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Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components

生物活性材料(英文) 2023年第1期19卷 642-652页

作者： Michaela B.Cooley Eric C.Abenojar Dana Wegierak anirban sen gupta Michael C.Kolios Agata A.Exner Department of Biomedical Engineering Case Western Reserve UniversityClevelandOH44106United States Department of Radiology Case Western Reserve UniversityClevelandOH44106United States Department of Physics Ryerson UniversityTorontoOntarioM5B 2K3Canada Institute for Biomedical Engineering and Science Technology A Partnership Between Ryerson University and St.Michael’s HospitalTorontoOntarioM5B 1T8Canada

Nanoscale ultrasound contrast agents,or nanobubbles,are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in *** sub-micron particles are approximately 10x smaller than clinically available *** allows them to effectively traverse compromised physiological barriers and circulate for extended periods of *** various aspects of nanobubble behavior have been previously examined,their behavior in human whole blood has not yet been ***,herein we examined,for the first time,the short and long-term effects of blood components on nanobubble acoustic *** observed differences in the kinetics of backscatter from nanobubble suspensions in whole blood compared to bubbles in phosphate buffered saline(PBS),plasma,or red blood cell solutions(RBCs).Specifically,after introducing nanobubbles to fresh human whole blood,signal enhancement,or the magnitude of nonlinear ultrasound signal,gradually increased by 22.8±13.1%throughout our experiment,with peak intensity reached within 145 *** contrast,nanobubbles in PBS had a stable signal with negligible change in intensity(􀀀1.7±3.2%)over 8 *** the same conditions,microbubbles made with the same lipid formulation showed a􀀀56.8±6.1%decrease in enhancement in whole *** confocal,fluorescent,and scanning electron microscopy analysis revealed attachment of the nanobubbles to the surface of RBCs,suggesting that direct interactions,or hitchhiking,of nanobubbles on RBCs in the presence of plasma may be a possible mechanism for the observed *** phenomenon could be key to extending nanobubble circulation time and has broad implications in drug delivery,where RBC interaction with nanoparticles could be exploited to improve delivery efficiency.

关键词： Nanobubbles Ultrasound contrast agents Red blood cells Hitchhiking Ultrasound Drug delivery

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Photo-catalytic decolourisation of toxic dye with N-doped titania:A case study with Acid Blue 25

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Journal of Environmental Sciences 2013年第5期25卷 1034-1043页

作者： Dhruba Chakrabortty Susmita sen gupta Department of Chemistry B N CollegeDhubriAssamIndia

Dyes are one of the hazardous water *** Acid Blue 25,an anthraquinonic dye,has been decolourised by photo-catalysing it with nitrogen doped titania in aqueous *** photo catalyst was prepared from 15% TiCl 3 and 25% aqueous NH 3 solution as *** and TEM revealed the formation of well crystalline anatase phase having particle size in the *** surface area of the sample was higher than that of pure anatase TiO *** showed higher absorption of radiation in visible range compared to pure anatase TiO *** revealed the presence of nitrogen in N-Ti-O *** experimental parameters,namely,photocatalyst dose,initial dye concentration as well as solution pH influence the decolourisation *** pH 3.0,the N-TiO 2 could decolourise almost 100% Acid Blue 25 within one *** influence of N-TiO 2 dose,initial concentration of Acid Blue 25 and solution pH on adsorption-desorption equilibrium is also *** adsorption process follows Lagergren first order kinetic

关键词： Acid Blue 25 decolourisation nitrogen-doped titania photocatalysis

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Identification,development,and application of cross-species intron-spanning markers in lentil(Lens culinaris Medik.)

