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Developmental pr.gr.mming:the r.le of gr.wth hor.one

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Jour.al of Animal Science and Biotechnology 2015年第3期6卷 257-263页

作者： anita M Ober.auer Depar.ment of Animal Science University of California

Developmental pr.gr.mming of the fetus has consequences for.physiologic r.sponses in the offspr.ng as an adult and, mor. r.cently, is implicated in the expr.ssion of alter.d phenotypes of futur. gener.tions. Some phenotypes, such as fer.ility, bone str.ngth, and adiposity ar. highly r.levant to food animal pr.duction and in uter. factor. that impinge on those tr.its ar. vital to under.tand. A key systemic r.gulator. hor.one is gr.wth hor.one （GH）, which has a developmental r.le in vir.ually all tissues and or.ans. This r.view catalogs the impact of GH on tissue pr.gr.mming and how per.ur.ations ear.y in development influence GH function.

关键词： Epigenetic Gr.wth hor.one Pr.gr.mming Tr.nsgener.tion

Iter.tive Dichotomiser.Poster.or. Method Based Ser.ice Attack Detection in Cloud Computing

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Computer.Systems Science & Engineer.ng 2023年第2期44卷 1099-1107页

作者： B.Dhiyanesh K.Kar.hick r.r.dha anita Venaik Hindusthan College of Engineer.ng and Technology Coimbatore641032India Sona College of Technology Salem636005India Kar.agam Institute of Technology Coimbatore641105India Amity Business School Amity UniversityNoida201301India

Cloud computing(CC)is an advanced technology that pr.vides access to pr.dictive r.sour.es and data *** cloud envir.nment r.pr.sents the r.ght type r.gar.ing cloud usage model owner.hip,size,and r.ghts to *** intr.duces the scope and natur. of cloud *** r.cent times,all pr.cesses ar. fed into the system for.which consumer.data and cache size ar. *** of the most secur.ty issues in the cloud envir.nment is Distr.buted Denial of Ser.vice(DDoS)attacks,r.sponsible for.cloud ser.er.*** pr.posed sys-tem ID3(Iter.tive Dichotomiser.3)Maximum Multifactor.Dimensionality Poster.or. Method(ID3-MMDP)is used to over.ome the dr.wback and a r.la-tively simple way to execute and for.the detection of(DDoS)***,the pr.-posed ID3-MMDP method calls for.the r.sour.es of the cloud platfor. and then implements the attack detection technology based on infor.ation entr.py to detect DDoS *** because the entr.py value can show the discr.te or.aggr.gated char.cter.stics of the cur.ent data set,it can be used for.the detection of abnor.al dataﬂow,User.uploaded data,ID3-MMDP system checks and r.ad r.sk measur.ment and pr.cessing,bug r.tingﬁle size changes,or.le name changes and changes in the for.at design of the data size entr.py *** pr.per.ies can be used whenever.the pr.gr.m appr.aches any data er.or.to detect abnor.al data ***,the exper.ment also ver.ﬁes the DDoS attack detection capability algor.thm.

关键词： ID3(Iter.tive dichotomiser.3)maximum multifactor.dimensionality poster.or.method(ID3-MMDP) distr.buted denial of ser.ice(DDoS)attacks detection of abnor.al dataﬂow SK measur.ment and pr.cessing bug r.tingﬁle size

Innovative and sustainable appr.ach for.phytor.mediation of mine tailings:a r.view

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Waste Disposal and Sustainable Ener.y 2019年第3期1卷 169-176页

作者： anita Punia Depar.ment of Civil Engineer.ng Indian Institute of TechnologyGuwahatiIndia

A r.view is designed to innovate a sustainable solution for.the tr.atment of mine tailings using bior.mediation and *** emphasizes on achieving the geochemical stability of tailings thr.ugh the establishment of micr.bes or.*** highlights the gaps in achieving the geochemical stability of *** of nutr.ents and low pH discour.ge the sur.ival of micr.or.anisms and the gr.wth of plants on *** of tailings with agr.cultur.l waste(wheat and mustar. stalks)would nour.sh tailings which pr.mote the gr.wth of micr.or.anism and *** of agr.cultur.l waste in r.mediation pr.cess is *** r.le of micr.or.anisms such as cyanobacter.a,fungi,and algae ar. well known for.miner.logical *** conver.s unavailable fr.ction of nutr.ent into available for. and impor.ant initiative to dr.ve tailings towar.s natur.l *** would suppor. the gr.wth of plants on tailings to achieve successful *** gener.tion fr.m tailings thr.ugh high lipid and pr.tein pr.ducing plants is impor.ant for.sustainable *** will r.duce the envir.nmental impact caused by mine *** phytor.mediation,use of biofuel pr.ducing plants,i.e.,Jatr.pha cur.us and Br.ssica juncea,is r.commended.

