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In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

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Nano Research 2024年第2期17卷 875-881页

作者： Rossella Labarile Danilo Vona maria Varsalona Matteo Grattieri Melania Reggente Roberto Comparelli Gianluca M.Farinola Fabian Fischer Ardemis A.Boghossian Massimo trotta Istituto per i Processi Chimico Fisici Consiglio Nazionale delle RicercheBari 70126Italy Dipartimento di Chimica Universitàdegli Studi di BariBari 70126Italy Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Institute of Life Technologies HES-SO Valais-Wallis1950 SionSwitzerland Institute for Renewable Energy HES-SO Valais-Wallis1950 SionSwitzerland

Recent advances in coupling light-harvesting microorganisms with electronic components have led to a new generation of biohybrid devices based on microbial *** devices are limited by the poorly conductive interface between phototrophs and synthetic materials that inhibit charge *** study focuses on overcoming this bottleneck through the metabolically-driven encapsulation of photosynthetic cells with a bio-inspired conductive *** of the purple non sulfur bacterium Rhodobacter sphaeroides were coated with a polydopamine(PDA)nanoparticle layer via the self-polymerization of dopamine under anaerobic *** treated cells show preserved light absorption of the photosynthetic pigments in the presence of dopamine concentrations ranging between 0.05–3.5 *** thickness and nanoparticle formation of the membrane-associated PDA matrix were further shown to vary with the dopamine concentrations in this *** to uncoated cells,the encapsulated cells show up to a 20-fold enhancement in transient photocurrent measurements under mediatorless *** biologically synthesized PDA can thus act as a matrix for electronically coupling the light-harvesting metabolisms of cells with conductive surfaces.

关键词： bioelectronics photosynthetic bacteria purple bacteria electron transfer polydopamine biophotovoltaics

CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not

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Cellular & Molecular Immunology 2015年第4期12卷 474-482页

作者： maria Neve Polimeno Caterina Ierano Crescenzo D'Alterio Nunzia Simona Losito maria Napolitano Luigi Portella Giosuè Scognamiglio Fabiana Tatangelo anna maria trotta Steven Curley Susan Costantini Raffaele Liuzzi Francesco Izzo Stefania Scala Oncological Immunology Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"-IRCCS-ITALIA Naples Italy. Pathology Unit Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"-IRCCS-ITALIA Naples Italy. Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston TX USA. CROM-Centro Ricerche Oncologiche Mercogliano Mercogliano (AV) Italy. Institute of Biostructure and Bioimaging (IBB) of the Italian National Research Council Naples Italy. Hepato-Biliary Surgery Unit Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"-IRCCS-ITALIA Naples Italy.

Hepatocellular carcinoma （HCC） is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expression was analyzed by immunohistochemistry in 86 HCC patients （training cohort） and validated in 42 unrelated HCC patients （validation cohort）. CXCR4 levels were low in 22.1% of patients, intermediate in 30.2%, and high in 47.7%, whereas CXCR7 levels were low in 9.3% of patients, intermediate in 44.2% and high in 46.5% of the patients in the training cohort. When correlated to patient outcome, only CXCR4 affected overall survival （P=-O.03）. CXCR4-CXCL12-CXCR7 mRNA levels were examined in 33/86 patients. Interestingly, the common CXCR4-CXCR7 ligand CXCL12 was expressed at significantly lower levels in tumor tissues compared to adjacent normal liver （P=0.032）. The expression and function of CXCR4 and CXCR7 was also analyzed in several human HCC cell lines. CXCR4 was expressed in Huh7, Hep3B, SNU398, SNU449 and SNU475 cells, whereas CXCR7 was expressed in HepG2, Huh7, SNU449 and SNU475 cells. Huh7, SNU449 and SNU475 cells migrated toward CXCL12, and this migration was inhibited by AMD3 lO0/anti-CXCR4 and by CCX771/anti-CXCR7. Moreover, SNU449 and Huh7 cells exhibited matrix invasion in the presence of CXCL12 and CXCL11, a ligand exclusive to CXCR7. In conclusion, CXCR4 affects the prognosis of HCC patients but CXCR7 does not. Therefore, the CXCR4-CXCL12-CXCR7 axis plays a role in the interaction of HCC with the surrounding normal tissue and represents a suitable therapeutic target.

