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Validation of the Glaucoma Quality of Life-15 Questionnaire in Serbian language

International Journal of Ophthalmology(English edition) 2018年第10期11卷 1674-1684页

作者： Ivan Sencanic Tatjana Gazibara Jelena Dotlic Miroslav Stamenkovic Vesna Jaksic Marija Bozic anita grgurevic Clinic for Eye Disease "Prof. dr Ivan Stankovic" University Medical Center "Zvezdara" Institute of Epidemiology Faculty of Medicine University of Belgrade Faculty of Medicine University of Belgrade Faculty of Special Education and Rehabilitation University of Belgrade Clinic for Eye Disease "Prof. dr Djordje Nesic" Clinical Center of Serbia

AIM：To translate the Glaucoma Quality of Life-15（GQL-15）to Serbian language and asses its validity and reliability in the population of Serbian ***：The study included 177 glaucoma *** parameters（visual acuity,mean defect and square root of loss variance of visual field）and socio-demographic data were *** were stratified according to the Nelson’s glaucoma staging system as mild,moderate and advanced *** patients filled out the GQL-15 and National Eye Institute Visual Function Questionnaire（NEI-VFQ 25）.The GQL-15 was translated following the internationally-accepted methodology,and its psychometric properties were assessed by using classical test theory and Rasch ***：The mean total score for the GQL-15 was 20.68±*** Cronbach’s alpha coefficient for the whole scale was 0.89（central and near vision,α=0.24;peripheral vision,α=0.85;glare and dark adaptation,α=0.83）.Factor analysis established 4 factors（70.3% of variance）：two corresponding to the original factors and two new factors specific for the Serbian *** GQL-15 score correlated positively with almost all clinical parameters and NEI-VFQ 25 proving good criterion *** of the GQL-15 total score on test-retest confirmed appropriate scale reproducibility（ρ=0.96,P〈0.001）.The GQL-15 discriminated well advanced from mild and moderate *** Rasch analysis we obtained adequate item（0.95）reliability *** all items had infit and outfit mean squares in the accepted ***：Serbian version of the GQL-15 demonstrates adequate reliability and *** version of the GQL-15is a valid instrument for evaluation of quality of life among Serbian speaking patients with glaucoma and can be applied in daily clinical work.

关键词： glaucoma GQL-15 scale validation Serbian

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Portal hypertension in patients with nonalcoholic fatty liver disease:Current knowledge and challenges

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World Journal of Gastroenterology 2024年第4期30卷 290-307页

作者： anita Madir Ivica grgurevic Emmanuel A Tsochatzis Massimo Pinzani Department of Gastroenterology Hepatology and Clinical NutritionUniversity Hospital DubravaZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia UCL Institute for Liver and Digestive Health Royal Free Hospital and University College LondonLondon NW32PFUnited Kingdom

Portal hypertension(PH)has traditionally been observed as a consequence of significant fibrosis and cirrhosis in advanced non-alcoholic fatty liver disease(NAFLD).However,recent studies have provided evidence that PH may develop in earlier stages of NAFLD,suggesting that there are additional pathogenetic mechanisms at work in addition to liver *** early development of PH in NAFLD is associated with hepatocellular lipid accumulation and ballooning,leading to the compression of liver *** compression and intraluminal obstacles cause mechanical forces such as strain,shear stress and elevated hydrostatic pressure that in turn activate mechanotransduction pathways,resulting in endothelial dysfunction and the development of *** spatial distribution of histological and functional changes in the periportal and perisinusoidal areas of the liver lobule are considered responsible for the pre-sinusoidal component of PH in patients with ***,current diagnostic methods such as hepatic venous pressure gradient(HVPG)measurement tend to underestimate portal pressure(PP)in NAFLD patients,who might decompensate below the HVPG threshold of 10 mmHg,which is traditionally considered the most relevant indicator of clinically significant portal hypertension(CSPH).This creates further challenges in finding a reliable diagnostic method to stratify the prognostic risk in this population of *** theory,the measurement of the portal pressure gradient guided by endoscopic ultrasound might overcome the limitations of HVPG measurement by avoiding the influence of the pre-sinusoidal component,but more investigations are needed to test its clinical utility for this *** and spleen stiffness measurement in combination with platelet count is currently the best-validated non-invasive approach for diagnosing CSPH and varices needing *** change remains the cornerstone of the treatment of PH in NAFLD,together with correcting the comp

关键词： Non-alcoholic fatty liver disease Portal hypertension Mechanotransduction Endothelial dysfunction Hepatic venous pressure gradient

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