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Optical tug-of-war tweezers:shaping light for dynamic control of bacterial cells(Invited Paper)

Chinese Optics Letters 2017年第9期15卷 37-40页

作者： Joshua Lamstein anna bezryadina Daryl Preece Joseph C. Chen Zhigang Chen Department of Physics and Astronomy San Francisco State University San Francisco California 94132 USA Department of Electrical and Computer Engineering University of California San Diego La Jolla California 92093 USA Department of NanoEngineering University of California San Diego La Jolla California 92093 USA Department of Biology San Francisco State University San Francisco California 94132 USA The MOE Key Laboratory of Weak-Light Nonlinear Photonics and TEDA Applied Physical Institute and School of Physics Nankai University Tianjin 300457 China

We design and demonstrate new types of optical tweezers with lateral pulling forces that allow full control of biological samples with complex geometric shapes. With appropriate beam shaping, the dual tug-of-war tweezers effectively hold and stretch elongated biological objects of different sizes, and the triangular tug-of-war tweezers with threefold rotational symmetry steadily hold asymmetric objects in the plane of observation and exert stretching forces along three directions. We successfully apply these tweezers to manipulate microparticles and bacterial cells in aqueous media.

关键词： Beam shaping Cylindrical lenses Optical trapping Optical tweezers Propagation methods Spatial light modulators

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Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions

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Light(Science & Applications) 2019年第1期8卷 927-935页

作者： Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang anna bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen Department of Physics and Astronomy San Francisco State UniversitySan FranciscoCA 94132USA Department of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37240USA MOE Key Lab of Weak-Light Nonlinear Photonics TEDA Applied Physics Institute and School of PhysicsNankai UniversityTianjin 300457China Guangxi Key Lab for Relativistic Astrophysics Guangxi Colleges and Universities Key Lab of Novel Energy Materials and Related TechnologySchool of Physical Science and TechnologyGuangxi UniversityNanningGuangxi 530004China Department of Physics and Astronomy California State University NorthridgeNorthridgeCA 91330USA Institut National de la Recherche Scientifique Universite du QuebecVarennesQC J3X 1S2Canada Department of Physics Chemistry and BiologyLinkoping UniversityLinkoping SE-58183Sweden School of Mathematical and Physical Sciences University of SussexSussex HouseFalmerBrighton BN19RHUK Department of Biomedical Engineering University of California IrvineIrvineCAUSA Clinical Laboratory Science Program San Francisco State UniversitySan FranciscoCA 94132USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Tech.of ChinaChengdu 610054China ITMO University Saint Petersburg 197101Russia

Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis.

关键词： nonlinearity suspensions nonlinear

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Optical disassembly of cellular clusters by tunable ‘tug-of-war’ tweezers

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Light(Science & Applications) 2016年第1期5卷 444-450页

作者： anna S bezryadina Daryl C Preece Joseph C Chen Zhigang Chen Department of Physics and Astronomy San Francisco State UniversitySan FranciscoCA 94132USA School of Mathematics and Physics The University of QueenslandBrisbaneQLD 4072Australia Department of NanoEngineering University of CaliforniaSan DiegoLa JollaCA 92093USA Department of Biology San Francisco State UniversitySan FranciscoCA 94132USA The MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Applied Physical Institute and School of PhysicsNankai UniversityTianjin 300457China

Bacterial biofilms underlie many persistent infections,posing major hurdles in antibiotic treatment.Here we design and demonstrate‘tug-of-war’optical tweezers that can facilitate the assessment of cell–cell adhesion—a key contributing factor to biofilm development,thanks to the combined actions of optical scattering and gradient forces.With a customized optical landscape distinct from that of conventional tweezers,not only can such‘tug-of-war’tweezers stably trap and stretch a rod-shaped bacterium in the observing plane,but,more importantly,they can also impose a tunable lateral force that pulls apart cellular clusters without any tethering or mechanical movement.As a proof of principle,we examined a Sinorhizobium meliloti strain that forms robust biofilms and found that the strength of intercellular adhesion depends on the growth medium.This technique may herald new photonic tools for optical manipulation and biofilm study,as well as other biological applications.

关键词： bacterial adhesion biofilm optical forces optical manipulation tug-of-war optical tweezers

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