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Gastric intestinal metaplasia development in African American predominant United States population

World Journal of Gastrointestinal Endoscopy 2022年第10期14卷 597-607页

作者： Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho Department of Internal Medicine MedStar Washington Hospital CenterWashingtonDC 20010United States Department of Internal Medicine Georgetown University School of MedicineWashingtonDC 20007United States Department of Gastroenterology and Hepatology INOVA Medical SystemLeesburgVA 20176United States

BACKGROUND Gastric cancer significantly contributes to cancer mortality *** intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric *** natural history of GIM formation and progression over time is not fully ***,there are no clear guidelines on GIM surveillance or management in the United *** To investigate factors associated with GIM development over time in African American-predominant study *** This is a retrospective longitudinal study in a single tertiary hospital in Washington *** retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December *** included in the study had undergone two or more EGDswith gastric *** with no GIM at baseline were followed up until they developed GIM or until the last available *** criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy *** study population was divided into two groups based on GIM *** and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(***)status on the GIM *** Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)*** gender difference was obse

关键词： Gastric intestinal metaplasia Gastric cancer Helicobacter pylori Retrospective longitudinal study Esophagogastroduodenoscopy African American population

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