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Diet and medical foods in Parkinson’s disease

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Food Science and Human Wellness 2019年第2期8卷 83-95页

作者： Klaus W.lange Yukiko Nakamura Ning Chen Jianjun Guo Shigehiko Kanaya Katharina M.lange Shiming Li Department of Experimental Psychology University of RegensburgRegensburgGermany Tianjiu Research and Development Center for Exercise Nutrition and Foods Hubei Key Laboratory of Exercise Training and MonitoringCollege of Health ScienceWuhan Sports UniversityWuhanChina China Institute of Sport Science BeijingChina Graduate School of Information Science Nara Institute of Science and TechnologyIkomaJapan Department of Psychology University of WinchesterWinchesterUnited Kingdom Department of Food Science Rutgers UniversityNew BrunswickNJUSA

Parkinson’s disease (PD) is a slowly progressive neurodegenerative disorder with motor and non-motorsigns, which begins long before the diagnosis can be made. Pharmacotherapy with dopaminergic drugsis the mainstay of PD therapy. There is no currently available cure or disease-modifying treatment. Dietand various foods have been proposed as possible risk factors for PD. Nutritional supplementation withomega-3 fatty acids, vitamin D, B vitamins, and coenzyme Q may have potential in the management ofPD. In addition, several strategies could possibly lead to the development of medical foods in PD. Forexample, ketogenic diets may have effects complementary to pharmacotherapy. Gut microbial dysbiosisand altered microbial metabolites found in PD may lead to chronic low-grade inflammation in gut andbrain. Interventions targeting gut microbiota, such as the supplementation of probiotics, may providenovel approaches to PD in regard to both symptomatic treatment and disease modification. High qualityrandomized controlled trials need to be conducted in order to evaluate whether these food-basedstrategies have symptomatic efficacy or the potential to delay the progression of PD.

关键词： Parkinson’s disease Diet Medical food Ketogenic diet Probiotics Prevention

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Prime time for base editing in the mitochondria

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2630-2631页

作者： Michael A.Morgan Lucas lange Axel Schambach Institute of Experimental Hematology Hannover Medical SchoolHannover 30625Germany REBIRTH Research Center for Translational Regenerative Medicine Hannover Medical SchoolHannover 30625Germany Division of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115USA

A recent study published in Cell by the Kim lab represents a great advance towards expanding DNA editing possibilities to mitochondrial DNA(mtDNA)as they show reasonable targeted A-to-G conversions in human mtDNA using base editors to broaden the arsenal of available tools.1 Mutations in mitochondrial DNA(mtDNA)are linked to several diseases(Fig.1),thus,development of gene therapy and editing approaches could lead to curative options for patients suffering from these *** this direction,gene editing tools such as zinc-finger nucleases(mitoZFN),transcription activator-like effector nucleases(mitoTALENs)and meganucleases(mitoARCUS)were shown to eliminate mutant mtDNA and shift heteroplasmy.

关键词： diseases base curative

Detection of NH_(2) Radical in Ammonia Radio-Frequency Plasmas by Laser-Induced Resonance Fluorescence

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Chinese Physics Letters 2001年第7期18卷 939-941页

作者： GONG Xue-Yu X.R.Duan H.lange A.A.Meyer-Plath Department of Technological Physics Nanhua UniversityHengyang 421001 Institute of Low Temperature Plasma Physics Greifswald17489 Germany

By means of one photon absorption laser-induced resonance fluorescence at 599.5 nm the relative concentrations of amidogen(NH_(2))radical in the ammonia(NH_(3))radio-frequency(rf)plasma source were measured under different discharge pressures and rf *** time dependence of the fluorescence which comes from the radiation 101-211 of the P-branches of the Σ vibronic sub-bands can be described by a single-exponential *** decay time of NH_(2)(A2A1)Σ(0,9,0)rovibronic state was *** spatial dependence of the NH_(2) density in discharge tube was measured.

关键词： decay Ammonia Fluorescence

Lichen species dominance and the resulting photosynthetic behavior of Sonoran Desert soil crust types(Baja California,Mexico)

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Ecological Processes 2013年第1期2卷 64-72页

作者： Burkhard Büdel Mercedes Vivas Otto L lange Plant Ecology and Systematics Biology DepartmentUniversity of KaiserslauternP.O.Box 3049D-67653KaiserslauternGermany Department of Plant Science Faculty of PharmacyUniversidad Complutense de Madrid Plaza Ramóny Cajal28040MadridSpain Julius-von-Sachs-Institut für Biowissenschaften University of WürzburgJulius-von-Sachs-Platz 3D-97082WürzburgGermany.

Introduction:Lichen dominated biological soil crusts(BSCs)occur over large areas in the Sonoran Desert of the southwestern USA and northwest *** Baja California BSCs show a distinct patchiness and several types can be *** chlorolichen-and two cyanolichen-dominated BSCs were *** hypothesize that patchiness and the resulting domination of certain functional lichen groups will result in patchiness of photosynthetic CO_(2)-uptake related to environmental factors as ***:Four different soil crust samples were placed in cuvettes and their CO_(2) exchange was recorded in an open system with an infrared gas *** blown over the BSCs had a controlled CO_(2) content of 350 *** cuvettes were operated in *** CO2 exchange was continually recorded throughout the ***:Besides the dominating chlorolichens Psora decipiens and Placidium squamulosum and the cyanolichens Peltula patellata and ***,several other lichen species and 12 cyanobacterial species were found in the biological soil crusts *** chlorolichen BSCs already gained positive net photosynthesis with high air humidity alone,while the cyanolichen types did not,but showed smaller CO_(2)-uptake depression after water *** specific net photosynthesis responses to mode of hydration and to crust water content seem to correlate with precipitation characteristics of their ***:Species specific photosynthetic performance related to activation of respiration and net photosynthesis as well as to crust water content help to explain niche occupation and species composition of *** functional types have to be considered when they have a patchy distribution.

