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Symptoms and Their Interpretation in Patients Self-Treating Abdominal Cramping and Pain with a Spasmolytic(Butylscopolamine Bromide)—A Pharmacy-Based Survey

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Pharmacology & Pharmacy 2011年第2期2卷 82-87页

作者： Stefan Müller-Lissner Eckhard Schafer anke Kondla Park-Klinik Weissensee Charite-Universitatsmedizin BerlinGermany Boehringer Ingelheim IngelheimGermany

Background: A majority of people suffering from functional abdominal complaints treat themselves with OTC medication. Aim: To gain information on symptoms and their interpretation in patients self-treating abdominal cramping and pain with a spasmolytic (butylscopolamine). Method: 4,680 questionnaires were distributed by 306 pharmacists in Germany to patients suffering from abdominal complaints and buying butylscopolamine. Key findings: Questionnaires from 1,539 respondents were returned, and 1,417 could be evaluated. Abdominal cramping was the major reason for buying butylscopolamine. Only a minority of respondents had consulted a general practitioner (27.3%) and even less a specialist (12.5%). Only a minority of subjects met expert criteria for irritable bowel syndrome (13%). There was a large overlap between self-reported dysmenorrhoea and bowel symptoms (35%). Conclusions: Real life conditions do not seem to be well covered by expert criteria. Differentiating bowel origin from uterine origin in pelvic pain syndromes seems especially problematic. This may particularly apply to the OTC market.

关键词： Abdominal Pain Butylscopolamine Bromide Irritable Bowel Syndrome(IBS) Dysmenorrhoea

OBIA:An Open Biomedical Imaging Archive

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1059-1065页

作者： Enhui Jin Dongli Zhao Gangao Wu Junwei Zhu Zhonghuang Wang Zhiyao Wei Sisi Zhang anke Wang Bixia Tang Xu Chen Yanling Sun Zhe Zhang Wenming Zhao Yuanguang Meng National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Chinese People’s Liberation Army(PLA)Medical School Beijing 100853China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Obstetrics and Gynecology Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China

With the development of artificial intelligence(AI)technologies,biomedical imaging data play an important role in scientific research and clinical application,but the available resources are *** we present Open Biomedical Imaging Archive(OBIA),a repository for archiving biomedical imaging and related clinical *** adopts five data objects(Collection,Individual,Study,Series,and Image)for data organization,and accepts the submission of biomedical images of multiple modalities,organs,and *** order to protect personal privacy,OBIA has formulated a unified de-identification and quality control *** addition,OBIA provides friendly and intuitive web interfaces for data submission,browsing,and retrieval,as well as image *** of September 2023,OBIA has housed data for a total of 937 individuals,4136 studies,24,701 series,and 1,938,309 images covering 9 modalities and 30 anatomical ***,OBIA provides a reliable platform for biomedical imaging data management and offers free open access to all publicly available data to support research activities throughout the *** can be accessed at https://***/obia.

关键词： Open Biomedical Imaging Archive Database Biomedical imaging De-identification Quality control

Gasification of plastic waste as waste-to-energy or waste-to-syngas recovery route

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Natural Science 2013年第6期5卷 695-704页

作者： anke Brems Raf Dewil Jan Baeyens Rui Zhang College of Life Science and Technology The Key Laboratory of Bioprocess of Beijing Beijing University of Chemical Technology Beijing China Department of Chemical Engineering Chemical and Biochemical Process Technology and Control Section Katholieke Universiteit Leuven Heverlee Belgium