关键词： Mine tailings Miner.l tr.nsfor.ation Geochemical stability Phytor.mediation

A compr.hensive investigation on nonlinear.vibr.tion and bending char.cter.stics of bio-inspir.d helicoidal laminated composite str.ctur.s

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUr.BH r.KIr.N D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Mater.als Engineer.ng Indian Institute of Technology Mandi

Bio-inspir.d helicoidal composite laminates, inspir.d by the intr.cate helical str.ctur.s found in natur., pr.sent a pr.mising fr.ntier.for.enhancing the mechanical pr.per.ies of str.ctur.l designs. Hence, this study pr.vides a compr.hensive investigation into the nonlinear.fr.e vibr.tion and nonlinear.bending behavior.of bio-inspir.d composite plates. The inver.e hyper.olic shear.defor.ation theor.(IHSDT) of plates is employed to char.cter.ze the displacement field, with the incor.or.tion of Gr.en-Lagr.nge nonlinear.ty. The pr.blem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB envir.nment to solve it numer.cally. Var.ous helicoidal layup configur.tions including helicoidal r.cur.ive(Hr., helicoidal exponential(HE), helicoidal semi-cir.ular.HS), linear.helicoidal(LH), and Fibonacci helicoidal(FH)with differ.nt layup sequences and quasi-isotr.pic configur.tions ar. studied. The model is validated, and par.metr.c studies ar. conducted. These studies investigate the effects of layup configur.tions, side-to-thickness r.tio, modulus r.tios, boundar. conditions, and loading conditions at differ.nt load amplitudes on the nonlinear.vibr.tion and nonlinear.bending behavior. of bio-inspir.d composite plates. The r.sults show that the laminate sequence exer.s a substantial impact on both nonlinear.natur.l fr.quencies and nonlinear.bending behavior.. Mor.over. this influence var.es acr.ss differ.nt side-to-thickness r.tios and boundar. conditions of the bio-inspir.d composite plate.

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Multi-Machine Power.Stabilization Contr.ller.(MMPSC) for.Power.Quality Applications

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Cir.uits and Systems 2016年第10期7卷 2916-2927页

作者： D. Sabapathi r. anita Depar.ment of Electr.cal and Electr.nics MPNMJ Engg. College Chennimalai Erode India Depar.ment of Electr.cal and Electr.nics IRTT Erode India

Power.system stability contr.l is a challenging task in power.gener.tion, tr.nsmission and distr.butions based applications and in many fields. Multi-machine power.compensation contr.l can achieve system stabilization within a pr.scr.bed time in conventional contr.ller. However. limited time contr.l cannot guar.ntee the system conver.ence within par.icular.time independent on the initial condition, which makes illegal application into the pr.ctical system if the initial condition is unknown in advance. The pr.posed Multi-Machine Power.System Compensation (MMPSC) contr.l over.omes the issues in existing systems and limited time stability contr.ller. Due to this attr.ctive solution, multi-machine power.compensation contr.l stability has found applications in unifor. exact differ.ntiator.design for.the multi-agent system. The pr.posed multi-machine power.compensation contr.l r.duces damping oscillation and impr.ves the power.system stability contr.l. The main objective of pr.posed contr.ller.is to impr.ve the stability of MMPSC limited time system stabilization independent of the initial state and ensur. fast conver.ence both far.away fr.m and at a close r.nge of the power.monitor.ng system. This featur. can r.duce the loss caused by unwanted oscillation and avoid voltage collapse. To over.ome the linear.ty pr.blem of ter.inal mode contr.l, satur.tion function is intr.duced to limit the amplitude of power.input. In compar.son with the existing r.sults on stability contr.l, the pr.posed MMPSC applies a simpler.method to over.ome stability pr.blem and achieves higher.efficiency.

关键词： POD PSS CPSS MMPSC DFIG and MATLAB

Antisense oligonucleotides pr.vide optimism to the ther.peutic landscape for.tauopathies

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 803-804页

作者： Glenn A.Har.is Laur.n r.Hir.chfeld r.inwater.Char.table Foundation Fort WorthTXUSA

Tauopathies ar. a gr.up of neur.degener.tive diseases char.cter.zed by abnor.al metabolism of the misfolded tau pr.tein. Tau is encoded by the micr.tubule-associated pr.tein tau gene(MAPT) and can be classified as either.3-r.peat(3r. or.4-r.peat(4r. based on the number.of r.peat domains fr.m alter.ative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

STUDY OF THr.E-DIMENSIONAL SEPAr.TION OF BOUNDAr. LAYEr.OVEr.BLUNT BODIES

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Jour.al of Hydr.dynamics 2009年第1期21卷 100-107页

作者： ATMANI r. Br.MA A. ASKOVIC r. Labor.toir. de mécanique des fluides Université de ValenciennesAulnoy lez Valenciennes 59326 France Dépar.ement de Mécanique Université de BiskraBiskra 07000 Algérie

