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Utility of high-resolution anterior segment optical coherence tomography in the diagnosis and management of sub-clinical ocular surface squamous neoplasia

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Eye and Vision 2019年第1期6卷 229-235页

作者： ann q.tran Nandini Venkateswaran Anat Galor Carol L.Karp Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900 NW 17th StMiamiFL 33136USA

Background:To evaluate the frequency and characteristics of sub-clinical ocular surface squamous neoplasia(OSSN)detected by high-resolution anterior segment tomography(HR-OCT)in patients with clinically unapparent disease following topical ***:A retrospective chart review of patients with OSSN identified through a pharmacy database at the Bascom Palmer Eye Institute from January 2013 to December 2018 was *** undergoing primary therapy with topical 5-fluorouracil 1%(5-FU)(4 times a day for 7 days with a 21-day break)or interferon-alpha-2b(IFN)(4 times a day)were *** were separated into two *** 1 included individuals whose clinical resolution of OSSN aligned with complete resolution on *** 2(sub-clinical OSSN group)included individuals with clinical OSSN resolution but with features of persistent disease on *** excluded included those treated at an outside institution and those who used topical therapy as a surgical ***:A total of 95 patients(95 eyes)were ***-clinical OSSN was detected at a frequency of 17%in our study patients(n=16 patients,9 treated with 5-FU and 7 treated with IFN).In the 16 individuals,the mean time to clinical resolution was 3.6±1.0 cycles for 5-FU and 4.0±0.0 months for *** additional 2.1±0.8 cycles for 5-FU and 1.2±0.4 months for IFN were needed to achieve HR-OCT resolution of *** in Group 1 was noted in 10 patients(12%)while no recurrences occurred in Group 2,the cohort with subclinical disease that received the extended medical *** mean follow-up was 24.0±17.9 ***:We found that at least 17%of individuals with apparent clinical resolution of OSSN have sub-clinical disease detected on *** information can be used to optimize treatment and extend therapy past the point of clinical resolution.

关键词： Ocular surface squamous neoplasia,High-resolution optical coherence tomography,Sub-clinical ocular surface squamous neoplasia,Ocular surface imaging ocular surface lesions

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The use of high resolution anterior segment optical coherence tomography for the characterization of conjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia

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Eye and Vision 2019年第1期6卷 123-130页

作者： Nandini Venkateswaran Carolina Mercado ann q.tran Armando Garcia Pedro Francisco Monsalve Diaz Sander R.Dubovy Anat Galor Carol L.Karp Bascom Palmer Eye Institute University of Miami Miller School of Medicine900 NW 17th StreetMiamiFL 33136USA Department of Ophthalmology Miami Veterans Administration Medical CenterMiamiFLUSA

Background:Conjunctival lymphoma,conjunctival amyloidosis and benign reactive lymphoid hyperplasia(BRLH)are conditions that often have a similar appearance on the ocular *** use of high resolution anterior segment optical coherence tomography(HR-OCT)enables clinicians to evaluate distinctive differences in tissue morphology and cellular patterns in various ocular surface *** this study,we characterize the morphological differences seen in conjunctival lymphoma,conjunctival amyloidosis and BRLH on HR-OCT ***:A retrospective chart review was performed of patients with biopsy proven conjunctival lymphoma,conjunctival amyloidosis and BRLH between 2012 and 2019 at the Bascom Palmer Eye *** were excluded if HR-OCT imaging was not performed on initial ***:Thirty-four total eyes of 27 patients were *** eyes had conjunctival lymphoma(16 patients),8 eyes had conjunctival amyloidosis(6 patients)and 6 eyes had BRLH(5 patients).All conditions appeared clinically as pink,red or yellow subepithelial lesions but had different features on *** lymphoma,HR-OCT images typically showed homogenous,dark subepithelial lesions with smooth borders,containing monomorphic dot-like ***-OCT images of amyloidosis typically showed heterogeneous,dark lesions with irregular borders,often containing hyperreflective linear ***-OCT images of BRLH showed variable infiltration of the subepithelial tissue,at times with homogenous lesions containing dot-like infiltrates like lymphoma and other times with more hyperreflective,subepithelial *** cytometry and gene rearrangement was needed for final differentiation between BRLH and lymphoma ***:Distinctive features on HR-OCT of conjunctival lymphoma,conjunctival amyloidosis and BRLH can help characterize these lesions beyond what is apparent with the clinical *** studies can further validate this technology’s use with m

