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Transcriptomic biomarkers for predicting response to neoadjuvant treatment in oesophageal cancer

Gastroenterology Report 2020年第6期8卷 411-424,I0001页

作者： anita lavery Richard C.Turkington Patrick G Johnston Centre for Cancer Research Queen’s University BelfastBelfastUK

Oesophageal cancer is a devastating disease with poor outcomes and is the sixth leading cause of cancer death *** the setting of resectable disease,there is clear evidence that neoadjuvant chemotherapy and chemoradiotherapy result in improved ***,only 15%-30%of patients obtain a histopathological response to neoadjuvant therapy,often at the expense of significant *** are no predictive biomarkers in routine clinical use in this setting and the ability to stratify patients for treatment could dramatically improve *** this review,we aim to outline current progress in evaluating predictive transcriptomic biomarkers for neoadjuvant therapy in oesophageal cancer and discuss the challenges facing biomarker development in this *** place these issues in the wider context of recommendations for biomarker development and *** majority of studies focus on messenger RNA(mRNA)and microRNA(miRNA)*** studies report a range of different genes involved in a wide variety of pathways and biological processes,and this is explained to a large extent by the different platforms and analysis methods *** studies are also vastly underpowered so are not suitable for identifying a candidate *** molecular subtypes of oesophageal cancer have been proposed,although little is known about how these relate to clinical *** anticipate that the accumulating wealth of genomic and transcriptomic data and clinical trial collaborations in the coming years will provide unique opportunities to stratify patients in this poor-prognosis disease and recommend that future biomarker development incorporates well-designed retrospective and prospective analyses.

关键词： oesophageal cancer predictive biomarkers chemotherapy radiotherapy gene expression pathological response

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Anthropomorphic Control of a Dexterous Artificial Hand via Task Dependent Temporally Synchronized Synergies

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Journal of Bionic Engineering 2014年第2期11卷 236-248页

作者： Benjamin A. Kcnt John lavery Erik D. Engeberg Department of Mechanical Engineering University of Akron Akron OH 44325 USA Department of Biomedical Engineering University of Akron Akron OH 44325 USA

Despite the recent influx of increasingly dexterous prostheses, there remains a lack of sufficiently intuitive control methods to fully utilize this dexterity. As a solution to this problem, a control framework is proposed which allows the control of an arbitrary number of Degrees of Freedom （DOF） through a single electromyogram （EMG） control input. Initially, the joint motions of nine test subjects were recorded while grasping and catching a cylinder. Inherent differences emerged depending upon whether the cylinder was grasped or caught. These data were used to form a distinct synergy for each task, described as the families of parametric functions of time that share a mutual time vector. These two Temporally Synchronized Synergies （TSS） were derived to reflect the task dependent control strategies adopted by the initial participants. These synergies were then mapped to a dexterous artificial hand that was subsequently controlled by two subjects with transradial amputations. The EMG signals from these subjects were used to replace the time vector shared by the synergies, enabling the subjects to perform both tasks with a dexterous artificial hand using only a single EMG input. After a ten minute training period, the subjects learned to use the dexterous artificial hand to grasp and catch the cylinder with 100.0% and 65.0% average success rates, respectively.

关键词： electromyogram dexterous hands grasp synergy prosthetics sliding mode control

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Redefining Quality in Higher Education:The Concept of Juakalization

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Sino-US English Teaching 2018年第9期15卷 415-428页

作者： Emmah M.Muema Matthew R.lavery Bowling Green State University OhioUSA

University education is the epitome of education that countries leverage for the delivery of national strategic plans,through the creation of skilled workforce for socio-economic *** public universities have experienced massification in the past three decades,a phenomenon resulting from the democratization of education,the advent of knowledge economy,and *** purpose of this study was to investigate whether the consequences of massification caused Juakalization in higher education in *** is the dilution and conversion of high quality university education to assume an artisan nature of mass production of low quality and unstandardized educational *** study used a systematic review of literature and public documents to analyze the consequences of massification in Kenya's higher *** indicate that the consequences of massification of overcapacity and insufficient infrastructure led to mass production of a low quality non-standardized university *** researcher compares the Kenyan Jua Kali artisan production process to that of higher education,where both work under adverse conditions to produce mass low quality *** analogy acts as a metaphor to describe the dilution and conversion of higher education to that of artisanship and coins the term Juakalization to describe this process in higher education.

