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Loss-of-function mutations of microRNA-142-3p promote AsH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying tan Li Zhang Wen-Tao Jiang school of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First central clinical school Tianjin Medical UniversityTianjin 300192China

BAcKGROUND Hepatocellular carcinoma(Hcc)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of Hcc are still *** has shown that the microRNA-142-3p level decreases in Hcc,whereas bioinformatics analysis of the cancer genome atlas database shows the AsH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and AsH1L affect the prognosis of Hcc patients and Hcc cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and AsH1L on the Hcc cell bioactivity and prognosis of Hcc *** In this study,we grouped Hcc patients according to their immunohistochemistry results of AsH1L with pathological tissues,and retrospectively analyzed the prognosis of Hcc ***,explored the roles and mechanisms of microRNA-142-3p and AsH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that Hcc patients with high expression of AsH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of Hcc and microRNA-142-3p exhibits reduced expression in Hcc tissues and interacts with AsH1L through targeting the AsH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of Hcc cell lines in vitro via *** the exploration mechanism,we found AsH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p AsH1L Immune evasion Tumor immune microenvironment Apoptosis

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copper-catalyzed c–H bond functionalization enabled by programmed alternating current

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science china chemistry 2025年第1期 10-11页

作者： Zhoumei tan Kun Xu chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in chemistry in 2023 by International Union of Pure and Applied chemistry (IUPAc)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (Dc).

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A case study of Heat Transfer from Hot Runner Mould to the Fix Platen of the Injection-moulding Machine

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厦门大学学报（自然科学版） 2002年第S1期41卷 97-98页

作者： c H tan K s Lee school of Mechanical & Manufacturing Engineering Department of Mechanical Engineering National University of Singapore Singapore Polytec hnic SingaporeSingapore

In an injection moulding process, the parallelism b et ween the tie bars of the injection moulding machine is very important as it will affect the mould closing and clamping system. In recent years, more and more ho t runner systems are being applied in the moulding industry to save material and decrease the losses of injection pressure. Heat transfer from hot runner system from the fixed half which is secured in the fix machine platen could transmit s o much heat that it may cause high temperature differential between the machine fix platen and moving platen. This will cause the tie bar to become unparallel. Part quality will be compromised and the wear of the tie bar will be excessive. Overhaul of the tie bar may be necessary after a short period of time which is c ostly. This raises the need to analyze the heat transfer from the hot runner sys tem to the machine fix platen and the methods of isolating or minimizing the hea t transfer. In this case study, a photo lens article mould was used. The mould w as built with a direct hot runner nozzle system. Heat conduction from hot runner and machine screw to machine fix platen were studied based on either using high temperature heat insulating plate put in placed between the mould and the mould ing machine fix platen or drill cooling channels in the front mould clamping pla te. The high temperature insulator is very costly as it is made out of glass re inforced polymer composite material. Experimental results were obtained and anal yzed to find the best method to minimize the unwanted heat transfer using the ch eapest and most effective method.

关键词： injection moulding cooling hot runner system i njection moulding machine platen tie bar

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structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles

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Progress in Natural science:Materials International 2016年第5期26卷 440-448页

作者： Eric c.Abenojar sameera Wickramasinghe Jesbaniris Bas-concepcion anna cristina s.samia Department of chemistry Case Western Reserve University chemistry Department University of Puerto Rico Rio Piedras Campus

Magnetic iron oxide nanoparticles(IONPs) are heavily explored as diagnostic and therapeutic agents due to their low cost, tunable properties, and biocompatibility. In particular, upon excitation with an alternating current(Ac) magnetic field, the NPs generate localized heat that can be exploited for therapeutic hyperthermia treatment of diseased cells or pathogenic microbes. In this review, we focus on how structural changes and inter-particle interactions affect the heating efficiency of iron oxide-based magnetic NPs. Moreover, we present an overview of the different approaches to evaluate the heating performance of IONPs and introduce a new theranostic modality based on magnetic imaging guided–hyperthermia.

