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The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13

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Cellular & Molecular Immunology 2021年第6期18卷 1512-1527页

作者： Floriana Mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi anna brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter Institute of Medical Microbiology and Hospital Hygiene Otto-von-Guericke University Magdeburg39120MagdeburgGermany Institute of Medical Microbiology and Hospital Epidemiology Hannover Medical School30625HannoverGermany Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical University325035WenzhouChina Department of Neuropathology Faculty of Medicine and University Hospital CologneUniversity of Cologne50931CologneGermany Institute for Experimental Infection Research TWINCORE Centre for Experimental and Clinical Infection Researcha joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research30625HannoverGermany Institute for Clinical Chemistry and Pathobiochemistry Otto-von-Guericke University Magdeburg39120MagdeburgGermany Cluster of Excellence-Resolving Infection Susceptibility(RESIST) Hannover Medical School30625HannoverGermany Department of Molecular Biosciences Stockholm University10691StockholmSweden Institute for Experimental Internal Medicine Otto-von-Guericke University Magdeburg39120MagdeburgGermany

Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to *** of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling ***,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely ***,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide *** of DCs with the TLR11/12 ligand *** profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and ***,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of *** infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic ***,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of *** contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced ***,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases.

关键词： OTUB1 dendritic cell signal transduction ubiquitination innate immunity

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Geographers and sustainability:Five research challenges

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Geography and Sustainability 2022年第1期3卷 68-73页

作者： Stanley D.brunn Department of Geography University of KentuckyLexington 40506-0028USA

Advances in scholarly research are routinely associated with specific fields and traditional *** fields such as sustainability,climate change,gender studies and“green knowledge”emerge with inter-and cross-disciplinary subject matter,methods and *** has emerged as an integrative research field on a global scale not only with contributions from the social and natural sciences in the past two decades but with contributions from the humanities and *** breakthroughs present challenges to traditional fields and opportunities for better understanding of processes and *** challenges facing geography include working with both visible and invisible worlds,going beyond“comfort zone”research boundaries,recognizing the importance of maps and mapping,and integrating politics in sustainability worlds at local,regional and global scales.

关键词： Sustainability Mapping Planet Earth Interdisciplinary research

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Methodology for Road Defect Detection and Administration Based on Mobile Mapping Data

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Computer Modeling in Engineering & Sciences 2021年第10期129卷 207-226页

作者： Marina Davidovic Tatjana Kuzmic Dejan Vasic Valentin Wich Ansgar brunn Vladimir Bulatovic Department for Civil Engineering and Geodesy Faculty of Technical SciencesUniversity of Novi SadNovi Sad21000Serbia University of Applied Sciences Wurzburg-Schweinfurt W urzburg-Schweinfurt97070Germany

A detailed inspection of roads requires highly detailed spatial data with sufficient precision to deliver an accurate geometry and to describe road defects *** paper presents a novel method for the detection of road *** input data for road defect detection included point clouds and orthomosaics gathered by mobile mapping *** defects were categorized in three major groups with the following geometric primitives:points,lines and *** method suggests the detection of point objects from matched point clouds,panoramic images and ortho *** were mapped as point,line or polygon geometries,directly derived from orthomosaics and panoramic *** the geometric position of road defects,all objects were assigned to a variety of attributes:defect type,surface material,center-of-gravity,area,length,corresponding image of the defect and degree of damage.A spatial dataset comprising defect values with a matching data type was created to perform the attribute analysis quickly and *** final product is a spatial vector data set,consisting of points,lines and polygons,which contains attributes with further information and *** paper demonstrates that mobile mapping suits a large-scale feature extraction of road infrastructure *** its simplicity and flexibility,the presented methodology allows it to be easily adapted to extract further feature types with their *** makes the proposed approach a vital tool for data extraction settings with multiple mobile mapping data analysts,e.g.,offline crowdsourcing.

