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Applications of magnetic nanoparticles in surface-enhanced Raman scattering(SERS)detection of environmental pollutants

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Journal of Environmental Sciences 2019年第6期31卷 14-34页

作者： Dan Song Rong Yang Feng Long anna Zhu School of Environment and Natural Resources Renmin University of China Research Institute of Chemical Defense Academy of Military Sciences PLA China State Key Laboratory of NBC Protection FOR Civilian

Environmental pollution, a major problem worldwide, poses considerable threat to human health and ecological environment. Efficient and reliable detection technologies, which focus on the appearance of emerging environmental and trace pollutants, are urgently needed. Surface-enhanced Raman scattering(SERS) has become an attractive analytical tool for sensing trace targets in environmental field because of its inherent molecular fingerprint specificity and high sensitivity. In this review, we focused on the recent developments in the integration of magnetic nanoparticles(MNPs) with SERS for facilitating sensitive detection of environmental pollutants. An overview and classification of different types of MNPs for SERS detection were initially provided, enabling us to categorize the huge amount of literature that was available in the interdisciplinary research field of MNPs based SERS technology. Then, the basic working principles and applications of MNPs in SERS detection were presented. Subsequently, the detection technologies integrating MNPs with SERS that eventually were used for the detection of various environmental pollutions were reviewed. Finally, the advantages of MNP-basedSERS detection technology for environmental pollutants were concluded, and the current challenges and future outlook of this technology in practical applications were highlighted. The application of the MNPsbasedSERS techniques for environmental analysis will be significantly advanced with the great progresses of the nanotechnologies, optics, and materials.

关键词： Magnetic nanoparticles Surface-enhanced Raman scattering SERS substrates Environmental pollutant detection

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Resveratrol corrects aberrant splicing of RYR1 pre-mRNA and Ca2+ signal in myotonic dystrophy type 1 myotubes

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Neural Regeneration Research 2020年第9期15卷 1757-1766页

作者： Massimo Santoro Roberto Piacentini Alessia Perna Eugenia Pisano anna Severino anna Modoni Claudio Grassi Gabriella Silvestri IRCCS Fondazione Don Carlo Gnocchi MilanItaly Department of Neuroscience Universita Cattolica del Sacro CuoreRomeItaly Department of Cardiovascular and Thoracic Sciences Universita Cattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCS RomeItaly

Myotonic dystrophy type 1(DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1(RYR1), sarcoplasmatic/endoplasmatic Ca^2+-ATPase(SERCA) and α1 S subunit of voltage-gated Ca^2+ channels(Cav1.1) is related to Ca^2+ homeostasis and excitation-contraction coupling impairment. Though no pharmacological treatment for DM1 exists, aberrant splicing correction represents one major therapeutic target for this disease. Resveratrol(RES, 3,5,4′-trihydroxy-trans-stilbene) is a promising pharmacological tools for DM1 treatment for its ability to directly bind the DNA and RNA influencing gene expression and alternative splicing. Herein, we analyzed the therapeutic effects of RES in DM1 myotubes in a pilot study including cultured myotubes from two DM1 patients and two healthy controls. Our results indicated that RES treatment corrected the aberrant splicing of RYR1, and this event appeared associated with restoring of depolarization-induced Ca^2+ release from RYR1 dependent on the electro-mechanical coupling between RYR1 and Cav1.1. Interestingly, immunoblotting studies showed that RES treatment was associated with a reduction in the levels of CUGBP Elav-like family member 1, while RYR1, Cav1.1 and SERCA1 protein levels were unchanged. Finally, RES treatment did not induce any major changes either in the amount of ribonuclear foci or sequestration of muscleblind-like splicing regulator 1. Overall, the results of this pilot study would support RES as an attractive compound for future clinical trials in DM1. Ethical approval was obtained from the Ethical Committee of IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy(rs9879/14) on May 20, 2014.

关键词： alternative splicing calcium homeostasis CUG-BP1 foci MBNL1 myotonic dystrophy type 1 myotubes resveratrol

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Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery

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Asian Journal of Pharmaceutical Sciences 2018年第6期13卷 592-599页

作者： anna Slita anna Egorova Eudald Casals Anton Kiselev Jessica M.Rosenholm Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringAbo Akademi University D.O.Ott Research Institute of Obstetrics Gynaecology and Reproductology