关键词： CXCR4 CXCR7 CXCL12 hepatocellular carcinoma prognosis

Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients:A matter of disease activity?

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World Journal of Gastroenterology 2024年第9期30卷 1132-1142页

作者： Antonietta Gerarda Gravina Iacopo Panarese maria Consiglia trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Hepatogastroenterology Division Department of Precision MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Pathology Division Department of Mental and Physical Health and Preventive MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Experimental Medicine Division of PharmacologyUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Advanced Medical and Surgical Sciences(DAMSS) University of Campania Luigi VanvitelliNaples 80138Italy Department of Pharmacy University of Naples Federico IINaples 80131Italy

BACKGROUND Melanocortin 3 and 5 receptors(i.e.,MC3R and MC5R)belong to the melanocortin ***,data regarding their role in inflammatory bowel diseases(IBD)are currently *** This study aims to ascertain their expression profiles in the colonic mucosa of Crohn’s disease(CD)and ulcerative colitis(UC),aligning them with IBD disease endoscopic and histologic *** Colonic mucosal biopsies from CD/UC patients were sampled,and immunohisto-chemical analyses were conducted to evaluate the expression of MC3R and *** sampling was performed on both traits with endoscopic scores(Mayo endoscopic score and CD endoscopic index of severity)consistent with inflamed mucosa and not consistent with disease activity(i.e.,normal appearing mucosa).RESULTS In both CD and UC inflamed mucosa,MC3R(CD:+7.7 fold vs normal mucosa,P<0.01;UC:+12 fold vs normal mucosa,P<0.01)and MC5R(CD:+5.5 fold vs normal mucosa,P<0.01;UC:+8.1 fold vs normal mucosa,P<0.01)were significantly more expressed compared to normal *** MC3R and MC5R are expressed in the colon of IBD ***,expression may differ according to disease endoscopic activity,with a higher degree of expression in the traits affected by disease activity in both CD and UC,suggesting a potential use of these receptors in IBD pharmacology.

关键词： Melanocortin 3 receptor Melanocortin 5 receptor Ulcerative colitis Crohn's disease Inflammatory bowel disease

Polydopamine-coated photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics

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Nano Research 2024年第2期17卷 866-874页

作者： Melania Reggente Charlotte Roullier Mohammed Mouhib Patricia Brandl Hanxuan Wang Stefano Tacconi Francesco Mura Luciana Dini Rossella Labarile Massimo trotta Fabian Fischer Ardemis A.Boghossian Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Biology and Biotechnology Charles Darwin Sapienza University of RomeRome 00185Italy Research Center on Nanotechnology Applied for Engineering of Sapienza(CNIS) University of Rome SapienzaRome 00185Italy CNR-IPCF Consiglio Nazionale delle Ricerche–Istituto per i Processi Chimico Fisici Bari 70126Italy Institute of Life Technologies HES-SO Valais-WallisSion 1950Switzerland Institute for Renewable Energy HES-SO Valais-WallisSion 1950Switzerland

Living photovoltaics are microbial electrochemical devices that use whole cell–electrode interactions to convert solar energy to *** bottleneck in these technologies is the limited electron transfer between the microbe and the electrode *** study focuses on enhancing this transfer by engineering a polydopamine(PDA)coating on the outer membrane of the photosynthetic microbe Synechocystis *** coating provides a conductive nanoparticle shell to increase electrode adhesion and improve microbial charge extraction.A combination of scanning electron microscopy(SEM),transmission electron microscopy(TEM),UV–Vis absorption,and Raman spectroscopy measurements were used to characterize the nanoparticle shell under various synthesis *** cell viability and activity were further assessed through oxygen evolution,growth curve,and confocal fluorescence microscopy *** results show sustained cell growth and detectable PDA surface coverage under slightly alkaline conditions(pH 7.5)and at low initial dopamine(DA)concentrations(1 mM).The exoelectrogenicity of the cells prepared under these conditions was also characterized through cyclic voltammetry(CV)and chronoamperometry(CA).The measurements show a three-fold enhancement in the photocurrent at an applied bias of 0.3 V(***/AgCl[3 M KCl])compared to non-coated *** study thus lays the framework for engineering the next generation of living photovoltaics with improved performances using biosynthetic electrodes.

