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Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia

World Journal of Gastroenterology 2018年第38期24卷 4393-4402页

作者： Franziska J Ammon anna kohlhaas Omar Elshaarawy Johannes Mueller Thomas Bruckner Christof Sohn Gabriele Fluhr Herbert Fluhr Sebastian Mueller Department of Obstetrics and Gynecology University of Heidelberg Department of Medicine and Center for Alcohol Research Liver Disease and NutritionSalem Medical CenterUniversity of Heidelberg Institute of Medical Biometry und Informatics University of Heidelberg

AIM To study liver stiffness(LS) during pregnancy and its association with complications during *** In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device(Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women(controls) while preeclampsia and intrahepatic cholestasis of pregnancy(ICP) developed in 22 and 40 women, *** In controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa(P < 0.001) in the third trimester. In the third trimester, 41% of women had a LS higher than 6 kPa. Elevated LS in controls was significantly correlated with alkaline phosphatase, leukocytes, gestational age and an increase in body weight and body mass index(BMI). In women with pregnancy complications, LS was significantly higher as compared to controls(P < 0.0001). Moreover, in multivariate analysis, LS was an independent predictor for preeclampsia with an odds ratio of 2.05(1.27-3.31) and a cut-off value of 7.6 kPa. In contrast, ICP could not be predicted by LS. Finally, LS rapidly decreased in all women within 24 h after delivery from 7.2 ± 3.3 kPa down to 4.9 ± 2.2 kPa(P < 0.001).CONCLUSION During pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent noninvasive predictor.

关键词： Pregnancy Transient elastography Liver stiffness Pregnancy complications Hemolysis,elevated liver enzymes and low platelets syndrome Intrahepatic cholestasis of pregnancy Preeclampsia

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Ab externo canaloplasty results and efficacy: a retrospective cohort study with a 12-month follow-up

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Eye and Vision 2019年第1期6卷 63-73页

作者： Iraklis Vastardis Sofia Fili Zisis Gatzioufas Markus kohlhaas Department of Retina and Vitreous Narayana Nethralaya#121/C1st R BlockChord RoadRajaji NagarBengaluru 560010India. Department of Cornea and Refractive surgery Narayana Nethralaya#121/C1st R BlockChord RoadRajaji NagarBengaluru 560010India

Background:The aim of this study is to review the outcomes of canaloplasty versus canaloplasty combined with phacoemulsification in a retrospective cohort study and to evaluate the efficacy of these methods in terms of intraocular pressure(IOP)lowering effect,postoperative complications and additional glaucoma surgery or reintroduction of medical therapy over a 12-month ***:In a retrospective cohort study,602 eyes with primary open angle glaucoma(POAG)were treated with canaloplasty or canaloplasty combined with *** results were evaluated separately in two main groups;group A canaloplasty(262 eyes)and group B canaloplasty combined with phaco(322 eyes).Each group was then subdivided into three additional groups according to the severity of *** criteria for successful treatment were evaluated between three IOP ranges;IOP≤16 mmHg,18 mmHg and 21 *** success was considered the percentage of eyes reaching target IOP with no medication and partial success with *** A and B subgroups were compared using the Kaplan Meier *** IOP,reduction of antiglaucoma agents and additional IOP lowering methods were also *** follow-up time was 12 *** significance was set at p<***:An incomplete intraoperative cannulation of Schlemm’s canal resulting in conversion to other glaucoma surgery occurred in 18 eyes(2.99%).In both of the main groups,postoperative hyphema,descemet membrane detachment and transient IOP rise were the most common postoperative *** mean IOP in group A and subgroups at 12 months was 13.26±4.5 mmHg,15.19±3.97 mmHg and 18.09±3.75 *** in group B mean IOP was 14.51±4.69 mmHg,14.40±4.11 mmHg and 14.25±2.76 *** success was achieved in group A in 69.19,74.51 and 74.31%of *** group B complete success was achieved in 81.60,77.33 and 83.33%of eyes *** Meier between groups A and B was statistically significant for IOP≤16

关键词： Canaloplasty Schlemm’s canal surgery POAG

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Preliminary results of Preserflo Microshunt versus Preserflo Microshunt and Ologen implantation

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Eye and Vision 2021年第1期8卷 324-337页

作者： Iraklis Vastardis Sofia Fili Georgios Perdikakis Kalliopi Kontopoulou Miltos Balidis Zisis Gatzioufas Markus kohlhaas Department of Ophthalmology St.Johannes Academic Hospital DortmundDortmundGermany Ophthalmica Eye Institute ThessalonikiGreece Department of Ophthalmology University Hospital BaselBaselSwitzerland

