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Soft Computing Based Discriminator Model for Glaucoma Diagnosis

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Computer Systems Science & Engineering 2022年第9期42卷 867-880页

作者： anisha Rebinth S.Mohan Kumar Department of Information Science and Engineering NHCEVisvesvaraya Technological UniversityBangaloreIndia Department of Computer Science and Engineering Nagarjuna College of Engineering and TechnologyBangaloreIndia

In this study, a Discriminator Model for Glaucoma Diagnosis (DMGD)using soft computing techniques is presented. As the biomedical images such asfundus images are often acquired in high resolution, the Region of Interest (ROI)for glaucoma diagnosis must be selected at first to reduce the complexity of anysystem. The DMGD system uses a series of pre-processing;initial cropping by thegreen channel’s intensity, Spatially Weighted Fuzzy C Means (SWFCM), bloodvessel detection and removal by Gaussian Derivative Filters (GDF) and inpaintingalgorithms. Once the ROI has been selected, the numerical features such as colour, spatial domain features from Local Binary Pattern (LBP) and frequencydomain features from LAWS are generated from the corresponding ROI forfurther classification using kernel based Support Vector Machine (SVM). TheDMGD system performances are validated using four fundus image databases;ORIGA, RIM-ONE, DRISHTI-GS1, and HRF with four different kernels;LinearKernel (LK), Polynomial Kernel (PK), Radial Basis Function (RBFK) kernel,Quadratic Kernel (QK) based SVM classifiers. Results show that the DMGD system classifies the fundus images accurately using the multiple features and kernelbased classifies from the properly segmented ROI.

关键词： Glaucoma support vector classification clustering technique spatial domain and frequency domain features

In vivo mouse models to study bile acid synthesis and signaling

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Hepatobiliary & Pancreatic Diseases International 2023年第5期22卷 466-473页

作者： anisha Bhattacharya Rulaiha E Taylor Grace L Guo Department of Pharmacology and Toxicology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNew JerseyUSA Rutgers Center for Lipid Research RutgersThe State University of New JerseyNew BrunswickNew JerseyUSA Environmental and Occupational Health Sciences Institute RutgersThe State University of New JerseyPiscatawayNew JerseyUSA VA New Jersey Health Care System Veterans Administration Medical CenterEast OrangeNew JerseyUSA

The synthesis of bile acids(BAs)is carried out by complex pathways characterized by sequential chemical reactions in the liver through various cytochromes P450(CYP)and other *** the integrity of these pathways is crucial for normal physiological function in mammals,encompassing hepatic and neurological *** on the deficiencies in BA synthesis genes offers valuable insights into the significance of BAs in modulating farnesoid X receptor(FXR)signaling and metabolic *** creating mouse knockout(KO)models,researchers can manipulate deficiencies in genes involved in BA synthesis,which can be used to study human diseases with BA *** KO mouse models allow for a more profound understanding of the functions and regulations of genes responsible for BA ***,KO mouse models shed light on the distinct characteristics of individual BA and their roles in nuclear receptor ***,alterations of BA synthesis genes in mouse models have distinct differences when compared to human diseases caused by the same BA synthesis gene *** review summarizes several mouse KO models used to study BA synthesis and related human diseases,including mice deficient in Cyp7a1,Cyp27a1,Cyp7a1/Cyp27a1,Cyp8b1,Cyp7b1,Cyp2c70,Cyp2a12,and Cyp2c70/Cyp2a12,as well as germ-free mice.

关键词： Bile acid Species difference Farnesoid X receptor Liver diseases

Tectono-magmatic evolution of Tethyan oceanic lithosphere in supra subduction zone fore arc regime:Geochemical fingerprints from crust-mantle sections of Naga Hills Ophiolite

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Geoscience Frontiers 2021年第3期12卷 19-41页

作者： anisha Verencar Abhishek Saha Sohini Ganguly Manikyamba C. CSIR-National Institute of Oceanography Dona PaulaGoa 403004India School of Earth Ocean and Atmospheric SciencesGoa UniversityTaleigão PlateauGoa 403206India CSIR-National Geophysical Research Institute Uppal RoadHyderabad 500007India

