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TRIO的扩增和高表达与膀胱肿瘤细胞的快速增殖有关

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肿瘤 2006年第2期26卷 127-130页

作者：郑敏 Sauter g Mihatsch MJ Moch H 华南肿瘤学国家重点实验室中山大学肿瘤防治中心妇科广州510060 瑞士巴塞尔大学病理所 Schonbeinstrasse40CH-4003BaselSwitzerland

目的TRIO基因位于染色体5p扩增区、编码1种在细胞周期调节中起主导作用的蛋白,本研究旨在了解TRIO的扩增和表达是否与膀胱肿瘤细胞的快速增殖有关。方法Ki67标记染色(Ki67LI)、荧光原位杂交(FISH)和定量PCR法(LightCyclerTMPCR)被用于... 详细信息

目的TRIO基因位于染色体5p扩增区、编码1种在细胞周期调节中起主导作用的蛋白,本研究旨在了解TRIO的扩增和表达是否与膀胱肿瘤细胞的快速增殖有关。方法Ki67标记染色(Ki67LI)、荧光原位杂交(FISH)和定量PCR法(LightCyclerTMPCR)被用于研究。结果TRIO基因扩增与膀胱肿瘤细胞的快速生长相关(Ppta)(9例/499例),而在膀胱癌(pT1-4)高达12.8%(62例/485例)。定量PCR法进一步证实TRIO在显示5p扩增的膀胱癌组织高表达。结论TRIO扩增与膀胱肿瘤细胞的快速增殖有关,TRIO扩增和高表达可能在膀胱癌的发展过程中发挥重要作用。

关键词：膀胱肿瘤基因,TRIO 原位杂交,荧光定量聚核酶链反应

Estimating Out-Crossing Rate of Bg 379-2 Using Morphological Markers and Confirmation by Molecular Markers

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Rice science 2012年第2期19卷 166-168页

作者： L.H.M.Y.K.SOMARATNE A.S.M.T.ABAYAWICKRAMA I.P.WICKRAMASINgHE W.L.g.SAMARASINgHE Department of Agricultural Biology Faculty of AgricultureUniversity of PeradeniyaSri Lanka Rice Research and Development Institute BatalagodaIbbagamuwaSri Lanka

Rice is largely self-fertilized and accordingly a field population of rice is completely composed of near homozygotes. Due to the emergence of off-types, homozygosity will be affected. With the time, this will cause the reduction of genetic purity in some rice varieties. One of the reasons has been suspected to be the high out-crossing frequencies of such varieties. Studies were conducted at the Rice Research and Development Institute, Batalagoda, Sri Lanka to estimate the out-crossing rate of Bg 379-2, a variety having the problem of maintaining genetic purity. Bg 379-2 was allowed to out-cross with Bg 450 and the number of out- crossed plants were counted using dominant morphological markers such as short-round grain and purple culm of pollen donor. A molecular confirmation of out-crossing was also performed using sequence tagged site （STS） molecular marker pta248. The variety Bg 379-2 showed a potential out-crossing rate of 3.41% and an average out-crossing rate of 1.29% using dominant morphological markers. Polymorphism was cleady detected between parents and out-crossed plants as well as selfed plants of Bg 379-2 using their banding patterns. A similar study can be performed to determine the out-crossing rates of other varieties which show high percentage of off-types in the population for the better understanding of the breeding behavior of the varieties.

关键词： rice genetic purity out-crossing marker polymorphism

局部溶栓治疗解剖外——动脉旁路移植血管的阻塞

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上海第二医科大学学报 1998年第2期18卷 153-155页

作者：方文强 Bartoli JM Moulin g 上海第二医科大学附属瑞金医院放射科 200025 法国马赛医科大学拉蒂蒙娜医院放射科

对3例解剖外——动脉旁路移植血管阻塞的患者进行了5次局部溶拴治疗,其中1例同时进行了血管成形术(pta)和内支架治疗。全组均获阻塞血管再开通,无1例并发症。局部溶栓治疗动脉旁路移植血管阻塞安全有效,并可与 pta、内支架治疗结合使用。

关键词：血管阻塞动脉旁路移植血管溶栓疗法

Comparative study of thermophilic and mesophilic anaerobic treatment of purified terephthalic acid (pta) wastewater

