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Bone mineral density and disorders of mineral metabolism in chronic liver disease

World Journal of Gastroenterology 2009年第28期15卷 3516-3522页

作者： Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane anjana karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah Department of Endocrinology Seth G.S. Medical College and KEM Hospital Department of Gastroenterology Seth G.S Medical College and KEM Hospital Department of Gastroenterology Jaslok Hospital

AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with ***:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class *** causes for metabolic bone disease and osteoporosis were ruled *** exposure, physical activity and dietary constituents were *** metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray *** BMD was defined as a Z score ***:Low BMD was found in 68% of *** spine was the most frequently and severely affected *** factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body *** intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus *** D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal ***-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both ***-1 was signiflcantly lower in patients with low *** osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high ***:Patients with cirrhosis have low *** factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level.

关键词：代谢紊乱矿物质骨密度肝病慢性

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