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The Crop Journal 2018年第3期6卷 299-305页

作者： Debjyoti sen gupta Jitendra Kumara Sunanda gupta Sonali Dubey Priyanka gupta Narendra Pratap Singh Gaurav Sablok Division of Crop Improvement ICAR-Institute of Pulses ResearchKanpur 208024UPIndia Division of Plant Biotechnology ICAR-Institute of Pulses ResearchKanpur 208024UPIndia Department of Biodiversity and Molecular Ecology Research and Innovation CentreFondazione Edmund MachVia E.Mach 138010 San Michele all'AdigeTrentoItaly

Lentil(Lens culinaris Medik) is one of the most important food legumes in the world. The use in lentil of molecular marker-assisted breeding is limited, owing to the low availability of polymorphic markers. In the present study, we developed a set of polymorphic intron-spanning markers(ISMs) using a cross-species mapping approach. In this approach, putative unique transcripts(PUTs) of L. culinaris were mapped onto the Medicago truncatula genome, exploiting its closeness with the lentil genome. Spliced alignment of the PUTs resulted in a total of 25,717 alignments, allowing the development of 1703 ISMs. From these, a subset of 105 ISMs were synthesized and validated with a 51% amplification success rate in 32 lentil genotypes. Of these ISMs, 40(74%) were polymorphic and generated 2–11 alleles per locus in a genetically diverse panel of 32 lentil genotypes including wild *** set of polymorphic ISMs along with their functional annotation data will be useful in lentil breeding.

关键词： Allele diversity Cross-species Genotypes Introns Lentil Molecular markers

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Population structure analysis and determination of neurotoxin content in a set of grass pea (Lathyrus sativus L.) accessions of Bangladesh origin

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The Crop Journal 2018年第4期6卷 435-442页

作者： Priyanka gupta Sripada M. Udupa Debjyoti sen gupta Jitendra Kumar Shiv Kumar International Center for Agricultural Research in the Dry Areas Rabat Institute Rabat Morocco Department of Plant Sciences North Dakota State University Fargo ND 58105 USA ICAR-Indian Institute of Pulses Research Kanpur Uttar Pradesh 208024 India

Grass pea(Lathyrus sativus L.) is a crop that is considered one of the more resilient to climate change. With protein-rich seeds and leaves, it has strong potential as human food as well as animal feed and fodder. However, genetic improvement in this crop remains stagnant owing to the poor characterization of its genetic resources. In this study, we characterized 118 accessions of grass pea with 18 EST-SSR markers. A total of 118 accessions, 101 of L. sativus(100 cultivated accessions from Bangladesh and one wild accession) and 17 wild accessions of other Lathyrus species, were used. A total of 67 alleles were detected, with an average of 3.72 alleles per locus and average polymorphism information content of 0.52. A dissimilarity matrix was formed and hierarchical cluster analysis performed using the UPGMA method grouped genotypes into four main clusters. Cluster analysis based on the genetic dissimilarity revealed a clear grouping of the 100 cultivated and 18 wild accessions into four main groups. Group I consisted of 20 accessions with high β-N-oxalyl-L-α,β-diaminopropionic acid(β-ODAP) concentration. Of these 20 accessions, 17 were wild accessions. Only one wild accession(L. cicera) was clustered in group II, which contained 35 accessions. Most of the group II accessions contained low β-ODAP. Group III was represented by 34 accessions, many of them with high β-ODAP. Group IV consisted of 29 accessions, a few of which had very high β-ODAP concentrations. Analysis of molecular variance of the microsatellite data showed significantly higher values of molecular variance between(83%) than within(17%) populations. These characterized accessions will be useful in grass pea breeding programs.

