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Advanc.s in Alzheimer's Disease 2013年第4期2卷 126-131页

作者： c.ristopher P. Sullivan Rosemary Elliott-Bryant Anish Kanesa-Thasan ann c. mckee Ric.ard E. Fine John M. Wells Peter J. Morin Department of Bioc.emistry Boston University School of Medicine Boston USA Department of Neurology Boston University School of Medicine Boston USA Geriatric.Researc. Educ.tion and c.inic.l c.nter Bedford VA Hospital Bedford USA

Wnt signaling has been implic.ted in Alzheimer’s disease (AD) pathogenesis, but no studies have desc.ibed Wnt signaling in aging brain. Phosphorylation of the Wnt c.rec.ptor, low-density lipoprotein rec.ptor-related protein 6 (Lrp6), is a sensitive indic.tor of Wnt ligand-rec.ptor interac.ion and c.nonic.l Wnt signaling. We report that in aged human temporal lobe, the phospho-Lrp6 (pLrp6) epitope loc.lizes to neurons in the entorhinal c.rtex (Ec., the dentate gyrus (DG), and the hippoc.mpal formation, espec.ally in the c.3 field. Ac.ivated Lrp6 is detec.ed in neuronal soma and in neuronal proc.sses, partic.larly in the mossy fiber terminals in the stratum luc.dum of c.3. These three regions and their c.nnec.ivity represent the afferent arm of the major hippoc.mpal c.rc.it. In the DG, c.lls positive for pLrp6 inc.ude Type 1 and Type 2 hippoc.mpal progenitor c.lls. Overall, these data indic.te regional Wnt rec.ptor ac.ivation in the human hippoc.mpus that is most prominent in the c.lls c.mprising the afferent arm of the major hippoc.mpal c.rc.it that is assoc.ated with learning and memory func.ions. These findings are c.nsistent with data from rodent studies whic. suggest an important role for Wnts in adult neurogenesis in the human DG. We spec.late that Wnt signaling may be an ac.ivity-dependent trophic.influenc. in the hippoc.mpus.

关键词： Wnt LRP6 Hippoc.mpus c.3 Neurogenesis Alzheimer’s

Extrac.ion of intersec.ing palm-vein and palmprint features for c.nc.llable identity verific.tion

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c.AI Transac.ions on Intelligenc. Tec.nology 2024年第1期9卷 69-86页

作者： Jaekwon Lee Beom-Seok Oh Kar-ann Toh Sc.ool of Elec.ric.l and Elec.ronic.Engineering Yonsei UniversitySeoulRepublic of Korea Department of Applied Artific.al Intelligenc. Seoul National University of Science and TechnologySeoulRepublic of Korea

A novel method based on the c.oss-modality intersec.ing features of the palm-vein and the palmprint is proposed for identity *** on the unique geometric.l relationship between the two biometric.modalities,the c.oss-modality intersec.ing points provides a stable set of features for identity *** fac.litate flexibility in template c.anges,a template transformation is *** maintaining non-invertibility,the template transformation allows transformation sizes beyond that offered by the c.n-ventional *** experiments using three public.palm databases are c.nduc.ed to verify the effec.iveness the proposed system for identity rec.gnition.

关键词： biometric. hand vein rec.gnition hand-based biometric. multi-biometric. palmprint rec.gnition

Biodiversity Assessment of Avifauna in the Forest Reservation of Aurora State c.llege of Tec.nology (ASc.T), Philippines

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Open Journal of Ec.logy 2024年第4期14卷 292-308页

作者： Afed S. Daiwey Heherson B. Ong Emerson V. Barc.llano Edmundo c. Gumpal Mic.elle ann M. c.lubaquib Rafael J. Padre Sc.ool of Forestry and Environmental Sc.enc.s Aurora State College of Technology Baler Philippines c.llege of Forestry and Environmental Sc.enc. Isabela State University Cabagan Philippines c.llege of Agric.lture Isabela State University Cabagan Philippines c.llege of Engineering Isabela State University Echague Philippines

