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Does ash dieback affect the reproductive ecology of Fraxinus excelsior L.?

Journal of Forestry Research 2024年第2期35卷 54-69页

作者： anna‑Katharina Eisen Lisa buchner Barbara Fussi Susanne Jochner‑Oette Physical Geography/Landscape Ecology and Sustainable Ecosystem Development Catholic University of Eichstätt-Ingolstadt85072 EichstättGermany Bavarian Office for Forest Genetics(AWG) 83317 TeisendorfGermany

Forest tree species reproduction is a key factor in maintaining the genetic diversity of future generations and the stability of forest *** ongoing ash dieback disease could affect the reproductive ecology of Fraxinus excelsior *** have a major impact on the quantity and quality of pollen and *** this study,we investigated pollen production and viability of pollen and seeds of ash trees with different health status from 2018 to *** were collected from 105 trees(pollen production),pollen from 125 trees(pollen viability),and seeds from 53 trees(seed quality)in two seed orchards and in one floodplain forest in southern *** all parameters were examined at every site every *** average pollen production per tree was estimated at 471.2±647.9 billion pollen *** addition,we found that a high number of inflorescences did not equate to high pollen production per *** production of healthy and diseased trees did not differ significantly,although only 47%of severely diseased male trees(vs.72%for healthy trees)produced *** regards to pollen viability,the TTC test showed an average viability of 73%±17%.Overall,there was a slight tendency for diseased trees to have less viable ***,a significant difference could only be calculated for trees in the floodplain *** percentage of germinable seeds in 2018 was 38%in the floodplain forest and 57%in one of the seed *** percentage of viable seeds(TTC test)ranged from 17 to 22%in the orchards in ***-viable seeds were usually heavily infested by *** general,seed quality was not significantly different between healthy and diseased *** results indicate that ash dieback affects flower formation and pollen viability but not pollen production or seed ***,the fact that hardly any flowering was observed,especially for trees that were seriously affected,suggests a negative effect of ash dieback on reproductive per

关键词： Common ash Seed orchard Floodplain forest Pollen production Viability TTC test Seed stratification Phenology

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建立一个窄带成像分型以减少胃息肉的常规活检

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Gastroenterology Report 2021年第3期9卷 219-225,I0002页

作者： Ivor B.Asztalos Caitlin A.Colling anna m.buchner Vinay Chandrasekhara Department of Pediatrics Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA Department of Internal medicine Massachusetts General HospitalBostonMAUSA Division of Gastroenterology and Hepatology Hospital of the University of PennsylvaniaPhiladelphiaPAUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

背景:上消化道内镜检查时意外发现的胃息肉大多都是低风险的,但目前的指南推荐对所有的胃息肉都进行活检以进行组织病理学分析。我们设计了一个简单的窄带成像(NBI)分型,旨在减少对低危胃息肉的常规活检。方法:筛选出具有组织病理学诊断... 详细信息

背景:上消化道内镜检查时意外发现的胃息肉大多都是低风险的,但目前的指南推荐对所有的胃息肉都进行活检以进行组织病理学分析。我们设计了一个简单的窄带成像(NBI)分型,旨在减少对低危胃息肉的常规活检。方法:筛选出具有组织病理学诊断的73枚息肉,提取其NBI影像和白光影像,进行诊断性队列研究。两名并不清楚息肉性质的内镜医生对每枚息肉的NBI特征进行独立评估,包括颜色、血管模式和表面结构,并将这些特征进行各种组合,从而建立一个分型标准,以鉴别低危息肉(基底腺性或增生性息肉)与高危息肉(腺瘤或腺癌)以及基底腺性息肉(FGP)和非FGP。结果:孤立网状的血管模式和均质或缺失的表面结构可有效鉴别低危与高危胃息肉。将这两个特征相结合来诊断高危息肉,可获得100%的阴性预测值(95%CI:100%-100%),阳性预测值为13.7%(95%CI:2.6%-24.8%),灵敏度和特异度分别为100%(95%CI:100%-100%)和53.7%(95%CI:45.3%-62.0%);可将需要活检的息肉数量减少50%的同时,不会漏掉一例高危息肉。采用孤立网状的血管模式来判断无需活检的FGP,其阴性预测值高达94.9%(95%CI:89.2%-100%),阳性预测值为63.2%(95%CI:47.2%-79.2%),灵敏度和特异度分别为94.8%(95%CI:89.5%-100%)和63.6%(95%CI:51.3%-76.0%)。结论:这项推导性队列研究发现,NBI有助于高危与低危胃息肉的鉴别,从而对减少低危息肉的常规活检。这些结果需要在不同的研究人群中进行验证。