关键词： High resolution anterior segment optical coherence tomography Ocular surface imaging Ocular surface lesions Conjunctival lymphoma Conjunctival amyloidosis Benign reactive lymphoid hyperplasia

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TGF-b:the sword,the wand,and the shield of FOXP3^(+)regulatory T cells

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Journal of Molecular Cell Biology 2012年第1期4卷 29-37页

作者： Dat q.tran Division of Pediatric Research Center Department of PediatricsThe University of Texas Medical School at HoustonHoustonTX 77030USA

Since its rediscovery in the mid-1990s,FOXP31 regulatory T cells(Tregs)have climbed the rank to become commander-in-chief of the immune *** possess diverse power and ability to orchestrate the immune system in time of inflammation and infection as well as in time of harmony and *** be the commander-in-chief,they must be equipped with both offensive and defensive *** review will focus on the function of transforming growth factor-b(TGF-b)as the sword,the wand,and the shield of *** as a sword,this review will begin with a discussion of the evidence that supports how Tregs utilize TGFb to paralyze cell activation and differentiation to suppress immune *** will next provide evidence on how TGF-b from Tregs acts as a wand to convert naıve T cells into iTregs and Th17 to aid in their combat against inflammation and ***,the review will present evidence on the role of TGF-b produced by Tregs in providing a shield to protect and maintain Tregs against apoptosis and destabilization when surrounded by inflammation and constant *** triadic function of TGF-b empowers Tregs with the responsibility and burden to maintain homeostasis,promote immune tolerance,and regulate host defense against foreign pathogens.

关键词： Foxp3 TGF-b LAP LRRC32 GARP Tregs autoimmunity tolerance transplantation

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Persistence in tillage decisions: Aggregate data analysis

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International Soil and Water Conservation Research 2019年第2期7卷 109-118页

作者： Dat q.tran Lyubov A.Kurkalova University of Arkansas at Fayetteville AR 72701Department of Agricultural Economics and AgribusinessUSA Can Tho University Department of Hydraulic EngineeringVietnam 1601 E.Market St. GreensboroNC27411North Carolina A&T State UniversityDepartment of EconomicsUSA 1601 E.Market St. GreensboroNC27411North Carolina A&T State UniversityDepartment of Energy and Environmental SystemsUSA

The Emission Gap Report 2013 from the United Nations Environment Program showed that adopting conservation tillage such as no-till,as an alternative to conventional tillage,contributes significantly to climate change mitigation through carbon ***,substantial amounts of soil carbon are lost when farmers interrupt continuous use of conservation tillage with conventional *** tillage is spreading,but little is known about the behavioral persistence in tillage *** address the gap in the literature,we estimate county-specific Markov models of tillage-crop choices,and use the predicted probabilities of alternative two-and three-year tillage rotations to evaluate spatial variation and temporal persistence in conservation tillage adoption for the state of lowa (U.S).We find that the county-average probabilities of continuous conservation tillage range between 0.133 and 0.295,and vary significantly among crop *** also find a statistically strong positive effect of the incidence of the highly erodible land on the county-average use of continuous conservation *** results underscore the importance of dynamic modeling for understanding behavioral persistence in tillage decisions,and the interdependence between farmers' crop and tillage rotations.

关键词： Aggregate data Continuous conservation tillage Markov chain model Crop rotations Highly erodible land

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An Enhanced Ensemble-Based Long Short-Term Memory Approach for Traffic Volume Prediction

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Computers, Materials & Continua 2024年第3期78卷 3585-3602页

作者： Duy quang tran Huy q.tran Minh Van Nguyen Faculty of Civil Engineering Nha Trang UniversityNha Trang650000Vietnam Robotics and Mechatronics Research Group Faculty of Engineering and TechnologyNguyen Tat Thanh UniversityHo Chi Minh City700000Vietnam Department of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City700000Vietnam