关键词： Iron oxide nanoparticles Magnetic hyperthermia Magneto-structural effects Magnetic dipolar interactions Magnetic imaging guided–hyperthermia

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Advances in centrifugal separators for Particulate Matter control from stationary sources

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Journal of Thermal science 2002年第3期11卷 283-288页

作者： Z.c.tan University of Illinois Urbana USA

This paper summarized recent developments in centrifugal separators for particulate matter (PM) emission control. Airborne particulate matter, which is responsible for many health and environmental problems, is generated mostly from combustion processes in stationary sources such as house burners and power plants and other production facilities, except field dust. Reverse flow cyclones are centrifugal separators having been widely used for industrial particulate matter removal. Typical pressure drops of these cyclones for air cleaning are 500 Pa or higher, and were believed to be only able to separate particles larger than 10 μm. An aerodynamic deduster that could separate particles as small as 1μm at a pressure drop of 200 Pa was recently developed. Field evaluation showed that the deduster can be effectively used in reducing particulate matter emission from stationary sources.

关键词： particulate matter emission control centrifugal separator cyclones aerodynamic deduster particle cut size.

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged fromcells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBAsE,Ovid MEDLINE,Web of science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(sIRT1/P Gc-1α),sIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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synthesis and characterization of cNT/ce-TiO_2 nanocomposite for phenol degradation

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Journal of Rare Earths 2012年第7期30卷 651-658页

作者： shaari N tan s H Mohamed A R school of chemical Engineering Engineering Campus University Sains Malaysia

An innovative photocatalyst, carbon nanotube （cNT） supported ce-TiO2 nanocomposite was successfully synthesized via modi-fied sol gel method and investigated in a batch reactor for abolition of phenol under UV light spectrum. characterization of catalyst micro-structure and internal properties were done by means of X-ray diffraction （XRD）, Brunauer-Emmett-Teller （BET）, scanning electron micros-copy （sEM）, transmission electron microscopy （TEM） and UV-vis diffuse reflectance spectra （DRs）. ce doping can inhibit phase transfor-mation from anatase to rutile and eliminate the recombination of electron-hole pairs in the catalyst. The presence of cNT in TiO2 composite can both increase the photoactivity under UV and change surface properties to achieve sensitivity to visible light. The optimum mass ratio of cNT support and cerium （ce） dopant in TiO2 was the prominent factor to harvest cNT/ce-TiO2 photocatalyst nanocomposite. The results demonstrated that optimum mass ratio of cNT：TiO2：ce was 0.02：1.0：0.06, which resulted in the great performance of the photocatalyst to de-grade about 94% of phenol in a 50 mg/L solution in only 3 h. In this paper, dissimilar role of cNT support and ce dopant in the TiO2 photo-catalysis of phenol was also discussed.

关键词： carbon nanotube (cNT) cerium TiO2 nanocomposite photocatalyst phenol rare earths

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ERROR ANALYsIs OF A sTABILIZED FINITE ELEMENT METHOD FOR THE GENERALIZED sTOKEs PROBLEM

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Journal of computational Mathematics 2020年第2期38卷 254-290页

作者： Huoyuan Duan Roger c.E.tan school of Mathematics and statistics Wuhan UniversityWuhan 430072China Department of Mathematics National University of SingaporeSingapore

This paper is devoted to the establishment of sharper a priori stability and error estimates of a stabilized finite element method proposed by Barrenechea and Valentin for solving the generalized stokes problem,which involves a viscosity v and a reaction consta nt *** the establishmen t of sharper st ability estimates and the help of ad hoc finite element projections,we can explicitly establish the dependence of error bounds of velocity and pressure on the viscosity z/,the reaction constant cr,and the mesh size *** analysis reveals that the viscosity y and the reaction constant a respectively act in the numerator position and the denominator position in the error estimates of velocity and pressure in standard norms without any ***,the stabilization method is indeed suitable for the generalized stokes problem with a small viscosity u and a large reaction constant *** sharper error estimates agree very well with the numerical results.

关键词： Generalized stokes equations stabilized finite element method Error estimates.

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