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Terminalia arjuna bark extract attenuates picrotoxin-induced behavioral changes by activation of serotonergic,dopaminergic,GABAergic and antioxidant systems

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Chinese Journal of Natural Medicines 2017年第8期15卷 584-596页

作者： Chandra Sekhar Y Phani kumar G anilakumar k.r. Applied Nutrition Division Defence Food Research LaboratoryDRDOMysore-570011KarnatakaIndia

Stress and emotion are associated with several illnesses from headaches to heart diseases and immune deficiencies to central nervous system. Terminalia arjuna has been referred as traditional Indian medicine for several ailments. The present study aimed to elucidate the effect of T. arjuna bark extract(TA) against picrotoxin-induced anxiety. Forty two male Balb/c mice were randomly divided into six experimental groups(n = 7): control, diazepam(1.5 mg·kg^(–1)), picrotoxin(1 mg·kg^(–1)) and three TA treatemt groups(25, 50, and 100 mg/kg). Behavioral paradigms and PCr studies were performed to determine the effect of TA against picrotoxin-induced anxiety. The results showed that TA supplementation increased locomotion towards open arm(EPM) and illuminated area(light-dark box test), and increased rearing frequency(open field test) in a dose dependent manner, compared to picrotoxin(P rthermore, TA increased number of licks and shocks in Vogel's conflict. PCr studies showed an up-regulation of several genes, such as BDNF, IP_3, D_2L, CrEB, GABAA, SOD, GPx, and Gr in TA administered groups. In conclusion, alcoholic extract of TA bark showed protective activity against picrotoxin in mice by modulation of genes related to synaptic plasticity, neurotransmitters, and antioxidant enzymes.

关键词： Anxiety Terminalia arjuna Gene expression Picrotoxin Neurotransmitters LC-MS

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Anxiolytic property of Lactuca sativa,effect on anxiety behaviour induced by novel food and height

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 532-536页

作者： SN Harsha kr anilakumar Biochemistry and Applied Nutrition Discipline.Defence Food Research Laboratory Mysore-570011.India

Objective:To study anxiolytic property of hydro alchohol extract and to estimate polyphenols present in the extract by ***:To evaluate anxiolytic properly two animal models were used *** T maze and ***(1 mg/kg body wt.) served as the standard anxiolvtic agent for all the *** dried extract of the plant leaf in doses of 100.200 and 400 mg/kg body weight was administered orally to mice for duration of 1? or 30 days and locomotor and anxiolytic activities were *** was estimated using HPLC. results:The HPLC analysis of the polyphenols revealed the presence chlorogenic acid,vanillin, epicatechin,caffeic acid,rutin hydrate,sinapic acid,quercetin-3-rhamnoside.p-coumeric acid and *** spent and number of entries into the open arm was improved in 30 days treated animals than that of 15 days treated groups,200 and 400 mg/kg body weight treated group showed significant results when comparing with the control ***:Te hydro alcohol extract rich in Polyphenols and other secondary metabolites is a potent anxiolytic agent.

关键词： Anxiety Lactuca sativa Polyphenols Hyponeophagia Elevated T maze test

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Anxiolytic property of hydro-alcohol extract of Lactuca sativa and its effect on behavioral activities of mice

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The Journal of Biomedical research 2013年第1期27卷 37-42页

作者： Singapura Nagesh Harsha kandangath raghavan anilakumar Applied Nutrition Discipline Defence Food Research Laboratory

Lactuca sativa, belonging to the Asteraceae family, is a leafy vegetable known for its medicinal properties. This study aimed to understand the mechanism of Lactuca sativa extract with respect to pharmacological action. We investigated the anxiolytic effects of hydro-alcoholic extract of leaves of Lactuca sativa on mice. The behav- ioral tests performed on mice models to assess anti-anxiety properties were： open field test （OFT）, elevated plus maze test （EPM）, elevated T maze test, and marble burying test. Increased locomotor activity and time spent in the ＂open-ann＂ were observed in extract fed group. Malondialdehyde （MDA） and nitrite levels were decreased, cata- lase and glutathione levels were increased in Lactuca sativa treated mice. The data obtained in the present study suggests that the extract of Lactuca sativa can afford significant protection against anxiolytic activity.

关键词： Lactuca sativa anxiety nitrite open field test (OFT) elevated plus maze test (EPM) malondialde-hyde (MDA)

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