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Cryoglobulinemia in elderly patients with HCV-related chronic hepatitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第2期1卷 72-74页

作者： Francesco Giuseppe Foschi anna chiara dall'aglio Arianna Lanzi Giorgio Marano Sara Savini Pietro Andreone Mauro Bernardi Giuseppe Francesco Stefanini Department of Internal Medicine Faenza Hospital Department of Clinical Medicine Bologna University

Hepatitis C virus(HCV) infection affects about 3% of the world's population and often leads to chronic liver *** some industrialized countries,HCV prevalence increases with age,but the optimal management of older patients has not been accurately *** infection can also lead to lymphoproliferative disorders,the most common being mixed cryoglobulinemia(MC),and also for this condition that frequently affects elderly patients,the optimal therapeutic strategy is still *** report the case of a 77-year-old Caucasian woman with HCV-related chronic hepatitis and cutaneous manifestations consisting of urticaria and pruritus related to MC resistant to *** patient underwent a treatment with interferon and *** a treatment led to early biochemical and virological response associated with the resolution of cryoglobulinemia and cutaneous *** the end of treatment,HCV replication relapsed,but cryoglobulinemia and cutaneous symptoms did not *** the absence of definite treatment guidelines in this particular context,our experience suggests that the presence of symptoms related to HCV-infection that deeply affect patient quality of life warrants antiviral therapy even beyond the age limits that currently exclude patients from treatment.

关键词： Cryoglobulinemia Elderly patients Hepatitis C virus chronic hepatitis Antiviral treatment

Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： Antonio Masone chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Standardization issues in botanicals:A metabolomic and in silico approach to Monascus purpureus food supplements

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Food Bioscience 2022年第6期50卷 1064-1073页

作者： Laura Righetti Luca Dellafiora Enrico Rolli chiara dall’Asta Renato Bruni Dipartimento di Scienze degli Alimenti e del Farmaco University of ParmaParco Area delle Scienze27a43124ParmaItaly Dipartimento di Scienze Chimiche della Vita e della Sostenibilità AmbientaleUniversity of ParmaParco Area delle Scienze11a43124ParmaItaly

A metabolomic strategy was explored to profile 33 Monascus purpureus botanicals,revealing low standardization levels in terms of monacolins and Monascus pigments.A fast and highly accurate screening method was applied by means of UHPLC-TWIMS-QTOF,enabling the monitoring of 36 monacolins and 8 *** confirmed that very different fermentation processes are used for red yeast rice production,resulting in erratic profiles and large variability among ***,minor monacolins represented on average a 37%(range 8–54%)of the sum of monacolins and *** and dihydromonacolins were spanning from 7 to 43%with as many as 26 products containing a relative percentage exceeding 20%.Total pigments average ranged between traces and 65%,with a percentage exceeding 20%in 12 *** silico docking results showed that monacolins other than Monacolin K had lower but not negligeable inhibitory potential for 3-hydroxy-3-methylglutaryl coenzyme A reductase for precise structural *** results confirms that standardization of Monascus purpureus botanicals is dubious and strict quality control must be *** the same time,they reinforce the opportunity to take advantage of new metabolomic tools to properly describe raw materials or food supplements used in investigations and clinical trials,suggesting extensive phytochemical analysis beyond the mere quantification of Monacolin K.

关键词： Food supplements Metabolomics Monacus pigments Monacolins Ion mobility Standardization

Autoimmune hepatitis in genetic syndromes:A literature review

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World Journal of Hepatology 2021年第10期13卷 1328-1340页

作者： anna Paola Capra Emanuele chiara Silvana Briuglia Department of Biomedical DentalMorphological and Functional Imaging SciencesUniversity of MessinaMessina 98100Italy Department of Clinical Pathology University of MessinaMessina 98100Italy

Genetic syndromes represent relevant and rare *** conditions include a large amount of epidemiological,pathogenetic and clinical ***,a systematic approach to genetic syndromes is often prevented by the rareness of these ***,although clinical features are usually precisely defined,nowadays more uncommon associations between genetic syndromes and internal medicine related diseases have been insufficiently *** hepatitis(AIH)is a chronic liver disease caused by loss of tolerance to hepatocyte-specific ***,a better knowledge about specific genetic syndromes in which AIH is more frequent could be important in the clinical management of patients,both for an early diagnosis and for a prompt ***,a systematic approach could explain if onset,clinical course,and response to treatment of AIH are typical for specific genetic *** took in consideration all the scientific articles reported in PubMed in the last 10 years,from 2010 to *** purpose of this review is to explore the prevalence of AIH in genetic syndrome,but also to suggest new classification,that could be useful for pathogenetic hypothesis and clinical approach to genetic *** the 139 publications selected using keywords“autoimmune hepatitis”and“genetic syndrome”,30 papers(21.6%)respected the chosen inclusion criteria,reporting the association between AIH in patients with a genetic *** have collected in all 47 patients with AIH and genetic syndrome,and with median age of *** suggest that when a patient presents a clinical picture of cryptogenic chronic hepatitis,that is unexplained,it is useful to explore differential diagnosis of AIH associated with genetic *** the clinical relevance of this topic,further reports are needed to demonstrate our hypothesis and collect new evidence in this field.