With the advancement of artificial intelligence,traffic forecasting is gaining more and more interest in optimizing route planning and enhancing service *** volume is an influential parameter for planning and operating traffic *** study proposed an improved ensemble-based deep learning method to solve traffic volume prediction problems.A set of optimal hyperparameters is also applied for the suggested approach to improve the performance of the learning *** fusion of these methodologies aims to harness ensemble empirical mode decomposition’s capacity to discern complex traffic patterns and long short-term memory’s proficiency in learning temporal ***,a dataset for automatic vehicle identification is obtained and utilized in the preprocessing stage of the ensemble empirical mode decomposition *** second aspect involves predicting traffic volume using the long short-term memory ***,the study employs a trial-and-error approach to select a set of optimal hyperparameters,including the lookback window,the number of neurons in the hidden layers,and the gradient descent ***,the fusion of the obtained results leads to a final traffic volume *** experimental results show that the proposed method outperforms other benchmarks regarding various evaluation measures,including mean absolute error,root mean squared error,mean absolute percentage error,and *** achieved R-squared value reaches an impressive 98%,while the other evaluation indices surpass the *** findings highlight the accuracy of traffic pattern ***,this offers promising prospects for enhancing transportation management systems and urban infrastructure planning.

关键词： Ensemble empirical mode decomposition traffic volume prediction long short-term memory optimal hyperparameters deep learning

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Fuzzy Feedback Control for Electro-Hydraulic Actuators

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Intelligent Automation & Soft Computing 2023年第5期36卷 2441-2456页

作者： Tan Nguyen Van Huy q.tran Vinh Xuan Ha Cheolkeun Ha Phu Huynh Minh School of Engineering-Technology Thu Dau Mot UniversityThu Dau Mot City590000Vietnam Faculty of Engineering-Technology Nguyen Tat Thanh UniversityHo Chi Minh City754000Vietnam Hue Industrial College Hue City530000Vietnam Robotics and Mechatronics Lab University of UlsanUlsan City44610Korea

Electro-hydraulic actuators(EHA)have recently played a signiﬁcant role in modern industrial applications,especially in systems requiring extremely high *** can be explained by EHA’s ability to precisely control the position and force through advanced sensors and innovative control *** of the promising approaches to improve control accuracy for EHA systems is applying classical to modern control algorithms,in which the proportional–inte-gral–derivative(PID)algorithm,fuzzy logic controller,and a hybrid of these methods are popular *** this paper,we developed a novel version of the fuzzy control algorithm and linear feedback control method,namely fuzzy lin-ear feedback control,to improve the control *** achieve the highest performance,weﬁrst designed a mathematical EHA model based on the Matlab/Simulink software packages thanks to the selected parameters,which are similar to a real EHA ***,we respectively applied PID,fuzzy PID(FPID),and fuzzy linear feedback control(FLFC)before comparing them to have a full view of the outstanding advantages of the proposed *** simulation results showed that the proposed FLFC algorithm is approximately 99%and 77%super-ior in performance to the PID and feedback control algorithms,respectively.

关键词： Electro-hydraulic actuator fuzzy PID feedback control

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Strong, lightweight, and highly conductive CNT/Au/Cu wires from sputtering and electroplating methods

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Journal of Materials Science & Technology 2020年第5期40卷 99-106页

作者： Thang q.tran Jeremy Kong Yoong Lee Amutha Chinnappan W.A.D.M.Jayathilaka Dongxiao Ji Vishnu Vijay Kumar Seeram Ramakrishna Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1EA-07-05Singapore 117575Singapore

In this study, we present a 2-step deposition method via sputtering and electroplating that uses carbon nanotube(CNT) wires synthesized from a wet-spinning technique to produce high-performance CNT/Au/Cu composite wires. After the Au sputtering pre-treatment, the deposition of Cu on the CNT wires was found to be much more homogeneous due to improved wettability and reactivity of the wire surface. At different electrodeposition time, the mechanical strength of the CNT/Au/Cu composite wires could be as high as 0.74 GPa(~2 times stronger than metal wires) while their electrical conductivity could reach 4.65 × 10~5 S/cm(~80% of that for copper). More importantly, the CNT/Au/Cu composite wires with high CNT volume fraction are expected to be lightweight(up to 42% lower than Cu mass density), suggesting that our high-performance composite wires are a promising candidate to substitute conventional heavy metal wires in the future applications.