关键词：胃息肉常规活检增生性息肉窄带成像腺性阴性预测值阳性预测值队列研究

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Neurovascular unit on a chip: the relevance and maturity as an advanced in vitro model

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Neural Regeneration Research 2024年第6期19卷 1165-1166页

作者： Sujey Palma-Florez anna Lagunas mònica mir Nanobioengineering Group Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology (BIST) Department of Electronics and Biomedical Engineering University of Barcelona CIBER-BBN ISCIII

The brain is a high-energy demanding organ, consuming around 20% of the metabolic energy generated. To fulfill this demand, cerebral blood flow(CBF) supplies oxygen and glucose continuously through the intricate network of cerebral blood vessels. Although for many years brain activity and blood flow were conceived as independent processes, mRI-based functional brain imaging demonstrated that there is a coupling between them,

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Cyclicity of the Lower Buntsandstein in the eastern part of the Central European Basin:implications for Early Triassic palaeogeography and for geochronological calibration

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Journal of Palaeogeography 2024年第2期13卷 252-292页

作者： anna Becker Polish Geological Institute-National Research Institute 4 Rakowiecka str.00-975 WarsawPoland

Lower Buntsandstein small—scale cycles recognized in the Central European Basin(CEB) are readily used for astrochronological calibration of the Early Triassic time scales,although they are not well studied *** borehole sections from the eastern part of the CEB,forming a south-north transect perpendicular to the basin axis,were studied in terms to better understand the depositional history of the Lower Buntsandstein developed as the Baltic Formation in the studied Polish part of the *** sedimentary facies were recognized,based on lithological and sedimentological investigations of 655.7 m of drill cores from the Otyń IG 1,Gorzów Wielkopolski IG 1 and Kamień Pomorski IG 1 *** facies can be grouped according to a lithological criterion into facies of predominantly siliciclastic lithology(including 9facies types) and facies of predominantly carbonate lithology(including 2 facies types).Facies analysis allowed to distinguish 8 facies associations of:1) alluvial fan,2) playa,3) sandy-muddy coastal plain,4)embayment and distal delta,5) lagoon,6) sand bars or shoals,7) ooidal shoals or bars,and 8) ***-upward(DC) and shallowing-upward(SC) sedimentary cycles were recognized in parts of the Baltic Formation,with DCs dominating in the southernmost located Otyń IG 1,and SCs dominating in Gorz ow Wielkopolski IG 1,located in the axial part of the *** cycles are very *** statistical significance of the sedimentary cycles is relatively low according to markov-chain analysis conducted with the phpSedistat software of Stanova et al.(2009).Analysis of small—scale cycles performed on well logs of investigated boreholes and additional boreholes in the vicinity of Otyń IG 1,implementing the earlier study of Becker(2005),showed that the correlation of well-log cycles(GR cycles) and sedimentary cycles is not *** cycles can be roughly correlated with lithological carbonate—siliciclastic cycles(c-s cycles),refle

关键词： Triassic Lower Buntsandstein Cyclicity Central European Basin

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millimetric devices for nerve stimulation:a promising path towards miniaturization

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Neural Regeneration Research 2024年第8期19卷 1702-1706页

作者： Ryan m.Dorrian anna V.Leonard Antonio Lauto Spinal Cord Injury Research Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerve stimulation is a rapidly developing field,demonstrating positive outcomes across several *** potential benefits,current nerve stimulation devices are large,complicated,and are powered via implanted pulse *** facto rs necessitate invasive surgical implantation and limit potential *** nerve stimulation devices to millimetric sizes would make these interventions less invasive and facilitate broader therapeutic ***,device miniaturization presents a serious engineering *** review presents significant advancements from several groups that have overcome this challenge and developed millimetricsized nerve stimulation *** are based on antennas,mini-coils,magneto-electric and optoelectronic materials,or receive ultrasound *** highlight key design elements,findings from pilot studies,and present several considerations for future applications of these devices.