关键词： Autoimmunity Hepatitis Gene Syndrome Liver Disease Immunity

Stem cells, a two-edged sword: Risks and potentials of regenerative medicine

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World Journal of Gastroenterology 2008年第27期14卷 4273-4279页

作者： anna chiara Piscaglia Department of Internal Medicine and Gastroenterology "GI & Liver Stem Cell Research Group" Catholic University of Rome

The recent advancements in stem cell (SC) biology have led to the concept of regenerative medicine, which is based on the potential of SC for therapies aimed to facilitate the repair of degenerating or injured tissues. Nonetheless, prior to large scale clinical appli- cations, critical aspects need to be further addressed, including the long-term safety, tolerability, and efficacy of SC-based treatments. Most problematic among the risks of SC-based therapies, in addition to the pos- sible rejection or loss of function of the infused cells, is their potential neoplastic transformation. Indeed, SCs may be used to cure devastating diseases, but their specific properties of self-renewal and clonogenicity may render them prone to generate cancers. In this respect, ‘Stemness’ might be seen as a two-edged sword, its bright side being represented by normal SCs, its dark side by cancer SCs. A better understand- ing of SC biology will help fulfill the promise of regen- erative medicine aimed at curing human pathologies and fighting cancer from its roots.

关键词： Stem cells Regenerative medicine Gastrointestinal diseases Chronic liver diseases Cell-basedtherapy

Carbon nanostructure morphology templates nanocomposites for phosphoproteomics

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Nano Research 2020年第2期13卷 380-388页

作者： Susy Piovesana Daniel Iglesias Manuel Melle-Franco Slavo Kralj chiara Cavaliere Michele Melchionna Aldo Laganà anna L.Capriotti Silvia Marchesan Piazzale A.Moro 5 Dipartimento di ChimicaSapienza Universitadi RomaRome 00185Italy Via L.Giorgieri 1 Dipartimento di Scienze Chimiche e FarmaceuticheUniversitd di TriesteTrieste 34127Italy CICECO University of AveiroAveiro 3810-193Portugal Jamova 39 Department for Materials SynthesisJozef Stefan InstituteLjubljana 1000Slovenia Via Monteroni Campus Ecotekne CNR NANOTECUniversity of SalentoLecce 73100Italy

Protein and peptide phosphorylation regulate numerous pathological processes,however,their characterization is challenging due to their low abundance and transient ***,nanomaterials are being developed to address this demanding *** particular,carbon nanostructures are attracting interest as scaffolds for functional nanocomposites,yet only isolated studies exist on the topic,and lttle is known on the effect of nanocarbon morphology on templating *** this work,we compared oxidized carbon nanotubes,graphene oxide,oxidized carbon nanohorns and oxidized graphitized carbon black,as scaffolds for magnetized *** nanomaterials were extensively characterized with experimental and in silico ***,they were applied to phosphopeptide enrichment from cancer cell lysates for NanoHPLC-MS/MS,with selectivity as high as nearly 90%and several-thousand identification ***,new insights emerged for the understanding and the design of nanocomposites for phosphoproteomics.

关键词： nanocomposites carbon nanotubes graphene oxide carbon nanohorns proteomics magnetic

2D MXenes as Co-catalysts in Photocatalysis:Synthetic Methods

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Nano-Micro Letters 2019年第4期11卷 403-424页

作者： Yuliang Sun Xing Meng Yohan dall’Agnese Chunxiang dall’Agnese Shengnan Duan Yu Gao Gang Chen Xiao-Feng Wang Key Laboratory of Physics and Technology for Advanced Batteries(Ministry of Education) College of PhysicsJilin UniversityChangchun 130012People’s Republic of China Jilin Key Engineering Laboratory of New Energy Materials and Technologies Jilin UniversityChangchun 130012People’s Republic of China A.J.Drexel Nanomaterials Institute and Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA 19104USA Institute for Materials Discovery Faculty of Maths and Physical SciencesUniversity College LondonLondon WC1E 7JEUK

Since their seminal discovery in 2011,two-dimensional(2D)transition metal carbides/nitrides known as MXenes,that constitute a large family of 2D materials,have been targeted toward various applications due to their outstanding electronic *** functioning as co-catalyst in combination with certain photocatalysts have been applied in photocatalytic systems to enhance photogenerated charge separation,suppress rapid charge recombination,and convert solar energy into chemical energy or use it in the degradation of organic *** photocatalytic performance greatly depends on the composition and morphology of the photocatalyst,which,in turn,are determined by the method of preparation ***,we review the four different synthesis methods(mechanical mixing,self-assembly,in situ decoration,and oxidation)reported for MXenes in view of their application as co-catalyst in *** addition,the working mechanism for MXenes application in photocatalysis is discussed and an outlook for future research is also provided.

