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Drugging in the absence of p53

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Journal of Molecular Cell Biology 2019年第3期11卷 255-264页

作者： Obed Akwasi aning Chit Fang Cheok Institute of Molecular and Cell Biology A*STARSingapore Department of Pathology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore

Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and *** quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed innovative strategies against p53-defective *** will discuss some of these latest studies with a focus on metabolic regulation and DNA damage response and also highlight novel functions of p53 in these pathways that may provide a contemporary rationale for targeting p53 loss in tumors.

关键词： therapeutics metabolism DNA damage replication stress p53 synthetic lethality

Operation Logic of the Internalized Confucian Culture in Patriarchal Clans

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学术界 2014年第5期 303-307页

作者： Jin aning Tian Yongquan Chen Yanqiu School of Public Health Central South University Changsha Hunan 410013 Youth League Committee Changchun University of Chinese Medicine Changchun Jilin 130117 School of Marxism Jilin University Changchun Jilin 130012

Confucian culture is a generic term with which the ruling class of the feudal society rules and controls thoughts and ideas of the masses. Throughout the history of mankind,it is the concerned issue for each and every political power that after the establishment of the regime,the mainstream ideology shall be established in order to maintain the belief structure of the political power and the foundation and value identity of the political system. In the feudal society of China,such a process was realized through patriarchal clans. The operation logic of internalizing the Confucian culture of patriarchal clans is as follows: transforming-transforming the deep and complicated Confucianism into domestic disciplines used by clan members daily,forming constraint force and seepage force to individuals in society;inculcating- inculcating Confucianism to clan members by clan education,ancestral hall education and etiquette education; enforcing- forcing clan members to obey domestic disciplines centered on Confucianism with rewards and punishment.

关键词：儒家文化逻辑操作内化封建社会政治制度通用术语意识形态

A Mini-Review of Machine Learning in Big Data Analytics:Applications,Challenges,and Prospects

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Big Data Mining and Analytics 2022年第2期5卷 81-97页

作者： Isaac Kofi Nti Juanita Ahia Quarcoo Justice aning Godfred Kusi Fosu the Department of Computer Science and Informatics University of Energy and Natural ResourcesSunyani BS2103Ghana the Department of Electrical&Electronic Engineering Sunyani Technical UniversitySunyani BS2103Ghana the Department of Computer Science Sunyani Technical UniversitySunyani BS2103Ghana

The availability of digital technology in the hands of every citizenry worldwide makes an available unprecedented massive amount of *** capability to process these gigantic amounts of data in real-time with Big Data Analytics(BDA)tools and Machine Learning(ML)algorithms carries many ***,the high number of free BDA tools,platforms,and data mining tools makes it challenging to select the appropriate one for the right *** paper presents a comprehensive mini-literature review of ML in BDA,using a keyword search;a total of 1512 published articles was *** articles were screened to 140 based on the study proposed novel *** study outcome shows that deep neural networks(15%),support vector machines(15%),artificial neural networks(14%),decision trees(12%),and ensemble learning techniques(11%)are widely applied in *** related applications fields,challenges,and most importantly the openings for future research,are detailed.

关键词： Big Data Analytics(BDA) Machine Learning(ML) Big Data(BD) Hadoop MapReduce

Insight into excitation wavelength and hotspot effect of noble metal nanoparticles dimer

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Optoelectronics Letters 2021年第10期17卷 577-580页

作者： MA aning WEI Wenjing LI Guojian WANG Yurong GENG Di ZHANG Zhongqiang School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China China Mobile Communication Corporation Lanzhou 730000China School of Electrical Engineering Northwest Minzu UniversityLanzhou 730030China

A proper excitation wavelength and strong hot-spot effect are of great importance for the application of surface-enhanced Raman spectroscopy(SERS)in the field of *** a popular SERS substrate,noble metal nanoparticles dimer is analyzed systematically in this *** hot-spot effect and the resonance peak position with varying geometric parameters of metal nanoparticles are ***,the excitation wavelength of bimetallic structure is discussed as *** conclusions can provide reference for the selection of metal material at different excitation wavelengths.

关键词： excitation noble dimer

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弹用永磁同步电机实时仿真研究

微电机 2014年第11期47卷 15-18页

作者：蔡阿宁中国空间技术研究院西安分院西安710010

永磁同步电机凭借其优异的性能在远程导弹动力辅助装置中得到重视和应用。对其高性能控制策略的快速原型验证十分重要。本文以永磁同步电机矢量控制策略为基础,展开仿真实时化分析和研究,并设计永磁同步电机实时仿真体系及系统。通过对... 详细信息

永磁同步电机凭借其优异的性能在远程导弹动力辅助装置中得到重视和应用。对其高性能控制策略的快速原型验证十分重要。本文以永磁同步电机矢量控制策略为基础,展开仿真实时化分析和研究,并设计永磁同步电机实时仿真体系及系统。通过对比离线仿真与实时仿真结果,验证了控制策略及实时仿真系统的有效性,也为今后进一步对更加复杂的控制策略进行实时仿真奠定了基础。

关键词：永磁同步电机 dSPACE 实时仿真

国际碳捕集、利用与封存发展战略与科技态势分析

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中国科学院院刊 2024年第8期39卷 1486-1496页

