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Fatty liver in H63D homozygotes with hyperferritinemia

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World Journal of Gastroenterology 2006年第11期12卷 1788-1792页

作者： Giada Sebastiani Daniel F Wallace Susan E Davies Vasu Kulhalli ann p walker James S Dooley Department of Medicine Royal Free and University College Medical School Royal Free CampusUniversity College LondonLondonUnited Kingdom Department of Medicine Royal Free and University College Medical School Royal Free CampusUniversity College LondonLondonUnited Kingdom and The Membrane Transport LaboratoryQueensland Institute of Medical ResearchBrisbaneQueenslandAustralia Department of Histopathology Royal Free and University College Medical School Royal Free CampusUniversity College LondonLondonUnited Kingdom Department of Gastroenterology Newham General Hospital LondonUnited Kingdom

To study the clinical correlates of the H63D mu-tation we have analysed the phenotype of H63D homozygotes identified through mutation analysis in a referral laboratory. A total of 366 blood samples referred for lIFE analysis were screened for C282Y and H63D mutations. Four H63D homozygotes were identified. All had raised serum ferritin but normal transferrin saturation. They were negative for hepatitis B and C and only one patient consumed excess alcohol. In all 4 cases ultrasonography revealed fatty liver. In two patients a liver biopsy was done and showed mild siderosis with an unusual distribution and macrovesicular steatosis. These data confirm the association between fatty liver, hyperferritinaemia and increased hepatic iron, but do not clarify whether siderosis was related to steatosis rather than homozygosity for the H63D mutation. patients with fatty liver may complicate the interpretation of data in population studies of the expression of H63D homozygosity.

关键词： Hyperferritinemia HFE gene H63D homozygosity Fatty liver

Sieve element occlusion provides resistance against Aphis gossypii in TGR-1551 melons

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Insect Science 2020年第1期27卷 33-48页

作者： Hsuan-Chieh peng Gregory p.walker Department of Microbiology and plant pathology University of CaliforniaRiversideCaliforniaUSA Department of Entomology University of CaliforniaRiversideCaliforniaUSA

Feeding behavior and plant response to feeding were studied for the aphid Aphis gossypii Glover on susceptible and resistant melons(*** and TGR-1551,respectively).Average phloem phase bout duration on TGR-1551 waspercent of aphids on TGR-1551 never produced a phloem phase that attained ingestion(EpG waveform E2)in contrast to only 7% of aphids on *** bout duration of waveform E2(scored as zero if phloem phase did not attain E2)on TGR-1551 waspG waveform El(sieve element salivation)was 2.8 times greater on TGR-1551 than on *** a second experiment,liquid nitrogen was used to rapidly cryofix leaves and aphids within a few minutes after the aphids penetrated a sieve *** near the penetration site was then examined by confocal laser scanning ***-six percent of penetrated sieve elements were occluded by protein in TGR-1551 in contrast to only 28% in *** in TGR-1551,occlusion was also observed in nearby nonpenetrated sieve ***,a calcium channel blocker,trivalent lanthanum,was used to prevent phloem occlusion in TGR-1551,and *** feeding behavior and the plants phloem response were compared between lanthanum-treated and control *** treatment eliminated the sieve element protein occlusion response and the aphids readily ingested phloem sap from treated *** study provides strong evidence that phloem occlusion is a mechanism for resistance against *** in TGR-1551.

关键词： aphid feeding behavior Aphis gossypii Cucumis melo insect-plant resistance phloem occlusion sieve element occlusion proteins

Restoration of the Western Himalaya： implications for metamorphic protoliths, thrust and normal faulting, and channel flow models

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Episodes 2007年第4期30卷 242-257页

作者： Michael p. Searle Ben Stephenson James walker Christian walker Dept. Earth Sciences Oxford University Parks Road Oxford OX1 3PR UK Shell Canada Energy 400 - 4th Ave. SW Calgary Alberta T2P 2H5 Canada Imperial Oil Resources ExxonMobil 237 4th Ave. SW Calgary Alberta T2P 3M9 Canada CHp Consulting London EC2N 2HA UK

