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Evaluation of Fusarium Graminearum Growth and Deoxynivalenol Content in Susceptible and Tolerant Varieties of Triticum Aestivum

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Journal of Life Sciences 2011年第2期5卷 81-90页

作者： Chiara Nobili Massimo Reverberi Alessandra Ricelli Valeria Scala Gabriella Aureli Flavia Pinzari anna adele fabbri Corrado Fanelli ENEA Via Anguillarese 301 Roma 00123 Italy Universith degli Studi ＂Sapienza ＂ Largo Cristina di Svezia 24 Roma 00165 Italy ICB-CNR P.le Aldo Moro 5 Roma 00185 Italy QCE-CRA Via Cassia 176 Roma 00100 Italy Istituto Centrale per il Restauro e la Conservazione del Patrimonio Librario Via Milano 76 Roma 00184 Italy

The aim of this work was to verify if the wheat susceptibility/tolerance phenotype to Fusarium head blight （FHB） into the field could be related to the ability of the re-activated seeds to hamper deoxynivalenol （DON） synthesis by Fusarium graminearum into non optimal （i.e. high humidity） storage conditions. On this purpose, two Fusariurn graminearum strains, Fg126 and Fg8308, were separately inoculated on active but not germinating kernels of Triticum aestivum L. cv ＂Sagittario＂（FHB-susceptible） and cv ＂Blasco＂（FHB-tolerant）, The growth of the fungal strains on wheat kernels was monitored from 0 to 15 days post inoculation through a quantitative SYBR green real-time PCR, as well as ergosterol content through HPLC for comparison. DON biosynthesis into the contaminated wheat seeds was quantified by HPLC method in the same time intervals as above. Significant differences in the ability to grow and synthesize DON, acetylated and glucosylated forms, emerged between the strains also in relation to the wheat variety on which the pathogen developed. The results obtained indicated that the wheat variety which from the epidemiological studies carried out into the field is FHB-tolerant, i.e. Blasco, resulted as the more efficient in hampering DON synthesis in both F. graminearum strains. Thus, this preliminary study could represent a contribution to find out less time consuming methods for screening the wheat varieties tolerant to DON accumulation in non optimal storage conditions.

关键词： Triticum aestiwtm Fusarium graminearum FHB-susceptible FHB-tolerant deoxynivalenol (DON) 15-acetyldeoxynivalenol (15-ADON) 3-acetyldeoxynivalenol (3-ADON) 3-glucosyldeoxynivalenol (3-GDON).

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Parallel pathways:A chronicle of evolution in rectal and breast cancer surgery

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1091-1096页

作者： Antonio Pesce Nicolòfabbri Diletta Iovino Carlo Vittorio Feo Unit of General Surgery University of FerraraAzienda USL of FerraraFerrara 44023LagosantoItaly

In this editorial,we have analyzed the historical evolution of rectal and breast cancer surgery,focusing on the progressive reduction of demolitive approaches and the increasing use of more conservative strategies,accompanied by a growing emphasis on perioperative treatments aimed at enhancing surgical *** of these changes have been made possible due to an increased awareness and understanding of oncological diseases and improved perioperative treatments.

关键词： Rectal cancer History Breast surgery Demolitive treatment Conservative surgery

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The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope:A multicenter retrospective international study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 71-76页

作者： Alessandro Fugazza Matteo Colombo Michel Kahaleh V.Raman Muthusamy Bick Benjamin Wim Laleman Carmelo Barbera Carlo fabbri Jose Nieto Abed Al-Lehibi Mohan Ramchandani Amy Tyberg Haroon Shahid Avik Sarkar Dean Ehrlich Stuart Shermand Cecilia Binda Marco Spadaccini Andrea Iannone Kareem Khalaf Nageshwar Reddy Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSVia Manzoni 5620089RozzanoMilanoItaly Gastroenterology Rutgers Robert Wood JohnsonNew BrunswickNew JerseyUSA Vatche and Tamar Manoukian Division of Digestive Diseases University of CaliforniaLos Angeles School of Medicine at UCLALos AngelesCaliforniaUSA Division of Digestive and Liver Disorders Indiana University School of MedicineIndianapolisINUSA Department of Gastroenterology and Hepatology University Hospitals LeuvenKU Leuven3000 LeuvenBelgium U.O.C.di Gastroenterologia ed Endoscopia Digestiva Ospedale Giuseppe MazziniASL TeramoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsAUSL RomagnaForlì-CesenaItaly Borland Groover Clinic JacksonvilleFloridaUSA Department of Gastroenterology and Hepatology King Fahad Medical CityRiyadhSaudi Arabia Asian Institute of Gastroenterology HyderabadIndia Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly

Background: Duodenoscope-related multidrug-resistant organism(MDRO) infections raise concerns. Disposable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography(ERCP) associated infections. The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy. Methods: This is a multicenter international, retrospective study combining all patients who underwent complex biliopancreatic interventions using the combination of a single-use duodenoscope and a single-use cholangioscope. The primary outcome was technical success defined as ERCP completion for the intended clinical indication. Secondary outcomes were procedural duration, rate of cross-over to reusable duodenoscope, operator-reported satisfaction score(1 to 10) on performance rating of the single-use duodenoscope, and adverse event(AE) rate. Results: A total of 66 patients(26, 39.4% female) were included in the study. ERCP was categorized according to ASGE ERCP grading system as 47(71.2%) grade 3 and 19(28.8%) grade 4. The technical success rate was 98.5%(65/66). Procedural duration was 64(interquartile range 15-189) min, cross-over rate to reusable duodenoscope was 1/66(1.5%). The satisfaction score of the single-use duodenoscope classified by the operators was 8.6 ± 1.3 points. Four patients(6.1%) experienced AEs not directly related to the single-use duodenoscope, namely 2 post-ERCP pancreatitis(PEP), 1 cholangitis and 1 ***: Single-use duodenoscope is effective, reliable and safe even in technically challenging procedures with a non-inferiority to reusable duodenoscope, making these devices a viable alternative to standard reusable equipment.

关键词： Single-operator cholangioscopy Single-use duodenoscope Endoscopic retrograde cholangiopancreatography Indeterminate biliary stricture Difficult biliary stones

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Asthma and gastroesophageal reflux disease: Effect of long-term pantoprazole therapy

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World Journal of Gastroenterology 2005年第48期11卷 7657-7660页

作者： Calabrese Carlo fabbri anna Areni Alessandra Scialpi Carlo Zahlane Desiree Di Febo Giulio Department of Internal Medicine and Gastroenterology

AIM： To define the prevalence of gastroesophageal reflux disease （GERD） in mild persistent asthma and to value the effect of pantoprazole therapy on asthmatic ***： Seven of thirty-four asthmatic patients without GERD served as the non-GERD control group. Twenty-seven of thirty-four asthmatic patients had GERD （7/27 also had erosive esophagitis, sixteen of them presented GERD symptoms. An upper gastrointestinal endoscopy was performed in all the subjects to obtain five biopsy specimens from the lower 5 cm of the esophagus. Patients were considered to have GERD when they had a dilation of intercellular space （DIS）〉0.74 μm at transmission electron microscopy. Patients with GERD were treated with pantoprazole, 80 mg/day. Forced expiratory volume in one second （FEV1） was performed at entry and after 6 mo of treatment. Asthmatic symptoms were recorded. The required frequency of inhaling rapid acting β2-agonists was self-recorded in the patients＇ ***： Seven symptomatic patients presented erosive esophagitis. Among the 18 asymptomatic patients, 11 presented DIS, while all symptomatic patients showed ultrastructural esophageal damage. Seven asymptomatic patients did not present DIS. At entry the mean of FEV1 was 1.91 L in symptomatic GERD patients and 1.88 L in asymptomatic GERD patients. After the treatment, 25 patients had a complete recovery of DIS and reflux symptoms. Twenty-three patients presented a regression of asthmatic symptoms with normalization of FEV1. Four patients reported a significant improvement of symptoms and their FEV1 was over 80%.CONCLUSION： GERD is a highly prevalent condition in asthma patients. Treatment with pantoprazole （80 mg/day） determines their improvement and complete regression.

