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Alterations of attention and impulsivity in the rat following a transgenerational decrease in dietary omega-3 fatty acids

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Food Science and Human Wellness 2018年第1期7卷 49-56页

作者： Joachim Hauser Ewelina Stollberg Andreas Reissmann Ivo Kaunzinger Klaus W.lange Department of Experimental Psychology University of Regensburg93040 RegensburgGermany

Polyunsaturated fatty acids(PUFAs),particularly the omega-3 PUFAs,are thought to be involved in neuronal processes,to play a role in neurodevelopmental disorders and to be important for the integrity of central nervous system *** present study investigated the effects of nutritional omega-3 PUFAs on attentional functions and impulsive behavior in Wistar *** this purpose,female Wistar rats were fed an omega-3 deficient diet over several generations,and the dams of the seventh generation were randomly assigned to two diet groups and fed an omega-3 deficient or an omega-3 sufficient *** addition,a group of previously untreated dams was fed an omega-3 sufficient *** male offspring of these three diet groups were tested using an established paradigm for the assessment of attention and impulsive behavior,i.e.a modified version of the five-choice-serial-reaction-time task(5CSRTT).The present data show that the deficiency of omega-3 PUFAs over generations led to substantial changes in attentional processes and impulsive *** impairments associated with an omega-3 deficiency were partly corrected by treatment with the omega-3 sufficient diet in the last generation of the omega-3 deficient group which showed substantial improvements in attention *** there were no significant effects of dietary modifications on psychomotor activity levels,there was some evidence for changes in impulsive *** conclusion,transgenerational dietary changes in the availability of omega-3 PUFAs led to changes in attentional processes and impulsive behavior in rats,supporting the hypothesis that omega-3 PUFAs play a role in cognitive and behavioral *** present findings offer a promising approach in the investigation of the role of omega-3 PUFAs in a variety of cognitive and behavioral domains.

关键词： Omega-3 fatty acid Polyunsaturated fatty acids Attention Impulsivity Activity Rat Neurodevelopmental disorders Psychiatric disorders

Diet and food in attention-deficit hyperactivity disorder

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Journal of Future Foods 2022年第2期2卷 112-118页

作者： Klaus W.lange Yukiko Nakamura Andreas Reissmann Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Deficiencies of nutrients,including vitamins,minerals and polyunsaturated fatty acids,and surpluses of food items,such as sucrose and artificial food additives,have not convincingly been shown to be involved in the etiology of *** group level,there is no conclusive evidence supporting dietary interventions for the treatment of *** identification of a role of food compounds in ADHD is hindered by the complex and ill-defined nature of *** view of the heterogeneity of the disorder,potential therapeutic benefits of nutritional interventions could be confined to subpopulations of children with ADHD as yet *** cumulative benefits of the range of ingredients comprising healthy diets may result in better outcomes compared to a supplementation of individual *** and nutrition interact with other lifestyle factors,such as physical activity,and the interrelationship between nutrition and lifestyle should play a more prominent role in research on treatment approaches to *** few-foods or oligoallergenic diet allows the design of individually tailored diets and may offer treatment opportunities in subgroups of children diagnosed with *** research is required to demonstrate the utility of nutrition-related interventions alone or in combination with other treatment approaches in ADHD.

关键词： Attention-deficit hyperactivity disorder Dietary patterns Food Nutrition Oligoallergenic diet

Can the 5-colour nutrition label“Nutri-Score”improve the health value of food?

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未来食品学报(英文) 2023年第4期3卷 306-311页

作者： Robin C.Hau Klaus W.lange Schmalkalden University of Applied Sciences Schmalkalden 98564Germany Faculty of Human Sciences University of RegensburgRegensburg 93040Germany

Obesity and other nutrition-related non-communicable diseases were virtually non-existent before the advent of industrialized food *** recent years,a 5-color front-of-package food label(“Nutri-Score”)seeking to demonstrate the overall nutritional value and healthiness of food products has been adopted for voluntary use in some European *** Nutri-Score is mainly based on the sugar,salt and calorie content of food *** present viewpoint discusses whether the Nutri-Score correctly identifies healthy and unhealthy food items and how large an impact the Nutri-Score may have on consumers’***,other benefits as well as hidden costs and drawbacks in implementing the Nutri-Score will be *** its reducing of the complex information regarding the contents of foods,the Nutri-Score may provide easily intelligible information regarding healthy nutrition and may become a valuable tool in educating consumers and influencing their food *** Nutri-Score may not become a game-changer in combating poor nutrition,but it is helpful in the right *** an inexpensive public policy,such as front-of-package labeling,makes some positive contribution,there is no reason to argue against its *** small effects may be relevant when a measure is adopted at population level.