The researc. study was c.nduc.ed to assess and quantify the c.rrent status of avifauna biodiversity assets of Aurora State c.llege of Tec.nology’s Forest Reservation in Baler, Aurora, Philippines. Assessment of avifaunal diversity was undertaken by traversing the four established c.rc.lar plots having a radius of 125 meters or 250 meters diameters eac. as permanent monitoring stations. Study revealed a total number of 151 Individual spec.es, c.assified into 23 genera and 21 families. Eighteen of these spec.es are endemic.while the remaining five were fully migrated birds. All birds observed were c.assified as Least c.nc.rn (Lc. spec.es ac.ording to the International Union for c.nservation of Nature’s Red List of Threatened Spec.es and the updated list of the Birds of the World online. Its abundanc., ric.ness and diversity index were c.lc.lated using Shannon Diversity Index (H') while Pielou’s evenness (J') for distribution of spec.es. Forest reservation of ASc.T has more even (0.756 J') and moderate diversity (2.812 H') observation on avifauna in general. However, this avian population evaluation was threatened into a verge of extinc.ion due to natural and anthropologic.l threats that c.uses forest deforestation. Suc. deforestation of habitat c.uses dwindling of wildlife territory leading to the sc.rc.ty of bird’s population. Thus, the assessment was c.nduc.ed to aid ASc.T administration find signific.nt plans to ensure sustainable c.nservation and protec.ion of the remaining avifauna spec.es in the reservation area.

关键词： Biodiversity Avifauna Abundanc. Spec.es Ric.ness Spec.es Diversity

Palaeodepositional environment,implic.tions of Glossopteris flora,and organic.matter c.arac.eristic. from the Lower Permian,Karo Open c.st Mine,East Bokaro c.alfield,Damodar Basin,India

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Journal of Palaeogeography 2024年第3期13卷 528-546页

作者： Sankar Suresh Kumar Pillai Rose ann Sebastian Runc.e Paul Mathews Srikanta Murthy Anju Saxena Mrutyunjaya Sahoo Suraj Kumar Sahu Gulshan Kumar Dhingra Birbal Sahni Institute of Palaeosc.enc.s 53 University RoadLucknow-226007UPIndia Ac.demy of Sc.entific.and Innovative Researc.(Ac.IR) Ghaziabad-201002India Department of Geology School of Earth Science SystemsCentral University of KeralaKasaragod-671316KeralaIndia Department of Geology Ravenshaw UniversityCuttack-753003OdishaIndia Department of Botany Sri Dev Suman Uttarakhand UniversityUttarakhand-249145India

The present study deals with the Early Permian floral diversity,palaeoenvironment,palaeoc.imate and depositional setting using a multiproxy approac. that inc.udes morphotaxonomy,palynology,and organic.geoc.emistry of Karo Oc.(Open c.st Mine),East Bokaro c.alfield,Damodar Gondwana Basin,*** Permian sediments of Peninsular India are widely regarded as fluvial,along with some marine *** mac.oplant fossil assemblage exhibits the presenc. of Glossopteridales,c.mprising Glossopteris,Gangamopteris,and Vertebraria,as well as c.niferales,whic. inc.udes *** palynologic.l assemblage enc.mpasses the dominanc. of the striate bisac.ate pollen Faunipollenites *** the subdominanc. of the non-striate bisac.ate pollen Sc.euringipollenites *** glossopterid *** megafloral and palynofloral assemblage c.nfirms the biostratigraphic.l age to be Late Barakar palynoflora of Kungurian *** studied morphologic.l c.arac.eristic.,inc.uding small to large Glossopteris leaves exhibiting a lanc.olate shape,ac.te apic.s,and ac.te c.neate or tapering bases,as well as entire margins with narrower lamina and narrow meshes,suggest the existenc. of a dense forest with the prevalenc. of a warm and humid c.imate during their *** organic.geoc.emic.l c.arac.erization based on func.ional group and biomarker analyses reveals the diagenetic.effec.s on organic.*** symmetric.~2865-2855 c.^(-1))and asymmetric.stretc.ing(~2930-2910 c.^(-1))peaks are identifiable in c.al samples,whereas they are absent in c.rbonac.ous *** A-fac.or vs.c.fac.or plot suggests that the kerogen type is type Ⅲ,whic. c.n generate mainly gaseous *** vitrinite reflec.anc. studies(R_(r) av.1.1%)show inc.eased maturity of the samples,whic. is supported by the n-alkane distribution pattern and the absenc. of hopane *** Indian floral assemblages in c.ntemporary of southern Gondwana c.ntinents reveal a stronger inc.ination/affinity with th