关键词： Carbon nanotube wires Sputtering Electrical conductivity Electrodeposition

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High-performance carbon fiber/gold/copper composite wires for lightweight electrical cables

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Journal of Materials Science & Technology 2020年第7期42卷 46-53页

作者： Thang q.tran Jeremy Kong Yoong Lee Amutha Chinnappan Nguyen Huu Loc Long T.tran Dongxiao Ji W.A.D.M.Jayathilaka Vishnu Vijay Kumar Seeram Ramakrishna Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1EA-07-05Singapore 117575Singapore Faculty of Mechanical Engineering Ho Chi Minh City University of TechnologyVNUHCM268 Ly Thuong KietDistrict 10Ho Chi Minh City 740400Viet Nam

In this study,we synthesized high-performance Carbon Fiber/Gold/Copper(CF/Au/Cu)composite wires by using a 2-step deposition method via sputtering and *** Au was sputtered on PANbased CFs as a pre-treatment,the wettability and surface reactivity of the CFs were improved,resulting in a homogeneous deposition of Cu on their *** different Cu electrodeposition time,the resulting CF/Au/Cu composite wires could possess a high strength of up to 3.27 GPa(~10 times stronger than copper wires)while their electrical conductivity could be as high as 4.4×10^5 S/cm(~75%of that for copper).More importantly,since the composite wires were lightweight(up to 70%lower than Cu mass density),they are a promising candidate to substitute conventional heavy metal wires in the future electrical applications.

关键词： Carbon fiber Copper composite wires Strength Electrical properties

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Complex Network Analysis of the Robustness of the Hanoi, Vietnam Bus Network

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Journal of Systems Science & Complexity 2019年第5期32卷 1251-1263页

作者： tran Vu Hieu CHEONG Siew ann BUI Ngoc Dung Faculty of Information Technology University of Transport and CommunicationsHanoiVietnam Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang Link637371Singapore Faculty of Information Technology University of Transport and CommunicationsHanoiVietnam.

Many complex networks exist to facilitate the transport of material or information. In this capacity, the authors are often concerned with the continued flow of material or information when a fraction of the links in the complex network is disrupted. In other words, the authors are interested in the robustness of the complex network. In this paper, the authors survey measures of robustness like the average path length, the average clustering coefficient, the global efficiency, the size of largest cluster and use these to analyze the robustness of the bus network in Hanoi, Vietnam. The authors find that the bus network is robust against random failure but sensitive to targeted attack, in agreement with its scale-free character. By examining sharp drops in the average path length within the largest cluster of the Hanoi bus network under successive targeted attack, the authors identify five nodes whose loss lead to the fragmentation of the network into five or six disconnected clusters. These isolated clusters represent geographically the Central, Western, Southern, and Northwestern districts of Hanoi. Special considerations must therefore be given to these five nodes when planners wish to expand the bus network, or make it more robust.

关键词： Complex network hanoi bus network random failure robustness targeted attack

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Mathematical modeling and numerical computation of the effective interfacial conditions for Stokes flow on an arbitrarily rough solid surface

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Applied Mathematics and Mechanics(English Edition) 2021年第5期42卷 721-746页

作者： A.T.tran H.LE qUANG q.C.HE D.H.NGUYEN Research and Application Center for Technology in Civil Engineering University of Transport and CommunicationsHanoi 10000Vietnam Laboratoire Modelisation et Simulation Multi-Echelle Unite Mixte de Recherche 8208Centre National de la Recherche ScientifiqueUniversite Gustave EiffelMarne-la-Vallee F-77454France School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China

The present work is concerned with a two-dimensional(2D)Stokes flow through a channel bounded by two parallel solid *** distance between the walls may be arbitrary,and the surface of one of the walls can be arbitrarily *** main objective of this work consists in homogenizing the heterogeneous interface between the rough wall and fluid so as to obtain an equivalent smooth slippery fluid/solid interface characterized by an effective slip *** solve the corresponding problem,two efficient numerical approaches are elaborated on the basis of the method of fundamental solution(MFS)and the boundary element methods(BEMs).They are applied to different cases where the fluid/solid interface is periodically or randomly *** results obtained by the proposed two methods are compared with those given by the finite element method and some relevant ones reported in the *** comparison shows that the two proposed methods are particularly efficient and accurate.

关键词： effective slip length method of fundamental solution(MFS) boundary element method(BEM) Stokeslet micro-channel fluid/solid interface

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