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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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脉宽连续可调并带前峰的大功率激光方波电源

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中国激光 1993年第1期20卷 42-46页

作者：毛伟民柳月英崔俊文李安民姜阅清中国科学院上海光机所 201800 国嘉光电公司 201800

本文给出了一种用快速大功率可控硅构成的带前峰的激光方波电源,方波宽度从0.5ms到连续,方波幅度从几十A到几百A分别连续可调。用可控硅做斩波器,比用功率晶体管做的斩波器具有电流大、耐压高、过载能力强等特点,文中对开关过程进行了分... 详细信息

本文给出了一种用快速大功率可控硅构成的带前峰的激光方波电源,方波宽度从0.5ms到连续,方波幅度从几十A到几百A分别连续可调。用可控硅做斩波器,比用功率晶体管做的斩波器具有电流大、耐压高、过载能力强等特点,文中对开关过程进行了分析,并提出了设计公式。

关键词：激光电源方波电路

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煤焦油中含水量与密度之间的关联研究

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煤化工 2014年第3期42卷 39-41页

作者：施国卿李安民王坤中煤九鑫焦化有限责任公司山西晋中031307 太原理工大学山西太原030024

以中煤九鑫焦化有限公司煤焦油为样品,探讨了不同温度下煤焦油水分与其密度之间的关联关系。结果表明,在不同温度下,含水质量分数4%焦油的密度随温度升高而不断降低;同一温度下,焦油密度随含水量升高而降低。实际生产中,可利用密度推算... 详细信息

以中煤九鑫焦化有限公司煤焦油为样品,探讨了不同温度下煤焦油水分与其密度之间的关联关系。结果表明,在不同温度下,含水质量分数4%焦油的密度随温度升高而不断降低;同一温度下,焦油密度随含水量升高而降低。实际生产中,可利用密度推算出一定温度下的焦油含水量,从而及时调整小氨水澄清槽焦油水分离以及焦油产品储槽自动控制水分脱除程度(≤4%),以减少脱水消耗蒸汽量。

关键词：煤焦油含水量密度温度关联

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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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国产与进口7N01铝合金应力腐蚀敏感性对比

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轻金属 2019年第5期 51-57页

作者：李安敏郑奇峰徐浩黄卓昉徐飞孔德明广西大学广西有色金属及特色材料加工重点实验室广西南宁530004 广西大学资源环境与材料学院广西南宁530004

对比了国产和进口7N01铝合金的微观组织、化学成分、应力腐蚀开裂(SCC)的敏感性及其开裂机理。结果表明:两种7N01铝合金在3.5%(质量分数,下同)的NaCl溶液中都具有较高的SCC敏感性;在3.5%的NaCl中性溶液及3.5%NaCl+0.5%H202溶液中,国产7... 详细信息

对比了国产和进口7N01铝合金的微观组织、化学成分、应力腐蚀开裂(SCC)的敏感性及其开裂机理。结果表明:两种7N01铝合金在3.5%(质量分数,下同)的NaCl溶液中都具有较高的SCC敏感性;在3.5%的NaCl中性溶液及3.5%NaCl+0.5%H202溶液中,国产7N01铝合金的SCC敏感性比进口7N01铝合金的高;国产与进口7N01铝合金板材的长横向比纵向都具有更高的SCC敏感性;进口7N01铝合金的开裂主要是沿晶开裂及穿晶解理开裂,而国产7N01铝合金的开裂是沿晶开裂和阳极通道开裂。

关键词：形变 7N01铝合金应力腐蚀开裂机理

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地下水地源热泵热源井设计方法研究

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暖通空调 2010年第9期40卷 82-87页

作者：倪龙押淑芳李安民易鸣王振兴马最良哈尔滨工业大学哈尔滨工业大学国核电力规划设计研究院新疆市政建筑设计研究院有限公司

结合水文地质、暖通空调、含水层储能等相关知识,给出了一套包含地下水动力学和热力学设计的热源井简化设计方法,设计内容包括抽水井和回灌井的井径、过滤网、井流量、井数、井间距等。该方法可以应用于工程设计。

关键词：地下水地源热泵热源井井间距工程设计

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Ni_xAlTiCrFeCoCu高熵合金的显微组织与性能

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机械工程材料 2017年第5期41卷 53-58页

作者：李安敏黄宇炜陈若怀欧阳志凤郑奇峰广西大学材料科学与工程学院南宁530004 广西玉柴动力机械有限公司玉林537000

利用真空电弧炉制备了Ni_xAlTiCrFeCoCu(x=0.5,1.0,1.5,2.0,2.5,3.0)高熵合金,研究了铸态合金的显微组织、压缩性能和耐腐蚀性能。结果表明:此高熵合金的显微组织主要由具有面心立方结构和体心立方结构的固溶体组成,有花瓣状α相、菊花... 详细信息

利用真空电弧炉制备了Ni_xAlTiCrFeCoCu(x=0.5,1.0,1.5,2.0,2.5,3.0)高熵合金,研究了铸态合金的显微组织、压缩性能和耐腐蚀性能。结果表明:此高熵合金的显微组织主要由具有面心立方结构和体心立方结构的固溶体组成,有花瓣状α相、菊花状共晶组织、富铜的晶间组织和富镍相等;随着镍含量增加,花瓣状α相逐渐减少并消失(当x=2.0时),继而出现富镍相;除了NiAlTiCrFeCoCu合金外,其他5种成分合金的屈服强度都高于1.5GPa,抗压强度约为2GPa,压缩断口都为脆性断口;x=2.0时高熵合金在H_2SO_4溶液中的耐腐蚀性能最好;在NaCl溶液中,x=1.5,2.0,3.0时高熵合金的耐腐蚀性能均优于304不锈钢的。

关键词：高熵合金显微组织压缩性能耐腐蚀性能

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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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齿轮传动特性影响因素的全局灵敏度分析

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机械工程师 2021年第10期 163-167页

作者：李安民于友明李梁张文盟东风汽车股份商品研发院武汉430100

鉴于齿轮传动系统非线性动力学模型的复杂性及参数的多样性,采用全局灵敏度分析方法,研究齿轮动力学模型参数及各参数间的耦合对其动态传递误差和动态啮合力的影响。结果表明,齿侧间隙和啮合刚度是影响齿轮动态传动精度的主要因素,啮合... 详细信息

鉴于齿轮传动系统非线性动力学模型的复杂性及参数的多样性,采用全局灵敏度分析方法,研究齿轮动力学模型参数及各参数间的耦合对其动态传递误差和动态啮合力的影响。结果表明,齿侧间隙和啮合刚度是影响齿轮动态传动精度的主要因素,啮合刚度、啮合阻尼和支撑阻尼的相互耦合对齿轮动态啮合力有显著影响,齿轮传动稳定性主要取决于啮合刚度和支撑阻尼。这可为高性能齿轮箱的动力学设计与制造提供指导。

关键词：动态传递误差动态啮合力全局灵敏度分析传动稳定性

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Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting Lv Hongfu li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

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