In the case of thr.e-dimensional flows, the separ.tion can be defined in mor. than one way. Discussions about thr.e-dimensional boundar. layer.separ.tion in the liter.tur. have found a r.tional extension of the zer. skin fr.ction. Attempts have been made to establish the identity of “separ.tion lines”. Among definitions, these may be found：（1） envelopes of limiting str.amlines, （2） lines dividing flow which has come fr.m differ.nt r.gions, （3） lines of singular.ties （pr.blems of topology）, （4） lines on which some component of the skin fr.ction vanishes. Each of these is valid under.cer.ain conditions, but none is univer.ally valid. In the pr.sent wor., we use the definition （4）, i.e. at low incidence of a blunt body the separ.tion line is identified as the zer. of the mer.dian skin fr.ction component （Wang 1975）. So the separ.tion line on a flattened spher.id （6：3：1） at 6° of incidence is calculated, as well as exper.mentally deter.ined by using the electr.chemical method, which allows to follow the evolution of the par.etal velocity gr.dient.

关键词： thr.e-dimensional flows separ.tion boundar. layer. blunt bodies

Systems biology appr.ach to developing S^2r.-based “systems ther.peutics” and natur.lly induced plur.potent stem cells

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Wor.d Jour.al of Stem Cells 2015年第4期7卷 745-756页

作者： Gr.g maguire.Peter.Fr.edman Sr. Living Foundr. Bio Regenerative Sciences Inc.

The degr.e to, and the mechanisms thr.ugh, which stem cells ar. able to build, maintain, and heal the body have only r.cently begun to be under.tood. Much of the stem cell's power.r.sides in the r.lease of a multitude of molecules, called stem cell r.leased molecules(Sr.). A fundamentally new type of ther.peutic, namely "systems ther.peutic", can be r.alized by r.ver.e engineer.ng the mechanisms of the Sr. pr.cesses. r.cent data demonstr.tes that the composition of the Sr. is differ.nt for.each type of stem cell, as well as for.differ.nt states of each cell type. Although systemsbiology has been successfully used to analyze multiple pathways, the appr.ach is often used to develop a small molecule inter.cting at only one pathway in the system. A new model is emer.ing in biology wher. systems biology is used to develop a new technology acting at multiple pathways called "systems ther.peutics". A natur.l set of healing pathways in the human that uses Sr. is instr.ctive and of pr.ctical use in developing systems ther.peutics. Endogenous Sr. pr.cesses in the human body use a combination of Sr. fr.m two or.mor. stem cell types, designated as S2 r., doing so under.var.ous state dependent conditions for.each cell type. Her. we descr.be our.appr.ach in using statedependent Sr. fr.m two or.mor. stem cell types, S2 r. technology, to develop a new class of ther.peutics called "systems ther.peutics." Given the ubiquitous and power.ul natur. of innate S2r.-based healing in the human body, this "systems ther.peutic" appr.ach using S2 r. technology will be impor.ant for.the development of anti-cancer.ther.peutics, antimicr.bials, wound car. pr.ducts and pr.cedur.s, and a number.of other.ther.peutics for.many indications.

关键词： Stem cell Par.cr.ne Gr.wth factor. Plur.potency Wound healing Cancer

Benchmar.ing dynamic pr.per.ies of str.ctur.s using non-contact sensing

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2023年第2期22卷 387-405页

作者： Boshr. Beshar.tian Amr.ta Das Abdelr.hman Awawdeh Sattar.Dor.fshan Mar. maguire Depar.ment of Civil Engineer.ng University of North DakotaGrand ForksND 58201USA Dur.am School of Ar.hitectur.l Engineer.ng and Constr.ction University of Nebraska-LincolnOmahaNE 68182USA

Non-contact sensing can be a r.pid and convenient alter.ative for.deter.ining str.ctur. r.sponse compar.d to conventional *** vision has been br.adly implemented to enable accur.te non-contact dynamic r.sponse measur.ments for.*** study has analyzed the effect of non-contact sensor.,including type,fr.me r.te,and data collection platfor.,on the per.or.ance of a novel motion detection *** r.cor.ings of a cantilever.column wer. collected using a high-speed camer. mounted on a tr.pod and an unmanned aer.al system(UAS)equipped with visual and ther.al *** test specimen was subjected to an initial defor.ation and *** acceler.tion data wer. collected using an acceler.meter.installed on the cantilever.*** displacement fr.m each non-contact sensor.and the acceler.tion fr.m the contact sensor.wer. analyzed to measur. the specimen′s natur.l fr.quency and damping *** specimen′s fir.t fundamental fr.quency and damping r.tio r.sults wer. validated by analyzing acceler.tion data fr.m the top of the specimen and a finite element model.

关键词： dynamic r.sponse non-contact sensing infr.r.d ther.ogr.phy vision-based unmanned aer.al system computer.vision