作者：秦阿宁孙玉玲中国科学院文献情报中心北京100190 中国科学院大学图书情报与档案管理系北京100190

作为应对气候变化和实现碳中和必不可少的技术,碳捕集、利用与封存(CCUS)技术研发和应用受到全球主要国家高度重视。文章梳理近年来美国、欧盟、英国、日本等主要国家和地区CCUS发展战略,并采用文献计量、文本聚类等方法对全球CCUS科技... 详细信息

作为应对气候变化和实现碳中和必不可少的技术,碳捕集、利用与封存(CCUS)技术研发和应用受到全球主要国家高度重视。文章梳理近年来美国、欧盟、英国、日本等主要国家和地区CCUS发展战略,并采用文献计量、文本聚类等方法对全球CCUS科技研发态势进行分析。研究发现,这些主要国家和地区相继出台CCUS相关战略,将发展CCUS上升到国家战略高度,明确提出到2030年、2040年、2050年不同发展阶段的目标和重点攻关方向。CCUS技术领域的研究产出呈现快速增长趋势,研究主要集中在新一代低能耗与低成本CO_(2)捕集技术、安全可靠的地质利用与封存技术及CO_(2)高效转化利用制高价值化学品/燃料等方向。

关键词：碳捕集、利用与封存战略研究文本挖掘研发态势

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2D Electrical Resistivity Imaging for Delineation of Crystalline Basement Aquifer in Northern Ghana

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Journal of Geoscience and Environment Protection 2019年第12期7卷 102-115页

作者： Akwasi Acheampong aning Charles Kwabena Sarfo Patrick Amankwaa Mainoo Reginald Mensah Noye Department of Physics Kwame Nkrumah University of Science and Technology Kumasi Ghana Water Research Institute (WRI) Council for Scientific and Industrial Research (CSIR) Accra Ghana

Lack of access to potable and adequate water is a major problem for sustainable development in northern Ghana. Developing groundwater resource is the best option for safe, reliable, and cost-efficient water supplies to these dispersed communities. In this study, nine 2D ERI profiles were carried out with the Schlumberger array in eight communities underlain by the crystalline basement rocks in the Bole District of the Savannah Region of Ghana. The aim was to delineate the aquifer zones and select points for groundwater extraction. Nine boreholes were drilled from the selected points. The yield was found to vary from 12 to 180 l/min with a depth range of 50 to 70 m. The weathered and fractured zones together with the bedrock topography were clearly marked. It is evident that the 2D electrical resistivity technique is useful tool in determining the availability of groundwater in weathered and fractured crystalline environment.

关键词： Electrical Resistivity Imaging Ghana Crystalline Aquifer Mapping

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从结束开始:快递末端投递法律问题再审视

大连理工大学学报（社会科学版） 2016年第4期37卷 98-104页

作者：郑佳宁中国政法大学民商经济法学院北京100088

我国快递末端投递通过直营、加盟连锁、代理和智能投递四种模式完成。直营模式是"总公司—子公司—分公司"组成的金字塔结构;加盟连锁模式是纵向法律关系和横向法律关系的交织结构;代理模式分为"快递公司—代理人"和"快递用户—代理人"... 详细信息

我国快递末端投递通过直营、加盟连锁、代理和智能投递四种模式完成。直营模式是"总公司—子公司—分公司"组成的金字塔结构;加盟连锁模式是纵向法律关系和横向法律关系的交织结构;代理模式分为"快递公司—代理人"和"快递用户—代理人"两种不同的代理模式,均遵循代理法则的基本结构;智能投递模式包括直营式智能快件箱和第三方智能快件箱,在后者中智能快件箱运营者与快递公司形成租赁和承揽的双重法律关系。快递立法应对这四种模式的法律结构进行深入且具体的剖析,并在此基础上,明晰相关主体之间的权利义务关系,确定责任的主体、类型、范围和具体的承担规则。

关键词：快递末端投递法律结构法律责任快递条例

Integrated Geophysical and Geological Mapping of the Lithological and Geological Structures at a Proposed Generator Site

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Journal of Geoscience and Environment Protection 2019年第12期7卷 73-85页

作者： Akwasi Acheampong aning Vandycke Sarpong Asare David Dotse Wemegah Reginald Mensah Noye Kwasi Preko Sylvester Kojo Danuor Department of Physics Kwame Nkrumah University of Science and Technology Kumasi Ghana

The discovery of oil in commercial quantity in Ghana has led to increase in infrastructural development to provide the needed services to the oil industry. The siting of these industries requires the characterization of the subsurface to determine its suitability to host these facilities. It is in this line that seismic refraction and geo-electrical surveys were conducted on a site near Takoradi, Ghana that has been planned to host a generator and its appurtenances for the oil industry. The objective of the survey was to provide subsurface information critical for the design of earthing system for the proposed generator plant and its appurtenances. The ABEM SAS4000 Terrameter with the Lund imaging system and a 24-channel ABEM Terraloc MK6 were respectively used for the electrical and seismic refraction data collection. The seismic refraction and resistivity results identify three lithological units namely, dry gravel, sand and silty clay layer, water saturated sand and silty clay layer and granodiorites basement rocks. The first layer has a thickness of 10 m and the second layer with thickness in the range of 5 to 10 m. The lithological classifications as obtained from these results correlate with the drill logs. Electrical grounding will be suitable at a depth of 10 m beneath resistivity profile two at a distance between 32 to 52 m.

关键词： Electrical Resistivity Tomography Seismic Refraction Borehole Subsurface Mapping