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Risk factors in cardiovascular patients:Challenges and opportunities to improve secondary prevention

World Journal of Cardiology 2023年第7期15卷 342-353页

作者： Rahima Gabulova anna marzà-florensa Uzeyir Rahimov Mahluga Isayeva Shahana Alasgarli Afag Musayeva Sona Gahramanova Firdovsi Ibrahimov Farid Aliyev Galib Imanov Rahmana Rasulova Ilonca Vaartjes Kerstin Klipstein-Grobusch Ian Graham Diederick E Grobbee Teaching-Therapeutical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht 3508 GANetherlands Department of Cardiology Baku Medical PlazaBaku AZ1014Azerbaijan Department of CHD and Arrhythmias Scientific-Research Institute of CardiologyBaku AZ1072Azerbaijan Department of Cardiology Central Clinic HospitalBaku AZ1006Azerbaijan Heart Center Baku Health CenterBaku AZ1072Azerbaijan Teaching-Surgical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Public Health Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Cardiology Trinity College DublinDublin Dublin-2Ireland

BACKGROUND Effective management of major cardiovascular risk factors is of great importance to reduce mortality from cardiovascular disease(CVD).The Survey of Risk Factors in Coronary Heart Disease(SURF CHD)II study is a clinical audit of the recording and management of CHD risk *** was developed in collaboration with the European Association of Preventive Cardiology and the European Society of Cardiology(ESC).Previous studies have shown that control of major cardiovascular risk factors in patients with established atherosclerotic CVD is generally *** is a country in the South Caucasus,a region at a very high risk for *** To assess adherence to ESC recommendations for secondary prevention of CVD based on the measurement of both modifiable major risk factors and their therapeutic management in patients with confirmed CHD at different hospitals in Baku(Azerbaijan).METHODS Six tertiary health care centers participated in the SURF CHD II study between 2019 and *** on demographics,risk factors,physical and laboratory data,and medications was collected using a standard questionnaire in consecutive patients aged≥18 years with established CHD during outpatient *** from 687 patients(mean age 59.6±9.58 years;24.9%female)were included in the *** Only 15.1%of participants were involved in cardiac rehabilitation *** rate of uncontrolled risk factors was high:Systolic blood pressure(BP)(SBP)(54.6%),low-density lipoprotein cholesterol(LDL-C)(86.8%),diabetes mellitus(DM)(60.6%),as well as overweight(66.6%)and obesity(25%).In addition,significant differences in the prevalence and control of some risk factors[smoking,body mass index(BMI),waist circumference,blood glucose(BG),and SBP]between female and male participants were *** cardiovascular health index score(CHIS)was calculated from the six risk factors:Non-or ex-smoker,BMI<25 kg/m2,moderate/vigorous physical activity,controlled BP(<140/90 mmHg;140/80 mmHg

关键词： Coronary heart disease Cardiovascular risk factors Secondary prevention Clinical practice guidelines Clinical audit Survey of risk factors

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Plasmonic metal‐organic frameworks

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SmartMat 2021年第4期2卷 446-465页

作者： Guangchao Zheng Isabel Pastoriza‐Santos Jorge Pérez‐Juste Luis M.Liz‐marzán School of Physics and Microelectronics Key Laboratory of Material PhysicsMinistry of EducationZhengzhou UniversityZhengzhouChina CINBIO Universidade de VigoDepartamento de Química FísicaVigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS‐UVIGOVigoSpain CIC biomaGUNE Basque Research and Technology Alliance(BRTA)Donostia‐San SebastianSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain Centro de Investigación Biomédica en Red BioingenieríaBiomateriales y NanomedicinaCIBER‐BBNDonostia‐San SebastiánSpain

Plasmonic metal‐organic frameworks are composite nanoparticles comprising plasmonic metal nanoparticles(NPs)embedded within a metalorganic framework(MOF)*** a result,not only the functionalities of the individual components are retained,but synergistic effects additionally provide improved chemical and physical *** progress in plasmonic MOFs has demonstrated the potential for nanofabrication and various nanotechnology *** challenges toward plasmonic MOFs have been recently addressed,resulting in new opportunities toward practical applications,such as surface‐enhanced Raman scattering,therapy,and *** impact of key parameters(thermodynamic ***)on the synthetic pathways of plasmonic MOFs is reviewed,while providing insight into related progress toward structure‐derived applications.