关键词： Lathyrus Population structure EST-SSRβ-ODAP Genetic diversity

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Comparison of a plant based natural surfactant with SDS for washing of As(V) from Fe rich soil

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Journal of Environmental Sciences 2013年第11期25卷 2247-2256页

作者： Soumyadeep Mukhopadhyay Mohd. Ali Hashim Jaya Narayan Sahu Ismail Yusoff Bhaskar sen gupta Department of Chemical Engineering University of Malaya Department of Geology University of Malaya School of Planning Architecture and Civil Engineering Queen's University Belfast

This study explores the possible application of a biodegradable plant based surfactant, obtained from Sapindus mukorossi, for washing low levels of arsenic （As） from an iron （Fe） rich soil. Natural association of As（Ⅴ） with Fe（Ⅲ） makes the process difficult. Soapnut solution was compared to anionic surfactant sodium dodecyl sulfate （SDS） in down-flow and a newly introduced suction mode for soil column washing. It was observed that soapnut attained up to 86% efficiency with respect to SDS in removing As. Full factorial design of experiment revealed a very good fit of data. The suction mode generated up to 83 kPa pressure inside column whilst down-flow mode generated a much higher pressure of 214 kPa, thus making the suction mode more efficient. Micellar solubilisation was found to be responsible for As desorption from the soil and it followed 1st order kinetics. Desorption rate coefficient of suction mode was found to be in the range of 0.005 to 0.01, much higher than down-flow mode values. Analysis of the PT-IR data suggested that the soapnut solution did not interact chemically with As, offering an option for reusing the surfactant. Soapnut can be considered as a soil washing agent for removing As even from soil with high Fe content.

关键词： soil washing soapnut Sapindus mukorossi arsenic plant based surfactant

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Optical spectroscopy and photometry of main-belt asteroids with a high orbital inclination

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Research in Astronomy and Astrophysics 2017年第2期17卷 43-50页

作者： Aya Iwai Yoichi Itoh Tsuyoshi Terai Ranjan gupta Asoke sen Jun Takahashi National Institute of Advanced Industrial Science and Technology Ibaraki 305-8563Japan Nishi-Harima Astronomical Observatory Center for AstronomyUniversity of HyogoISIyogo 679-5313Japan National Astronomical Observatory of Japan HiloHawaii 96720USA Inter-University Centre for Astronomy and Astrophysics GaneshkhindPune 411 007India Department of Physics Assam UniversitySilchar 788 001India

We carried out low-resolution optical spectroscopy of 51 main-belt asteroids, most of which have highly-inclined orbits. They are selected from D-type candidates in the SDSS-MOC 4 catalog. Using the University of Hawaii 2.2 m telescope and the Inter-University Centre for Astronomy and Astrophysics 2 m telescope in India, we determined the spectral types of 38 asteroids. Among them, eight asteroids were classified as D-type asteroids. Fractions of D-type asteroids are 3.0 ± 1.1% for low orbital inclination main-belt asteroids and 7.3 ± 2.0% for high orbital inclination main-belt asteroids. The results of our study indicate that some D-type asteroids were formed within the ecliptic region between the main belt and Jupiter, and were then perturbed by Jupiter.

关键词： minor planets, asteroids general -- techniques spectroscopic

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A comparative study of biopolymers and alum in the separation and recovery of pulp fibres from paper mill effluent by flocculation

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Journal of Environmental Sciences 2014年第9期26卷 1851-1860页

作者： Sumona Mukherjee Soumyadeep Mukhopadhyay Agamuthu Pariatamby Mohd. Ali Hashim Jaya Narayan Sahu Bhaskar sen gupta Institute of Biological Sciences University of Malaya50603 Kuala LumpurMalaysia Department of Chemical Engineering University of Malaya50603 Kuala LumpurMalaysia Department of Petroleum and Chemical Engineering Faculty of EngineeringInstitute Teknologi BruneiTungku GadongBrunei Darussalam School of Planning Architecture and Civil EngineeringQueen's University BelfastDavid Keir BuildingBelfast BT9 5AGUK

