Dear Editor,The activating receptor DnAX accessory molecule-1(DnAM-1)plays an important role in T and natural killer(nK)cell-mediated cytotoxicity via the interaction with its ligands poliovirus receptor(PVR,CD155)and...
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Dear Editor,The activating receptor DnAX accessory molecule-1(DnAM-1)plays an important role in T and natural killer(nK)cell-mediated cytotoxicity via the interaction with its ligands poliovirus receptor(PVR,CD155)and nectin-2(CD112).Compared with peripheral blood nK cells,tumor-infiltrating nK cells show reduced expression of DnAM-1 across several solid tumors,including ovarian and breast cancer resulting in impaired nK cell *** studies reported an inverse correlation between DnAM-1 expression and its ligands in leukemic blasts and ovarian cancer[1].
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