The Greater Himalayan Sequence （GHS） is composed of a sequence of Barrovianfacies metamorphic rocks up to kyanite or sillimanite ＋ K-feldspar grade, migmatites, layered stromatic migmatites and leucogranite sheets. These rocks were metamorphosed during the late Eocene to early Miocene, and are bounded below by a large-scale SW-vergent ductile shear zone-thrust fault （Main Central Thrust; MCT）, and above by a NE-dipping low-angle normal sense shear zone and fault （Zanskar Shear Zone; ZSZ）,

关键词：变形原岩喜玛拉雅山断层作用地质模型

Electricity Tariff Aware Model predictive Controller for Customer Battery Storage with Uncertain Daily Cycling Load

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Journal of Modern power Systems and Clean Energy 2022年第1期10卷 140-148页

作者： Dejan p.Jovanović Gerard F.Ledwich Geoffrey R.walker Institute of Electrical and Electronic Engineers QueenslandAustralia School of Electrical Engineering and Robotics Queensland University of TechnologyBrisbaneAustralia

To optimally control the energy storage system of the battery exposed to the volatile daily cycling load and electricity tariffs,a novel modification of a conventional model predictive control is *** uncertainty of daily cycling load prompts the need to design a new cost function which is able to quantify the associated *** modelling a probabilistic dependence among flow,load,and electricity tariffs,the expected cost function is obtained and used in the constrained *** proposed control strategy explicitly incorporates the cycling nature of customer ***,for daily cycling load,a fixed-end time and a fixed-end output problem are *** is demonstrated that the proposed control strategy is a convex optimization *** stochastic and robust model predictive controllers evaluate the cost concerning model constraints and parameter ***,the expected cost across the flow variations is *** density function of load probability improves load prediction over a progressive prediction horizon,and a nonlinear battery model is utilized.

关键词： Residential energy systems battery storage model predictive control nonlinear optimization cost of daily electricity consumption

Model predictive Control Strategy for Residential Battery Energy Storage System in Volatile Electricity Market with Uncertain Daily Cycling Load

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Journal of Modern power Systems and Clean Energy 2023年第2期11卷 534-543页

作者： Dejan p.Jovanović Gerard F.Ledwich Geoffrey R.walker Institute of Electrical and Electronic Engineers QueenslandAustralia School of Electrical Engineering&Robotics Queensland University of TechnologyBrisbaneAustralia

This paper presents a control strategy for residential battery energy storage systems,which is aware of volatile electricity markets and uncertain daily cycling *** economic benefits of energy trading for prosumers are achieved through a novel modification of a conventional model predictive control(MpC).The proposed control strategy guarantees an optimal global solution for the applied control action.A new cost function is introduced to model the effects of volatility on customer benefits more ***,the newly presented cost function models a probabilistic relation between the power exchanged with the grid,the net load,and the electricity *** probabilistic calculation of the cost function shows the dependence on the mathematical expectation of market price and net *** techniques for calculating this value are *** proposed strategy differs from the stochastic and robust MpC in that the cost is calculated across the market price and net load variations rather than across model constraints and parameter variations.

关键词： Optimal control model predictive control(MpC) energy market nonlinear constrained optimization revenue for battery energy storage system Gaussian mixture model autoregressive integrated moving average model

Cardiovascular care for older adults： hypertension and stroke in the older adult

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Journal of Geriatric Cardiology 2016年第5期13卷 373-379页

作者： Andrew p Miller ann M Navar Gary S Roubin Suzanne Oparil CardioVascular Associates Birmingham Alabama USA Duke Clinical Research Institute Durham North Carolina USA Vascular Biology & Hypertension program Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham Alabama USA

1 Introduction Hypertension and cerebrovascular disease incidence and prevalence rise dramatically with age, owing to longer exposure time to age-associated alterations in vascular function and structure and cardiovascular risk factors. This chapter is aimed at connecting age-related alterations in vascular function and structure to the resultant target organ damage, and to raise awareness of unique presentations and treatment strategies for hypertension and stroke in older adults.