关键词： biomedical engineering deep brain stimulation electrical engineering electrical stimulation neuromodulation peripheral nerve stimulation

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Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard Reynolds anna m.Barron Chih Hung Lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian School of medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

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Kriging-boosted CR modeling for prompt infill drilling optimization

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Petroleum 2024年第1期10卷 39-48页

作者： Elizaveta S.Gladchenko anna E.Gubanova Denis m.Orlov Dmitry A.Koroteev Skolkovo Institute of Science and Technology Russian Federation Digital Petroleum LLC Russian Federation

The capacitance-resistance model(CRm) has been a useful physics-based tool for obtaining production forecasts for decades. However, the model's limitations make it difficult to work with real field cases,where a lot of various events happen. Such events often include new well commissioning(NWC). We introduce a workflow that combines CRm concepts and kriging into a single tool to handle these types of events during history matching. moreover, it can be used for selecting a new well placement during infill drilling. To make the workflow even more versatile, an improved version of CRm was used. It takes into account wells shut-ins and performed workovers by additional adjustment of the model coefficients. By preliminary re-weighing and interpolating these coefficients using kriging, the coefficients for potential wells can be determined. The approach was validated using both synthetic and real datasets, from which the cases of putting new wells into operation were selected. The workflow allows a fast assessment of future well performance with a minimal set of reservoir data. This way, a lot of well placement scenarios can be considered, and the best ones could be chosen for more detailed studies.

关键词： Capacitance-resistance model (CRm) Field development optimization Infill drilling Interwell connectivity Kriging New well commissioning (NWC)

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methyltransferase-like 3(mETTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-PD1 therapy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： anna Brichkina Roman Suezov magdalena Huber Institute of Systems Immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

In a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase mETTL3 induced a formation of immunostimulatory doublestranded mRNAs(dsRNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of mETTL3 synergized with anti-PD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： PD1 immunity

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A review on transition metal oxides based photocatalysts for degradation of synthetic organic pollutants

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Journal of Environmental Sciences 2024年第5期139卷 389-417页

作者： Athira Krishnan anna Swarnalal Divine Das midhina Krishnan Viswanathan S.Saji SmAShibli Department of Chemistry Amrita Vishwa VidyapeethamAmritapuriKerala690525India Interdisciplinary Research Center for Advanced materials King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Chemistry University of KeralaKariavattom CampusThiruvananthapuramKerala695581India

This review provides insight into the current research trend in transition metal oxides(TmOs)-based photocatalysis in removing the organic colouring matters from *** easy understanding,the research progress has been presented in four generations according to the catalyst composition and mode of application,viz:single component TmOs(the firstgeneration),doped TmOs/binary TmOs/doped binary TmOs(the second-generation),inactive/active support-immobilized TmOs(the third-generation),and ternary/quaternary compositions(the fourth-generation).The first two generations represent suspended catalysts,the third generation is supported catalysts,and the fourth generation can be suspended or *** review provides an elaborated comparison between suspended and supported catalysts,their general/specific requirements,key factors controlling degradation,and the methodologies for performance *** the plausible fundamental and advanced dye degradation mechanisms involved in each generation of catalysts were *** existing challenges in TmOs-based photocatalysis and how the researchers approach the hitch to resolve it effectively are *** research trends are also presented.

关键词： Photocatalysis Dye degradation Transition metal oxides and composites Supported catalysts Suspended catalysts

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Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

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Oncology Research 2024年第7期32卷 1141-1162页

作者： PAULINA CHmIEL ALEKSANDRA SŁOWIKOWSKA ŁUKASZ BANASZEK anna SZUmERA-CIEĆKIEWICZ BARTŁOmIEJ SZOSTAKOWSKI mATEUSZ J.SPAŁEK TOmASZŚWITAJ PIOTR RUTKOWSKI anna m.CZARNECKA Department of Soft Tissue/Bone Sarcoma and melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of medicine Medical University of WarsawWarsaw02-091Poland Department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Department of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂammatory myoﬁbroblastic tumor(ImT)is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic *** challenges arise from the diverse pathological presentation,variable symptomatology,and lack of different imaging ***,ImT is identiﬁed by the fusion of the anaplastic lymphoma kinase(ALK)gene,which is present in approximately 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrmation of the *** surgery is the preferred approach for localized tumors,the optimal long-term treatment for advanced or metastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Administration(FDA)in 2020 to treat ImT with ALK ***,most patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** promising results have also been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations are still *** review analyzes the available research on ImT,including genetic disorders and their impact on the course of the disease,data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication,as well as summarizing general knowledge about prognostic and predictive factors,also in terms of resistance to systemic therapy.

关键词： Inﬂammatory myoﬁbroblastic tumor(ImT) Epithelioid inﬂammatory myoﬁbroblastic sarcoma Tyrosine kinase inhibitors(TKI) Anaplastic lymphoma kinase(ALK)

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