关键词： biophotovoltaics bioelectronics photosynthetic bacteria cyanobacteria polydopamine adherence

Contrasting responses of native and alien plant species to soil properties shed new light on the invasion of dune systems

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Journal of Plant Ecology 2020年第6期13卷 667-675页

作者： Stefano Vitti Elisa Pellegrini Valentino Casolo Giacomo trotta Francesco Boscutti Department of Life Sciences University of TriesteVia L.Giorgieri 1034127 TriesteItaly Department of Agricultural FoodEnvironmental and Animal SciencesUniversity of Udinevia delle Scienze 91Udine 33100Italy Department of Biology University of CopenhagenUniversitetsparken 42100 KøbenhavnØDenmark

在陆地生态系统中,沿海沙丘特别容易受到外来植物的入侵。许多研究将沙丘生境的入侵归因于人为因素,但对土壤性质和植物性状在植物入侵中的作用却知之甚少。本研究考察了沙丘系统土壤特征与外来植物入侵的关系,重点研究了土壤养分、土... 详细信息

在陆地生态系统中,沿海沙丘特别容易受到外来植物的入侵。许多研究将沙丘生境的入侵归因于人为因素,但对土壤性质和植物性状在植物入侵中的作用却知之甚少。本研究考察了沙丘系统土壤特征与外来植物入侵的关系,重点研究了土壤养分、土壤盐分和植物功能特征之间的相互作用。研究地点是马拉诺和格拉多泻湖(北亚得里亚海)的沙质堰洲岛。根据沙丘系统生态梯度上的主要生境(前沙丘、后沙丘和盐沼),在10个区域内选择100个地块(4 m×4 m)。在每个地块中记录所有植物物种的发生和丰度,并收集一个土壤核。对每个土壤样品进行土壤质地、电导率(代表土壤盐分)、有机碳和氮含量分析,并与本地和外来植物的种类数和覆盖度相关联。分析外来和本地物种主要的生殖功能和营养功能性状在生境中的变化。研究结果表明,土壤性质对外来物种库和本地物种库的影响不同,与植物整体多样性密切相关。在后沙丘(最易入侵)的生境中,高的土壤导电性限制了外来物种的数量,但土壤有机碳含量随着外来植物丰度的增加而增加,这也表明植物入侵与土壤之间存在潜在的反馈过程。只有在后沙丘生境中,随着环境条件的改善和植物竞争的加剧,本地植物和外来植物的功能性状谱有显著的趋同。本研究结果表明,在恶劣条件下,只有本地特有植物才能茁壮成长,而在中等条件下,土壤特性梯度与植物特性协同作用,抑制/促进外来植物丰富度。

关键词：外来入侵物种功能特性土壤养分植物群落沙丘系统

Effects of dielectric stoichiometry on the photoluminescence properties of encapsulated WSe2 monolayers

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Nano Research 2018年第3期11卷 1399-1414页

作者： Javier Martfn-Sanchez Antonio Mariscal Marta De Luca Aitana Tarazaga Martin-Luengo Georg Gramse Alma Halilovic Rosalia Serna Alberta Bonanni Ilaria Zardo Rinaldo trotta Armando Rastelli Institute of Semiconductor and Solid State Physics Johannes Kepler University Linz Altenbergerstrasse 69 A-4040 Linz Austria Laser Processing Group Instituto de Optica CSIC C/Serrano 121 28006 Madrid Spain Department of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Institute for Biophysics Johannes Kepler University Linz Gruberstrasse 40 A-4020 Linz Austria