关键词： Aging Cerebrovascular disease Clinical trials Hypertension Stroke

Competition between collective oblate rotation and non-collective prolate K isomerism in neutron-rich tungsten isotopes

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Science China(physics,Mechanics & Astronomy) 2012年第9期55卷 1613-1617页

作者： JIAO ChangFeng SHI Yue XU FuRong SUN Yang walker p M State Key Laboratory of Nuclear physics and Technology School of Physics Peking University Beijing 100871 China Center for Theoreiical Nuclear~physics National Laboratory-for Heavy lon Physics Lanzhou 730000 China Department of physics Shanghai Jiao Tong University Shanghai 200240 China Department of physics University of Surrey GuUdford Surrey GU2 7XH United Kingdom CERN CH-1211 Geneva 23 Switzerland

Recent experiments open up the possibility to investigate oblate rotation-aligned states and prolate high-K isomers in neutron-rich tungsten *** the present work,we perform the projected-shell-model calculations for A ～ 190 tungsten *** 190 W results are compared with experimental *** observed 8 + isomer is assigned as a two-quasiproton K π = 8 + ***-lying high-K four-quasiparticle states are *** particular interest is the prediction of the K π = 20 + state in 190,192 W,which may form a long-lived spin *** competition with the prolate high-K states,rotational alignment leads to near-yrast collective oblate rotation.

关键词： prolate and oblate shapes isomers rotational alignment projected shell model

Development of a fall prevention protocol for replication in a virtual environment

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Advances in Aging Research 2012年第2期1卷 47-52页

作者： Beth ann walker Lesa L. Huber School of Health Physical Education and Recreation Indiana University Bloomington USA School of Occupational Therapy University of Indianapolis Indianapolis USA

Several effective fall prevention exercise programs address the problem of falls. The primary challenge is not to develop effective programs, but to find ways to motivate older people to begin and maintain these programs while delivering these programs to as many older adults as possible. This short-term pilot study collected preliminary data on the design and testing of a balance rehabilitation protocol that could be replicated in a virtual gaming environment like the Wii Fit. The protocol, based on evidence- based practice, focused on strength, endurance, and functional reach. Eight older adults participated in twelve one hour sessions with an occupational therapist and exercise professional. Outcome measures included the Modified Falls Efficacy Scale, Life Space Questionnaire, and postural sway. Results suggest that the protocol was effective in improving postural sway (as measured by a force plate), reducing fear of falling, and increasing perceived life space.

关键词： Fall prevention Virtual Gaming Exercise Older Adults Balance

Immunosuppressive,antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes(Hymenoptera:Braconidae)

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Insect Science 2023年第4期30卷 1105-1117页

作者： Ciro p.G.pinto Andrew A.walker Glenn F.King Guilherme D.Rossi School of Agricultural and Veterinarian Sciences Sao Paulo State University(UNESP)JaboticabalBrazil Institute for Molecular Bioscience The University of QueenslandSt LuciaBrisbaneQueenslandAustralia Australian Research Council Centre of Excellence for Innovations in peptide and protein Science The University of QueenslandQueenslandSt LuciaAustralia

Teratocytes are specialized cells released by parasitoid wasps into their *** are known for producing regulatory molecules that aid the development of imma-ture *** have recently reported the primary structures of cystine-rich peptides,including some containing inhibitor cystine knot(ICK)motifs,produced by teratocytes of the parasitoid Cotesia flavipes(Hymenoptera:Braconidae).ICKs are known for their stability and diverse biological *** this study,we produced four putative ICK peptides from the teratocytes of *** using solid-phase peptide synthesis or recom-binant expression in ***,and investigated their functions on host immune modulation as well their potential to impair the development of two lepidopterans after ingestion of the *** addition,the peptides were assayed against pathogens and human *** peptides did not influence total hemocyte count but suppressed cellular immunity,detectable as a reduction of hemocyte encapsulation(CtICK-I,CftICK-II,CtICK-I)and spread indexes(CftICK-IV)in the *** of the peptides influenced the activi-ties of prophenoloxidase and phenoloxidase in the hemolymph of larval Diatraea sacchar-alis(Lepidoptera:Crambidae).CftICK-I and CftICK-II with previously unknown function showed antifungal activity against Candida albicans but were non-toxic to human ***-I,CftICK-II,and CftICK-II increased larval mortality and reduced leaf consump-tion of ***,a permissive host for *** CftICK-III also increased larval mortality and reduced leaf consumption of Spodoptera frugiperda(Lepidoptera:Noctuidae),a non-permissive host for *** study highlights biological func-tions and biotechnological potential of ICK peptides from the teratocytes of ***.

关键词： biocontrol encapsulation host regulation Hymenoptera parasitoid phe-noloxidase