Purpose:To report preliminary 6-month results on the use of the Preserflo Microshunt implant with and without Ologen in 50 pseudophakic eyes with moderate to advanced primary open-angle glaucoma(POAG).Methods:Fifty pseudophakic eyes underwent ab externo Preserflo Microshunt *** was gathered retrospectively and two groups were then created,group A with application of MMC 0.2 mg/ml and group B with MMC 0.2 mg/ml and Ologen collagen matrix(OCM)*** success was regarded as the percentage of eyes achieving:a)5≤intraocular pressure(IOP)≤13 mmHg,b)5≤IOP≤16 mmHg,and c)5≤IOP≤21 mmHg without additional medication or surgery and qualified success was regarded as the percentage of eyes achieving a)IOP≤13 mmHg,b)IOP≤16 mmHg,and c)IOP≤21 mmHg with or without *** was performed using a log-rank Kaplan-Meier test.A scatterplot analysis presented the treatment effect data of all eyes with a minimum of 20%IOP reduction per *** was defined as requiring additional surgery,IOP greater than 21 mmHg with or without medication and failure to reach 20%IOP ***:Mean postoperative IOP was significantly lower in both *** decreased by 49.06%in group A and by 53.01%in group B at 6 months(P0.05).Cumulative IOP results per case were not statistically different in group A compared with group *** revision surgery in group A(4%failure rate)and three in group B(12%failure rate)were ***:Both groups showed equal results in terms of cumulative and mean IOP reduction,medication reduction as well as in absolute and qualified success *** significant difference was found in any parameters tested between Preserflo Microshunt with MMC 0.2 mg/ml and with or without OCM implantation at 6 ***-term follow-up is required to fu

关键词： Micro invasive glaucoma surgery Ab externo surgery Refractory POAG SIBS polymer Mitomycin C

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贮纬补纬装置的工作及应用

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国外纺织技术(纺织分册) 1981年第33期 26-30页

作者： O.kohlhaas 刘安远

图1 引纬时的速度曲线 A、织机的纬纱退绕速度 B、时间 C、织机的纬纱平均退绕速度 D、贮纬装置的退绕速度 1.筒子 2.贮纬装置 3.织机 4.引纬图1画出了引纬时纱线的基本速度变化。上图是不用贮纬装置,下图是使用贮纬装置。当不用贮纬装... 详细信息

图1 引纬时的速度曲线 A、织机的纬纱退绕速度 B、时间 C、织机的纬纱平均退绕速度 D、贮纬装置的退绕速度 1.筒子 2.贮纬装置 3.织机 4.引纬图1画出了引纬时纱线的基本速度变化。上图是不用贮纬装置,下图是使用贮纬装置。当不用贮纬装置时,很明显,所有的张力波动都直接传到所引入的纬纱上,这些

关键词：纱线断头纬纱装置拈度退绕速度筒子织机布机织造机械

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Impact of Pharmaceutical Care on Self-Administration of Outpatient Low-Molecular-Weight Heparin Therapy

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Pharmacology & Pharmacy 2014年第4期5卷 372-385页

作者： Seraina Mengiardi Dimitrios A. Tsakiris Viviane Molnar Urs kohlhaas-Styk Michael Mittag Stephan Kraehenbuehl Kurt E. Hersberger Clinic for Orthopedic Surgery and Traumatology Kantonss-pital Baselland Bruderholz Switzerland Division of Clinical Pharmacology and Toxicology University Hospital Basel Basel Switzerland Division of Hematology University Hospital Basel Basel Switzerland Pharmaceutical Care Research Group University of Basel Basel Switzerland

Outpatient subcutaneous (s.c.) therapies are becoming more and more common in the treatment of different diseases. The effectiveness of community-pharmacy-based interventions in preventing problems that arise during s.c. self-injections of low-molecular-weight heparins (LMWH) is unknown. Our objective was to provide a standard operating procedure (SOP) for community pharmacists and to compare pharmaceutical vs. standard care in both clinical and daily life settings. We hypothesized that: pharmaceutical care results in improved adherence, safety, and satisfaction, and in fewer complications;the interventions used are feasible in daily life;and the results achieved in clinical and daily life settings are comparable. In the clinical setting (randomized controlled trial), patients were recruited sequentially in hospital wards;in the daily life setting (quasi-experimental design with a comparison group), recruitment took place in community pharmacies by pharmacists and trained master students during their internship. Interventions were offered according to patient needs. Data were collected by means of a monitored self-injection at home and structured questionnaire-based telephone interviews at the beginning and the end of the LMWH treatment. The main outcome measures were: scores to assess patient’s skills;syringe count to assess adherence;and frequency, effectiveness, and patient’s assessment of received interventions. The results show a median age of the 139 patients of 54 years. Interventions resulted in improved application quality (p p = 0.03). Oral instructions were pivotal for improving patients’ application quality. We found no significant score differences between the intervention groups in the clinical and daily life settings. Patients’ baseline skills were high, with the lowest score being 0.86 (score range ?2.00 to +2.00). Adherence rate was high (95.8%). In conclusion, our SOP for pharmacist interventions was of good quality, adequate, appreciated, and feas