Two-dimensional transition metal dichalcogenide semiconductors have emerged as promising candidates for optoelectronic devices with unprecedented properties and ultra-compact footprints. However, the high sensitivity of atomically thin materials to the surrounding dielectric media imposes severe limitations on their practical applicability. Hence, to enable the effective integration of these materials in devices, the development of reliable encapsulation procedures that preserve their physical properties is required. Here, the excitonic photoluminescence （at room temperature and 10 K） is assessed on mechanically exfoliated WSe2 monolayer flakes encapsulated with SiOx and AlxOy layers by means of chemical and physical deposition techniques. Conformal coating on untreated and non- functionalized flakes is successfully achieved by all the techniques examined, with the exception of atomic layer deposition, for which a cluster-like oxide coating is formed. No significant compositional or strain state changes in the flakes are detected upon encapsulation, independently of the technique adopted. Remarkably, our results show that the optical emission of the flakes is strongly influenced by the stoichiometry quality of the encapsulating oxide. When the encapsulation is carried out with slightly sub-stoichiometric oxides, two remarkable phenomena are observed. First, dominant trion （charged exciton） photoluminescence is detected at room temperature, revealing a clear electrical doping of the monolayers. Second, a strong decrease in the optical emission of the monolayers is observed, and attributed to non-radiative recombination processes and/or carrier transfer from the flake to the oxide. Power- and temperature-dependent photoluminescence measurements further confirm that stoichiometric oxides obtained by physical deposition lead to a successful encapsulation, opening a promising route for the development of integrated two-dimensional devices.

关键词： two dimensional (2D)materials dielectric encapsulation transition metaldichalcogenides semiconductors photoluminescence WSe2

Mechanochemical Synthesis and Characterization of Molybdenum Dioxide-Hematite Nanostructures with Different Molarities

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Journal of Minerals and Materials Characterization and Engineering 2018年第6期6卷 587-600页

作者： Matthew Knauss Felicia Tolea Mihaela Valeanu Lucian Diamandescu Richard trotta Kelly Wood Agnieszka Grabias Monica Sorescu Department of Physics Duquesne University Pittsburgh USA Department of Materials Science National Institute of Materials Physics Bucharest-Magurele Romania Department of Materials Science Institute of Electronic Materials Technology Warsaw Poland

xMoO2-(1-x)α-Fe2O3 nanoparticle system with molarities x = 0.1, 0.3, 0.5 and 0.7 was successfully synthesized by mechanochemical activation of MoO2 and α-Fe2O3 mixtures for 0 - 12 hours of ball milling time. X-ray powder diffraction (XRD), Mössbauer spectroscopy and magnetic measurements were used to study the phase evolution of the molybdenum dioxide-hematite nanoparticle system under the mechanochemical activation process. Rietveld refinement of the XRD patterns yielded the values of the crystallite size and lattice parameters as function of milling times and indicated the presence of Mo-substituted hematite and Fe-doped molybdenum dioxide at long milling times. The Mössbauer studies yielded the magnetic hyperfine fields and the relative abundance of a quadrupole-split doublet as function of the milling time for all molar concentrations involved. Recoilless fraction was determined using our dual absorber method and was found to decrease with increasing ball milling time. Magnetic measurements recorded at 5 and 300 K in an applied magnetic field of 50,000 Oe showed the magnetic properties in the antiferromagnetic and canted ferromagnetic states. The Morin transformation was evidenced by zero-field cooling-field cooling (ZFC-FC) measurements in a magnetic field of 200 Oe.

关键词： Milling Spectroscopy Magnetic Properties

Most People Can＇t Live Without High-speed Internet

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英语画刊（高三·社会综合版） 2011年第4期 8-8页

作者： Daniel trotta

评价孕期接种A／H1N1疫苗的安全性：队列研究

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中华预防医学杂志 2015年第3期49卷 201-201页

作者： trotta F Da Cas R Spila Aleqiani S

目的评价孕期接种含佐剂的A／H1N1疫苗（代号MF59）时母亲、胎儿以及新生儿的风险。地点意大利伦巴第（Lombardy）地区单胎妊娠的常住孕妇。参与者所有在2009年10月1日-2010年9月30日间分娩的单胎妊娠孕妇。获取观察对象的A／H1N1疫... 详细信息

目的评价孕期接种含佐剂的A／H1N1疫苗（代号MF59）时母亲、胎儿以及新生儿的风险。地点意大利伦巴第（Lombardy）地区单胎妊娠的常住孕妇。参与者所有在2009年10月1日-2010年9月30日间分娩的单胎妊娠孕妇。获取观察对象的A／H1N1疫苗接种情况、孕期情况以及分娩结局的数据。以倾向性评分分配（propensity score matched analysis）方法分析接种疫苗与未接种疫苗孕妇不良结局的发生风险。

关键词：未接种疫苗接种情况队列研究孕期安全性妊娠孕妇单胎妊娠发生风险