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Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer

World Journal of Gastrointestinal Oncology 2019年第2期11卷 117-138页

作者： anna Maria Berghella anna aureli Angelica Canossi Tiziana Del Beato Alessia Colanardi Patrizia Pellegrini Istituto di Farmacologia Traslazionale Consiglio Nazionale delle Ricerche

BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical *** To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer *** A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumornode-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131 H/R and FcγRIIIa-158 V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze *** study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems".RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth factor beta(TGFβ) with Trx1, whereas males had one with TGFβ and RTrx1. Trx1/CD30 controls the redox immune homeostasis, and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor. This event happens through different gender-specific cytokine pathways. Our study demonstrated that the serum levels ofTrx1/RTrx1, TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγ and IL2 combination constitute a predictive gender specific biomarker system. This is relevant for clinical screening to detect the risk of the potential development or progression of a *** Oxidative stress on Trx1/CD30 is a trigger of cancer disease, and the selected oxid

关键词： Aging and cancer biomarker Cancer personalized treatments Oxidation and immune biomarkers Trx1/CD30 target KIRs and FcγR polymorphisms Th cytokines Aging and disease Cancer-related mechanisms

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Determination of the standardized ileal digestible calcium requirement of Ross broilers from hatch to day 14 post-hatch

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Animal Nutrition 2024年第1期16卷 122-129页

作者： Carrie L.Walk Raffaella aureli Pauline Jenn DSM Nutritional Products Delves RoadHeanorDerbyshireDE757SGUnited Kingdom Research Center for Animal Nutrition and Health DSM Nutritional ProductsVillage-Neuf68128France

An experiment was conducted to determine the standardized ileal digestible(SID)calcium requirement of fast-growing broilers from hatch to d 14 *** 308(n=360)male broilers were obtained on day of hatch and allocated to 1 of 5 treatments in battery *** were 6 birds per cage and 12 pens per *** treatments were formulated to contain 0.60%,0.46%,0.32%or 0.18%SID *** final treatment was formulated using total Ca to meet or exceed all nutrient requirements,including 0.90%total Ca and 0.49%non-phytate P(nPP),using the same *** treatment was the reference diet for comparison and validation of the SID Ca *** and feed were weighed at placement and on d *** and ileal contents were obtained on d 14 and excreta was collected per pen and pooled on d *** were analyzed using JMP Pro and requirements were estimated using 3different non-linear regression *** the SID Ca content in the diet from 0.18%to 0.60%improved(quadratic,P<0.05)body weight gain and mortality corrected feed conversion ratio(mFCR).The estimated SID Ca requirement to optimize gain or m FCR was between 0.39%and 0.52%.Tibia ash percent and weight increased(quadratic,P<0.05)as SID Ca content in the diet increased and the estimated SID Ca requirement was between 0.32%and 0.58%.Phosphorus utilization was improved in birds fed diets formulated using SID Ca compared with birds fed the reference *** conclusion,the SID Ca requirement of fast-growing broilers from hatch to d 14 was estimated between 0.534%and 0.398%when quadratic,straight-broken line,or quadratic-broken line regressions were *** results agree with previously published data evaluating the SID Ca requirement of fast-growth broilers from hatch to d 10.

关键词： Apparent ileal digestibility Digestible calcium Requirements Retention Tibia ash

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Evaluation of Fusarium Graminearum Growth and Deoxynivalenol Content in Susceptible and Tolerant Varieties of Triticum Aestivum

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Journal of Life Sciences 2011年第2期5卷 81-90页

作者： Chiara Nobili Massimo Reverberi Alessandra Ricelli Valeria Scala Gabriella aureli Flavia Pinzari anna Adele Fabbri Corrado Fanelli ENEA Via Anguillarese 301 Roma 00123 Italy Universith degli Studi ＂Sapienza ＂ Largo Cristina di Svezia 24 Roma 00165 Italy ICB-CNR P.le Aldo Moro 5 Roma 00185 Italy QCE-CRA Via Cassia 176 Roma 00100 Italy Istituto Centrale per il Restauro e la Conservazione del Patrimonio Librario Via Milano 76 Roma 00184 Italy

The aim of this work was to verify if the wheat susceptibility/tolerance phenotype to Fusarium head blight （FHB） into the field could be related to the ability of the re-activated seeds to hamper deoxynivalenol （DON） synthesis by Fusarium graminearum into non optimal （i.e. high humidity） storage conditions. On this purpose, two Fusariurn graminearum strains, Fg126 and Fg8308, were separately inoculated on active but not germinating kernels of Triticum aestivum L. cv ＂Sagittario＂（FHB-susceptible） and cv ＂Blasco＂（FHB-tolerant）, The growth of the fungal strains on wheat kernels was monitored from 0 to 15 days post inoculation through a quantitative SYBR green real-time PCR, as well as ergosterol content through HPLC for comparison. DON biosynthesis into the contaminated wheat seeds was quantified by HPLC method in the same time intervals as above. Significant differences in the ability to grow and synthesize DON, acetylated and glucosylated forms, emerged between the strains also in relation to the wheat variety on which the pathogen developed. The results obtained indicated that the wheat variety which from the epidemiological studies carried out into the field is FHB-tolerant, i.e. Blasco, resulted as the more efficient in hampering DON synthesis in both F. graminearum strains. Thus, this preliminary study could represent a contribution to find out less time consuming methods for screening the wheat varieties tolerant to DON accumulation in non optimal storage conditions.

