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Deoxyribonucleic acid methylation driven aberrations in pancreatic cancer-related pathways

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1505-1519页

作者： Akash Bararia Amlan Das Sangeeta mitra Sudeep Banerjee aniruddha Chatterjee Nilabja Sikdar Human Genetics Unit Indian Statistical InstituteKolkata 700108India Department of Biochemistry Royal Global UniversityAssam 781035India Department of Biochemistry and Biophysics University of KalyaniWest Bengal 741235India Department of Gastrointestinal Surgery Tata Medical CenterKolkata 700160India Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand School of Health Sciences and Technology University of Petroleum and Energy StudiesDehradun 248007India

Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment *** genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic *** beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under *** of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa *** studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic *** thus promises to generate a significant amount of new knowledge of biological and medical *** review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to *** aim to highlight the possibilities that exist and the potential therapeutic interventions.

关键词： Methylation driven pathways Pancreatic cancer methylation markers Signaling pathway targeted therapy PanCa enriched methylated pathway Pre-cancer methylated pathways

Novel synthesis with an atomized microemulsion technique and characterization of nano-calcium carbonate(CaCO_3)/poly(methyl methacrylate) core-shell nanoparticles

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Particuology 2013年第6期11卷 760-767页

作者： aniruddha Chatterjee Satyendra Mishra University Institute of Chemical Technology North Maharashtra University

The synthesis of hard-core/soft-shell calcium carbonate （CaCO3）/poly（methyl methacrylate）（PMMA） hybrid structured nanoparticles （〈100nm） by an atomized microemulsion polymerization process is reported. The polymer chains were anchored onto the surface of nano-CaCO3 through use of a cou- pling agent, triethoxyvinyl silane （TEVS）. Ammonium persulfate （APS）, sodium dodecyl sulfate （SDS） and n-pentanol were used as the initiator, surfactant and cosurfactant, respectively. The polymeriza- tion mechanism of the core-shell latex particles is discussed. The encapsulation of nano-CaCO3 by PMMA was confirmed using a transmission electron microscope （TEM）. The grafting percentage of the core-shell particles was investigated by thermogravimetric analysis （TGA）. The nano-CaCO3/PMMA core-shell par- ticles were characterized by Fourier transform infrared （FTIR） spectroscopy and differential scanning calorimetry （DSC）. The FTIR results revealed the existence of a strong interaction at the interface of the nano-CaCO3 particle and the PMMA, which implies that the polymer chains were successfully grafted onto the surface of the nano-CaCO3 particles through the link of the coupling agent, In addition, the TGA and DSC results indicated an enhancement of the thermal stability of the core-shell materials compared with that of the pure nano-PMMA, The nano-CaCO3/PMMA particles were blended into a polypropylene （PP） matrix by melt processing. It can also be observed using scanning electron microscopy （SEM） that the PMMA chains grafted onto the CaCO3 nanoparticles interfere with the aggregation of CaCO3 in the polymer matrix （PP matrix） and thus improve the compatibility of the CaCO3 nanoparticles with the PP matrix.

关键词： Atomized microemulsion Core-shell nanoparticles Thermal properties Compatibility of core-shell nanoparticles with polymer matrix

Effect of a less permeable stronger soil layer on the stability of non-homogeneous unsaturated slopes

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Frontiers of Structural and Civil Engineering 2020年第6期14卷 1462-1475页

作者： Nabarun DEY aniruddha SENGUPTA Department of Civil Engineering Indian Institute of Technology KharagpurKharagpur 721302India

Slope failure occurs due to an increase in the saturation level and a subsequent decrease in matric suction in unsaturated *** paper presents the results of a series of centrifuge experiments and numerical analyses on a 55°inclined unsaturated sandy slope with less permeable,stronger silty sand layer inclusion within *** is observed that a less permeable,stronger silty sand layer in an otherwise homogeneous sandy soil slope hinders the infiltration of *** water content of the slope just above the stronger layer increases significantly,compared to *** shear band is found to initiate in a homogeneous sandy soil slope,whereas for a non-homogeneous slope,they initiate just above the less pervious,stronger layer.A discontinuity of the shear zone is also observed for the case of a non-homogeneous soil *** factor of safety of a non-homogeneous,unsaturated soil slope decreases because of the less permeable,stronger *** decreases significantly if this less permeable,stronger soil layer is located near the toe of the slope.