关键词： Asthma Gastroesophageal reflux disease Pantoprazole NERD ERD Dilated intercellular spaces TEN

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Risk, Contract Management, and Financing of the Gotthard Base Tunnel in Switzerland

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Engineering 2019年第3期5卷 379-383页

作者： Davide fabbri Lombardi Engineering Ltd. Minusio 6648 Switzerland

1. Introduction With the opening ceremony of the Gotthard Base Tunnel on 1 June 2016, a new world record was established: the commissioning of the longest railway tunnel in the world. Many challenges have been overcome and many technical innovations have been developed and considered in this project. As of 11 December 2016, the Gotthard Base Tunnel has been an integral part of the new timetable of the Swiss Federal Railways (SBB-CFF-FFS), and is in full operation. With a total length of 57 km and a cruising speed of 200 km·h^-1 for passenger trains, the Gotthard Base Tunnel reduces the journey time through the Alps by 40 min, significantly reducing the distance between the south and north of Europe.

关键词： Risk Contract Management Financing Gotthard Base Tunnel Switzerland

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Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux

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World Journal of Gastroenterology 2005年第12期11卷 1876-1880页

作者： Carlo Calabrese anna fabbri Mauro Bortolotti Giovanna Cenacchi Scialpi Carlo Desiree Zahlane Mario Miglioli Giulio Di Febo Dipartimento di Medicina Interna e Gastroenterologia

AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER. METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry. Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TEM). Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed. RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERD). At histology, of the 6 patients with erosive esophagitis, 5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis. After 3 mo of therapy, 13/15 patients (86.7%,P<0.01) showed a complete recovery of DIS and disappearance of heartburn. Of the 2 patients treated for 3 more months, complete recovery of DIS and heartburn were achieved in one. CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGER, NERD and ERD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases.

关键词： Duodenogastroesophageal reflux Gastroeso phageal reflux disease Transmission Electron Microscopy Dilated Intercellular Spaces Non-erosive reflux disease

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New oral agents for erectile dysfunction: what is changing in our practice?

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Asian Journal of Andrology 2001年第3期3卷 175-179页

作者： Antonio Aversa Andrea fabbri AFaR-CRCC Fatebenefratelli-Isola Tiberina Hospital and Endocrinology Unit Department of Internal Medicine University of Rome 'Tor Vergata' 00133 Rome ItalyEndocrinology Unit Department of Internal Medicine University of Rome 'Tor Vergata' 00133 Rome Italy

Erectile dysfunction (ED) is a highly prevalent disorder affecting an estimated 152 million men worldwide and isassociated with a variety of behavioral risk factors, such as cigarette smoking and excessive alcohol consumption, aswell as numerous age - related medical conditions, notably type-2 diabetes mellitus and cardiovascular disease. A ratio-nal step - wise approach which includes comprehensive medical and sexual history, a focused physical examination andessential laboratory tests such as fasting glucose, lipid profile and testosterone assay is to be preferred. Current diagnos-tic work - up does not recommend any of the specialized tests which were previously considered mandatory-i. e. penilepharmacotesting, Duplex ultrasound and nocturnal penile tumescence. Hormonal replacement therapy is appropriate onlyin the hypogonadal male with ED. Prior to direct intervention, the physician should consider altering modifiable riskfactors or causes, although frequently insufficient to reverse ED completely. When indicated, oral therapy with newmolecules (phosphodiesterase inhibitors or apomorphine) is the first - line treatment for the majority of patients becauseof potential benefits and lack of invasiveness. (Asian J Androl 2001 Sep; 3: 175-179 )

关键词： erectile dysfunction oral medicine therapy phosphodiesterase inhibitors apomorphine nitric oxide

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Pancreatic ductal adenocarcinoma screening:New perspectives

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World Journal of Gastroenterology 2012年第36期18卷 4973-4977页

作者： Raffaele Pezzilli Dario fabbri Andrea Imbrogno Department of Digestive Diseases and Internal Medicine Sant'OrsolaMalpighi Hospital40138 BolognaItaly