关键词： Triticum aestiwtm Fusarium graminearum FHB-susceptible FHB-tolerant deoxynivalenol (DON) 15-acetyldeoxynivalenol (15-ADON) 3-acetyldeoxynivalenol (3-ADON) 3-glucosyldeoxynivalenol (3-GDON).

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说长道短话汉外词典

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辞书研究 1997年第2期 119-122页

作者： Silvia.aureli

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活力新生巴塞罗那EL VILLA Vermouth酒吧

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室内设计与装修 2018年第11期 68-71页

作者：小西(编译) aureli mora omar ornaque amoo 不详

EL VILLA Vermouth酒吧位于巴塞罗那Gracia街区一栋建筑的首层，该建筑已经被列入了一个C级保护项目。从20世纪90年代起，这里就成了一家拥有混合牌照的酒吧。其内部是一个狭长的空间，后面有一个小天井。为了改造空间内部的老旧状况，... 详细信息

EL VILLA Vermouth酒吧位于巴塞罗那Gracia街区一栋建筑的首层，该建筑已经被列入了一个C级保护项目。从20世纪90年代起，这里就成了一家拥有混合牌照的酒吧。其内部是一个狭长的空间，后面有一个小天井。为了改造空间内部的老旧状况，设计团队AM00进行了综合考量，力图为大家呈现一个时尚、精致的酒吧空间。

关键词：巴塞罗那酒吧 EL 新生活力空间建筑街区

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定制生活巴塞罗那某公寓改造

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室内设计与装修 2022年第9期 134-137页

作者： [西班牙]AMOO|aureli Mora+Omar Ornaque(设计) 西竹(编译) AMOO|aureli Mora+Omar Ornaque

该公寓位于巴塞罗那Eixample’s Nova Esquerra街区,坐落在一栋建于1950年的建筑的二层。建筑内每一层均有4间独立公寓,根据建筑师*** Corsini记录的市政工作档案,这里原本是提供给中产阶级居住的折扣住房。

关键词：巴塞罗那市政工作公寓中产阶级建筑师街区

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前海港湾小学

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世界建筑导报 2023年第3期38卷 14-15页

作者：无 Pier Vittorio aureli 朱亦民李晓雯任超丘健海黄晓滢程梦琪伍兆林 ACF域图(摄影) 道格玛(DOGMA)X广州图岸建筑设计有限公司不详

深圳前海港湾小学于2015年建成投入使用,建筑面积9500平方米,1555学生,是龙海家园住宅区和周边社区的配套学校。港湾小学的校园环境非常特殊。由于整个前海片区采用了立体交通系统和高架地面层的城市空间,校园本身虽然位于地面层,但周... 详细信息

深圳前海港湾小学于2015年建成投入使用,建筑面积9500平方米,1555学生,是龙海家园住宅区和周边社区的配套学校。港湾小学的校园环境非常特殊。由于整个前海片区采用了立体交通系统和高架地面层的城市空间,校园本身虽然位于地面层,但周围龙海家园小区的地面层位于16米高的大裙楼顶上,从东、南、北三个面俯视校园。三层高的裙楼内除了车库外,主要是深圳地铁的设施用房,把校园围在当中。学校西侧是差不多同样高度的城市高架路,使校园成了一个被“围观”的洼地。

关键词：地面层立体交通校园环境周边社区住宅区深圳地铁前海龙海

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图解之后

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时代建筑 2015年第4期58卷 180-184页

作者：皮耶·维托里奥·奥雷利余佳浩伦敦建筑联盟学院美国南加州建筑学院

在建筑学和城市领域中,图解无疑是一种强大的工具。它具备建立、设计、揭示一个想法的能力,同时又倾向于把作品中的复杂性简化、抽象为一种简单的符号。它不断地更新对一件作品的再现,继而将其缩减为一幅处于不断变动中的图像。因此,图... 详细信息

在建筑学和城市领域中,图解无疑是一种强大的工具。它具备建立、设计、揭示一个想法的能力,同时又倾向于把作品中的复杂性简化、抽象为一种简单的符号。它不断地更新对一件作品的再现,继而将其缩减为一幅处于不断变动中的图像。因此,图解很容易成为对事物和事件的消费,成为对我们对所处世界的体验的消费。文章批判性地指出图解不仅仅是一种对现实的伪装,或者一种社会建构的现实,它同样是一种虚无主义的表现。

关键词：图解虚无主义再现真实消费

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