关键词： Deformation detection engineering visual inspection data analyses mobile mapping GIS

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Compiling and Mapping an International Climate Change Database: Worlds of Gaps and Unevenness

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Natural Resources 2023年第3期14卷 27-44页

作者： Stanley D. brunn Department of Geography University of Kentucky Lexington Kentucky USA

Daily and weekly reporting events of climate change and impacts on populations, cultures, economies and politics at local, national, regional and international scales suggest the need to construct databases that will be useful in future scientific inquiry and global human/environmental policies. That need is evident in constructing a geographic or locational knowledge base that examines countries, regions and cities. This study constructs a database on the impacts of climate change using Google Scholar entries for 200 countries and capital cities. A series of maps reveal the vast unevenness in the database, especially between Global North and Global South countries. The discussion explores these sharp differences and suggests future research topics for much-needed global, interdisciplinary and international research.

关键词： Climate Change Maps Capital Cities Knowledge Gaps Climate Impacts Global Climate

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A Geopolitical and Geovisualization Challenge: Increasing the Awareness of Global Environmental Change through Postage Stamp Issues

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Natural Resources 2017年第3期8卷 130-158页

作者： Stanley D. brunn Department of Geography University of Kentucky Lexington KY USA

Global environmental change is one of the major distinguishing features associated with the contemporary world political map. It is significant not only because it illustrates the intersections between geopolitics and environmental change, but also because identifying the major environmental features and solving existing and future problems are primarily political in nature. Key features of global environmental change include global warming impacts on the poleward shifts in biodiversity and agricultural patterns, rising sea levels and human adjustments, changing coastal habitats, and promoting increased environmental awareness especially in urban clusters, where most people live. In the contemporary geopolitical and environmental world, visualization is a key feature not only used to inform both planetary inhabitants, environmental organizations and governments, but also serves as an effective policy, that is, to “show” or demonstrate effective changes and the need for action. States are key institutions in this thinking as they can both inform and address the impacts of global environmental change through various images: maps, earth-based photographs, satellite coverage, websites and educational venues including curriculum content and stamps. Visual geopolitics is already recognized as being an important source influencing public opinion, as evidenced in the attractive visible layouts, graphics, colors, often “seductive” designing of official websites. Postage stamps is an additional important and “informing” visible way that states inform both insiders and outsiders about how they “see” their place in the world. They also provide a view into how a state sees its “own” place in the world of environmental change and how it sees “the world beyond its own borders”. I introduce the concept of “visual geopolitics” and use recent postage stamp issues about global environmental change from a number of countries to illustrate how they are informing views of their own and t

关键词： Global Environmental Change Environmental Awareness Geovisualization Geopolitics Postage Stamps Planetary Futures

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Small fiber neuropathy

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中华物理医学与康复杂志 2018年第7期 554-554页

作者： Flossdorf P Haupt WF brunn A

BACKGROUND AND OBJECTIVE Small fiber neuropathy(SFN)is characterized by the dysfunction of small-caliber sensory and/or autonomic nerve *** small fibers can be affected in several pathological conditions,it is thought that SFN may represent an early stage of other *** study was designed to better understand the clinical course of idiopathic SFN.

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抛石结构的稳定性和易损性

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水运工程 1983年第2期 10-15页

作者： Per brunn 李棣荣

为了保持稳定,受波浪冲击的抛石堤必须满足整体和单个块体的稳定性要求。当抛石结构主要由天然块石构成时,结构整体稳定性和单个块体抵抗移动的稳定性是最有意义的。然而,采用混凝土块体尚应注意其结

关键词：抛石防波堤块体波浪作用堤心防浪墙石堤易损性

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抛石防波堤的稳定性和脆性

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中国港湾建设 1983年第1期 48-50页

作者： Per brunn 李德镍

前言在1981年11月出版的“船坞港口管理”(The Dock Harbour Authority)杂志上,发表了Whilloch的“对抛石防波堤的评价”一文。回顾了抛石防波堤的发展情况,概述了迄今所取得的一些经验,特别指出:Hudson公式没有考虑到波浪周期对护面块... 详细信息

前言在1981年11月出版的“船坞港口管理”(The Dock Harbour Authority)杂志上,发表了Whilloch的“对抛石防波堤的评价”一文。回顾了抛石防波堤的发展情况,概述了迄今所取得的一些经验,特别指出:Hudson公式没有考虑到波浪周期对护面块体稳定重量的影响。这对于形状简单的块体,关

关键词：抛石防波堤护面块体波浪作用

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