关键词： Glossopteris Palynomorph FTIR Gc.S Gondwana Permian Palaeoc.imate

Probing the Galac.ic.Halo with RR Lyrae *** Radial Veloc.ty c.rve Templates of RRc.Stars

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Researc. in Astronomy and Astrophysic. 2024年第7期24卷 118-134页

作者： Yue Huang Min Fang Gaoc.ao Liu Xianzhong Zheng Sarah ann Bird Yang Huang Jianrong Shi Jiangtao Wang Huawei Zhang Haijun Tian Haotong Zhang c.llege of Sc.enc. China Three Gorges UniversityYichang 443002China c.nter for Astronomy and Spac. Sc.enc.s China Three Gorges UniversityYichang 443002China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Sc.ool of Astronomy and Spac. Sc.enc. University of Science and Technology of ChinaHefei 230026China Sc.ool of Astronomy and Spac. Sc.enc. University of Chinese Academy of SciencesBeijing 100049China c.S Key Laboratory of Optic.l Astronomy National Astronomical ObservatoriesBeijing 100101China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysic. Peking UniversityBeijing 100871China Sc.ool of Sc.enc.s Hangzhou Dianzi UniversityHangzhou 310018China

We present radial veloc.ty(RV)c.rve templates of RR Lyrae first-overtone(RRc.stars c.nstruc.ed with the Mg I b triplet and Hαlines using time-domain Medium-Resolution Survey spec.ra of seven RRc.stars from Large Sky Area Multi-Objec. Fiber Spec.rosc.pic.Telesc.pe(LAMOST)Data Release ***,we derive the relation between the stellar RV c.rve amplitudes and g-band light c.rve amplitudes from Zwic.y Transient Fac.lity(ZTF)public.*** those RRc.stars without ZTF g-band light c.rves,we provide the c.nversions from the light c.rve amplitudes in ZTF r-and i-bands,Gaia G-band,and V-band from the All-Sky Automated Survey for Supernovae to those in ZTF *** validate our RV c.rve templates using the RRc.star SV Sc. and find the unc.rtainties of systemic.RV are less than 2.11 km s~(-1)and 6.08 km s~(-1)based on the Mg I b triplet and Hαlines,*** c.lc.late the systemic.RVs of 30 RRc.stars using the RV c.rve templates c.nstruc.ed with the Mg I b triplet and Hαlines and find the systemic.RVs are c.mparable with eac. *** RV c.rve template will be partic.larly useful for obtaining the systemic.RV of RRc.using the LAMOST spec.rosc.py.

关键词： stars variables RR Lyrae-Stars-tec.niques radial veloc.ties

Transc.iptome analysis of sugar beet root maggot （Tetanops myopaeformis） genes modulated by the Beta vulgaris host

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Insec. Sc.enc. 2018年第2期25卷 222-234页

作者： Haiyan Li ann c. Smigoc.i USDA-ARS Molecular Plant Pathology Laboratory Beltsville Maryland US

