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Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development

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BIOCELL 2022年第1期46卷 87-95页

作者： YANYAN LI SHAHANAVAJ KHAN anis ahmad chaudhary HASSAN AHMED RUDAYNI ABDUL MALIK ASHWAG SHAMI Department of Oncology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou450007China Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)Muzaffarnagar251001India Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)Riyadh11623Saudi Arabia Department of Biology College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11617Saudi Arabia

Available reports have confirmed a link between bacterial infection and the progression of different types of cancers,including colon,lungs,and prostate *** we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum(ER)using in-silico approaches and their possible role in lung cancer *** predicted 48 proteins that target human ER,which may be associated with protein folding and protein-protein interactions during *** results showed *** proteins targeting human ER and their implications in lung cancer *** targeted proteins may be involved in competitive interactions between host and bacterial proteins,which may change the usual pathway functions and trigger the development of lung ***,*** unfolded protein accumulation in the human ER possibly induces ER stress,consequently activating the unfolded protein response(UPR),and providing a favorable microenvironment for cancer *** current study showed the *** protein targeting in ER of host cell and their implication in lung cancer *** results may help researchers better manage lung cancer and establish a molecular mechanism for *** lung cancer association.

关键词： Bacterial infection C.pneumoniae Proteomes ER Lung cancer

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A Novel Krill Herd Based Random Forest Algorithm for Monitoring Patient Health

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Computers, Materials & Continua 2023年第5期75卷 4553-4571页

作者： Md.Moddassir Alam Md Mottahir Alam Muhammad Moinuddin Mohammad Tauheed ahmad Jabir Hakami anis ahmad chaudhary Asif Irshad Khan Tauheed Khan Mohd Department of Health Information Management and Technology University of Hafr Al-BatinSaudi Arabia Department of Electrical and Computer Engineering Faculty of EngineeringKing AbdulazizJeddah21589Saudi Arabia Center of Excellence in Intelligent Engineering Systems King Abdul Aziz UniversityJeddahSaudi Arabia College of Medicine King Khalid UniversityAbhaSaudi Arabia Department of Physics College of ScienceJazan UniversityP.O.Box.114Jazan45142Saudi Arabia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11623Saudi Arabia Computer Science Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Math and Computer Science Augustana CollegeIL61201United States

Artificial Intelligence(AI)is finding increasing application in healthcare *** learning systems are utilized for monitoring patient health through the use of IoT sensor,which keep track of the physiological state by way of various health ***,early detection of any disease or derangement can aid doctors in saving patients’***,there are some challenges associated with predicting health status using the common algorithms,such as time requirements,chances of errors,and improper *** propose an Artificial Krill Herd based on the Random Forest(AKHRF)technique for monitoring patients’health and eliciting an optimal prescription based on their health *** begin with,various patient datasets were collected and trained into the system using IoT *** a result,the framework developed includes four processes:preprocessing,feature extraction,classification,and result ***,preprocessing removes errors,noise,and missing values from the dataset,whereas feature extraction extracts the relevant ***,in the classification layer,we updated the fitness function of the krill herd to classify the patient’s health status and also generate a *** found that the results fromthe proposed framework are comparable to the results from other state-of-the-art techniques in terms of sensitivity,specificity,Area under the Curve(AUC),accuracy,precision,recall,and F-measure.

关键词： Healthcare system health monitoring clinical decision support internet of things artificial intelligence machine learning diagnosis

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Calcium supplementation in colorectal cancer prevention:A systematic meta-analysis of adverse events

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BIOCELL 2022年第3期46卷 759-767页

作者： XUE MEI LUO SHAHANAVAJ KHAN ABDUL MALIK FAHAD M.ALDAKHEEL anis ahmad chaudhary SHOUKI BAZARBASHI FATEMEH TABATABAIE Department of General Surgery Mianzhu People’s Hospital of SichuanMianzhuChina Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)MuzaffarnagarIndia Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)RiyadhSaudi Arabia Oncology Center King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Shiraz University of Medical Sciences ShirazIran

Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer,most of the associated adverse effects are not systematically *** aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic *** searched Medline,PubMed Central,EMBASE(Excerpta Medica database),Scopus,Cochrane Central Register of Controlled Trials,and Web of Science published in English from database inception up to 31 July *** the current systematic meta-analysis,we included human studies(including cohort studies,clinical trials,case-control studies)on supplementation of calcium in patients with or at risk of colorectal *** of the quality of included studies was performed by Jadad *** on the patient population,number of enrolled subjects in each group,dose of calcium supplementation,duration of calcium supplementation,and reported adverse events were *** data were pooled for incidence rates for any adverse event during the study period regardless of causality *** identified 6 studies,comprising 4583 participants that met the inclusion ***-analysis on pooled incidence rates for adverse event during study period showed no statistically significant increased risk for cancer(OR=0.92,95%CI:0.70–1.21,P=0.577;I^(2)=0.0%,P=0.731),coronary revascularization(OR=1.12,95%CI:0.79–1.59,P=0.492;I^(2)=0.0%,P=0.957),myocardial infarction(OR=0.81,95%CI:0.34–1.91,P=0.634;I^(2)=67.9%,P=0.047),stroke(OR=0.75,95%CI:0.42–1.33,P=0.332,I^(2)=0.00%,P=0.717),Transient Ischemic Attack(TIA)(OR=1.37,95%CI:0.28–6.51,P=0.692,I^(2)=81.9%,P=0.002),urolithiasis(OR=1.23,95%CI:0.75–2.01,P=0.410;I^(2)=0.0%,P=0.851),fracture(OR=0.98,95%CI:0.70–1.37,P=0.938;I^(2)=37.8%,P=0.152)and death(OR=1.05,95%CI:0.71–1.56,P=0.786,I^(2)=12.2%,P=0.317)in patients receiving calcium supplementation for colo

关键词： Colorectal cancer Calcium Supplement Adverse event Systematic reviewed Meta-analysis

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Consequences of Rényi entropy on the thermal geometries and Hawking evaporation of topological dyonic dilaton black hole

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Communications in Theoretical Physics 2024年第2期76卷 102-110页

作者： Muhammad Yasir Xia Tiecheng Muhammad Usman Shahid chaudhary Department of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai UniversityShanghai200444China Department of Natural Sciences and Humanities University of Engineering and Technology LahoreNew CampusPakistan

The thermodynamics of black holes(BHs)has had a profound impact on theoretical physics,providing insight into the nature of gravity,the quantum structure of spacetime and the fundamental laws governing the *** this study,we investigate thermal geometries and Hawking evaporation of the recently proposed topological dyonic dilaton BH in anti-de Sitter(Ad S)*** consider Rényi entropy and obtain the relations for pressure,heat capacity and Gibbs free energy and observe that the Rényi parameter and dilaton field play a vital role in the phase transition and stability of the ***,we use Weinhold,Ruppeiner and Hendi Panahiyah Eslam Momennia models to evaluate the scalar curvature of the BH and find out that the divergence points of the scalar curvature coincides with the zero of specific ***,using Stefan–Boltzmann law,we determine that the BH without a dilaton field evaporates far more quickly compared to the dilaton BH in Ad S space.

关键词： topological dyonic dilaton black hole phase transition thermal geometry Hawking evaporation

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Iron supplementation during malaria infection in pregnancy and childhood:A review

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 12-20页

作者： Neha Surela Amrendra chaudhary Poonam Kataria Jyoti Das National Institute of Malaria Research Sector-8DwarkaNew Delhi-110077India

Malaria presents a significant global public health challenge,with severe malarial anaemia being a primary manifestation of the *** understanding of anaemia caused by malaria remains incomplete,making the treatment more *** is a crucial micronutrient essential for haemoglobin synthesis,oxygen delivery,and other vital metabolic functions in the *** is indispensable for the growth of human beings,as well as bacteria,protozoa,and viruses in vitro and in *** deficiency is among the most common nutritional deficiencies and can have detrimental effects during developmental stages of ***-induced iron deficiency occurs due to the hemolysis of erythrocytes and the suppression of erythropoiesis,leading to *** iron requirements is particularly critical during pivotal life stages such as pregnancy,infancy,and *** intake alone may not suffice to meet adequate iron requirements,thus highlighting the vital role of iron *** iron supplementation can alleviate iron deficiency,it can exacerbate malaria infection by providing additional iron for the ***,in the context of pregnancy and childhood,iron supplementation combined with malaria prevention and treatment has been shown to be beneficial in improving birth outcomes and ensuring proper growth and development,*** review aims to identify the role and impact of iron supplementation in malaria infection during the life stages of pregnancy and childhood.

关键词： Iron supplementation Malaria Pregnancy Childhood

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On the existence and stability of traversable wormhole solutions with novel shapefunctions in the framework of F(R,L_(m))gravity

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Communications in Theoretical Physics 2024年第5期76卷 114-127页

作者： Sourav chaudhary Jitendra Kumar S K Maurya Sweeti Kiroriwal Abdul Aziz Department of Mathematics Central University of HaryanaJant-PaliMahendergarhIndia Department of Mathematical and Physical Sciences College of Arts and ScienceUniversity of NizwaP.O.Box 33Nizwa 616Oman

In this work,we have explored wormhole(WH)solutions in F(R,L_(m))gravity by assuming the Morris-Thorne WH metric and F(R,Lm)=R/2+(1+γR)L_(m),whereγis the free model *** determined the WH solutions by utilizing two newly developed shape functions(SF)that satisfy all basic conditions for a WH’s physical *** also observe that the null energy condition(NEC)behaves ***,for both models,we use the volume integral quantifier(VIQ)and Tolman-Oppenheimer-Volkoff(TOV)equation to determine how much exotic matter is needed near the WH throat and the stability of the *** extensive detailed discussions of the matter components have been done via graphical *** obtained WH geometries meet the physically acceptable conditions for a stable wormhole.