关键词： MXenes Photocatalysis Co-catalyst Synthetic methods

Anionic liposomes for small interfering ribonucleic acid （siRNA） delivery to primary neuronal cells： Evaluation of alpha-synuclein knockdown efficacy

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Nano Research 2017年第10期10卷 3496-3508页

作者： Michele Schlich Francesca Longhena Gaia Faustini Caitriona M. O'Driscoll chiara Sinico anna Maria Fadda Arianna Bellucci Francesco Lai Department of Life and Environmental Sciences University of Cagliari Cagliari 09124 Italy Division of Pharmacology Department of Molecular and Translational Medicine University of Brescia Brescia 25123 Italy Pharmacodelivery Group School of Pharmacy University College Cork Cork Ireland

Alpha-synuclein （a-syn） deposition in Lewy bodies （LB） is one of the main neuropathological hallmarks of Parkinson＇s disease （PD）. LB accumulation is considered a causative factor of PD, which suggests that strategies aimed at reducing a-syn levels could be relevant for its treatment. In the present study, we developed novel nanocarriers suitable for systemic delivery of small interfering ribonucleic acid （siRNA） that were specifically designed to reduce neuronal α-syn by RNA interference. Anionic liposomes loaded with an siRNA-protamine complex for α-syn gene silencing and decorated with a rabies virus glycoprotein （RVG）-derived peptide as a targeting agent were prepared. The nanoparticles were characterized for their ability to load, protect, and deliver the functional siRNA to mouse primary hippocampal and cortical neurons as well as their efficiency to induce gene silencing in these cells. Moreover, the nanocarriers were evaluated for their stability in serum. The RVG-decorated liposomes displayed suitable characteristics for future in vivo applications and successfully induced α-syn gene silencing in primary neurons without altering cell viability. Collectively, our results indicate that RVG-decorated liposomes may be an ideal tool for further studies aimed at achieving efficient in vivo α-syn gene silencing in mouse models of PD.

关键词： rabies virus glycoprotein (RVG) peptide liposomes small interfering ribonudeic acid (siRNA) alpha-synuclein primary neuronal cells Parkinson's disease

Female indris determine the rhythmic structure of the song and sustain a higher cost when the chorus size increases

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Current Zoology 2019年第1期65卷 89-97页

作者： chiara De Gregorio anna Zanoli Daria Valente Valeria Torti Giovanna Bonadonna Rose Marie Randrianarison Cristina Giacoma Marco Gamba Dipartimento di Scienze della Vita e Biologia dei Sistemi Universita di Torino via Accademia Albertina Torino Italia Dipartimento di Scienze Chimiche della Vita e della Sostenibilita Ambientale Universita di Parma Parma Italia Group d'Ttude et de Recherche sur les Primates de Madagascar (GERP) Antananarivo Madagascar Departement de Anthropobiologie et Developpement Durable Universite d'Antananarivo Faculte des Sciences Antananarivo Madagascar

Among the behavioral traits shared by some nonhuman primate species and humans there is singing. Unfortunately, our understanding of animals' rhythmic abilities is still in its infancy. Indris are the only lemurs who sing and live in monogamous pairs, usually forming a group with their offspri ng. All adult members of a group usually participate in choruses that are emitted regularly and play a role in advertising territorial occupa ncy and in tergroup spaci ng. Males and females emit phrases that have similar frequency ranges but may differ in their temporal structure. We examined whether the individuals' contribution to the song may change according to chorus size, the total duration of the song or the duration of the individual con tribution using the in ter-on set intervals within a phrase and between phrases. We found that the rhythmic structure of indri's songs depends on factors that are different for males and females. We showed that females have sigrdficantly higher variation in the rhythm of their contribution to the song and that, changes according to chorus size. Our findings indicate that female indris sustain a higher cost of singing than males whe n the nu mber of singers in creases. These results suggest that cross-species investigatio ns will be crucial to un derstanding the evoluti on ary frame in which such sexually dimorphic traits occurred.

关键词： chorus coordination duets lemurs singing synchrony