The disposal of plastic solid waste (PSW) has become a major worldwide environmental problem. New sustainable processes have emerged, i.e. either advanced mechanical recycling of PSW as virgin or second grade plastic feedstock, or thermal treatments to recycle the waste as virgin monomer, as synthetic fuel gas, or as heat source (incineration with energy recovery). These processes avoid land filling, where the non-biodegradable plastics remain a lasting environmental burden. Within the thermal treatments, gasification and pyrolysis gain increased interest. Gasification has been widely studied and applied for biomass and coal, with results reported and published in literature. The application to the treatment of PSW is less documented. Gasification is commonly operated at high temperatures (> 600℃ to 800℃) in an air-lean environment (or oxygen-deficient in some applications): the air factor is generally between 20% and 40% of the amount of air needed for the combustion of the PSW. Gasification produces mostly a gas phase and a solid residue (char and ashes). The use of air introduces N2 in the product gases, thus considerably reducing the calorific value of the syngas, because of the dilution. The paper will review the existing literature data on PSW gasification, both as the result of laboratory and pilot-scale research. Processes developed in the past will be illustrated. Recently, the use of a sequential gasification and combustion system (at very high temperatures) has been applied to various plastic-containing wastes, with atmospheric emissions shown to be invariably below the legal limits. Operating results and conditions will be reviewed in the paper, and completed with recent own lab-scale experimental results. These results demonstrate that gasification of PSW can be considered as a first order reaction, with values of the activation energy in the order of 187 to 289 kJ/mol as a function of the PSW nature.

关键词： Plastic Waste Re-Use Gasification Syngas Char Sustainability Reaction Rate

Skin Anti-Aging Benefits of a 2% Resveratrol Emulsion

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第2期11卷 155-168页

作者： anke Schulte to Brinke Ciska Janssens-Böcker Martina Kerscher Department of Clinical Affairs MedSkin Solutions Dr. Suwelack AG Billerbeck Germany Dermatology at the Division of Cosmetic Science Department of Chemistry University of Hamburg Hamburg Germany

Background: Young and intact skin is highly responsive. As skin ages, its responsiveness decreases. Production of structural components of the skin slows down and signs of skin aging appear. External influences like UV radiation and pollution contribute to signs of skin aging. They lead to an increased formation of so-called free radicals. Bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health by free radical scavenging. The purpose of this study was to evaluate the topical effects of new and highly concentrated resveratrol containing emulsion (Medskin Solutions Dr. Suwelack AG, 2% trans-resveratrol) on age-related alterations to the skin. Methods: A clinical observation study was performed on 20 subjects to observe the effects of a 2% resveratrol emulsion on typical signs of skin aging. Product was applied once daily for a period of 8 weeks in combination with a standardized treatment. Tested parameters were skin elasticity, skin barrier function, skin smoothness, skin thickness and density. Results: After 8 weeks of treatment, skin pH value is significantly lowered and skin barrier function improved. The value of skin elasticity (+5.3%), and skin density (+ 10.7%) had increased, while skin roughness (-6.4%) and skin dispensability (-45.9%) had diminished. Intensity of skin redness had decreased. Furthermore, expert and participant evaluations show satisfaction, especially with regard to skin smoothness and skin moisture. Conclusion: The resveratrol emulsion shows positive outcomes by supporting reduction of skin wrinkling and increasing skin firmness, as well as reducing skin redness, and is therefore an all-round anti-aging treatment.

关键词： Resveratrol Emulsion Skin Care Skin Aging

金属-有机骨架(MOFs)用于锂硫电池硫正极材料改性的研究进展

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材料导报 2021年第13期35卷 13052-13057,13066页

作者：魏安柯王磊王祎西安石油大学材料科学与工程学院西安710065

随着便携式电子设备和电动汽车的发展,目前广泛使用的锂离子电池已不能满足市场的需求,锂硫电池作为一种非常有前途的高能化学电源,因其高理论比容量(1675 mAh·g^(-1))和高理论能量密度(2600 Wh·kg^(-1))引起了研究者的广泛关注。然而... 详细信息

随着便携式电子设备和电动汽车的发展,目前广泛使用的锂离子电池已不能满足市场的需求,锂硫电池作为一种非常有前途的高能化学电源,因其高理论比容量(1675 mAh·g^(-1))和高理论能量密度(2600 Wh·kg^(-1))引起了研究者的广泛关注。然而,在锂硫电池的发展过程中,一些突出的问题制约了其发展,包括硫本征导电性差、充放电前后体积变化大、较差的循环稳定性以及生成的多硫化物易溶解等。相关研究表明,将硫与金属-有机骨架(MOFs)材料复合,构筑成具有特殊微观结构的复合正极材料,可显著改善其导电性、循环稳定性和多硫化物的溶解等问题。本文从锂硫电池的工作原理出发,总结了MOFs作为硫载体的优势特点,综述了近几年MOFs材料在锂硫电池正极方面的研究进展,最后对锂硫电池MOFs基正极材料未来的研究思路与发展趋势进行了分析和展望。