关键词： non-homogeneous slope stronger soil layer factor of safety centrifuge model test unsaturated soils

Behavior of braced wall embedded in saturated liquefiable sand under seismic loading

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 361-375页

作者： Sanku Konai aniruddha Sengupta Kousik Deb Department of Civil Engineering Indian Institute of Technology KharagpurKharagpur 721302India

It is well known that the generation of excess pore water pressure and/or liquefaction in foundation soils during an earthquake often cause structural *** paper describes the behavior of a small-scale braced wall embedded in saturated liquefiable sand under dynamic *** table tests are performed in the laboratory on embedded retaining walls with single *** tests are conducted for different excavation depths and base *** influences of the peak magnitude of the ground motions and the excavation depth on the axial forces in the bracing,the lateral displacement and the bending moments in the braced walls are *** shake table tests are simulated numerically using FLAC 2D and the results are compared with the corresponding experimental *** pore water pressures developed in the soil are found to influence the behavior of the braced wall structures during a dynamic *** is found that the excess pore water pressure development in the soil below the excavation is higher compared to the soil beside the ***,the soil below the excavation level is more susceptible to the liquefaction compared to the soil beside the walls.

关键词： braced wall FLAC 2D liquefaction seismic analysis shake table test

Seismic behavior of cantilever wall embedded in dry and saturated sand

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 690-705页

作者： Sanku KONAI aniruddha SENGUPTA Kousik DEB Department of Civil Engineering Indian Institute of Technology KharagpurKharagpur 721302India

The embedded cantilever retaining walls are often required for excavation to construct the undergroundfacilities. Significant numbers of numerical and experimental studies have been performed to understand the behavior ofembedded cantilever retaining walls under static condition. However, very limited studies have been conducted on thebehavior of embedded retaining walls under seismic condition. In this paper, the behavior of a small scale modelembedded cantilever retaining wall in dry and saturated sand under seismic loading condition is investigated by shaketable tests in the laboratory and numerically using software FLAC2D. The embedded cantilever walls are subjected tosinusoidal dynamic motions. The behaviors of the cantilever walls in terms of lateral displacement and bending momentare studied with the variation of the two important design parameters, peak amplitude of the base motions and excavationdepth. The variation of the pore water pressures within the sand is also observed in the cases of saturated sand. Themaximum lateral displacement of a cantilever wall due to seismic loading is below 1% of the total height of the wall in drysand, but in case of saturated sand, it can go up to 12.75% of the total height of the wall.

关键词： embedded cantilever wall shake table test FLAC2D seismic loading,saturated and dry sand

Behavior of braced excavation in sand under a seismic condition: experimental and numerical studies

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Earthquake Engineering and Engineering Vibration 2018年第2期17卷 311-324页

作者： Sanku Konai aniruddha Sengupta Kousik Deb Department of Civil Engineering Indian Institute of Technology Kharagpur

The behavior of braced excavation in dry sand under a seismic condition is investigated in this paper.A series of shake table tests on a reduced scale model of a retaining wall with one level of bracing were conducted to study the effect of different design parameters such as excavation depth,acceleration amplitude and wall *** analyses using FLAC 2D were also performed considering one level of *** strut forces,lateral displacements and bending moments in the wall at the end of earthquake motion were compared with experimental *** study showed that in a post-seismic condition,when other factors were constant,lateral displacement,bending moment,strut forces and maximum ground surface displacement increased with excavation depth and the amplitude of base *** study also showed that as wall stiffness decreased,the lateral displacement of the wall and ground surface displacement increased,but the bending moment of the wall and strut forces *** net earth pressure behind the walls was influenced by excavation depth and the peak acceleration amplitude,but did not change significantly with wall *** force was the least affected parameter when compared with others under a seismic condition.