关键词： catalysis drug delivery metal‐organic frameworks nanocomposites plasmonic metal nanoparticles plasmonic MOFs surface‐enhanced Raman scattering

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Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 430-442页

作者： Akash Srivastava Emanuel Barth Maria A.Ermolaeva Madlen Guenther Christiane Frahm Manja marz Otto W.Witte Hans-Berger Department of Neurology University Hospital JenaFriedrich Schiller University Jena07747 JenaGermany Bioinformatics/High Throughput Analysis Friedrich Schiller University Jena07743 JenaGermany FLI Leibniz Institute for Age Research 07745 JenaGermany

Aging is a complex process that can be characterized by functional and cognitive decline in an individual. Aging can be assessed based on the functional capacity of vital organs and their intricate interactions with one another. Thus, the nature of aging can be described by focusing on a specific organ and an individual itself. However, to fully understand the complexity of aging,one must investigate not only a single tissue or biological process but also its complex interplay and interdependencies with other biological processes. Here, using RNA-seq, we monitored changes in the transcriptome during aging in four tissues(including brain, blood, skin and liver) in mice at9 months, 15 months, and 24 months, with a final evaluation at the very old age of 30 *** identified several genes and processes that were differentially regulated during aging in both tissue-dependent and tissue-independent manners. Most importantly, we found that the electron transport chain(ETC) of mitochondria was similarly affected at the transcriptome level in the four tissues during the aging process. We also identified the liver as the tissue showing the largest variety of differentially expressed genes(DEGs) over time. Lcn2(Lipocalin-2) was found to be similarly regulated among all tissues, and its effect on longevity and survival was validated using its orthologue in Caenorhabditis elegans. Our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue’s specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.

关键词： Aging RNA-seq analysis Inflammaging Electron transport chain Tissue aging

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Cyclicity of the Lower Buntsandstein in the eastern part of the Central European Basin:implications for Early Triassic palaeogeography and for geochronological calibration

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Journal of Palaeogeography 2024年第2期13卷 252-292页

作者： anna Becker Polish Geological Institute-National Research Institute 4 Rakowiecka str.00-975 WarsawPoland

Lower Buntsandstein small—scale cycles recognized in the Central European Basin(CEB) are readily used for astrochronological calibration of the Early Triassic time scales,although they are not well studied *** borehole sections from the eastern part of the CEB,forming a south-north transect perpendicular to the basin axis,were studied in terms to better understand the depositional history of the Lower Buntsandstein developed as the Baltic Formation in the studied Polish part of the *** sedimentary facies were recognized,based on lithological and sedimentological investigations of 655.7 m of drill cores from the Otyń IG 1,Gorzów Wielkopolski IG 1 and Kamień Pomorski IG 1 *** facies can be grouped according to a lithological criterion into facies of predominantly siliciclastic lithology(including 9facies types) and facies of predominantly carbonate lithology(including 2 facies types).Facies analysis allowed to distinguish 8 facies associations of:1) alluvial fan,2) playa,3) sandy-muddy coastal plain,4)embayment and distal delta,5) lagoon,6) sand bars or shoals,7) ooidal shoals or bars,and 8) ***-upward(DC) and shallowing-upward(SC) sedimentary cycles were recognized in parts of the Baltic Formation,with DCs dominating in the southernmost located Otyń IG 1,and SCs dominating in Gorz ow Wielkopolski IG 1,located in the axial part of the *** cycles are very *** statistical significance of the sedimentary cycles is relatively low according to Markov-chain analysis conducted with the phpSedistat software of Stanova et al.(2009).Analysis of small—scale cycles performed on well logs of investigated boreholes and additional boreholes in the vicinity of Otyń IG 1,implementing the earlier study of Becker(2005),showed that the correlation of well-log cycles(GR cycles) and sedimentary cycles is not *** cycles can be roughly correlated with lithological carbonate—siliciclastic cycles(c-s cycles),refle

关键词： Triassic Lower Buntsandstein Cyclicity Central European Basin

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Cornea modelling

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Eye and Vision 2020年第1期7卷 11-25页

