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Biology and pathology of the uterine micro environ merit and its natural killer cells

Cellular & Molecular Immunology 2021年第9期18卷 2101-2113页

作者： Fuyan Wang anita ellen qualls Laia Marques-Fernandez Francesco Colucci Department of Obstetrics&Gynaecology University of CambridgeNational Institute for Health Research Cambridge Biomedical Research CentreCambridge CB20SWUK Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of PathophysiologySchool of MedicineNingbo UniversityNingbo 315211China Centre for Trophoblast Research University of CambridgeCambridge CB23EGUK

Tissues are the new frontier of discoveries in *** of the immune system are an integral part of tissue physiology and *** how immune cells inhabit,housekeep,and defend gut,lung,brain,liver,uterus,and other organs helps revealing the intimate details of tissue physiology and may offer new therapeutic targets to treat *** uterine microenvironment modulates the development and function of innate lymphoid cells[ILC,largely represented by natural killer(NK)cells],macrophages,T cells,and dendritic *** immune cells,in turn,contribute to tissue *** by ovarian hormones,the human uterine mucosa(endometrium)undergoes ~400 monthly cycles of breakdown and regeneration from menarche to menopause,with its fibroblasts,glands,blood vessels,and immune cells remodeling the tissue into the transient *** more transformative changes occur upon blastocyst *** the placenta is formed,the endometrial glands feed the embryo by histiotrophic nutrition while the uterine spiral arteries are stripped of their endothelial layer and smooth muscle *** arterial remodeling is carried out by invading fetal trophoblast and maternal immune cells,chiefly uterine NK(uNK)cells,which also assist fetal *** tran sformed arteries no Ion ger resp ond to mater nal stimuli and meet the increasi ng dema nds of the growing *** review focuses on how the everchanging uterine microenvironment affects uNK cells and how uNK cells regulate homeostasis of the decidua,placenta development,and fetal *** these pathways will help understand the causes of major pregnancy complications.

关键词： Natural killer cells Uterine microenvironment Pregnancy Decidua uNK

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