The Naga Hills Ophiolite(NHO)belt in the Indo-Myanmar range(IMR)represents a segment of Tethyan oceanic crust and upper mantle that was involved in an eastward convergence and collision of the Indian Plate with the Burmese Plate during the Late ***,we present a detailed petrological and geochemical account for the mantle and crustal sections of NHO,northeastern India to address(i)the mantle processes and tectonic regimes involved in their genesis and(ii)their coherence in terms of the thermo-tectonic evolution of Tethyan oceanic crust and upper *** NHO suite comprises well preserved crustal and mantle sections discretely exposed at Moki,Ziphu,Molen,Washelo and Lacham *** ultramafic-mafic lithologies of NHO are mineralogically composed of variable proportions of olivine,orthopyroxene,clinopyroxene and *** primary igneous textures for the mantle peridotites have been overprinted by extensive serpentinisation whereas the crustal section rocks reflect crystal cumulation in a magma *** normalised REE profiles for the cumulate peridotite-olivine gabbro-gabbro assemblage constituting the crustal section of NHO show flat to depleted LREE patterns consistent with their generation from depleted MORB-type precursor melt in an extensional tectonic setting,while the mantle peridotites depict U-shaped REE patterns marked by relative enrichment of LREE and HREE over *** features collectively imply a dual role of depleted MORB-type and enriched arc-type mantle components for their genesis with imprints of melt-rock and fluid-rock ***,studied lithologies from NHO correspond to a boninitic to slab-proximal Island Arc Tholeiite affinity thereby conforming to an intraoceanic supra subduction zone(SSZ)fore-arc regime coherent with the subduction initiation *** geochemical attributes for the crustal and mantle sections of NHO as mirrored by Zr/Hf,Zr/Sm,Nb/Ta,Zr/Nb,Nb/U,Ba/Nb,Ba/Th,Ba/La and Nd/

关键词： Tethyan Ocean Naga Hills Ophiolite Suprasubduction Zone Subduction initiation Fore arc extension Mantle refertilisation

In vivo imaging of structural,metabolic and functional brain changes in glaucoma

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Neural Regeneration Research 2019年第3期14卷 446-449页

作者： anisha Kasi Muneeb A.Faiq Kevin C.Chan NYU Langone Eye Center Department of Ophthalmology NYU School of Medicine NYU Langone Health New York University Department of Radiology NYU School of Medicine NYU Langone Health New York University Center for Neural Science Faculty of Arts and Science New York University

Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. There has been a growing amount of literature suggesting glaucoma as a neurodegenerative disease of the visual system. However, it remains debatable whether the observed pathophysiological conditions are causes or consequences. This review summarizes recent in vivo imaging studies that helped advance the understanding of early glaucoma involvements and disease progression in the brains of humans and experimental animal models. In particular, we focused on the non-invasive detection of early structural and functional brain changes before substantial clinical visual field loss in glaucoma patients; the eye-brain interactions across disease severity; the metabolic changes occurring in the brain's visual system in glaucoma; and, the widespread brain involvements beyond the visual pathway as well as the potential behavioral relevance. If the mechanisms of glaucomatous brain changes are reliably identified, novel neurotherapeutics that target parameters beyond intraocular pressure lowering can be the promise of the near future, which would lead to reduced prevalence of this irreversible but preventable disease.

关键词： glaucoma intraocular pressure eye-brain-behavior relationship irreversible blindness magnetic resonance imaging metabolic brain changes sensitivity disease progression

Bacterial extracellular vesicle applications in cancer immunotherapy

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Bioactive Materials 2023年第4期22卷 551-566页

作者： Kanika Suri anisha D’Souza Di Huang Aashray Bhavsar Mansoor Amiji Department of Bioengineering College of EngineeringNortheastern UniversityBostonMA02115USA Department of Pharmaceutical Sciences School of PharmacyNortheastern UniversityBostonMA02115USA Massachusetts Eye and Ear Infirmary Harvard Medical SchoolBostonMA20115USA Department of Chemical Engineering College of EngineeringNortheastern UniversityBostonMA02115USA

Cancer therapy is undergoing a paradigm shift toward immunotherapy focusing on various approaches to activate the host immune *** research to identify appropriate immune cells and activate anti-tumor immunity continues to expand,scientists are looking at microbial sources given their inherent ability to elicit an immune *** extracellular vesicles(BEVs)are actively studied to control systemic humoral and cellular immune responses instead of using whole microorganisms or other types of extracellular vesicles(EVs).BEVs also provide the opportunity as versatile drug delivery *** mammalian EVs,BEVs have already made it to the clinic with the meningococcal vaccine(Bexsero®).However,there are still many unanswered questions in the use of BEVs,especially for chronic systemically administered *** this review,we address the opportunities and challenges in the use of BEVs for cancer immunotherapy and provide an outlook towards development of BEV products that can ultimately translate to the clinic.