关键词： Low-Molecular-Weight Heparin Outpatients Subcutaneous Injections Self Administration Pharmaceutical Care Community Pharmacy Switzerland

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对高速钢显微组织的观察

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理化检验-物理分册 1980年第3期 47-50+36页

作者： Alfred Fischer Erich kohlhaas 唐元祈湖南湘潭大学

在显微组织研究方面,现在不仅能够显示各相的形态和分布,而且在大多数情况下还能测定晶体结构和化学成分。在高速钢领域所取得的进展,已能对其显微组织进行完整的描述。由于高速钢的成分复杂,要准确地描述从液相到固相以及随后的转变所... 详细信息

在显微组织研究方面,现在不仅能够显示各相的形态和分布,而且在大多数情况下还能测定晶体结构和化学成分。在高速钢领域所取得的进展,已能对其显微组织进行完整的描述。由于高速钢的成分复杂,要准确地描述从液相到固相以及随后的转变所发生的反应是困难的。许多新近的包括示差热分析的研究已经帮助阐明了S6-5-2钢的相图(图1)。首先,一种低碳高合金的铁素体(α-固溶体)从溶体中析出,当进一步冷却时,一种高碳的奥氏体开始析出。随后包晶相变发生在四相区。

关键词：高速钢高速工具钢刃具钢碳化物沉淀残余奥氏体显微组织金相组织

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马戏团的警报

马戏团的警报

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1958年

作者：（德）库哈司（W.kohlhaas）（德）库比许（H.Kubisch）游炳译

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科隆—莱茵/美茵高速铁路SICAT~H1.0型接触网(续)

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电气化铁道 2003年第5期14卷 14-17页

作者： Jürgen kohlhaas Werner Ortstdt Frankfurt am Main Rainer Puschmann Henrz Schmidt Erlangen 门汉文西门子中国有限公司交通技术集团

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A CORRECTION FORMULA FOR THE RE-AL IOP AFTER LASIK

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国际眼科杂志 2003年第1期3卷 12-12页

作者： D.Sandner L.E.Pillunat K.Pollack M.kohlhaas E.Spoerl Department of Ohthalmology University Eye Clinic GermanyDepartment of OhthalmologyUniversity Eye Clinic GermanyDepartment of OhthalmologyUniversity Eye Clinic GermanyDepartment of OhthalmologyUniversity Eye Clinic GermanyDepartment of OhthalmologyUniversity Eye Clinic Germany

Purpose: The measured IOP values after Lasik are lower than real ones. The influence of the flap, of the changed corneal thickness and corneal curvature on the IOP-measurement with Goldmann applanation tonometry after Lasik is still unknown. Aim of this study was to evaluate a correction formula in order to determine the real IOP after Lasik assuming that the pre- and postoperative IOP-values are equal. Methods: 102 Lasik-treat-

关键词： LASIK 术后 IOP 测量值校正公式

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维生素B_2/长波紫外线(UVA)光交联:治疗LASIK术后角膜膨出的一种新法

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 59-59页

作者： kohlhaas M. Spoerl E. Speck A. 陈立军 Universitts-Augenklinik Carl Gustav Carus Dresden Fetscherstraβe 74 01307 Dresden GermanyDr.

Background: Keratectasia is one of the most severe complications after refract ive laser surgery. Usually penetrating keratoplasty is the treatment of choice t o achieve an optical rehabilitation in such cases. Patients and Methods: We repo rt on a female patient who developed keratectasia in both eyes 4 weeks after LAS IK. Due to a severe keratectasia 10 months after LASIK, a treatment with ribofla vin/UVA cross-linking was performed. Results: Due to the induced collagen cross linking the biomechanical status of the cornea was stabilized and a progression of the keratectasia was prevented. The postoperative refraction and corneal topo graphy have been stable for 18 months. Conclusion: Collagen cross-linking leads to a stiffening of the anterior parts of the corneal stroma. The increase of bi omechanical stability can stop the progression of a keratectasia after LASIK by means of a simple procedure.

关键词：角膜膨出 LASIK术 UVA 长波紫外线光交联角膜地形图屈光性激光手术全层角膜移植术力学稳定性

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