作者： anna Pandolfi Department of Civil and Environmental Engineering Politecnico di MilanoPiazza Leonardo da Vinci 3220133 MilanoItaly

Background:Biomechanics introduces numerous technologies to support clinical practice in ophthalmology,with the goal of improving surgical outcomes and to develop new advanced technologies with minimum impact on clinical ***,a few misconceptions on the way that computational methods should be applied to living tissues contributes to a lack of confidence towards computer-based ***:Corneal biomechanics relies on sound theories of mechanics,including concepts of equilibrium,geometrical measurements,and complex material *** peculiarities of biological tissues require the consideration of multi-physics,typical of the eye environment,and to adopt customized geometrical models constructed on the basis of advanced optical imaging and in-vivo ***:Patient-specific models are able to predict the outcomes of refractive surgery and to exploit the results of in-vivo test to characterize the material properties of the corneal ***:Corneal biomechanics can become an important support to clinical practice,provided that methods are based on the actual multi-physics and use customized geometrical and mechanical models.

关键词： Corneal biomechanics Physiologic configuration Tonometry modelling Refractive surgery modelling

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Joint power and spectrum allocation algorithm in cognitive radio networks

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Journal of Systems Engineering and Electronics 2011年第4期22卷 691-701页

作者： anna Auguste Anghuwo Communication Research Center Harbin Institute of Technology

The spectrum sharing problem between primary and cognitive users is mainly investigated. Since the interference for primary users and the total power for cognitive users are constrained, based on the well-known water-filling theorem, a novel one-user water-filling algorithm is proposed, and then the corresponding simulation results are given to analyze the feasibility and validity. After that this algorithm is used to solve the communication utility optimization problem subject to the power constraints in cognitive radio network. First, through the gain to noise ratio for cognitive users, a subcarrier and power allocation algorithm based on the optimal frequency partition is proposed for two cognitive users. Then the spectrum sharing algorithm is extended to multiuser conditions such that the greedy and parallel algorithms are proposed for spectrum sharing. Theory and simulation analysis show that the subcarrier and power allocation algorithms can not only protect the primary users but also effectively solve the spectrum and power allocation problem for cognitive users.

关键词： cognitive radio spectrum sharing water-filling algo-rithm interference constraint communication overhead.

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Plasma-assisted oxidation of benzoic acid

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Frontiers of Chemical Science and Engineering 2020年第4期14卷 513-521页

作者： anna Khlyustova Nikolay Sirotkin Laboratory of Chemistry of Hybrid Nanomaterials and Supermolecular Systems G.A.Krestov Institute of Solution Chemitry of Russian Academy of SciencesIvanovo 153045Russia

Plasma-assisted oxidation of organic com-pounds is one of the developing technologies for wastewater *** effectively accelerate degradation processes due to plasma generated reactive species and ultra-violet *** of BA in aqueous solutions by the atmospheric pressure glow discharge and underwater diaphragm discharge was studied and monitored by fluorescence and spectrophoto-metric *** type and solution pH affect the formation rates of mono-and dihydroxybenzoic *** derivatives were formed only by glow discharge *** yields of hydroxyl radical were estimated on the kinetics data for the hydroxylation of benzoic *** steps of the hydroxylation processes and further oxidation were described.

关键词： atmospheric pressure glow discharge under-water diaphragm discharge oxidation benzoic acid hydroxyl radical

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Each coin has 2 sides: a positive role of alien Potamopyrgus antipodarum (Grey, 1843) snails in reducing the infection of native lymnaeids with trematodes

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Current Zoology 2024年第2期70卷 262-269页

作者： anna Cichy anna Stanicka Elzbieta Zbikowska Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in TorunLwowska 187-100 TorunPoland

