into three treat-ment groups:a standard nursery diet including pharmacological doses of Zn and Cu(Con),a group fed a commercial prebiotic only(Preb)based on an Aspergillus oryzae fermentation extract,and a group fed the same prebiotic plus Zn and Cu(Preb+ZnCu).Results Although there were no differences in vaginal microbiome composition between primiparous and mul-tiparous sows,fecal microbiome composition was different(R^(2)=0.02,P=0.03).The fecal microbiomes of primiparous offspring displayed significantly higher bacterial diversity compared to multiparous offspring at d 0 and d 21 post-weaning(P<0.01),with differences in community composition observed at d 21(R^(2)=0.03,P=0.04).When analyzing the effects of maternal parity within each treatment,only the Preb diet triggered significant microbiome distinc-tions between primiparous and multiparous offspring(d 21:R^(2)=0.13,P=0.01;d 42:R^(2)=0.19,P=0.001).Composi-tional differences in pig fecal microbiomes between treatments were observed only at d 21(R^(2)=0.12,P=0.001).Pigs in the Con group gained significantly more weight throughout the nursery period when compared to those in the Preb+ZnCu *** Nursery pig gut microbiome composition was influenced by supplementation with an Aspergillus oryzae fermentation extract,with varying effects on performance

关键词： Aspergillus prebiotic Copper Feed additives Maternal Nursery pig microbiome Parity Swine microbiome Trace minerals Zinc

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Perception of artificial conspecifics by bearded dragons(Pogona vitticeps)

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Integrative Zoology 2019年第2期14卷 214-222页

作者： anna FROHNWIESER Thomas W.PIKE John C.murray anna WILKINSON School of Life Sciences University of LincolnLincolnUK School of Computer Science University of LincolnLincolnUK Wildlife Research Center Kyoto UniversityKyotoJapan

Artificial animals are increasingly used as conspecific stimuli in animal behavior ***,researchers often have an incomplete understanding of how the species under study perceives conspecifics,and,hence,which features are needed for a stimulus to be perceived *** investigate the features that bearded dragons(Pogona vitticeps)attend to,we measured their lateralized eye use when assessing a successive range of *** ranged through several stages of realism in artificial conspecifics,to see how features such as color,the presence of eyes,body shape and motion influence *** found differences in lateralized eye use depending on the sex of the observing bearded dragon and the artificial conspecific,as well as the artificial conspecific’s ***,this approach can inform the design of robotic animals that elicit biologically-meaningful responses in live animals.

关键词： bearded dragons conspecifics lateralized eye use perception

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加拿大央行打响了背离美联储的第一枪

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商业周刊（中文版） 2024年第9期 20-22页

作者： Erik Hertzberg Randy Thanthong-Knight Jay Zhao-murray 杨(译) 不详

加拿大央行行长蒂夫·麦克勒姆明确表示,尽管加元可能面临下行压力,但加拿大的利率政策不需要与美国亦步亦趋。加拿大央行行长蒂夫·麦克勒姆(Tiff Macklem)率先在七国集团(G-7)中降息,他对这一举措的信心,或有助于让其他央行放下心来,... 详细信息

加拿大央行行长蒂夫·麦克勒姆明确表示,尽管加元可能面临下行压力,但加拿大的利率政策不需要与美国亦步亦趋。加拿大央行行长蒂夫·麦克勒姆(Tiff Macklem)率先在七国集团(G-7)中降息,他对这一举措的信心,或有助于让其他央行放下心来,他们也可以在美联储之前降息。

关键词：七国集团克勒姆降息利率政策央行第一枪美联储加拿大

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Competitive effects of humic acid and wastewater on adsorption of Methylene Blue dye by activated carbon and non-imprinted polymers

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Journal of Environmental Sciences 2018年第4期30卷 310-317页

作者： Audrey murray Banu Ormeci Department of Civil and Environmental Engineering Carleton UniversityOttawa ON K1S 5B6 Canada

Natural organic matter（NOM）, present in natural waters and wastewater, decreases adsorption of micropollutants, increasing treatment costs. This research investigated mechanisms of competition for non-imprinted polymers（NIPs） and activated carbon with humic acid and wastewater. Three different types of activated carbons（Norit PAC 200,Darco KB-M, and Darco S-51） were used for comparison with the NIP. The lower surface area and micropore to mesopore ratio of the NIP led to decreased adsorption capacity in comparison to the activated carbons. In addition, experiments were conducted for single-solute adsorption of Methylene Blue（MB） dye, simultaneous adsorption with humic acid and wastewater, and pre-loading with humic acid and wastewater followed by adsorption of MB dye using NIP and Norit PAC 200. Both the NIP and PAC 200 showed significant decreases of 27% for NIP（p = 0.087） and 29% for PAC 200（p = 0.096） during simultaneous exposure to humic acid and MB dye. There was no corresponding decrease for NIP or PAC 200 pre-loaded with humic acid and then exposed to MB. In fact, for PAC 200, the adsorption capacity of the activated carbon increased when it was pre-loaded with humic acid by 39%（p = 0.0005）. For wastewater, the NIP showed no significant increase or decrease in adsorption capacity during either simultaneous exposure or pre-loading. The adsorption capacity of PAC 200 increased by 40%（p = 0.001） for simultaneous exposure to wastewater and MB. Pre-loading with wastewater had no effect on MB adsorption by PAC 200.