关键词： Front-of-package food labeling Nutri-Score Food choice Food health value Obesity

Stents for malignant ureteral obstruction

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Asian Journal of Urology 2016年第3期3卷 142-149页

作者： Kristina Pavlovic Dirk lange Ben H.Chew Department of Urologic Sciences The Stone Centre at Vancouver General HospitalUniversity of British ColumbiaVancouverCanada

Malignant ureteral obstruction can result in renal dysfunction or urosepsis and can limit the physician’s ability to treat the underlying *** are multiple methods to deal with ureteral obstruction including regular polymeric double J stents(DJS),tandem DJS,nephrostomy tubes,and then more specialized products such as solid metal stents(e.g.,Resonance Stent,Cook Medical)and polyurethane stents reinforced with nickel-titanium(e.g.,UVENTA stents,TaeWoong Medical).In patients who require long-term stenting,a nephrostomy tube could be transformed subcutaneously into an extra-anatomic stent that is then inserted into the bladder *** outline the most recent developments published since 2012 and report on identifiable risk factors that predict for failure of urinary *** failures are typically a sign of cancer progression and the natural history of the disease rather than the individual type of drainage *** that were identified to predict drainage failure included low serum albumin,bilateral hydronephrosis,elevated C-reactive protein,and the presence of pleural ***-to-head studies show that metal stents are superior to polymeric DJS in terms of maintaining *** with the patient should take into consideration the frequency that exchanges will be needed,the need for externalized hardware(with nephrostomy tubes),or severe urinary symptoms in the case of internal *** review will highlight the current state of diversions in the setting of malignant ureteral obstruction.

关键词： Malignant ureteral obstruction Ureteral stent Hydronephrosis

Identification of characteristic plant co-occurrences in neotropical secondary montane forests

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Journal of Plant Ecology 2009年第1期2卷 31-41页

作者： Miguel D.Mahecha Alfredo Martı´nez Holger lange Markus Reichstein Erwin Beck Max Planck Institute for Biogeochemistry PO Box 10016407701 JenaGermany Department of Environmental Sciences Swiss Federal Institute of Technology—ETH Zurich8092 ZurichSwitzerland Bayreuth Centre for Ecology and Environmental Research University of Bayreuth95440 BayreuthGermany Fundacion Cordillera Tropical Jaime Roldos 4-80 y Huayna CapacEd.El Consorcio of.412CuencaEcuador Norwegian Forest and Landscape Institute PO Box 1151431 AsNorway

Aims Inferring environmental conditions from characteristic patterns of plant co-occurrences can be crucial for the development of conservation strategies concerning secondary neotropical ***,nomethodological agreement has been achieved so far regarding the identification and classification of characteristic groups of vascular plant species in the *** study examines botanical and,in particular,statistical aspects to beconsidered in such *** on these,we propose a novel data-driven approach for the identification of characteristic plantco-oc currences in neotropical secondary mountain *** Floristic inventory data were gathered in secondary tropical mountain forests in *** classification was performed by coupling locally adaptive isometric feature mapping,a non-linear ordination method and fuzzy-c-means *** approach was designed for dealing with underlying non-linearities and uncertainties in the inventory *** Findings The results indicate that the applied non-linear mapping in combination with fuzzy classification of species occurrence allows an effective identification of characteristic groups of co-occurring species as fuzzy-defined *** selected species indicated groups representing characteristic life-form distributions,as they correspond to various stages of forest *** the identified‘characteristic species groups’with meta-information derived from accompanying studies indicated that the clusters can also be related to habitat *** conclusion,we identified species groups either characteristic of different stages of forest succession after clear-cutting or of impact by fire or a *** expect that the proposed data-mining method will be useful for vegetation classification where no a priori knowledge is available.

关键词： secondary tropical mountain forests characteristic species groups non-linear ordination fuzzy-c-means clustering Ecuador

Distinct antifibrogenic effects of erlotinib,sunitinib and sorafenib on rat pancreatic stellate cells

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World Journal of Gastroenterology 2014年第24期20卷 7914-7925页

作者： anne Elsner Falko lange Brit Fitzner Martin Heuschkel Bernd Joachim Krause Robert Jaster Department of Medicine Ⅱ Division of GastroenterologyUniversity Medicine Rostock18057 RostockGermany Department of Neurology University Medicine Rostock18119 RostockGermany Department of Nuclear Medicine University Medicine Rostock18057 RostockGermany

AIM: To study if three clinically available small molecule kinase inhibitors (SMI), erlotinib, sunitinib and sorafenib, exert antifibrogenic effects on pancreatic stellate cells (PSC) and analyze the basis of their ac... 详细信息

