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Emerging therapeutic options for non-alcoholic fatty liver disease:A systematic review

世界肝病学杂志:英文版(电子版) 2023年第8期15卷 1001-1012页

作者： Jasmine Tidwell Natalie Balassiano anjiya shaikh Mahmoud Nassar Department of Internal Medicine University of ConnecticutFarmingtonCT 06032United States Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC Health+Hospitals/QueensNew YorkNY 11432United States Department of Internal Medicine Division of EndocrinologyDiabetes and MetabolismJacobs School of Medicine and Biomedical SciencesUniversity of BuffaloBuffaloNY 14221United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)has become a prevalent cause of chronic liver disease and ranks third among the causes of *** the United States alone,annual medical costs are approximately 100 billion ***,there is no Federal Drug Administration(FDA)-approved medication for its ***,various clinical trials are investigating several therapeutic classes that could potentially treat *** is valuable to have a compilation of the data available on their *** To assess the efficacy of cyclophilin inhibitors,fibroblast growth factor 21 analogs(FGF21),and dual and pan peroxisome proliferator-activated receptor(PPAR)agonists for treating *** A comprehensive literature search using keywords including cyclophilin inhibitor,FGF agonist,pan-PPAR agonists,dual-PPAR agonist,NAFLD,nonalcoholic steatohepatitis,and fatty liver was conducted on October 29,2022,in PubMed,EMBASE,Cochrane Library,Scopus and Web of *** and human research,case reports,and published articles in English from all countries with patients aged 18 and above were *** articles with a National Institutes of Health(NIH)Quality Assessment score of five or higher out of eight points were *** that were narrative or systematic reviews,abstracts,not in English,focused on patients under 18 years old,did not measure outcomes of interest,were inaccessible,or had a low NIH Quality Assessment score were *** article was screened by two independent researchers evaluating relevance and *** were scored based on the NIH Quality Assessment Score;then,pertinent data was extracted in a spreadsheet and descriptively *** Of the 681 records screened,29 met the necessary criteria and were included in this *** records included 12 human studies and 17 animal ***,there were four studies on cyclophilin inhibitors,four on FGF agonists/analogs,eleven on pan-PPAR

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Cyclophilin inhibitors Fibroblast growth factor 21 analogs Dual peroxisome proliferator-activated receptor agonists Pan peroxisome proliferator-activated receptor agonists

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