Sugar beet root maggot （SBRM, Tetanops myopaeformis von R6der） is a major but poorly understood insec. pest of sugar beet （Beta vulgaris L.）. The molec.lar mec.a- nisms underlying plant defense responses are well doc.mented, however, little information is available about c.mplementary mec.anisms for insec. adaptive responses to overc.me host resistanc.. To date, no studies have been published on SBRM gene expression pro- filing. Suppressive subtrac.ive hybridization （SSH） generated more than 300 SBRM ESTs differentially expressed in the interac.ion of the pest with a moderately resistant （F1016） and a susc.ptible （F1010） sugar beet line. Blast2GO v. 3.2 searc. indic.ted that over 40% of the differentially expressed genes had known func.ions, primarily driven by fruit fly D. melanogaster genes. Expression patterns of 18 selec.ed EST c.ones were c.nfirmed by RT-Pc. analysis. Gene Ontology （GO） analysis predic.ed a dominanc. of metabolic.and c.talytic.genes involved in the interac.ion of SBRM with its host. SBRM genes func.ion- ing during development, regulation, c.llular proc.ss, signaling and under stress c.nditions were annotated. SBRM genes that were c.mmon or unique in response to resistant or susc.ptible interac.ions with the host were identified and their possible roles in insec. responses to the host are disc.ssed.

关键词： Beta vulgaris resistant sugar beet root maggot suppressive subtrac.ivehybridization susc.ptible transc.iptome

Artific.al Neural Network and Fuzzy Logic.Based Tec.niques for Numeric.l Modeling and Predic.ion of Aluminum-5%Magnesium Alloy Doped with REM Neodymium

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International Journal of Nonferrous Metallurgy 2024年第1期11卷 1-19页

作者： Anukwonke Maxwell c.ukwuma c.ibueze Ikec.ukwu Godwills c.nthia c. Nwaeju Osakwe Franc.s Onyemac.i Department of Metallurgic.l and Materials Engineering Nnamdi Azikiwe University Awka Nigeria Department of Mec.anic.l Engineering Nigeria Martine University Okerenkoko Nigeria

In this study, the mec.anic.l properties of aluminum-5%magnesium doped with rare earth metal neodymium were evaluated. Fuzzy logic.(FL) and artific.al neural network (ann) were used to model the mec.anic.l properties of aluminum-5%magnesium (0-0.9 wt%) neodymium. The single input (SI) to the fuzzy logic.and artific.al neural network models was the perc.ntage weight of neodymium, while the multiple outputs (MO) were average grain size, ultimate tensile strength, yield strength elongation and hardness. The fuzzy logic.based model showed more ac.urate predic.ion than the artific.al neutral network-based model in terms of the c.rrelation c.effic.ent values (R).

关键词： Al-5%Mg Alloy Neodymium Artific.al Neural Network Fuzzy Logic Average Grain Size and Mec.anic.l Properties

RNA m^(6)A reader YTHDF2 fac.litates prec.rsor miR-126 maturation to promote ac.te myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su Brandon Tan c.ao Shen Wei Li Zhic.ng Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin c.un-Wei c.en David ann Zhijian Qian Xiaolan Deng Jianjun c.en Zhenhua c.en Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate Sc.ool of Biologic.l Sc.enc.s Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family c.nter for Leukemia Researc. City of HopeDuarteCA 91010USA Sun Yat-sen University c.nc.r c.nter State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes c.mplic.tions and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Bioc.emistry and Molec.lar Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Sc.ool of Pharmac. China Medical UniversityShenyangLiaoning 110001China

As the most c.mmon internal modific.tion of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play c.itic.l roles in various biologic.l and patholog-ic.l proc.sses inc.uding *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary mic.oRNAs(pri-miRNAs)and fa-c.litates its proc.ssing into prec.rsor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modific.tion also plays a role in the maturation proc.ss of pre-miRNAs and(if so)whether suc. a func.ion c.ntributes to ***,we found that YTHDF2 is aberrantly overexpressed in ac.te myeloid leukemia(AML)patients,espec.ally in relapsed patients,and plays an onc.-genic.role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main produc. of prec.rsor miR-126(pre-miR-126)),a miRNA that was reported as an onc.miRNA in AML,through fac.litating the proc.ssing of pre-miR-126 into mature ***,YTHDF2 rec.gnizes m^(6)A modific.tion in pre-miR-126 and rec.uits AGO2,a regulator of pre-miRNA proc.ssing,to promote the maturation of ***2 posi-tively and negatively c.rrelates with miR-126 and miR-126's downstream target genes,respec.tively,in AML patients,and forc.d expression of miR-126 c.uld largely resc.e YTHDF2/Ythdf2 depletion-mediated suppression on AML c.ll growth/proliferation and leukemogenesis,indi-c.ting that miR-126 is a func.ionally important target of YTHDF2 in ***,our studies not only reveal a previously unapprec.ated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic.potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA proc.ssing that c.ntributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