关键词： Cancer immunotherapy Bacterial extracellular vesicles Membrane vesicles Outer membrane vesicles Mammalian extracellular vesicles

Glymphatic imaging and modulation of the optic nerve

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Neural Regeneration Research 2022年第5期17卷 937-947页

作者： anisha Kasi Crystal Liu Muneeb A.Faiq Kevin C.Chan Department of Ophthalmology NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Department of Radiology NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Neuroscience Institute NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Center for Neural Science College of Arts and ScienceNew York UniversityNew YorkNYUSA

Optic nerve health is essential for proper function of the visual ***,the pathophysiology of certain neurodegenerative disease processes affecting the optic nerve,such as glaucoma,is not fully ***,it was hypothesized that a lack of proper clearance of neurotoxins contributes to neurodegenerative *** ability to clear metabolic waste is essential for tissue homeostasis in mammals,including *** the brain lacks the traditional lymphatic drainage system identified in other anatomical regions,there is growing evidence of a glymphatic system in the central nervous system,which structurally includes the optic *** to acknowledge the supportive role of astroglial cells,this perivascular fluid drainage system is essential to remove toxic metabolites from the central nervous ***,we review existing literature describing the physiology and dysfunction of the glymphatic system specifically as it relates to the optic *** summarize key imaging studies demonstrating the existence of a glymphatic system in the optic nerves of wild-type rodents,aquaporin 4-null rodents,and humans;glymphatic imaging studies in diseases where the optic nerve is impaired;and current evidence regarding pharmacological and lifestyle interventions that may help promote glymphatic function to improve optic nerve *** conclude by highlighting future research directions that could be applied to improve imaging detection and guide therapeutic interventions for diseases affecting the optic nerve.

关键词： aquaporin-4 cerebrospinal fluid glaucoma glymphatic system hydrocephalus imaging metabolic waste clearance optic nerve perivascular pharmacological and lifestyle interventions

Hydro-uvarovite from Mantle Peridotites of Naga Hills Ophiolite: A Mineral Tracer for Neo-Tethyan Mantle Wedge Metasomatism

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 867-877页

作者： anisha VERENCAR Abhishek SAHA Nilanjana SORCAR Sohini GANGULY Pankaj KUMAR Atul Kumar SINGH CSIR-National Institute of Oceanography Dona PaulaGoa 403004India School of Earth Ocean and Atmospheric SciencesGoa UniversityTaleigao PlateauGoa 403206India National Centre for Earth Science Studies ThiruvananthapuramKeralaIndia Inter University Accelerator Centre(IUAC) New Delhi 110067India North-Eastern Hill University ShillongMeghalaya 793022India

Hydrous Cr-bearing uvarovite garnets are rare in natural occurrences and belong to the ugrandite series and exist in binary solid solutions with grossular and andradite garnets. Here, we report the occurrence of hydrous uvarovite garnet having Cr_(2)O_(3) upto 19.66 wt% and CaO of 32.12–35.14 wt% in the serpentinized mantle peridotites of Naga Hills Ophiolite(NHO), India. They occur in association with low-Cr diopsides. They are enriched in LILE(Ba, Sr), LREEs, with fractionating LREE-MREE [avg.(La/Sm)_(N) = 2.16] with flat MREE/HREE patterns [avg.(Sm/Yb)_(N) = 0.95]. Raman spectra indicate the presence of hydroxyl(OH^(–)) peaks from 3500 to 3700 cm^(-1). Relative abundances in fluid mobile elements and their close association with clinopyroxenes are suggestive of the formation of uvarovite garnets through low temperature metasomatic alteration of low-Cr diopsides by hydrothermal slab fluids. The high LREE concentration and absence of Eu anomaly in the garnet further attest to alkaline nature of the transporting slab dehydrated fluid rather the involvement of low-p H solution. The chemical characteristics of the hydroxyl bearing uvarovite hosted by the mantle peridotite of NHO deviate from the classical features of uvarovite garnet, and their origin is attributed to the fluid-induced metasomatism of the sub arc mantle wedge in a suprasubduction zone regime.