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Natural Science 2011年第5期3卷 371-378页

作者： Michael O. Daramola Elizabeth F. Aransiola Adeniyi g. Adeogun 不详

The paper provides a critical comparison between mesophilic and thermophilic anaerobic treatment of pta wastewater through diagnosis of a case study. Aspects covered are bioavailability, biodegradability, microbial population, thermodynamics, kinetics involved and bio-reactor design for pta wastewater treatment. The results of the case study suggests that one- stage thermophilic anaerobic reactor coupled with coagulation-flocculation pre-treatment unit and an aerobic post treatment unit could be techno-economically viable for pta wastewater treatment to ensure that the final effluent quality conforms to the international standard. The in-formation emanated from this study could be useful and thought provoking to the professionals and academia in the area of pta wastewater treatment and can serve as impetus toward the development of research lines in similar problems like the treatment of other petrochemical wastewater such as phenol-con- taining wastewater, benzene/benzoic acid-con- taining wastewater or wastewater from other similar industrial settings.

关键词： Terephthalic Acid Wastewater Treatment Anaerobic and Aerobic Treatment Me-sophilic and Thermophilic Conditions Bioreactors

Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

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Cancer Communications 2024年第4期44卷 508-513页

作者： Andrés Pastor-Fernández Manuel Montero gómez de las Heras Jose Ignacio Escrig-Larena Marta Barradas Cristina Pantoja Adrian Plaza Jose Luis Lopez-Aceituno Esther Durán Alejo Efeyan Maria Mittelbrunn Lola Martinez Pablo Jose Fernandez-Marcos Metabolic Syndrome group(BIOPROMET) Madrid Institute for Advanced Studies(IMDEA)FoodE28049MadridSpain Molecular Biology Center Severo Ochoa(CBMSO) Spanish National Research Council(CSIC)Madrid Autonoma University(UAM)MadridSpain Department of Basic Medical Sciences Institute of Applied Molecular MedicineSchool of MedicineUniversity Studies Center(CEU)-San Pablo UniversityMadridSpain Metabolism and Cell Signaling Laboratory Spanish National Cancer Research Centre(CNIO) MadridSpain 5Flow Cytometry UnitBiotechnology ProgrammeSpanish National Cancer Research Centre(CNIO)MadridSpain

Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)T cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fast... 详细信息

关键词： chemotherapy fasting immune

生物功能化磁性金复合纳米颗粒可作为结直肠癌肝转移的光热消融催化剂

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国际医学放射学杂志 2018年第1期 100-101页

作者： S.B.White D.H.Kim Y.guo W.g.Li Y.H.Yang J.Chen 周波 Department of Radiology Northwestern University

摘要目的证明Mg1抗体结合的磁性金复合纳米颗粒(HNP)在结直肠癌肝转移光热消融(pta)治疗中可作为催化剂从而增大消融面积。材料与方法所有实验已获得动物管

关键词：结直肠癌 HNP 肝转移复合纳米颗粒催化剂

Intelligent Back Analysis of Displacements Using Precedent Type Analysis For Tunneling

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Intelligent Back Analysis of Displacements Using Precedent T...

前庭神经鞘瘤的分级质子放射治疗和听力保存:前瞻性2期临床试验的初步分析

中国科学院地质与地球物理研究所2002学术年会

作者： Y.J.Shang~a J.g.Cai~b W.D.Hao~c X.Y.Wu~c S.H.Li~(a,c) a Institute of geology and geophysics,Chinese Academy of Sciences,P.R.China b Nanyang Technological University,Singapore c Beijing Canbao Architectural Design Institute,P.R.China

Based on comprehensive monitored data obtained from typical tunnel projects,and by using engineering experiences of experts together with numerical modeling results,the Precedent Type Analysis(pta) technique developed was for back-analyzing in situ stress and elastic modulus of rock masses surrounding ***,the pta is used as a supporting technique in the method of Intelligent Back Analysis(IBA).The IBA method can integrate the mechanism analysis with experimental *** integration is based on ’certainty factors’,and is implemented with the computer program BMP90 with a global inference *** program BMP90 can solve a series of back analysis problems - such as identifying potential problems to be encountered during back analysis,assessing the strategy to be adopted,selecting criteria for back analysis,and ensuring convergence of back analysis *** on the engineering applications to about 100 tunnel projects in China,it is found that the IBA method supported by the pta technique can be successfully applied to tunnel projects,*** analyzing the lateral in situ stress factor(λ),and the elastic modulus(E) of rock *** method of Intelligent Back Analysis(IBA) supported by Precedent Type Analysis(pta) and its application to a tunnel project are presented in this paper.