关键词： Juakalization artisanship massification Jua Kali unstandardized mass production

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Evaluation of Data Replacement Strategies for CASTNET Dry Deposition Modeling

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Journal of Environmental Science and Engineering(B) 2012年第6期1卷 789-799页

作者： Christopher Rogers Thomas lavery Kevin Mishoe Ralph Baumgardner AMEC Environment & Infrastructure Inc. Jacksonville FL 32207 USA Fuss & O 'Neill Inc. Providence R102908 USA AMEC Environment & Infrastructure Inc. Newberry FL 32669 USA U.S. Environmental Protection Agency Research Triangle Park NC 27711 USA

The U.S. EPA （Environmental Protection Agency） established the CASTNET （Clean Air Status and Trends Network） and its predecessor, the NDDN （national dry deposition network）, as national air quality and meteorological monitoring networks. Both CASTNET and NDDN were designed to measure concentrations of sulfur and nitrogen gases and particles. Both networks also estimate dry deposition using an inferential model. The design was based on the concept that atmospheric dry deposition flux could be estimated as the product of a measured air pollutant concentration and a modeled deposition velocity （Vd）. The MLM （multi-layer model）, the computer model used to simulate dry deposition, requires information on meteorological conditions and vegetative cover as model input. The MLM calculates hourly Fa for each pollutant, but any missing meteorological data for an hour renders Vd missing for that hour. Because of percent completeness requirements for aggregating data for long-term estimates, annual deposition rates for some sites are not always available primarily because of missing or invalid meteorological input data. In this work, three methods for replacing missing on-site measurements are investigated. These include （1） using historical values of deposition velocity or （2） historical meteorological measurements from the site being modeled or （3） current meteorological data from nearby sites to substitute for missing inputs and thereby improve data completeness for the network＇s dry deposition estimates. Results for a CASTNET site used to test the methods show promise for using historical measurements of weekly average meteorological parameters.

关键词： Dry deposition deposition velocity leaf area index MLM (Multi-Layer Model)

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婴儿广泛瘙痒性皮疹一例

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英国医学杂志中文版 2021年第8期24卷 479-480页

作者： Michael J lavery Deborah Woodcock Will Simmons Ali Al-Sharqi 秦思(译) Department of Dermatology Alder Hey Children′s Hospital NHS Foundation TrustLiverpoolUK Department of Histopathology Alder Hey Children′s Hospital NHS Foundation TrustLiverpoolUK 广东省第二人民医院皮肤科

1名7月龄的婴儿因全身广泛瘙痒性皮疹3个月就诊于皮肤科门诊,皮疹主要分布在躯干和四肢。家庭医生予以患儿外用糖皮质激素和口服抗生素治疗,未见明显好转。患儿一般情况良好。体格检查:全身弥漫分布多形性皮疹,伴有红斑丘疹、结节、粘... 详细信息

1名7月龄的婴儿因全身广泛瘙痒性皮疹3个月就诊于皮肤科门诊,皮疹主要分布在躯干和四肢。家庭医生予以患儿外用糖皮质激素和口服抗生素治疗,未见明显好转。患儿一般情况良好。体格检查:全身弥漫分布多形性皮疹,伴有红斑丘疹、结节、粘连斑块(图1)。掌指关节和指间隙有结痂丘疹。双足底可见匐行隧道,皮肤镜下可见数个黑点。面部也有受累,左侧眶周和左侧鼻部可见皮疹。

关键词：掌指关节家庭医生红斑丘疹瘙痒性皮疹多形性皮疹皮肤镜眶周皮肤科门诊

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Magnitude and Trends of High-elevation Cloud Water Pollutant Concentrations and Modeled Deposition Fluxes

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Journal of Environmental Science and Engineering(B) 2017年第3期6卷 127-143页

作者： Selma Isil Thomas lavery Kristi Gebhart Christopher Rogers Carol Armbrust Wanta Amee Foster Wheeler Environment & Infrastructure Inc. Newberry Florida 32669-3000 USA Air Quality Science Cranston Rhode Island 02920 USA U.S. National Park Service Air Resources Division Colorado State University Fort Collins Colorado 80523 USA