关键词： braced excavation shake table test seismic FLAC 2D displacement

Transfer Matrix Approach for Two-State Scattering Problem with Arbitrary Coupling

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Chinese Physics Letters 2015年第7期32卷 5-8页

作者： Diwaker aniruddha Chakraborty School of Basic Sciences Indian Institute of Technology Mandi

The present work deals with the calculation of transition probability between two diabatic potentials coupled by any arbitrary coupling. The method presented in this work is applicable to any type of coupling while for numerical calculations we have assumed the arbitrary coupling as Gaussian coupling. This arbitrary coupling is expressed as a collection of Dirac delta functions and by the use of the transfer matrix technique the transition probability from one diabatic potential to another diabatic potential is calculated. We examine our approach by considering the case of two constant potentials coupled by Gaussian coupling as an arbitrary coupling.

关键词： Transfer Matrix Approach for Two-State Scattering Problem with Arbitrary Coupling

Effect of Graphene Nanoplate and Silicon Carbide Nanoparticle Reinforcement on Mechanical and Tribological Properties of Spark Plasma Sintered Magnesium Matrix Composites

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Journal of Materials Science & Technology 2014年第11期30卷 1059-1070页

作者： aniruddha Das Sandip P.Harimkar School of Mechanical and Aerospace Engineering Oklahoma State UniversityStillwaterOK 74078USA

Processing of magnesium （Mg） matrix composites reinforced with low reinforcement content （up to 4-5 vol.%） of graphene nanoplates （GNPs） and silicon carbide （SIC） nanoparticles using bait milling and spark plasma sintering （SPS） is reported. Near full densification was observed for all the composite compositions at the sintering temperature of 450 ~C （soaking time of 5 min and applied pressure of 50 MPa）. Detailed analysis of the microstructure and mechanical and tribological （under dry sliding contact with alumina counter-face） properties with reinforcement content in Mg-GNP and Mg-SiC is presented. Mg-GNP and Mg-SiC composites reinforced with about 2 vol.% of reinforcement content exhibited significant improvement in microhardness and wear resistance as compared with Mg compacts.

关键词： Microstructure and properties Wear Tribology Magnesium matrix composites

Electro-magnetohydrodynamic Flow of Biofluid Induced by Peristaltic Wave： A Non-newtonian Model

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Journal of Bionic Engineering 2016年第3期13卷 436-448页

作者： Gopal Chandra Shit Nayan Kumar Ranjit aniruddha Sinha Department of Mathematics Jadavpur University Kolkata - 700032 India Yogoda Satsanga Palpara Mahavidyalaya Purba Medinipur - 721458 India

This article aims to develop a mathematical model for peristaltic transport of magnetohydrodynamic flow of biofluids through a micro-channel with rhythmically contracting and expanding walls under the influence of an applied electric field. The couple stress fluid model is considered to represent the non-Newtonian characteristics ofbiofluids. The velocity slip condition at the channel walls is taken into account because of the hyclrophilic/hydrophobic interaction with negatively charged walls. The essential features of the electromagnetohydrodynamic flow of biofluid through micro-channels are clearly highlighted in the variations of the non-dimensional parameters of the physical quantities of interest such as the velocity, wall shear stress, pressure gradient, pressure rise per wave length, frictional force at the channel walls and the distribution of stream function. It reveals that the flow ofhiofluid is appreciably influenced by the sufficient strength of externally applied magnetic field and electro-osmotic parameter. The velocity slip condition reduces the frictional force at the channel wall. Moreover, the formation of the trapping bolus strongly depends on electro-osmotic parameter and magnetic field strength.

关键词： peristaltic transport couple stress fluid magnetohydrodynamics electro-osmosis