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Iron:An emerging factor in colorectal carcinogenesis

World Journal of Gastroenterology 2010年第6期16卷 663-672页

作者： anita cg chua Borut Klopcic Ian C Lawrance John K Olynyk Debbie Trinder Debbie Trinder School of Medicine and PharmacologyThe University of Western AustraliaFremantle Hospital Western Australian Institute for Medical Research Fremantle Hospital The Centre for Inflammatory Bowel Diseases Fremantle Hospital

The carcinogenic potential of iron in colorectal cancer(CRC) is not fully *** is able to undergo reduction and oxidation,making it important in many physiological *** inherent redox property of iron,however,also renders it toxic when it is present in ***-mediated generation of reactive oxygen species via the Fenton reaction,if uncontrolled,may lead to cell damage as a result of lipid peroxidation and oxidative DNA and protein *** may promote carcinogenesis through increased genomic instability,chromosomal rearrangements as well as mutations of proto-oncogenes and tumour suppressor genes. Carcinogenesis is also affected by inflammation which is exacerbated by *** studies indicate an association between high dietary iron intake and CRC *** this editorial,we examine the link betweeniron-induced oxidative stress and inflammation on the pathogenesis of CRC.

关键词： Iron Haem Colorectal cancer Oxidative stress Inflammation Haemochromatosis

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Liver iron transport

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World Journal of Gastroenterology 2007年第35期13卷 4725-4736页

作者： Ross M Graham anita cg chua Carly E Herbison John K Olynyk Debbie Trinder School of Medicine and Pharmacology Fremantle HospitalUniversity of Western AustraliaFremantleWestern AustraliaAustralia School of Medicine and Pharmacology Fremantle HospitalUniversity of Western AustraliaFremantleWestern AustraliaAustralia Western Australian Institute for Medical ResearchNedlandsWestern AustraliaAustralia

The liver plays a central role in iron metabolism. It is the major storage site for iron and also expresses a complex range of molecules which are involved in iron transport and regulation of iron homeostasis. An increasing number of genes associated with hepatic iron transport or regulation have been identified. These include transferrin receptors （TFRI and 2）, a ferrireductase （STEAP3）, the transporters divalent metal transporter-1 （DMT1） and ferroportin （FPN） as well as the haemochromatosis protein, HFE and haemojuvelin （HJV）, which are signalling molecules. Many of these genes also participate in iron regulatory pathways which focus on the hepatic peptide hepcidin. However, we are still only beginning to understand the complex interactions between liver iron transport and iron homeostasis. This review outlines our current knowledge of molecules of iron metabolism and their roles in iron transport and regulation of iron homeostasis.

关键词： Liver Iron homeostasis Iron uptake Iron release Iron transporters Hereditary haemochromatosis

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Optical coherence tomography angiography for the anterior segment

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Eye and Vision 2019年第1期6卷 23-31页

作者： Wen Di Lee Kavya Devarajan Jacqueline chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang Singapore Eye Research Institute Singapore National Eye CenterSingaporeSingapore Eye-ACP Duke-NUS Graduate Medical SchoolSingaporeSingapore Department of Clinical Pharmacology Medical University of ViennaViennaAustria Center for Medical Physics and Biomedical Engineering Medical University of ViennaViennaAustria Nanyang Technological University SingaporeSingapore

Optical coherence tomography angiography(OCTA)is a rapid and non-invasive technique for imaging vasculature in the *** OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest,it has become a promising method for anterior segment ***,OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent ***,conventional OCTA systems are typically designed and optimized for the posterior segment of the eye,and thus using OCTA for anterior segment imaging can present several difficulties and *** this review,we summarized the recent developments and clinical applications in anterior segment OCTA(AS-OCTA)imaging,such as for the cornea,iris,sclera and *** also compared commercially available OCTA systems,discussed the limitations of adapting current OCTA technology for the anterior segment imaging,and proposed possible future directions for AS-OCTA ***-OCTA provides potential for future clinical applications such as diagnosis of corneal and iris pathologies,pre-operative surgical planning,assessment of new antiangiogenic therapeutics or evaluation of limbal stem cell *** further development,OCTA for anterior segment imaging in the clinics may become common in the near future.

关键词： Optical coherence tomography angiography Vascularisation Cornea Iris Anterior segment

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