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Positive attitudes towards priority setting in clinical guidelines among Danish general practitioners: A web based survey

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Health 2013年第2期5卷 188-192页

作者： ann nielsen Benedicte Carlsen Pia K. Kjellberg KORA—Danish Institute for Local and Regional Government Research Copenhagen Denmark Uni Rokkan Centre Uni Research Bergen Norway

Aims: Increasing focus on improvement and optimisation of the treatment in primary care and reduction of healthcare costs emphasize the need to understand which factors determines adherence and non-adherence to clinical guidelines. In the present study, we examined attitudes towards clinical guidelines in Danish general practitioners (GPs). Methods: We conducted a survey among Danish GPs from all five regions of Denmark. In total, 443 GPs answered the web-based questionnaire that contained questions about attitudes and barriers to clinical guidelines. Results: More than 90% of the GPs reported that they have good knowledge of the guidelines and in general follows the guidelines. A majority of the GPs (81%) found it acceptable that economic considerations are part of the guidelines. The most important factors for non- adherence to guidelines were “need of adjustment to clinical practice” and “lack of confidence in guidelines”. The attitudes to clinical guidelines were not significantly associated with practice characteristics such as gender, years of experience, practice organisation and localisation. Conclusions: Our findings show that clinical guidelines are an integrated or internalised part of everyday practice among GPs in Denmark. Furthermore, the findings indicate that Danish GPs are positive towards applying priority setting in their practice. This is decisive in the light of rising healthcare costs due to development of new expensive technologies and ageing populations that puts pressure on the healthcare system in general and primary healthcare in particular.

关键词： Clinical Guidelines General Practitioners Adherence Attitudes Barriers

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HPV infection among 2,460 Danish men-Status Before Vaccination

HPV infection among 2,460 Danish men-Status Before Vaccinati...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Susanne Kruger Kjaer Chnstlan Munk Bugge Nohr ann nielsen Gabrielle Breugelmans Kai-Li Liaw Thomas lftner Danish Cancer Society Danish Cancer Society Danish Cancer Society Danish Cancer Society Sanofi Pasteur MSD Merck Research Laboratories Dept of Medical Virology University Hospital of Tubingen

＜正＞Background Before HPV vaccination is implemented,it is important to gain knowledge on the prevalence of HPV and the distribution of the different HPV types in population-based *** natural history of HPV infection in men has been much less studied than in *** assessed the overall and age stratified prevalence,type-specific HPV distribution and risk factors for HPV infection in ＞ 2,400 men from the Danish military using two different HPV testing Methods.

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Plant exocytosis: Weaving distinct pathways to the plant plasma membrane

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Molecular Plant 2022年第3期15卷 382-384页

作者： Erik nielsen Department of Molecular Cellularand Developmental BiologyUniversity of MichiganAnn ArborMI 48109USA

During plant growth and development newly synthesized proteins and other cargo molecules must be selectively targeted to a variety of cellular *** the most important targeting involves the trafficking of proteins to the plasma membrane,where they control interactions with the environment and neighboring *** this process,proteins entering the secretory pathway are imported into the endoplasmic reticulum where they are folded and *** are then sorted and delivered to the Golgi complex,where they are further processed and modified.

关键词： neighboring processed complex

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Targeting and Regulation of Cell Wall Synthesis During Tip Growth in Plants

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Journal of Integrative Plant Biology 2013年第9期55卷 835-846页

作者： Fangwei Gu Erik nielsen Department of Molecular Cellular and Developmental Biology University of MichiganAnn Arbor Michigan 48109 USA

Root hairs and pollen tubes are formed through tip growth, a process requiring synthesis of new cell wall material and the precise targeting and integration of these components to a selected apical plasma membrane domain in the growing tips of these cells. Presence of a tip-focused calcium gradient, control of actin cytoskeleton dynamics, and formation and targeting of secretory vesicles are essential to tip growth. Similar to cells undergoing diffuse growth, cellulose, hemi-celluloses, and pectins are also deposited in the growing apices of tip-growing cells. However, differences in the manner in which these cell wall components are targeted and inserted in the expanding portion of tip-growing cells is reflected by the identification of elements of the plant cell wall synthesis machinery which have been shown to play unique roles in tip-growing cells. In this review, we summarize our current understanding of the tip growth process, with a particular focus on the subcellular targeting of newly synthesized cell wall components, and their roles in this form of plant cell expansion.

关键词： Cellulose membrane trafficking plant cell wall pollen tube root hair tip growth.

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