The change in the distribution of organisms in freshwater ecosystems due to natural or manmade processes raises the question of the impact of alien species on local *** most studies indicate a negative effect,the positive one is more difficult to discern,espe-cially in multispecies systems,including hosts and *** purpose of the study was to check whether the presence of an alien host,Potamopyrgus antipodarum,reduces the intensity of Echinoparyphium aconiatum metacercariae in a native host,Radix *** additionally tested the impact of water temperature and the biomass of the alien host on the dilution *** experimentally studied(1)the lifespan of echinostome cercariae in different temperatures,(2)the infectivity of cercariae toward the alien host and native host,and(3)the impact of different biomass of the alien host on the intensity of metacercariae in the native *** found that cercarial survival and infectivity were tem-perature ***,cercarial survival decreased with increasing temperature,contrary to cercarial *** cercariae entered the renal cavity of both the native host and alien host,and successfully transformed into *** number of metacercariae in the native host decreased with the increasing biomass of the alien *** results indicate that lymnaeids may benefit from the co-occur-rence with P antipodarum,as the presence of additional hosts of different origins may reduce the prevalence of parasites in native ***,the scale of the dilution effect depends not only on the increased spectrum of susceptible hosts but also on the other variables of the environment,including water temperature and host density.

关键词： biological invasion density dilution effect echinostomes Radix spp. temperature.

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Regulation of Meristem Size by Cytokinin Signaling

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Journal of Integrative Plant Biology 2011年第6期53卷 446-454页

作者： anna Skylar Molecular and Computational Biology University of Southern CaliforniaLos AngelesCA

The plant meristems possess unique features that involve maintaining the stem cell populations while providing cells for continued development. Although both the primary shoot apical meristem （SAM） and the root apical meristem （RAM） are specified during embryogenesis, post-embryonic tissue proliferation is required for their full establishment and maintenance throughout a plants＇ life. The phytohormone cytokinin （CK） interacts with other systemic signals and is a key regulator of meristem size and functions. The SAM and the RAM respond to CK stimulations in different manners： CK promotes tissue proliferation in the SAM through pathways dominated by homeobox transcription factors, including the class I KNOX genes, ST^P, and WUS; and curiously, it favors proliferation at low levels and differentiation at a slightly higher concentration in the RAM instead. Here we review the current understanding of the molecular mechanisms underlying CK actions in regulating meristematic tissue proliferation.

关键词： cytokinin signaling meristem tissue proliferation.

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家族性高胆固醇血症国内外诊疗异同

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中国全科医学 2025年第6期28卷 655-665页

作者：马弘阳岳岸娜孙康云南京医科大学附属苏州市立医院心血管内科江苏省苏州市215000

家族性高胆固醇血症(FH)是一种常见的遗传代谢性疾病,主要特征是低密度脂蛋白胆固醇(LDL-C)异常升高,可表现为角膜弓、黄色瘤等症状。长期高水平的LDL-C会增加动脉粥样硬化性心血管疾病(ASCVD)的风险。FH患者早发ASCVD的风险较高,纯合型... 详细信息

家族性高胆固醇血症(FH)是一种常见的遗传代谢性疾病,主要特征是低密度脂蛋白胆固醇(LDL-C)异常升高,可表现为角膜弓、黄色瘤等症状。长期高水平的LDL-C会增加动脉粥样硬化性心血管疾病(ASCVD)的风险。FH患者早发ASCVD的风险较高,纯合型的FH病情更为严重。全球FH的流行率逐渐受到重视,但诊断和治疗仍存在不足。借着《2023年中国血脂管理指南》的发布,本文主要比较了国内外关于FH筛查、诊断的不同,用于强调筛查血脂情况的重要性,并建议早期识别FH患者。同时,基因检测也被推荐,不仅限于少数基因,还应包含其他相关基因或全基因组检测。此外,本文也比较了不同指南对于FH患者LDL-C控制管理水平的差异,以及对于不同LDL-C划分的ASCVD危险因素新要素;比较了不同指南在饮食、生活方式、药物控制等方面的差别,指出国内外一致认为他汀类药物是主要的降脂药物,联合应用尤为重要,但对于最大剂量后LDL-C控制未达标的患者国际血脂护理指南有一定更新。同时,对于纯合型FH(HoFH)患者,高强度他汀类药物联合其他药物治疗是首选,早期的治疗更为关键,适当提早脂蛋白单采术与前蛋白转换酶枯草溶菌素9(PCSK9)抑制剂的应用有助于降低ASCVD的发病率和死亡率。

关键词：高胆固醇血症分子基础诊断诊疗方案指南差异

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