Pancreatic ductal adenocarcinoma accounts for more than 90% of all pancreatic cancers and its incidence has increased significantly *** with pancreatic ductal adenocarcinoma have a poor outcome and more than 95% of the people affected die from the disease within 12 mo after *** is the first-line treatment in the case of resectable neoplasm,but only 20% of patients are candidates for this *** of the reasons there are few candidates for surgery is that,during the early phases of the disease,the symptoms are poor or *** diagnosis is of crucial importance to improve patient outcome;therefore,we are looking for a good screening *** screening test must identify the disease in an early stage in order to be effective;having said this,a need exists to introduce the concept of "early" ductal *** has been reported that at least five additional years after the occurrence of the initiating mutation are required for the acquisition of metastatic ability of pancreatic adenocarcinoma and patients die an average of two years *** have reviewed the most recent literature in order to evaluate the present and future perspectives of screening programs of this deadly disease.

关键词： Pancreatic neoplasms Study population Prevention Therapeutics

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Conservative management of an early abdominal complication during a Tullio percutaneous endoscopic excision of renal pelvis urothelial carcinoma:A case report

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World Journal of Clinical Urology 2024年第1期13卷 1-6页

作者： Massimiliano Bernabei Nicolòfabbri Danila Romeo Elisa Paiolo Martina Bandi Maurizio Simone Department of Urology Azienda USL di FerraraFerrara 44100Italy Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraFerrara 44100FerraraItaly Local Health Agency of Ferrara Ferrara 44100Italy

BACKGROUND Upper tract urothelial carcinoma(UTUC)representing only a small fraction of all urothelial *** predominantly affects the renal pelvis in men,often coexisting with bladder *** displays a more aggressive genetic profile compared to bladder neoplasms,with the majority of patients presenting with advanced ***,about a quarter of UTUC cases exhibit high-grade subtypes,associated with a worse *** use and past exposure to aromatic amines are significant risk factors for *** modalities such as Uro-computed tomography and magnetic resonance imaging play crucial roles in *** is vital for direct visualization and biopsy sampling,but its limited sampling capacity presents challenges in determining tumor depth and ***,nephroureterectomy with bladder cuff excision has been the gold-standard treatment for *** conservative treatment has recently emerged as a viable option for selected patients,offering comparable oncological outcomes to radical *** access is also feasible for larger intrarenal *** SUMMARY We present a case of an 84-year-old woman who underwent percutaneous endoscopic excision of a renal pelvis neoplasm using the Tullio *** successful tumor removal,the patient experienced a postoperative complication with abdominal fluid *** management effectively resolved the *** the patient's age and refusal for radical surgery,the conservative approach proved to be a valid therapeutic *** Overall,UTUC remains a diagnostic and therapeutic challenge due to its ***,advances in endoscopic and percutaneous techniques provide valuable alternatives for selected patients,warranting further exploration in this evolving field.

关键词： Upper tract urothelial carcinoma Endoscopic treatment Damage management Case report

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MicroRNAs and drug modulation in cancer:an intertwined new story

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Frontiers in Biology 2011年第5期6卷 351-356页

作者： Francesca FANINI Ivan VANNINI Muller fabbri Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola47014Italy Department of Molecular Virology Immunologyand Medical Genetics and Comprehensive Cancer CenterOhio State UniversityColumbusOH 43210USA

MicroRNAs(miRNAs)are endogenous small non-coding RNAs(ncRNAs)which play important regulatory roles in physiological processes such as cellular differentiation,proliferation,development,apoptosis and stem cell *** increasing number of papers have clearly claimed their involvement in cancer,providing,in some cases,also the molecular mechanisms *** studies led to the conclusion that miRNAs can be effectively used as anticancer agents alone or in combination with existing anticancer *** particular,miRNAs can be effectively used to overcome drug resistance,one of the main factors responsible for anticancer treatment *** of the main questions remains how to modulate the expression of miRNAs in cancer ***,a few studies have shown that the expression of miRNAs is affected by drugs(including some drugs currently used as anticancer agents),therefore providing the rationale for an intertwined scenario in which miRNAs can be modulated by drugs and,in turn,can affect drug sensitivity of cancer cells.

关键词： miRNAs cancer multidrug resistance transcription factor chemotherapy

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