关键词： Molecularly imprinted polymer Non-imprinted polymer Water treatment Wastewater treatment Activated carbon Micropollutants Pore-blocking Adsorption

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Use of polymeric sub-micron ion-exchange resins for removal of lead,copper,zinc,and nickel from natural waters

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Journal of Environmental Sciences 2019年第1期31卷 247-254页

作者： Audrey murray Banu ?rmeci Department of Civil and Environmental Engineering Carleton University

This research investigated the removal capacity of polymeric sub-micron ion-exchange resins(SMR) for removal of lead, copper, zinc, and nickel from natural waters in competition with natural organic matter(NOM). Polymeric SMR particles were created and tested to ensure that they were adequately dispersed in the solution. They removed little NOM(10%or less) from river water and wastewater, indicating that competition from NOM was not a major concern. SMR were able to remove 82% ± 0.2% of lead, 46% ± 0.6% of copper, 55% ±20% of zinc, and 17% ± 2% of nickel from river water spiked with 500 μg/L of each. Similarly,in wastewater, they were able to remove 86% ± 0.1% of lead, 38% ± 0.8% of copper, 28% ± 1%of zinc, and 11% ± 1% of nickel.

关键词： Water Wastewater Heavy metals Ion exchange Polymeric submicron resin Natural organic matter (NOM)

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Comparative analyses of current three-dimensional numerical solar wind models

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Science China Earth Sciences 2015年第6期58卷 839-858页

作者： Shi Tsan WU murray DRYER Center for Space Plasma and Aeronomic Research the University of Alabama in Huntsville Space Weather Predictions Center National Weather Service National Oceanic and Atmospheric Administration

We present a comparative study of the most advanced three-dimensional time-dependent numerical simulation models of solar wind. These models can be classified into two categories：（I） theoretical, empirical and numerically based models and （Ⅱ） self-consistent multi-dimensional numerical magnetohydrodynamic （MHD） models. The models of Category I are used to sep- arately describe the solar wind solution in two plasma flows regions： transonic/trans-Alfvrnic and supersonic/super-Alfvenic, respectively. Models of Category II construct a complete, single, numerical solar wind solution through subsonic/sub-Alfvrnic region into supersonic/super-Alfvrnic region. The Wang-Sheeley-Arge （WSA）/ENLIL in CISM is the most successful space weather model that belongs to Category I, and the Block-Adaptive-Tree-Solarwind-Roe-Upwind-Scheme （BATS-R-US） code in SWMF （Space Weather Modeling Framework） and the solar-interplanetary conservative element solution element MHD （SIP-CESE MHD） model in SWIM （Space Weather Integrated Model） are the most commonly-used models that belong to Category II. We review the structures of their frameworks, the main results for solar wind background studies that are essential for solar transient event studies, and discuss the common features and differences between these two categories of solar wind models. Finally, we conclude that the transition of these two categories of models to operational use depends on the availability of computational resources at reasonable cost and point out that the models＇ prediction capabilities may be improved by employing finer computational grids, incorporating more observational data and by adding more physical constraints to the models.

关键词： space weather solar wind models comparative analyses

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TCR-pMHC: may the force be of you?

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Cellular & Molecular Immunology 2021年第7期18卷 1622-1623页

作者： Joseph S.murray Xenolaüs Genetics LLC Los AngelesCA90024USA

Theα/βcomponent of the T-cell antigen receptor(TCR)is a transmembrane heterodimer containing genetically variable(V)domains and constant domains within each polypeptide chain.1 The Vαand Vβdomains bind with a clonally unique(clonotypic)interface angle,2 and the complementary determining regions(CDR1,CDR2,and CDR3)manifest as‘loops’between anti-parallelβ-strands of the overall sandwich ofβ-sheets with a central disulfide *** with immunoglobulins,the CDR1 and CDR2 loops are encoded in the germline via the particular V-region DNA segment involved in the RAG1/RAG2 recombination mechanism responsible for somatic construction,together with the D-and/or J-segment,of the third loop,CDR3.1,3 As shown by multiple solved X-ray crystallography structures,the CDRs contain the closest amino acid(a.a.)contacts with the peptide(p)plus the major histocompatibility complex(MHC)protein(together abbrev.,pMHC)composite *** rigorous selection in the thymus for only those TCRs that should function properly in the particular individual after birth(MHC restriction),4 T cells function clonally as well,i.e.,different T-cell clones display differential responses to not only different pMHC ligands but also perhaps more importantly,to the same pMHC ligands.5,6 A long-standing question is how(not whether)TCR V-domain binding to pMHC is ultimately responsible for such vast biological outcomes as protection *** to infectious diseases,atopy,the onset of autoimmune diseases,and the success of various types of transplantation.

关键词： properly sandwich rigorous

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