关键词： Biological soil crust Lichens Cyanobacteria Photosy

Back to pluripotency:fully chemically induced reboot of human somatic cells

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2658-2659页

作者： Lucas lange Miguel A.Esteban Axel Schambach Institute of Experimental Hematology Hannover Medical SchoolHannover 30625Germany REBIRTH Research Center for Translational Regenerative Medicine Hannover Medical SchoolHannover 30625Germany Laboratory of Integrative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Division of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115USA

In a recent study published in Nature,Guan et al.1 showed an exciting strategy to reprogram human somatic cells into human chemically induced pluripotent stem cells(hCiPSCs).Thereby,they identified crucial steps and p... 详细信息

关键词： al. chemically steps

团体积极心理干预对研究生生命意义感和社会支持的效果

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中国健康心理学杂志 2024年第3期32卷 445-450页

作者：张平张兰鸽涂翠平李雅北京邮电大学心理素质教育中心 100876 北京邮电大学人工智能学院

目的:验证积极心理干预提升研究生生命意义感及社会支持的有效性。方法:将59名研究生(年龄22.76±0.97岁)分为干预组(n=44)和对照组(n=15),干预组完成了6次团体积极心理干预,对照组等待实施干预,前测与后测均填写了生命意义感量表(MLQ)... 详细信息

目的:验证积极心理干预提升研究生生命意义感及社会支持的有效性。方法:将59名研究生(年龄22.76±0.97岁)分为干预组(n=44)和对照组(n=15),干预组完成了6次团体积极心理干预,对照组等待实施干预,前测与后测均填写了生命意义感量表(MLQ)和领悟社会支持量表(PSSS)。结果:①干预组在生命意义感、领悟社会支持得分上的变化量均显著高于对照组(t=2.02,2.60;P<0.05);②与前测相比,干预组在干预后生命意义感和领悟社会支持显著提升(t=3.80,3.71;P<0.001)。结论:团体积极心理干预可以有效提升研究生的生命意义感和社会支持。

关键词：团体积极心理干预生命意义感社会支持研究生

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Ketogenic diets and Alzheimer’s disease

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Food Science and Human Wellness 2017年第1期6卷 1-9页

作者： Klaus W.lange Katharina M.lange Ewelina Makulska-Gertruda Yukiko Nakamura Andreas Reissmann Shigehiko Kanaya Joachim Hauser Department of Experimental Psychology University of Regensburg93040 RegensburgGermany Department of Psychology University of WinchesterUK Graduate School of Information Science Nara Institute of Science and TechnologyJapan

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid-peptide plaques and neurofibrillary *** glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in *** early decline in brain glucose metabolism in AD has become a potential target for therapeutic *** has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is *** present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of *** the direct administration of ketone bodies and the use of high-fat,low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD *** mechanism underlying the efficacy of ketogenic diets remains unclear,but some evidence points to the normalization of aberrant energy *** present there is only limited evidence of the usefulness of ketogenic diets in ***,this dietary approach seems to be promising and deserves further clinical investigations.

关键词： Alzheimer’s disease Ketone bodies Ketogenic diet Therapy

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理工科大学生的抑郁、焦虑及与心理弹性的关系

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北京邮电大学学报（社会科学版） 2024年第2期26卷 112-120页

作者：张平涂翠平张兰鸽王培北京邮电大学心理素质教育中心北京100876

采取整群取样的方式,选取高校17180名理工科大学生作为研究对象,应用抑郁自评量表、焦虑自评量表、心理弹性量表进行调查。结果表明:(1)大学生的抑郁平均得分为42.8,焦虑平均得分为39.16,高于常模的平均水平。抑郁和焦虑的检出率分别为2... 详细信息

采取整群取样的方式,选取高校17180名理工科大学生作为研究对象,应用抑郁自评量表、焦虑自评量表、心理弹性量表进行调查。结果表明:(1)大学生的抑郁平均得分为42.8,焦虑平均得分为39.16,高于常模的平均水平。抑郁和焦虑的检出率分别为23.11%和10.05%。(2)男生的抑郁和焦虑检出率、标准分均高于女生,本科生的抑郁和焦虑检出率、标准分均为最高。(3)心理弹性负向预测抑郁和焦虑,分别解释57%和43%的变异。研究结论为从心理弹性的视角进行情绪健康干预提供了启示。

关键词：理工科大学生抑郁焦虑心理弹性

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The contribution of food bioactives and nutrition to the management of COVID-19

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Journal of Future Foods 2022年第1期2卷 13-17页

作者： Klaus W.lange Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Poor nutrition predisposes to infection,and various food compounds,such as micronutrients,are key elements of immune competence.A large number of scientific publications have suggested a role of phytochemicals,food bioactives and nutrition in combating the current coronavirus *** dietary components and specific food supplements have been proposed to be helpful in the prevention or therapy of *** findings in preclinical models suggest that food bioactives and micronutrients may potentially augment viral defense,evidence supporting antiviral and immunomodulatory efficacy of these compounds in the prevention or management of COVID-19 is ***-scale epidemiological and well-designed clinical studies investigating dosage and combinations of food compounds in different age groups and populations are needed before any recommendations can be *** malnutrition and overnutrition can adversely affect the immune *** at population level appears to be associated with elevated rates of fatal outcomes of *** and non-communicable diseases have been found to be a prognostic risk factor associated with worse COVID-19 outcomes.A focus on obesity and nutrition-related chronic diseases should be a key element of public *** approach would be more effective than the far less promising search for food bioactives with potential immune-supportive efficacy.

关键词： COVID-19 Food bioactives Micronutrients Nutrition Obesity