关键词： energy conditions wormhole exotic matter F(R L_(m))gravity

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Pre‑hatch thermal manipulation of embryos and post‑hatch baicalein supplementation mitigated heat stress in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1071-1085页

作者： Sadid Al Amaz Ajay chaudhary Prem Lal Mahato Rajesh Jha Birendra Mishra Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawai’i at ManoaAgSci 2161955 East‑West RdHonoluluHI 96822USA

Background High environmental temperatures induce heat stress in broiler chickens,affecting their health and pro-duction *** dietary,managerial,and genetics strategies have been tested with some success in mitigating heat stress(HS)in *** novel HS mitigation strategies for sustaining broiler production is critically *** study investigated the effects of pre-hatch thermal manipulation(TM)and post-hatch baica-lein supplementation on growth performance and health parameters in heat-stressed *** Six hundred fertile Cobb 500 eggs were incubated for 21 *** candling on embryonic day(ED)10,238 eggs were thermally manipulated at 38.5℃ with 55%relative humidity(RH)from ED 12 to 18,then transferred to the hatcher(ED 19 to 21,standard temperature)and 236 eggs were incubated at a controlled temperature(37.5℃)till *** hatch,180-day-old chicks from both groups were raised in 36 pens(n=10 birds/pen,6 replicates per treatment).The treatments were:1)Control,2)TM,3)control heat stress(CHS),4)thermal manipulation heat stress(TMHS),5)control heat stress supplement(CHSS),and 6)thermal manipulation heat stress supplement(TMHSS).All birds were raised under the standard environment for 21 d,followed by chronic heat stress from d 22 to 35(32–33℃ for 8 h)in the CHS,TMHS,CHSS,and TMHSS groups.A thermoneutral(22–24℃)environment was maintained in the Control and TM *** was constant(50%±5%)throughout the *** the data were analyzed using one-way ANOVA in R and GraphPad software at P<0.05 and are presented as mean±*** stress significantly decreased(P<0.05)the final body weight and ADG in CHS and TMHS groups compared to the other *** TM significantly increased(P<0.05)the expression of heat shock protein-related genes(HSP70,HSP90,and HSPH1)and antioxidant-related genes(GPX1 and TXN).TMHS birds showed a significant increment(P<0.05)in total cecal volatile fatty acid(VFA)concentration compared to the CHS bird

关键词： Baicalein Growth performance Gut microbiota Heat stress Thermal manipulation

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Genetics of biochemical attributes regulating morpho-physiology of upland cotton under high temperature conditions

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Journal of Cotton Research 2024年第1期7卷 29-44页

作者： MAJEED Sajid chaudhary Muhammad Tanees MUBARIK Muhammad Salman RANA Iqrar ahmad SHABAN Muhammad TAN Daniel KY JIA Yinhua DU Xiongming HINZE Lori AZHAR Muhammad Tehseen Federal Seed Certification and Registration Department Ministry of National Food Security and ResearchIslamabad 44090Pakistan Horticultural Research Institute National Agricultural Research CentreIslamabad 44000Pakistan Department of Biotechnology University of NarowalNarowal 51600Pakistan Centre of Agricultural Biochemistry and Biotechnology University of AgricultureFaisalabad 38400Pakistan Department of Plant Breeding and Genetics University of Agriculture FaisalabadSub-Campus BurewalaVehariPakistan Faculty of Science School of Life and Environ-mental SciencesPlant Breeding InstituteSydney Institute of AgricultureThe University of SydneySydneyNSW 2006Australia State Key Laboratory of Cotton Biology Institute of Cotton Research of Chinese Academy of Agri-cultural ScienceAnyang 455000China Agricultural Research Service USDASouthern Plains Agricultural Research CentreCollege StationTX 77845USA Department of Plant Breeding and Genetics University of AgricultureFaisal-abad 38400Pakistan School of Agriculture Sciences Zhengzhou UniversityZhengzhou 450000China.