Recovery of cellulose fibres from paper mill effluent has been studied using common polysacchatides or biopolymers such as Guar gum, Xanthan gum and Locust bean gum as flocculent. Guar gum is commonly used in sizing paper and routinely used in paper making. The results have been compared with the performance of alum, which is a common coagulant and a key ingredient of the paper industry. Guar gum recovered about 3.86 mg/L of fibre and was most effective among the biopolyrners. Settling velocity distribution curves demonstrated that Guar gum was able to settle the fibres faster than the other biopolymers; however, alum displayed the highest particle removal rate than all the biopolymers at any of the settling velocities. Alum, Guar gum, Xanthan gum and Locust bean gum removed 97.46%, 94.68%, 92.39% and 92.46% turbidity of raw effluent at a settling velocity of 0.5 cm/min, respectively. The conditions for obtaining the lowest sludge volume index such as pH, dose and mixing speed were optimised for guar gum which was the most effective among the biopolymers. Response surface methodology was used to design all experiments, and an optimum operational setting was proposed. The test results indicate similar performance of alum and Guar gum in terms of fioc settling velocities and sludge volume index. Since Guar gum is a plant derived natural substance, it is environmentally benign and offers a green treatment option to the paper mills for pulp recycling.

关键词： BiopolymerRecovery of fibresGuar gumFlocculationPaper industry

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Extremist Politics as an Instrument of Ethnic Assertions among the Bodos of Northeast India

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Journalism and Mass Communication 2014年第8期4卷 527-534页

作者： Susmita sen gupta North-Eastern Hill University Shillong India

Ethnic assertions worldwide have assumed different forms ranging from moderate methods of articulation of autonomy to extremist means of violent struggle. Resort to extremism by some sections of an ethnic group usually triggers inter-ethnic conflicts with other groups on the one hand and leads to confrontation with the state on the other. This paper seeks to examine the dynamics of this phenomenon in the context of Bodos, the largest plains tribe of Assam, a State of Northeast India. The paper enquires as to whether extremist politics has met the Bodo aspirations for self-determination or has intensified the conflicts and contradictions within the Bodo society with ramifications for other ethnic groups inhabiting the Bodo-dominated areas. It is also necessary to explore the responses of the Union and State governments to Bodo extremist politics for an understanding of the conflict management process.

关键词： extremism extremist politics ethnic assertions conflict management

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Aberrant cell cycle induction is pivotal for mitochondrial biogenesis after traumatic brain injury

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Neural Regeneration Research 2019年第7期14卷 1215-1216页

作者： Nilkantha sen Department of Neurological Surgery University of Pittsburgh

Cell cycle regulation and brain injury:Traumatic brain injury(TBI)is one of the primary causes of morbidity and mortality in patients,and it affects more than 1.7 million Americans each *** than direct damage resulting from TBI,the brain injury triggers several secondary mechanisms which either individually or in combination contribute to the neurological deficits after TBI(gupta and sen,2016).These secondary mechanisms include neuronal death and stimulate proliferation of astrocytes and microglial cells,which in turn triggers neuro-inflammation(Simon et al.,2017).

关键词： Cell cycle brain injury direct damage

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High Dimensionality Effects on the Efficient Frontier: A Tri-Nation Study

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Journal of Data Analysis and Information Processing 2016年第1期4卷 13-20页

作者： Rituparna sen Pulkit gupta Debanjana Dey Indian Statistical Institute Chennai India Indian Institute of Technology Kharagpur India Indian Institute of Management Calcutta India

Markowitz Portfolio theory under-estimates the risk associated with the return of a portfolio in case of high dimensional data. El Karoui mathematically proved this in [1] and suggested improved estimators for unbiased estimation of this risk under specific model assumptions. Norm constrained portfolios have recently been studied to keep the effective dimension low. In this paper we consider three sets of high dimensional data, the stock market prices for three countries, namely US, UK and India. We compare the Markowitz efficient frontier to those obtained by unbiasedness corrections and imposing norm-constraints in these real data scenarios. We also study the out-of-sample performance of the different procedures. We find that the 2-norm constrained portfolio has best overall performance.

关键词： High Dimensional Covariance Matrix Estimation Minimum-Variance Portfolio Norm Con-Strained Portfolio

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