Cloud water samples, LWC （Liquid Water Content） and meteorological data were collected at the Clingmans Dome, Tennessee, high-elevation site in Great Smoky Mountains National Park during the warm season from 1994 through 2011. This paper presents results from 2000 through the conclusion of the study in 2011. Samples were analyzed for SO42＂, NO3, NH4＋ and H＋. These measurements were supplemented by measurements of ambient air and precipitation concentrations to estimate dry and wet deposition. Cloud water concentrations, LWC, cloud frequency, various meteorological measurements and information on nearby forest canopy were used to model cloud water deposition to gauge trends in deposition. Total deposition was calculated as the sum of cloud, dry and wet deposition estimates. Concentrations and deposition fluxes declined over the study period. The decreases in cloud water SO42＂ and NO3 concentrations were 40 percent and 26 percent, respectively. Three-year mean 5042 and NO3 deposition rates decreased by 71 percent and 70 percent, respectively. Trends in concentrations and depositions were comparable with trends in SO2 and NOx emissions from Tennessee Valley Authority power plants and aggregated emission reductions from electric generating units in adjacent states. Back trajectories were simulated with the HYSPLIT model and aggregated over cloud sampling periods from 2000 through 2007 and 2009 through 2011. Trajectories during periods with high H＋ concentrations traveled over local EGU （Electric Generating Unit） emission sources in Tennessee and Kentucky to the Ohio River Valley, Alabama and Georgia with the conclusion that these source regions contributed to acidic cloud water deposition at Clingmans Dome. This work was supported by U.S. Environmental Protection Agency and the Tennessee Valley Authority with infrastructure support provided by the National Park Service.

关键词： Cloud water acid deposition liquid water content emissions back trajectory high elevation.

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在RoHS安装环境下减轻锡须的有效办法

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今日电子 2006年第12期 52-53页

作者： Patrick lavery Vicor公司

锡须现象是低熔点材料(锡,镉,铟)的一种故障模式,这些材料常被用来提高焊接的性能.人们在多年以前就认识到了这种现象,并通过在镀层中掺入铅来解决这个问题,但现在铅已经被认为是有害物质,并被RoHS指令禁止使用.

关键词： RoHS指令锡须安装环境故障模式有害物质低熔点材料焊接

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负压创伤疗法治疗糖尿病足损伤是否安全有效?

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继续医学教育 2007年第5期21卷 48-50页

作者： Armstrong DG lavery LA 美国芝加哥Rosalind Franklin医科大学Scholl下肢步行研究(CLEAR)中心 60064 美国德克萨斯A&M大学医学院健康科学中心Scott&White医院

足创伤是糖尿病最常见、最复杂、治疗费用最高的并发症之一。即使是最表浅的创伤，治疗也是非常困难的，治愈率低，并发症发生率高。尽管目前有几项先进的技术可改善糖尿病足损伤的治疗，但治疗结局未得到很大改观，并不比基本的传统疗... 详细信息

足创伤是糖尿病最常见、最复杂、治疗费用最高的并发症之一。即使是最表浅的创伤，治疗也是非常困难的，治愈率低，并发症发生率高。尽管目前有几项先进的技术可改善糖尿病足损伤的治疗，但治疗结局未得到很大改观，并不比基本的传统疗法（适当的清创和减压术）更好。

关键词：治疗费用创伤疗法糖尿病足损伤并发症发生率安全负压传统疗法

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海上帝国

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作者： (英)布莱恩·莱弗里(Brian lavery)

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氟-寻找火山岩硫化物矿床的指示元素

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宝石和宝石学杂志(中英文) 1987年第2期 63-67页

作者： Norman G.lavery 李世明

对于火山岩中块状硫化物矿床的勘探涉及到识别象绿岩带这样有利的地质环境和确认其岩带中最有利于进行详勘的地区.经常用路线地质和地球物理测量来确定有利的地质环境,还经常可以用蚀变矿物学和成矿元素地球化学的知识,参照已知矿床周... 详细信息

对于火山岩中块状硫化物矿床的勘探涉及到识别象绿岩带这样有利的地质环境和确认其岩带中最有利于进行详勘的地区.经常用路线地质和地球物理测量来确定有利的地质环境,还经常可以用蚀变矿物学和成矿元素地球化学的知识,参照已知矿床周围出现的模式来确定靶区.热液成因的绿泥石的出现以及许多火山岩矿床下部补给带内异常富的铜含量就是这种特征的例子.热液绿泥石和铜的高含量出现在矿体附近,且范围局限.它们一旦在初期钻孔中

关键词：火山岩喷出岩火成岩块状硫化物矿床黄铁矿型多金属矿床硫化物矿体岩石类型岩石分类

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