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可持续混凝土的奇特来源

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 14-15,41页

作者： Elissaveta m.brandon 不详

08建筑师对不寻常的建筑材料并不陌生:大麻纤维、龙舌兰酒产业的龙舌兰浆、破碎的马桶、不可回收的塑料,现在更有……用过的尿布?日本北九州市立大学的一群研究人员研发出一种混凝土,可以用碎尿布取代多达40%的沙子。

关键词：建筑材料龙舌兰酒马桶大麻纤维可持续混凝土建筑师

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可爱面面观可爱如何演变并影响消费主义

空中英语教室（高级版．彭蒙惠英语） 2024年第8期 34-35,49,50页

作者： Elissaveta m.brandon 不详

猫咪一直都这么可爱吗?伦敦萨默塞特郡最近的一个展览,尝试通过说明当代文化中可爱的崛起与流行来回答那个问题展览名称就是简单的“可爱”二字,展出数百件毛绒玩具、菲比精灵、护理机器人、宝可梦卡牌、机器狗、拓麻歌子、玩具屋、可... 详细信息

猫咪一直都这么可爱吗?伦敦萨默塞特郡最近的一个展览,尝试通过说明当代文化中可爱的崛起与流行来回答那个问题展览名称就是简单的“可爱”二字,展出数百件毛绒玩具、菲比精灵、护理机器人、宝可梦卡牌、机器狗、拓麻歌子、玩具屋、可爱小雕像——还有,数量极大的猫咪。最后以Hello Kitty装置结尾,庆祝Hello Kitty诞生50周年。

关键词：毛绒玩具机器狗萨默塞特消费主义可爱当代文化

Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency medicine 2024年第4期15卷 283-288页

作者： David Ahmad Haidar David mintz brandon m Wubben Omar Rizvi Srikar Adhikari Department of Emergency medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of medicine Tucson 85724USA Department of Emergency medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

利用大麦虫生物降解低密度聚乙烯及聚苯乙烯塑料:全位解聚与有限解聚

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环境卫生工程 2021年第3期29卷 96-96页

作者：彭博宇李宜然范蕊陈志彬陈家斌 anja m.brandon Craig S.Criddle 张亚雷吴唯民彭博宇(译) 吴唯民(审查) 同济大学环境科学与工程学院污染控制与资源化研究国家重点实验室上海200092 斯坦福大学土木与环境工程系斯坦福大学Codiga资源回收中心美国斯坦福CA 94305-4020 同济大学斯坦福大学

1研究亮点*证实拟步行科大麦虫能够摄食消化低密度聚乙烯(LDPE)以及聚苯乙烯(PS)塑料;*中美两国虫源的大麦虫均通过有限解聚降解LDPE、分别通过全位解聚和有限解聚的反应降解PS;*抗菌素试验表明大麦虫降解LDPE/PS依赖肠道微生物。2背景... 详细信息

1研究亮点*证实拟步行科大麦虫能够摄食消化低密度聚乙烯(LDPE)以及聚苯乙烯(PS)塑料;*中美两国虫源的大麦虫均通过有限解聚降解LDPE、分别通过全位解聚和有限解聚的反应降解PS;*抗菌素试验表明大麦虫降解LDPE/PS依赖肠道微生物。2背景全世界每年生产超过3.6×10^(8)t塑料,聚乙烯(29.7%)和聚苯乙烯(6.4%),是塑料固体废弃物的主要构成。大麦虫属于鞘翅目拟步行科(Zophobas atratus,Coleoptera:Tenebrionidae),是全世界人工饲养的主要经济昆虫之一。本研究探讨了大麦虫降解LDPE和PS的可行性,比较中美两国虫源的大麦虫对LDPE和PS的降解能力,研究了降解过程与肠道菌群体系的关系。

关键词：聚乙烯聚苯乙烯生物降解大麦虫

Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson brandon J.Vilarello Tiana m.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.Gary David A.Gudis Paule V.Joseph D.P.Devanand Terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su brandon Tan Chao Shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung mark Boldin Chun-Wei Chen David Ann Zhijian Qian Xiaolan Deng Jianjun Chen Zhenhua Chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(mETTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AmL)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AmL,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AmL patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AmL cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AmL and highlight the ther-apeutic potential of targeting this axis for AmL treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AmL miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

A reproducible and sensitive method for generating high-quality transcriptomes from single whitefly salivary glands and other low-input tissues

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Insect Science 2022年第5期29卷 1318-1328页

作者： marco Gebiola brandon H.Le Kerry Emauck Department of Entomology University of California RiversideRiversideCalifornia Department of Botany and Plant Sciences University of California RiversideRiversideCalifornia Institute of Integrative Genome Biology University of California RiversideRiversideCaliforniaUSA

Transcriptomic studies are an important tool for understanding the molecular pathways underlying host plant use by agricultural pests,including vectors of damaging plant *** far,bulk RNA-Seq has been the main approach for non-model *** method relies on pooling large numbers of whole organisms or hundreds of individually dissected *** latter approach is logistically challenging,may introduce artifacts of handling and storage,and is not compatible with biological ***,we tested an approach to generate transcriptomes of individual salivary glands and other low-input body tissues from whiteflies(Bemisia tabaci mEAm1),which are major vectors of plant *** comparing our outputs to published bulk RNA-Seq datasets for whole whitefly bodies and pools of salivary glands,we demonstrate that this approach recovers similar numbers of transcripts relative to bulk RNA-Seq in a tissue-specific manner,and for some metrics,exceeds performance of bulk tissue *** generated from individual salivary glands also yielded additional novel transcripts not identified in pooled salivary gland datasets,and had hundreds of enriched transcripts when compared with whole head ***,our study demonstrates that it is feasible to produce high quality,replicated transcriptomes of whitefly salivary glands and other low-input *** anticipate that our approach will expand hypothesis-driven research on salivary glands of whiteflies and other Hemiptera,thus enabling novel control strategies to disrupt feeding and virus transmission.

关键词： Aleyrodidae Bemisia tabaci bulk RNA-Seq insect vectors low-input RNA-Seq plant pathogens

Phylogenetic endemism of the orchids of megamexico reveals complementary areas for conservation

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Plant Diversity 2022年第4期44卷 351-359页

作者： brandon E.Gutierrez-Rodríguez marilyn Vasquez-Cruz Victoria Sosa Instituto de Ecología AC Carretera Antigua a Coatepec 351El Haya91073 XalapaVeracruzMexico Unidad de Genomica Avanzada Laboratorio Nacional de Genomica para La BiodiversidadCentro de Investigaciony Estudios Avanzados IrapuatoLibramiento Norte Carretera Leon Km.9.636821 IrapuatoGuanajuatoMexico

Orchid diversity provides a unique opportunity to further our understanding of biotic and abiotic factors linked to patterns of richness,endemism,and phylogenetic endemism in many ***,orchid diversity is consistently threatened by illegal trade and habitat ***,we identified areas critical for orchid conservation in the biogeographic province of *** this purpose,we evaluated orchid endemism,phylogenetic diversity,and phylogenetic endemism within megamexico and characterized orchid life *** results indicate that the majority of the regions with the highest estimates of endemism and phylogenetic endemism are in southern mexico and northern Central America,mostly located on the Pacific side of *** the most important orchid lineages,several belong to epiphytic lineages such as Pleurothallidinae,Laeliinae and *** also found that species from diverse and distantly related lineages converge in montane forests where suitable substrates for epiphytes ***,the southernmost areas of phylogenetic diversity and endemism of megamexico are in unprotected ***,we conclude that the most critical areas for orchid conservation in megamexico are located in southern mexico and northern Central *** recommend that these areas should be given priority by the mexican system of natural protected areas as complementary conservation areas.

关键词： Epiphytes Geophytes Orchids Phylogenetic endemism Weighted endemism

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

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Animal Nutrition 2023年第1期12卷 334-344页

作者： Jinan Zhao brandon Pike Jin Huang Zhihua Feng Jack Odle Xi Lin Laboratory of Developmental Nutrition Department of Animal SciencesNorth Carolina State UniversityRaleighNC 27695USA Zinpro Corporation Eden PrairieMN 55344USA College of Biological Engineering Henan University of TechnologyZhengzhou450001China College of Animal Science and Technology Agricultural University of HebeiBaoding071001China

To investigate whether increasing tricarboxylic acid(TCA)cycle activity and ketogenic capacity would augment fatty acid(FA)oxidation induced by the peroxisome proliferator-activated receptor-alpha(PPARα)agonist clofibrate,suckling newborn piglets(n=54)were assigned to 8 groups following a 2(±clofibrate)×4(glycerol succinate[SUC],triglycerides of 2-methylpentanoic acid[T2m],valeric acid[TC5]and hexanoic acid[TC6])factorial *** group was fed an isocaloric milk formula containing either 0%or 0.35%clofibrate(wt/wt,dry matter basis)with 5%SUC,T2m,TC5 or TC6 for 5 *** 6 pigs served as newborn *** acid oxidation was examined in fresh homogenates of liver collected on d 6 using[1-^(14)C]palmitic acid(1 mm)as a substrate(0.265μCi/μmol).measurements were performed in the absence or presence of L-carnitine(1 mm)or inhibitors of 3-hydroxy-3-methylglutaryl-CoA synthase(L659699,1.6μm)or acetoacetate-CoA deacylase(iodoacetamide,50μm).Without clofibrate stimulation,^(14)C accumulation in CO_(2) was higher from piglets fed diets containing T2m and TC5 than SUC,but similar to those fed *** clofibrate stimulation,accumulation also was higher in homogenates from piglets fed TC5 than all other dietary *** between clofibrate and carnitine or the inhibitors were observed(P=0.0004)for acid soluble products(ASP).In vitro addition of carnitine increased^(14)C-ASP(Pments,regardless of clofibrate *** percentage of^(14)C in CO_(2) was higher(P=0.0023)in TC5 than in the control *** these results we suggest that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-CoA(product ofβ-oxidation)via alteration of TCA cycle activity,but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα.In addition,the availability of carnitine is a critical element to maintain FA oxidation during the neonatal perio

关键词： PPARα Clofibrate Newborn piglets medium chain triglyceride(mCT) Hepatic fatty acid oxidation