关键词： Pancreatic stellate cell Fibrosis Erlotinib Sunitinib Sorafenib

Sport and physical exercise in sustainable mental health care of common mental disorders:Lessons from the COVID-19 pandemic

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Sports Medicine and Health Science 2023年第2期5卷 151-155页

作者： Klaus W.lange Yukiko Nakamura Andreas Reissmann Faculty of Human Sciences(Psychology Education and Sport Science)University of RegensburgRegensburgBavariaGermany

The large-scale disruptions to physical activity during the coronavirus pandemic have been found to be a leading predictor of common mental *** addition,regular physical exercise has been found to alleviate anxiety,sadness and depression during the *** findings,together with numerous studies published before the pandemic on the effects of physical activity on mental health,should be considered in the provision of mental health care following the ***-sectional research has revealed that all types of exercise and sport are associated with a reduced mental health ***,the effectiveness of exercise and sport participation in sustainable mental health care as well as the causal relationship between exercise,psychosocial health and common mental disorders merit further *** activity and sport,with their global accessibility,significant and clinically meaningful efficacy as well as virtual absence of adverse effects,offer a promising option for the promotion of mental health,including the prevention and treatment of common mental *** exercise and sport are likely to become valuable public mental health resources in the future.

关键词： Anxiety Depression Mental health Physical exercise COVID-19

Draft Genome Sequence of Mentha Iongifolia and Development of Resources for Mint Cultivar Improvement

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Molecular Plant 2017年第2期10卷 323-339页

作者： Kelly J. Vining Sean R. Johnson Amirhossein Ahkami Iris lange Amber N. Parrish Susan C. Trapp Rodney B. Croteau Shannon C.K. Straub Iovanna Pandelova B. Markus lange Department of Horticulture Oregon State University Corvallis OR 97331 USA M. J. Murdock Metabolomics Laboratory Institute of Biological Chemistry Washington State University Pullman WA 99164-6340 USA Department of Biology Hobart and William Smith Colleges Geneva NY 14456 USA Present address: Pacific Northwest National Laboratory Environmental Molecular Sciences Laboratory (EMSL) Richiand WA 99354 USA Present address: Medifluidics Inc. Fort Collins. CO 80525 USA

The genus Mentha encompasses mint species cultivated for their essential oils, which are formulated into a vast array of consumer products. Desirable oil characteristics and resistance to the fungal disease Verti- cillium wilt are top priorities for the mint industry. However, cultivated mints have complex polyploid ge- homes and are sterile. Breeding efforts, therefore, require the development of genomic resources for fertile mint species. Here, we present draft de novo genome and plastome assemblies for a wilt-resistant South African accession of Mentha Iongifolia （L.） Huds., a diploid species ancestral to cultivated peppermint and spearmint. The 353 Mb genome contains 35 597 predicted protein-coding genes, including 292 disease resistance gene homologs, and nine genes determining essential oil characteristics. A genetic linkage map ordered 1397 genome scaffolds on 12 pseudochromosomes. More than two million simple sequence repeats were identified, which will facilitate molecular marker development. The M. Iongifolia genome is a valuable resource for both metabolic engineering and molecular breeding. This is exemplified by employing the genome sequence to clone and functionally characterize the promoters in a peppermint cultivar, and demonstrating the utility of a glandular trichome-specific promoter to increase expression of a biosynthetic gene, thereby modulating essential oil composition.

关键词： aromatic plant essential oil genome mint Verticillium wilt

Dietary seaweeds and obesity

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Food Science and Human Wellness 2015年第3期4卷 87-96页

作者： Klaus W.lange Joachim Hauser Yukiko Nakamura Shigehiko Kanaya Department of Experimental Psychology University of RegensburgRegensburgGermany Graduate School of Information Science Nara Institute of Science and TechnologyIkomaJapan

Potential therapeutic benefits of seaweed consumption have been reported in the management of body weight and *** vitro and in vivo animal studies provide the majority of data available at *** majority of studies assessing the short-term effects of alginate consumption indicate that alginate may increase satiety,reduce energy intake and support weight *** suggested for these effects include delayed gastric clearance,stimulation of gastric stretch receptors and attenuated nutrient ***-term studies in humans are required in order to allow firm *** studies have investigated potential anti-obesity effects of seaweeds on adipogenesis and the inhibition of major lipid hydrolyzing and metabolizing *** results of these studies suggest beneficial effects of seaweed components such as fucoxanthin on body weight and the percentage of abdominal white adipose *** is premature to extrapolate these findings to humans since consistent findings are still *** is at present no solid evidence indicating that seaweeds are effective in long-term weight ***,available findings suggest potential benefits of seaweed components on *** investigations are required to establish the therapeutic efficacy in the management of overweight and obesity in humans and elucidate the underlying mechanisms of actions.

关键词： obesity stimulation intake