关键词： Tunnel Precedent type analysis Intelligent back analysis of displacements

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中华神经外科疾病研究杂志 2024年第1期18卷 90-90页

作者： Anurag Saraf Luke R.g.Pike Kevin H.Franck

背景:前庭神经鞘瘤(VS)的局部治疗与良好的局部控制有关,重点是保持长期有用的听力。由于质子放射治疗(FPRT)的独特剂量学特性,可能与更大的听力保存有关。目的:研究成年VS患者FPRT的听力保存率,并评估局部控制和治疗的相关毒性。方法:... 详细信息

背景:前庭神经鞘瘤(VS)的局部治疗与良好的局部控制有关,重点是保持长期有用的听力。由于质子放射治疗(FPRT)的独特剂量学特性,可能与更大的听力保存有关。目的:研究成年VS患者FPRT的听力保存率,并评估局部控制和治疗的相关毒性。方法:对2010年至2019年的VS患者进行了前瞻性、单组、2期临床试验。所有患者在基线时都有良好的听力,并接受了FPRT治疗,总剂量为50.4-54gy相对生物有效性(relative biological effectiveness,RBE),超过28至30次照射。可用的听力保存被定义为加德纳-罗伯逊分数(gardner-Robertsonscore)为1-2,纯音平均(pta)为≤50dB,单词识别分数(WRS)为≥50%。

关键词：局部控制罗伯逊总剂量单词识别前瞻性

Budd-Chiari综合征的经皮再通术:单一中心117例中国病人通畅性和生存模式的11年回顾性研究

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国际医学放射学杂志 2013年第2期 178-178页

作者： g.H. Han X.S. Qi W. Zhang C.Y. He Z.X. Yin J.H. Wang 郭凌飞 Department of Digestive Interventional Radiology Xijing Hospital of Digestive Diseases Fourth Military Medical University

目的评估经皮再通术的长期效果,确定在大样本的Budd-Chiari（BCS）综合征中国病人中对通畅性和生存的预测因素。材料与方法机构伦理委员会批准了该项回顾性研究。所有病人在参加本研究前均签订知情同意书。在1999年7月—2010年8月,177... 详细信息

目的评估经皮再通术的长期效果,确定在大样本的Budd-Chiari（BCS）综合征中国病人中对通畅性和生存的预测因素。材料与方法机构伦理委员会批准了该项回顾性研究。所有病人在参加本研究前均签订知情同意书。在1999年7月—2010年8月,177例连续原发BCS中国病人接收了经皮再通术,随访至死亡或至最后一次临床评估。记录再通治疗策略和并发症。累积的通畅性和生存率通过Kaplan-Meier曲线进行分析。使用Cox回归分析模型来计算通畅和生存的独立预测因素。结果 177例病人中有168例（95%）接受经皮再通术获得成功。168例病人中有51例（30%）单独接收了经皮腔内血管成形术（pta）,117例病人接收了pta和支架植入术。168例病人中有7例出现了与该治疗有关的并发症。1、5、10年累积的初始通畅率分别为95%、77%、58%。闭塞的独立预测因素为白细胞计数的增加和单独使用pta。1、5、10年累积的二次通畅率分别为97%、90%、86%。在中位值30个月的随访中有22例病人死亡（范围0.25;37个月）。1、5、10年累积的生存率分别为96%、83%、73%。与生存有关的独立预测因素为静脉曲张性出血、碱性磷酸酶及血尿素氮水平升高、再闭塞。结论在有BCS的大部分中国病人中经皮再通术可以达到很好的长期通畅性和生存效果。pta联合支架植入可以减少再次闭塞的发生率和与其相关的死亡率。

关键词：再通术通畅性 Budd-Chiari 经皮回顾性研究病人综合征综合病症中华人民共和国