关键词：锂硫电池硫正极金属-有机骨架(MOFs) 复合材料电化学性能

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牲畜补碘及其对人类的影响

地方病译丛 1993年第5期14卷 29-31页

作者： M. anke 项建梅

牲畜补碘主要取决于他们的习性,与海洋的距离以及它们的食物和它们对致甲状腺肿物质的摄取。在德国曾经以进口鱼粉来保证农场牲畜足够的碘供应。这一惯例被取消以后在德国的New Lands(原东德)发现农场牲畜有广泛缺碘的迹象,而且这一现... 详细信息

牲畜补碘主要取决于他们的习性,与海洋的距离以及它们的食物和它们对致甲状腺肿物质的摄取。在德国曾经以进口鱼粉来保证农场牲畜足够的碘供应。这一惯例被取消以后在德国的New Lands(原东德)发现农场牲畜有广泛缺碘的迹象,而且这一现象由于用植物蛋白取代鱼蛋白而加剧。

关键词：碘碘缺乏动物甲状腺肿

Acidification of the Skin and Maintenance of the Physiological Skin pH Value by Buffered Skin Care Products Formulated around pH 4

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第1期11卷 44-57页

作者： anke Schulte to Brinke Antje Mehlich Claudia Doberenz Ciska Janssens-Böcker Department of Clinical Affairs MedSkin Solutions Dr. Suwelack AG Billerbeck Germany Department of Innovation and Development MedSkin Solutions Dr. Suwelack AG Billerbeck Germany

Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. The skin pH is crucial for physiological skin function. In aged or diseased skin, pH increase is observed and may negatively affect skin health. Skin care products with a pH that is slightly more acidic than the average normal skin pH and have an adequate buffering capacity, are considered beneficial for the skin. However, the buffer capacity of these products also plays an important role. In the present study, a possible normalization or acidification of skin surface pH and influence on skin hydration and skin barrier function was assessed via application of buffered skin care products that are formulated with pH ≤ 4.5. 48 subjects aged above 50 were treated with three different skin care products (Vitamin C Spheres, Collagen Spray, and Collagen Mask) and skin surface pH, skin hydration and barrier integrity were assessed before treatment start and after 4 weeks. The results show that after 4-week treatment with Vitamin C, the skin pH is acidified. Treatment with Collagen Spray and Collagen Mask showed maintenance of a physiological skin pH. Subgroup analysis of subjects that had a higher than average skin pH at study start demonstrated that all three tested skin care products were able to acidify the skin surface. In addition, skin hydration was also increased for two of the three tested products, whereas skin barrier is not significantly changed. This demonstrates that buffered skin care products formulated to a pH ≤ 4.5 are able to acidify and maintain physiological skin pH and may contribute to a physiological skin function.

关键词： Skin pH Buffer Capacity Skin Care Skin Aging Acidification

FAST SPEECH TIMING IN DUTCH: DURATIONAL CORRELATES OF LEXICAL STRESS AND PITCH ACCENT

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FAST SPEECH TIMING IN DUTCH: DURATIONAL CORRELATES OF LEXICA...

Observer-based H∞ control of discrete-time systems with redundant channels

6～(th) International Conference on Spoken Language Processing

作者： Esther Janse anke Sennema＆AnnekeSlis Utrecht institute of Linguistics OTS Utrecht University The Netherlands Utrecht institute of Linguistics OTS Utrecht University The Netherlands

＜正＞ In this study we investigated the durational correlates of lexical stress and pitch accent at normal and fast speech rate in Dutch. Previous literature on English shows that durations of lexically unstressed vowels are reduced more than stressed vowels when speakers increase their speech rate. We found that the same holds liar Dutch, irrespective of whether the unstressed vowel is schwa or a （?）ull’ vowel. In the same line. we expected that vowels in words without a pitch accent would be shortened relatively more than vowels in words with a pitch accent. This was not the case: if anything, the accented vowels were shortened relatively more than the unaccented vowels. We conclude that duration is an important cue for lexical stress, but not for pitch accent.

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Observer-based H∞ control of discrete-time systems with red...