Gene therapy using siRNA molecules is nowadays considered as a promising approach. For successful therapy, development of a stable and reliable vector for siRNA is crucial. Non-viral and non-organic vectors like mesoporous silica nanoparticles(MSN) are associated with lack of most viral vector drawbacks, such as toxicity, immunogenicity, but also generally a low nucleic acid carrying capacity. To overcome this hurdle, we here modified the pore walls of MSNs with surface-hyperbranching polymerized poly(ethyleneimine)(hbPEI), which provides an abundance of amino-groups for loading of a larger amount of siRNA molecules via electrostatic adsorption. After loading, the particles were covered with a second layer of pre-polymerized PEI to provide better protection of siRNA inside the pores, more effective cellular uptake and endosomal escape. To test the transfection efficiency of PEI covered si RNA/MSNs, MDA-MB 231 breast cancer cells stably expressing GFP were used. We demonstrate that PEI-coated si RNA/MSN complexes provide more effective delivery of si RNAs compared to unmodified MSNs. Thus, it can be concluded that appropriately surface-modified MSNs can be considered as prospective vectors for therapeutic siRNA delivery.

关键词： Gene therapy Nanocarriers siRNA delivery Mesoporous silica nanoparticles

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Pancreatic cancer stroma:understanding biology leads to new therapeutic strategies

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World Journal of Gastroenterology 2014年第9期20卷 2237-2246页

作者： Agnieszka anna Rucki Lei Zheng Department of Oncology The Sidney Kimmel Cancer Center the Skip Viragh Clinical Pancreatic Cancer Center and the Sol Goldman Pancreatic Cancer Center Johns Hopkins University Baltimore MD 21287 United States

Pancreatic ductal adenocarcinoma(PDA)is among the deadliest cancers in the United States and in the *** diagnosis,early metastasis and lack of effective therapy are among the reasons why only 6%of patients diagnosed with PDA survive past 5 *** development of targeted therapy against other cancers,little progression has been made in the treatment of ***,there is an urgent need for the development of new ***,in order to proceed with treatments,the complicated biology of PDA needs to be understood ***,majority of the tumor volume is not made of malignant epithelial cells but of *** recent years,it has become evident that there is an important interaction between the stromal compartment and the less prevalent malignant cells,leading to cancer *** stroma not only serves as a growth promoting source of signals but it is also a physical barrier to drug *** the tumor-stroma signaling leading to development of desmoplastic reaction and tumor progression can lead to the development of therapies to decrease stromal activity and improve drug *** this review,we focus on how the current understanding of biology of the pancreatic tumor microenvironment can be translated into the development of targeted therapy.

关键词： Pancreatic ductal adenocarcinoma Stroma Tumor microenvironment Pancreatic stellate cells Cancer associated fibroblast Sonic hedgehog Hepatic growth factor Fibroblast activation protein

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Advanced gastric cancer:Current treatment landscape and future perspectives

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World Journal of Gastroenterology 2016年第8期22卷 2403-2414页

作者： Antonia Digklia anna Dorothea Wagner Departement d’Oncologie Centre Hospitalier Universitaire Vaudois

Gastric cancer currently ranks fourth in cancer-related mortality worldwide. In the western world, it is most often diagnosed at an advanced stage, after becoming metastatic at distant sites. Patients with advanced disease(locally advanced or metastatic) have a somber prognosis, with a median overall survival of 10-12 mo, and palliative chemotherapy is the mainstay of treatment. In recent years, novel approaches using inhibition of human epidermal growth factor receptor 2(HER2) have demonstrated significant improvements in progression-free and overall survival, compared with chemotherapy alone, in first-line treatment of patients with overexpression of HER2. In addition, both second-line chemotherapy and treatment with the vascular endothelial growth factor receptor-inhibitor ramucirumab demonstrated significant benefits in terms of overall survival, compared with best supportive care, in randomized studies. Moreover, ramucirumab in combination with chemotherapy demonstrated further significant benefits in terms of progression-free and overall survival, compared with chemotherapy alone, in second-line treatment for patients with metastatic gastric cancer. A recently published molecular classification of gastric cancer is expected to improve patient stratification and selection for clinical trials and provide a roadmap for future drug development. Nevertheless, despite these developments the prognosis of patients with advanced gastric cancer remains poor. In this review we discuss current standards of care and outline major topics of drug development in gastric cancer.

关键词： Gastric cancer Phase III Clinical trials Chemotherapy Targeted therapy Perspectives

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Nonlinear Backstepping Ship Course Controller

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International Journal of Automation and computing 2009年第3期6卷 277-284页

作者： anna Witkowska Roman Smierzchalski Gdansk University of Technology Faculty of Electrical Engineering and Automatic Narutowicza 11/12

A ship, as an object of course control, is characterized by a nonlinear function describing the static maneuvering characteristics. The backstepping method is one of the methods that can be used during the designing process of a nonlinear course controller for ships. The method has been used for the purpose of designing two configurations of nonlinear controllers, which were then used to control the ship course. One of the configurations took dynamic characteristic of a steering gear into account during the designing stage. The parameters of the obtained nonlinear control structures have been tuned to optimise the operation of the control system. The optimisation process has been performed by means of genetic algorithms. The quality of operation of the designed control algorithms has been checked in simulation tests performed on the mathematical model of a tanker. The results of simulation experiments have been compared with the performance of the system containing a conventional proportional-derivative （PD） controller.