关键词： uvarovite hydroxyl metasomatic alteration low-Cr diopsides serpentinization mantle peridotite

Internal hemorrhoid harboring adenocarcinoma:A case report

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World Journal of Gastrointestinal Oncology 2021年第1期13卷 87-91页

作者： Michael L Caparelli Jason C Batey anisha Tailor Timothy Braverman Cory Barrat of Surgery The Jewish HospitalCincinnatiOH 45236United States Department of Pathology The Jewish HospitalCincinnatiOH 45236United States

BACKGROUND The incidence of carcinoma found within an internal hemorrhoid specimen is exceptionally ***,the presence of primary anal canal adenocarcinoma within internal hemorrhoids is even more *** describe a case in which anal canal adenocarcinoma was found within an internal hemorrhoidectomy specimen and perform a review of the current *** SUMMARY The patient was a 79-year-old male who presented with rectal bleeding and was found to have large thrombosed internal hemorrhoids during screening *** patient subsequently underwent a three-column *** analysis revealed one of three specimens containing a 1.5 cm moderate-to-poorly differentiated adenocarcinoma of anal origin with superficial submucosal *** three-month follow up,he was taken to the operating theatre for biopsy and re-excision of his non-healing wound,which showed no *** wound has since healed and he was cancer free at ten-month follow *** When faced with primary anal canal adenocarcinoma an interdisciplinary approach to treatment should be *** pathological analysis of hemorrhoidectomy specimens may be beneficial due to the severity of anal canal carcinomas if left undiagnosed and untreated in a timely manner.

关键词： Hemorrhoidectomy Adenocarcinoma Colorectal Anal canal Oncology Hematochezia Case report

Biological insights in non-small cell lung cancer

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Cancer Biology & Medicine 2023年第7期20卷 500-518页

作者： Rafael Rosell anisha Jain Jordi Codony-Servat Eloisa Jantus-Lewintre Blake Morrison Jordi Barretina Ginesta María González-Cao Germans Trias i Pujol Research Institute Badalona 08028Spain IOR Hospital Quiron-DexeusBarcelona 08028Spain Department of Microbiology JSS Academy of Higher Education&ResearchMysuru 570015India Pangaea Oncology Hospital Quiron-DexeusBarcelona 08028Spain Department of Biotechnology Universitat Politècnica de ValenciaMixed Unit TRIAL(General University Hospital of Valencia Research Foundation and Príncipe Felipe Research Center)CIBERONCValencia 46014Spain Sumitomo Pharma Oncology Inc.CambridgeMA and LehiUT 84043USA

Lung oncogenesis relies on intracellular cysteine to overcome oxidative *** tumor types,including non-small cell lung cancer(NSCLC),upregulate the system x-c cystine/glutamate antiporter(xCT)through overexpression of the cystine transporter SLC7A11,thus sustaining intracellular cysteine levels to support glutathione *** factor erythroid 2-related factor 2(NRF2)serves as a master regulator of oxidative stress resistance by regulating SLC7A11,whereas Kelch-like ECH-associated protein(KEAP1)acts as a cytoplasmic repressor of the oxidative responsive transcription factor *** in KEAP1/NRF2 and p53 induce SLC7A11 activation in *** cystine is crucial in supplying the intracellular cysteine levels necessary to combat oxidative *** in cystine availability lead to iron-dependent lipid peroxidation,thus resulting in a type of cell death called *** inhibitors of xCT(either SLC7A11 or GPX4)induce ferroptosis of NSCLC cells and other tumor *** cystine uptake is impaired,the intracellular cysteine pool can be sustained by the transsulfuration pathway,which is catalyzed by cystathionine-B-synthase(CBS)and cystathionine g-lyase(CSE).The involvement of exogenous cysteine/cystine and the transsulfuration pathway in the cysteine pool and downstream metabolites results in compromised CD8^(+)T cell function and evasion of immunotherapy,diminishing immune response and potentially reducing the effectiveness of immunotherapeutic *** is a previously unrecognized form of regulated cell *** NSCLCs driven by EGFR,ALK,or KRAS,selective inhibitors induce pyroptotic cell death as well as *** targeted therapy,the mitochondrial intrinsic apoptotic pathway is activated,thus leading to the cleavage and activation of ***,gasdermin E is activated,thus leading to permeabilization of the cytoplasmic membrane and cell-lytic pyroptosis(indicated by characte

关键词： Solute carrier family 7 member 11(SLC7A11) nuclear factor erythroid 2-related factor 2(NRF2) ferroptosis pyroptosis KRAS G12C allele-specific inhibitors non-small cell lung cancer(NSCLC)