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Mechanisms involved in Helicobacter pylori induced duodenal ulcer disease:an overview

World Journal of Gastroenterology 2000年第5期6卷 619-623页

作者： Lars Olbe Lars Fndriks annika Hamlet ann-mari svennerholm ann-Catrin Thoreson Centre for Gastroenterological Research University of GteborgSweden

Duodenal ulcer (DU) can be developed viaseveral different *** ofgastric acid is,however,a common *** hypersecretion of acid can by itself evoke aDU,*** the Zollinger-Ellison *** of the mechanism behind thedevelopment ... 详细信息

关键词： Helicobacter pylori Helicobacter infection gastric acid gastric mucosa duodenal ulcer bicarbonates gastric metaplasia

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Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer’s disease

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Translational Neurodegeneration 2021年第2期10卷 230-239页

作者： mari Aksnes Hans Christian DAass ann Tiiman Trine Holt Edwin Lars Terenius Nenad Bogdanovic Vladana Vukojevic anne-Brita Knapskog Department of Geriatric Medicine Institute of Clinical MedicineFaculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Clinical Neurosciences(CNS) Center for Molecular Medicine CMM L8:01Karolinska InstitutetStockholmSweden Department of Geriatric Medicine The Memory ClinicOslo University HospitalOsloNorway Institute of Health and Society Faculty of MedicineUniversity of OsloOsloNorway Norwegian National Advisory Unit on Ageing and Health Vestfold Hospital TrustTonsbergNorway Department of Neurobiology Care Science and Society(NVS)Division of Clinical GeriatricsKarolinska InstitutetHuddingeSweden

Background:The aggregation of amyloidβ(Aβ)is central in the pathogenesis of Alzheimer’s disease(AD).Recently it has been shown that specifically,larger,Thioflavin T-binding Aβaggregates are associated with increased neuroinflammation and cytokine *** study was aimed to quantify fibrillary amyloid aggregates,so-called nanoplaques,and investigate their relationship with cytokines in the cerebrospinal fluid(CSF).Methods:CSF was collected from 111 patients assessed for cognitive complaints at the Oslo University Hospital Memory *** patients were grouped based on their amyloid *** CSF nanoplaque concentration was quantified with the Thioflavin T-fluorescence correlation spectroscopy(ThT-FCS)*** levels of nine cytokines(eotaxin-1,granulocyte stimulating factor,interleukin[IL]-6,IL-7,IL-8,monocyte chemoattractant protein-1,gammainduced protein 10,macrophage inflammatory protein[MIP]-1α,and MIP-1β)were quantified with a magnetic bead-based multiplex assay and read on a Luminex IS 200 ***:There were 49 amyloid-negative and 62 amyloid-positive patients in the cohort;none of the cytokines differed significantly between the amyloid *** increased nanoplaque levels were associated with levels of MIP-1βbelow the lower limit of quantification,and with decreased levels of MIP-1αand *** associations remained significant when adjusted for age,sex,cognitive function,apolipoproteinε4 status and CSF core biomarker ***:The cytokine levels were not associated with amyloid status in this *** nanoplaque levels were negatively associated with MIP-1β,MIP-1αand IL-8,which is in line with recent findings suggesting that the upregulation of some cytokine markers has a protective role and is negatively associated with AD progression.

关键词： Alzheimer's disease Amyloid Amyloid beta peptides Amyloidogenic proteins Biomarkers Cerebrospinal fluid Cytokines Inflammation Fluorescence correlation spectroscopy Thioflavin T

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Optical diagnosis of colorectal polyps using high-definition i-scan: An educational experience

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World Journal of Gastroenterology 2013年第27期19卷 4334-4343页

作者： mariёlle WE Bouwens Rogier de Ridder Ad AM Masclee ann Driessen Robert G Riedl Bjorn Winkens Silvia Sanduleanu Division of Gastroenterology and Hepatology Department of Internal MedicineMaastricht University Medical Center NUTRIM School for NutritionToxicology and MetabolismMaastricht University Medical Center Department of Pathology Maastricht University Medical Center Department of Methodology and Statistics Maastricht University Medical Center GROW School for Oncology and Developmental BiologyMaastricht University Medical Center

AIM:To examine performances regarding prediction of polyp histology using high-definition (HD) i-scan in a group of endoscopists with varying levels of experience. METHODS:We used a digital library of HD i-scan still images, comprising twin pictures (surface enhancement and tone enhancement), collected at our university hospital. We defined endoscopic features of adenomatous and non-adenomatous polyps, according to the following parameters:color, surface pattern and vascular pattern. We familiarized the participating endoscopists on optical diagnosis of colorectal polyps using a 20-min didactic training session. All endoscopists were asked to evaluate an image set of 50 colorectal polyps with regard to polyp histology. We classified the diagnoses into high confidence (i.e., cases in which the endoscopist could assign a diagnosis with certainty) and low confidence diagnoses (i.e., cases in which the endoscopist preferred to send the polyp for formal histology). Mean sensitivity, specificity and accuracy per endoscopist/image were computed and differences between groups tested using independent-samples t tests. High vs low confidence diagnoses were compared using the pairedsamples t test. RESULTS:Eleven endoscopists without previous experience on optical diagnosis evaluated a total of 550 images (396 adenomatous, 154 non-adenomatous). Mean sensitivity, specificity and accuracy for diagnosing adenomas were 79.3%, 85.7% and 81.1%, respectively. No significant differences were found between gastroenterologists and trainees regarding performances of optical diagnosis (mean accuracy 78.0%vs 82.9%,P = 0.098). Diminutive lesions were predicted with a lower mean accuracy as compared to non-diminutive lesions (74.2% vs 93.1%, P = 0.008). A total of 446 (81.1%) diagnoses were made with high confidence. High confidence diagnoses corresponded to a significantly higher mean accuracy than low confidence diagnoses (84.0% vs 64.3%, P = 0.008). A total of 319 (58.0%) images were evalu

关键词： Colonoscopy High-definition i-scan Optical diagnosis Colorectal polyps Training

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对直肠硬胶囊剂滑动衣层的评价

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药学进展 1987年第4期 47-47页

作者： ann-mari Hannula 何常福

为使硬胶囊顺利地引入直肠,有时需要在胶囊外壳包一层滑动衣,该衣层接触体液可膨胀形成水凝胶,使胶囊滑润而易于塞入。本文设计们评价了直肠硬胶囊剂的滑动衣。由于胶囊壁质地光滑,无吸附性,包衣材料很难粘附胶壳,因此硬胶囊包衣远比片... 详细信息

为使硬胶囊顺利地引入直肠,有时需要在胶囊外壳包一层滑动衣,该衣层接触体液可膨胀形成水凝胶,使胶囊滑润而易于塞入。本文设计们评价了直肠硬胶囊剂的滑动衣。由于胶囊壁质地光滑,无吸附性,包衣材料很难粘附胶壳,因此硬胶囊包衣远比片剂包衣困难。本文以乳糖填充的0号胶囊作为包衣模型,采用空气悬浮包衣技术,根据滑动衣层的质量,滑动效果,质地,粘附性,胶壳弹性和崩解时间,考查和评价了三

关键词：乙醇溶液聚丙烯酸弹性丙烯酸类高聚物力学性能硬胶囊剂粘附性聚乙二醇直肠大肠

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