Background Cotton is a strategically important fibre crop for global textile *** profoundly impacts several countries’industrial and agricultural *** cotton production is continuously threatened by the unpre-dictable changes in climate,specifically high *** heat-tolerant,high-yielding cotton cultivars with wide adaptability to be grown in the regions with rising temperatures is one of the primary objectives of modern cotton breeding ***,the main objective of the current study is to figure out the effective breed-ing approach to imparting heat tolerance as well as the judicious utilization of commercially significant and stress-tolerant attributes in cotton ***,the two most notable heat-susceptible(FH-115 and NIAB Kiran)and tolerant(IUB-13 and GH-Mubarak)cotton cultivars were spotted to develop filial and backcross populations to accom-plish the preceding study *** heat tolerant cultivars were screened on the basis of various morphological(seed cotton yield per plant,ginning turnout percentage),physiological(pollen viability,cell membrane thermostabil-ity)and biochemical(peroxidase activity,proline content,hydrogen peroxide content)*** The results clearly exhibited that heat stress consequently had a detrimental impact on every studied plant trait,as revealed by the ability of crossing and their backcross populations to tolerate high ***,when considering overall yield,biochemical,and physiological traits,the IUB-13×FH-115 cross went over particularly well at both normal and high temperature ***,overall seed cotton yield per plant exhibited a posi-tive correlation with both pollen viability and antioxidant levels(POD activity and proline content).Conclusions Selection from segregation population and criteria involving pollen viability and antioxidant levels concluded to be an effective strategy for the screening of heat-tolerant cotton g

关键词： Accessions Biochemical Breeding Cotton Generation mean analysis Heat stress

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Impact of index admission cholecystectomy vs interval cholecystectomy on readmission rate in acute cholangitis: National Readmission Database survey

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 350-360页

作者： Abdullah Sohail Ahmed Shehadah Ammad chaudhary Khadija Naseem Amna Iqbal ahmad Khan Shailendra Singh Department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Henry Ford HospitalDetroitMI 48202United States Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44195-0001United States Department of Internal Medicine University of ToledoToledoOH 43606United States Department of Gastroenterology and Hepatology Case Western Reserve University HospitalClevelandOH 44106United States Division of Gastroenterology and Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Elective cholecystectomy(CCY)is recommended for patients with gallstone-related acute cholangitis(AC)following endoscopic decompression to prevent recurrent biliary ***,the optimal timing and implications of CCY remain *** To examine the impact of same-admission CCY compared to interval CCY on patients with gallstone-related AC using the National Readmission Database(NRD).METHODS We queried the NRD to identify all gallstone-related AC hospitalizations in adult patients with and without the same admission CCY between 2016 and *** primary outcome was all-cause 30-d readmission rates,and secondary outcomes included in-hospital mortality,length of stay(LOS),and hospitalization *** Among the 124964 gallstone-related AC hospitalizations,only 14.67%underwent the same admission *** all-cause 30-d readmissions in the same admission CCY group were almost half that of the non-CCY group(5.56%vs 11.50%).Patients in the same admission CCY group had a longer mean LOS and higher hospitalization costs attrib-utable to *** the most common reason for readmission was sepsis in both groups,the second most common reason was AC in the interval CCY *** Our study suggests that patients with gallstone-related AC who do not undergo the same admission CCY have twice the risk of readmission compared to those who undergo CCY during the same *** readmis-sions can potentially be prevented by performing same-admission CCY in appropriate patients,which may reduce subsequent hospitalization costs secondary to readmissions.

关键词： Acute cholangitis Gallstone-related complications National Readmission Database 30-d readmission rates Resource utilization In-hospital mortality

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Direct recycling of Li-ion batteries from cell to pack level:Challenges and prospects on technology,scalability,sustainability,and economics

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Carbon Energy 2024年第6期6卷 1-39页

作者： Joseph Jegan Roy Do Minh Phuong Vivek Verma Richa chaudhary Michael Carboni Daniel Meyer Bin Cao Madhavi Srinivasan Energy Research Institute@NTU(ERI@N) SCARCE LaboratoryNanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore CEA CNRSENSCMUniversity of MontpellierUMR 5257(ICSM)Bagnols-sur-Cèze CedexFrance School of Civil and Environmental Engineering Nanyang Technological UniversitySingaporeSingapore

Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium-ion battery(LIB)recycling processes and has gained considerable attention from the academic and industrial sectors in recent *** primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical *** technology's advantages over traditional pyrometallurgy and hydrometallurgy are costeffectiveness,energy efficiency,and sustainability,and it preserves the material structure and morphology and can shorten the overall recycling *** review extensively discusses the advancements in the direct recycling of LIBs,including battery sorting,pretreatment processes,separation of cathode and anode materials,and regeneration and quality enhancement of electrode *** encompasses various approaches to successfully regenerate high-value electrode materials and streamlining the recovery process without compromising their electrochemical ***,we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives:(1)battery design,(2)disassembling,(3)electrode delamination,and(4)commercialization and *** on these challenges and changing market trends,a few strategies are discussed to aid direct recycling efforts,such as binders,electrolyte selection,and alternative battery designs;and recent transitions and technological advancements in the battery industry are presented.

关键词： battery design cathode regeneration direct recycling graphite recycling lithium-ion battery,scaling-up

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