关键词： Backstepping method genetic algorithm marine ships control nonlinear control tuning parameters.

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Research on cooperative detection and multiple access for cognitive radio system

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Journal of Harbin Institute of Technology(New Series) 2011年第6期18卷 86-92页

作者： anna Auguste Anghuwo 刘鑫谭学治 Communication Research Center Harbin Institute of Technology

As cognitive radio (CR) needs to detect spectrum accurately and utilize the idle spectrum efficiently,a new model of CR is *** model adopts energy detection with auto-adapted threshold and produces spectrum mark *** basis function is obtained through making IDFT to the inner product of spectrum and phase vectors,and it is variable with the spectrum *** are sent through modulation on the basis function,and it can be estimated by correlation in the receiving *** cooperative detection and multiple access of this model are also researched in this paper,and the performance is finally *** show the cooperative detection of this model can obtain higher detection probability,and the disaccord of the basis functions between sending and receiving ends can lower its performance.

关键词： cognitive radio energy detection basis function

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Utilization of molecular genetic approaches for colorectal cancer screening

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World Journal of Gastroenterology 2024年第46期30卷 4950-4957页

作者： Marina A Emelyanova anna Y Ikonnikova Center for Precision Genome Editing and Genetic Technologies for Biomedicine Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

The feasibility of population screening for colorectal cancer has been demonstrated in several *** of these studies have considered individual characteristics,diagnostic approaches,epidemiological data,and socioeconomic *** this article,we comment on an editorial by Metaxas et al published in the recent issue of the *** authors emphasized the need to raise public awareness through health education programs and the possibility of using easily accessible non-invasive screening ***,we focus on non-invasive molecular genetic approaches that can aid in colorectal cancer *** the one hand,we highlighted the use of tumor DNA/RNA markers directly for screening and,on the other hand,underline the use of polygenic risk assessment and hereditary predisposition to select individuals for more thorough cancer screening.

关键词： Colorectal cancer Cancer screening Non-invasive screening Liquid biopsy Polygenic risk score

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Putting the brakes on pollen wall development:A conserved negative feedback loop regulates pollen exine formation in flowering plants

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Molecular Plant 2023年第9期16卷 1376-1378页

作者： Yuan Zhou anna A.Dobritsa Department of Molecular Genetics Ohio State UniversityColumbusOH 43210USA

Pollen grains are covered by a complex multi-layered structure,the pollen ***,the outermost layer of this wall,is made from the biopolymer sporopollenin that exhibits remarkable physical and chemical *** different plants,exine,which shields pollen from harsh environmental stresses,has very diverse morphologies and forms different patterns(Wang and Dobritsa,2018).It also contributes to pollination,pollen–stigma interaction,pollen hydration,and eventual release of the pollen *** of exine begins after male meiosis when four microspores are arranged in a tetrad configuration and enclosed by the callose wall(Ariizumi and Toriyama,2011).At this stage,microspores secrete primexine,the precursor of exine that accumulates between the microspore plasma membrane and the callose wall,providing a scaffold for exine patterning(Wang et al.,2021).As the callose wall gradually gets degraded,sporopollenin is secreted by the nearby tapetal cells and deposited onto the primexine template to form mature *** process requires coordination of activities between microspores and the surrounding tapetum.

关键词： template conserved pollen

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Variation of Ⅰ–Ⅴ characteristics due to process parameters as base for modeling the component variability for LDD MOSFET devices

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第2期9卷 103-114页

作者： Roberto Marani anna Gina Perr Consiglio Nazionale delle Ricerche Istituto di Studi sui Sistemi Intelligenti per l’Automazione(ISSIA) Bari 70125Italy Electronic Devices Laboratory Department of Electrical and Information Engineering Polytechnic University of Bari 70125 Italy

In this paper,we present the effect of process parameters variations on Ⅰ-Ⅴ characteristics of LDD MOSFETs through a simulation study,applying also to any submicron *** particular,we examine the effect of variation of ionic implantation for different channel doping involved in MOSFET *** last,we examine a linear Ⅰ-Ⅴ model to simulate more adequately the effects of variation of the process parameters as correction to the base model.

关键词： LDD MOSFET drain engineering device simulations.

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