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Evaluation of the Secretome Profile and Functional Characteristics of Human Bone Marrow Mesenchymal Stromal Cells-Derived Conditioned Medium Suggest Potential for Skin Rejuvenation

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 99-117页

作者： Sudha Balasubramanian Charan Thej ankita walvekar Priyanka Swamynathan Pawan K. Gupta Raviraja N. Seetharam Anish S. Majumdar Stempeutics Research Pvt. Ltd. Bangalore India Manipal University Manipal India

Background/Purpose: Multipotent bone marrow-derived mesenchymal stromal cells (BMMSC) have been shown to possess the potential for tissue regeneration. The application of mesenchymal stromal cells (MSC)-derived growth factors and cytokines (GF/CKs) has been implicated for the repair and regeneration of the damaged skin that occurs due to aging and exposure to environmental stress factors. Methods: We have used both qualitative and quantitative measurements of the GF/CKs from the conditioned medium (CM) of a pooled population of BMMSC by antibody array analysis as well as by enzyme-linked immunosorbent assay (ELISA). Furthermore, the CM was also used in a variety of in vitro biological assays to measure its protective properties in human skin fibroblasts. Results: We have characterized the secretome of BMMSC by analyzing the composition of the CM using a forty-one growth factor array system. Thirteen of these GF/CK/extra cellular matrix (ECM)/ matrix metalloproteinases (MMP)-inhibitors in the CM were quantified owing to their involvement in skin repair cascade. In addition, we report that the BMMSC-CM was also able to protect dermal fibroblasts against tert-Butyl hydro peroxide (tbOH) induced oxidative stress and ultra violet B (UV-B) radiation induced cell damage. Conclusion: Based on the data presented here, we propose that BMMSC-derived CM may have the potential to promote health and rejuvenation of the aging skin.

关键词： Bone Marrow-Derived MSC Conditioned Medium Secretome Oxidative Stress UV-B Damage

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MXenes and heterostructures-based electrocatalysts for hydrogen evolution reaction:Recent developments and future outlook

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Journal of Energy Chemistry 2024年第5期92卷 176-206页

作者： Abdul Hanan Hafiz Taimoor Ahmed Awan Faiza Bibi Raja Rafidah Raja Sulaiman Wai Yin Wong Rashmi walvekar Seema Singh Mohammad Khalid Sunway Centre for Electrochemical Energy and Sustainable Technology(SCEEST) School of Engineering and TechnologySunway UniversityNo.5 Jalan UniversitiBandar Sunway47500 Petaling JayaSelangorMalaysia Fuel Cell Institute Universiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Faculty of Innovation and Technology School of EngineeringChemical Engineering ProgrammeNo.1 Jalan Taylor’sTaylor’s University Malaysia47500 Subang JayaSelangorMalaysia Chitkara Centre for Research and Development Chitkara UniversityHimachal Pradesh 174103India School of Applied and Life Sciences Uttaranchal UniversityDehradunUttarakhand 248007India Manipal Institute of Technology Manipal Academy of Higher EducationManipal 576104KarnatakaIndia Centre of Research Impact and Outcome Chitkara UniversityPunjab 140401India

The increasing focus on electrocatalysis for sustainable hydrogen(H_(2))production has prompted significant interest in MXenes,a class of two-dimensional(2D)materials comprising metal carbides,carbonitrides,and *** materials exhibit intriguing chemical and physical properties,including excellent electrical conductivity and a large surface area,making them attractive candidates for the hydrogen evolution reaction(HER).This scientific review explores recent advancements in MXene-based electrocatalysts for HER *** discusses various compositions,functionalities,and explicit design principles while providing a comprehensive overview of synthesis methods,exceptional properties,and electro-catalytic approaches for H_(2) production via electrochemical ***,challenges and future prospects in designing MXenes-based electrocatalysts with enhanced kinetics are highlighted,emphasizing the potential of incorporating different metals to expand the scope of electrochemical *** review suggests possible efforts for developing advanced MXenes-based electrocatalysts,particularly for efficient H_(2) generation through electrochemical water-splitting reactions..

关键词： MXenes Electrocatalyst Water Splitting Hydrogen Generation Clean Energy

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水平管中油水分散紊流的数值模拟研究

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油气地球物理 2010年第4期8卷 57-60页

作者： Rashmi G．walvekar 张磊（摘译）师文静（摘译）中石油西部管道有限责任公司中国石油大学（北京）石油天然气工程学院

本文用数值模拟的方法研究了水平管中油水两相流动的三维模拟。其中,采用商业软件FLUENT6.2实现两相分散流的数值模拟,选择油水两相流为研究系统,选用k———ε模型来描述连续相的紊流。依据分散相的资料和平均持液率描述数值模拟。数... 详细信息

本文用数值模拟的方法研究了水平管中油水两相流动的三维模拟。其中,采用商业软件FLUENT6.2实现两相分散流的数值模拟,选择油水两相流为研究系统,选用k———ε模型来描述连续相的紊流。依据分散相的资料和平均持液率描述数值模拟。数值模拟结果与实验结果的一致性得到了证明。

关键词：水平管油水两相分散流数值模拟

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