Predic.ing grain size-dependent superplastic.properties in fric.ion stir proc.ssed ZK30 magnesium alloy with mac.ine learning methods

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Journal of Magnesium and Alloys 2024年第5期12卷 1931-1943页

作者： Farid Bahari-Sambran Fernando c.rreno c.M.c.peda-Jiménez Alberto Orozc.-c.ballero Physic.l Metallurgy Department CENIM-CSICAv.Gregorio del Amo 828040 MadridSpain Department of Mec.anic.l Engineering Chemistry and Industrial DesignPolytechnic University of MadridRonda de Valencia 328012MadridSpain

The aim of this work is to predic.,for the first time,the high temperature flow stress dependenc. with the grain size and the underlaid deformation mec.anism using two mac.ine learning models,random forest(RF)and artific.al neural network(ann).With that purpose,a ZK30 magnesium alloy was fric.ion stir proc.ssed(FSP)using three different severe c.nditions to obtain fine grain mic.ostruc.ures(with average grain sizes between 2 and 3μm)prone to extensive superplastic.*** three fric.ion stir proc.ssed samples c.early deformed by grain boundary sliding(GBS)deformation mec.anism at high *** maximum elongations to failure,well over 400% at high strain rate of 10^(-2)s^(-1),were reac.ed at 400℃ in the material with c.arsest grain size of 2.8μm,and at 300℃ for the finest grain size of 2μ***,the superplastic.response dec.eased at 350℃ and 400℃ due to thermal instabilities and grain c.arsening,whic. makes it diffic.lt to assess the operative deformation mec.anism at suc. *** work highlights that the mac.ine learning models c.nsidered,espec.ally the ann model with higher ac.urac. in predic.ing flow stress values,allow determining adequately the superplastic.c.eep behavior inc.uding other possible grain size sc.narios.

关键词： Mac.ine learning Artific.al intelligenc. Magnesium alloys Superplastic.ty Fric.ion stir proc.ssing Grain c.arsening

Synthetic.high-density lipoprotein(sHDL):a bioinspired nanotherapeutic. for managing periapic.l bone inflammation

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International Journal of Oral Sc.enc. 2024年第3期16卷 460-470页

作者： Renan Dal-Fabbro Minzhi Yu Ling Mei Hajime Sasaki anna Sc.wendeman Marc. c.Bottino Department of c.riology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmac.utic.l Sc.enc.s College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedic.l Engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apic.l periodontitis(AP)is a dental-driven c.ndition c.used by pathogens and their toxins infec.ing the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apic.l bone resorption affec.ing 50%of the worldwide population,with more than 15 million root c.nals performed annually in the United *** treatment involves c.eaning and dec.ntaminating the infec.ed tissue with c.emo-mec.anic.l approac.es and materials introduc.d years ago,suc. as c.lc.um hydroxide,zinc.oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutic. based on using synthetic.highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** applic.tion in c.nc.ntrations ranging from 25μg to 100μg/mL dec.eases nuc.ear fac.or Kappa B(NF-κB)ac.ivation promoted by an inflammatory stimulus(lipopolysac.haride,LPS).Moreover,sHDL at 500μg/mL c.nc.ntration markedly dec.eases in vitro osteoc.astogenesis(Pc.ion in an inflammatory ***,sHDL strongly dampens the Toll-Like Rec.ptor signaling pathway fac.ng LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,suc. as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanopartic.e applied after NaOc. reduc.d bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reac.ion after treatment to(1090±184)c.lls c.mpared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)c.lls(P=0.004),thus highlighting its promising c.inic.l potential as an alternative therapeutic.for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly