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Liver re-transplantation for donor-derived neuroendocrine tumor: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2794-2801页

作者： Anna Mrzljak Branislav Kocman anita skrtic Ivana Furac Jelena Popic Lucija Franusic Renata Zunec Davor Mayer Danko Mikulic Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Surgery Merkur University HospitalZagreb 10000Croatia Department of Pathology and Cytology Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia DNA Laboratory Institute of Forensic Medicine and CriminalisticsSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Radiology Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department for Tissue Typing Clinical Hospital Centre ZagrebZagreb 10000Croatia Institute of Forensic Medicine and Criminalistics School of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND Donor-origin cancer is a well-recognized but rare complication after liver transplantation (LT). The rise in the use of extended criteria donors due to the current shortage of organs increases the risk. Data on donor-origin neuroendocrine neoplasms (NENs) and the most appropriate treatment are scarce. Here, we report a case of a patient who developed a NEN confined to the liver after LT and was treated with liver re-transplantation (re-LT). CASE SUMMARY A 49-year-old man with no other medical co-morbidities underwent LT in 2013 for alcoholic liver cirrhosis. The donor was a 73-year-old female with no known malignancies. Early after LT, a hypoechogenic (15 mm) lesion was detected in the left hepatic lobe on abdominal ultrasound. The lesion was stable for next 11 mo, when abdominal magnetic resonance identified two hypovascular lesions (20 and 11 mm) with atypical enhancement pattern. Follow-up abdominal ultrasound revealed no new lesions for the next 2.5 years, when magnetic resonance showed a progression in size and number of lesions, also confirmed by abdominal computed tomography. Liver biopsy proved a well-differentiated NEN. Genetic analysis of the NEN confirmed donor origin of the neoplasm. As NEN was confined to liver graft only, in 2018, the patient underwent his second LT. At 12 mo after re-LT the patient is well with no signs of NEN dissemination. CONCLUSION The benefits of graft explantation should be weighed against the risks of re-LT and the likelihood of NEN dissemination beyond the graft.

关键词： Donor-origin tumor Neuroendocrine tumor Liver transplantation Donor Case report

Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances,ischemia-reperfusion injury following Pringle maneuver,and Budd-Chiari syndrome

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World Journal of Gastroenterology 2022年第1期28卷 23-46页

作者： Predrag Sikiric anita skrtic Slaven Gojkovic Ivan Krezic Helena Zizek Eva Lovric Suncana Sikiric Mario Knezevic Sanja Strbe Marija Milavic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Department of Pharmacology School of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Pathology School of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Anatomy and Neuroscience Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia

The stable gastric pentadecapeptide BPC 157 counteracts various venous occlusion-induced *** are all these arguments,in the Robert’s cytoprotection concept terms,to substantiate the resolution of different major vessel occlusion disturbances,in particular ischemia-reperfusion injury following the Pringle maneuver and Budd-Chiari syndrome,which was obtained by BPC 157 ***,there is new point(bypassed occluded or ruptured vessel,the equation endothelium maintenance→epithelium maintenance=blood vessel recruitment and activation towards defect or bypassing vessel occlusion),the recruitment of collateral blood vessels to compensate for vessel occlusion and reestablish blood *** this paper,we summarize the evidence of the native cytoprotective gastric pentadecapeptide BPC 157,which is stable in the human gastric juice,is a membrane stabilizer and counteracts gut-leaky *** a particular target,it is distinctive from the standard peptide growth factors,with particular molecular pathways involved,controlling VEGF and NO *** the early 1990s,BPC 157 appeared as a late outbreak of the Robert’s and Szabo’s cytoprotection-organoprotection concept,epithelium,endothelium protection as previous theoretical/practical breakthrough in the 1980s,and brain-gut axis and gut-brain *** the time went on,with its reported effects,it is likely most useful theory practical implementation and ***,several reviews suggest that BPC 157,which does not have a lethal dose(LD1),has profound cytoprotective activity,used to be demonstrated in ulcerative colitis and invented to multiple sclerosis ***,it may bring the theory to practical application,starting with the initial argument,no degradation in human gastric juice for more than 24 h,and thereby,the therapeutic effectiveness(including therapeutic per-oral regimen)and pleiotropic beneficial effects.

关键词： Gastric pentadecapeptide BPC 157 Cytoprotection Major vessel occlusion disturbances Pringle maneuver Budd-Chiari syndrome Therapy

Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

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World Journal of Gastroenterology 2023年第27期29卷 4289-4316页

作者： Luka Kalogjera Ivan Krezic Ivan Maria Smoday Hrvoje Vranes Helena Zizek Haidi Yago Katarina Oroz Vlasta Vukovic Ivana Kavelj Luka Novosel Slavica Zubcic Ivan Barisic Lidija Beketic Oreskovic Sanja Strbe Marko Sever Ivica Sjekavica anita skrtic Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric Department of Pharmacology School of MedicineZagreb 10000Croatia Division of Oncology and Radiotherapy University Hospital for TumorsSestre milosrdnice University Hospital CentreZagreb 10000Croatia Department of Pathology School of MedicineZagreb 10000Croatia

BACKGROUND Using rat stomach perforation as a prototypic direct lesion applied in cytoprotection research,we focused on the first demonstration of the severe occlusion/occlusion-like syndrome induced by stomach *** revealed stomachinduced occlusion/occlusion-like syndrome corresponds to the previously described occlusion/occlusion-like syndromes in rats suffering multicausal pathology and shared severe vascular and multiorgan *** general point was particularly *** in all the described occlusion/occlusion-like syndromes with permanent occlusion of major vessels,peripheral and central,and other similar noxious procedures that severely affect endothelium function,the stable gastric pentadecapeptide BPC 157 was resolving *** To reveal the stomach perforation-induced general occlusion/occlusion-like syndrome and BPC 157 therapy *** The procedure included deeply anesthetized rats,complete calvariectomy,laparotomy at 15 min thereafter,and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like *** 5 min post-perforation time,rats received therapy[BPC 157(10μg or 10 ng/kg)or saline(5 mL/kg,1 mL/rat)(controls)]into the perforated defect in the stomach).Sacrifice was at 15 min or 60 min post-perforation ***(gross and microscopy;volume)included:Brain swelling,peripheral vessels(azygos vein,superior mesenteric vein,portal vein,inferior caval vein)and heart,other organs lesions(i.e.,stomach,defect closing or widening);superior sagittal sinus,and peripherally the portal vein,inferior caval vein,and abdominal aorta blood pressures and clots;electrocardiograms;and bleeding time from the perforation(s).RESULTS BPC 157 beneficial effects accord with those noted before in the healing of the perforated defect(raised vessel presentation;less bleeding,defect contraction)and occlusion/occlusion-like syndromes *** 157 therapy(into the perforated defect),induced immediate

关键词： Stomach perforation General occlusion/occlusion-like syndrome Stable gastric pentadecapeptide BPC 157 Cytoprotection Therapy Rats

导弹重量、费用、进度交互作用及风险评估的初步设计分析

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空天技术 1987年第7期 1-17+39页

作者： Milan skrtic Rodger St. John 廖朝佩

在产品初步设计中,经常需要评价各种备选方案、材料和日后在保持基本性能特性的同时允许进行产品改进的能力,在导弹产品的改进中,亦会遇到这种情况。本文介绍了一种在导弹设计或建议阶段评价包含要求变更或产品改进的各种备选方案的方法... 详细信息

在产品初步设计中,经常需要评价各种备选方案、材料和日后在保持基本性能特性的同时允许进行产品改进的能力,在导弹产品的改进中,亦会遇到这种情况。本文介绍了一种在导弹设计或建议阶段评价包含要求变更或产品改进的各种备选方案的方法,评估了在保持性能不变的情况下各种备选方案对费用和进度的影响。这对于我们在初步设计阶段初步估计费用和进度风险是有借鉴价值的。

关键词：战术导弹—成本估算战术导弹—计划管理战术导弹—系统工程

利用PET/MR进行全身成像来评估组织特异性胰岛素敏感度和体部分布:一项可行性研究

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国际医学放射学杂志 2018年第2期 220-221页

作者： E.Johansson M.Lubberink K.Heurling J.W.Eriksson S.skrtic H.Ahlstrm 卜玮艺 Section of Radiology Uppsala University

摘要目的本研究旨在发展、评估和阐述利用全身成像序列评价胰岛素组织特异性介导18F-FDG的流入速率、组织沉积和全身胰岛素敏感度（被称为M值）。材料与方法联合

关键词：组织特异性 FDG MR PET/MR 胰岛素敏感度

NOTUM inhibition increases endocortical bone formation and bone strength

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Bone Research 2019年第1期7卷 54-65页

作者： Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu Lexicon Pharmaceuticals The WoodlandsTXUSA Wntrix HoustonTXUSA PRA Health Sciences RaleighNCUSA University of Pennsylvania PhiladelphiaPAUSA Regeneron Pharmaceuticals TarrytownNYUSA University of Texas HoustonTXUSA Centre for Bone and Arthritis Research Institute of MedicineThe Sahlgrenska Academy at University of GothenburgGothenburgSweden Centre for Bone and Arthritis Research University of GothenburgGothenburgSweden Biogen CambridgeMAUSA St.Jude Children’s Research Hospital MemphisTNUSA MD Anderson Cancer Center HoustonTXUSA Bethyl Laboratories MontgomeryTXUSA Merck RahwayNJUSA Nurix San FranciscoCAUSA

The disability,mortality and costs caused by non-vertebral osteoporotic fractures are *** osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral *** bone is a major determinant of non-vertebral bone *** identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable *** bone thickness was substantially elevated in Notum?/?*** is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not *** orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were *** increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone ***,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.

关键词： disability osteoporosis fractures