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Calcarea carbonica treatment rescues lipopolysaccharide-induced inflammatory response in human mononuclear cells via downregulation of inducible cyclooxygenase pathway

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Journal of Integrative Medicine 2020年第5期18卷 441-449页

作者： Swatantra Kumar Vimal KMaurya Debadatta Nayak anil khurana Raj KManchanda Srinivasulu Gadugu Madan LBBhatt Shailendra K.Saxena Centre for Advanced Research Faculy of MedicineKing George's Medical UniversityLucknow 226003India Central Council for Research in Homoeopathty.Ministry of Ayush.Janakpuri.New Delhi 10058 India Deparment of Medicine Jaisoorya and Potti Sreeramulu Government Medical Cllege.Hyderabad 500013India

Objective: Prolonged use of nonsteroidal anti-inflammatory drugs is associated with severe side effects and toxicity. Therefore, we studied the anti-inflammatory role of Calcarea carbonica which had minimal toxicity at the low ***: THP-1 human mononuclear cells were treated with C. carbonica to evaluate the 50% cytotoxicity concentration(CC_(50)) and 50% effective concentration(EC_(50)). Cell survival was evaluated in lipopolysaccharide-stimulated C. carbonica-treated cells. Nitric oxide(NO) and tumor necrosis factor-a(TNF-a) were measured to evaluate the anti-inflammatory activity of C. carbonica. Cyclooxygenase-2(COX-2) protein expression was determined by Western blotting analysis, and the interaction of C. carbonica with the COX-2 protein was evaluated using molecular docking ***: The CC_(50) and EC_(50) of C. carbonica were found to be 43.26 and 11.99 mg/mL, respectively. The cell survival assay showed a 1.192-fold(P = 0.0129), 1.443-fold(P = 0.0009) and 1.605-fold(P = 0.0004)increase in cell survival at 24, 48 and 72 h after initiating C. carbonica treatment, respectively. C. carbonica-treated cells showed a reduction in NO levels by 2.355 folds(P = 0.0001), 2.181 folds(P = 0.0001) and 2.071 folds(P = 0.0001) at 24, 48 and 72 h, respectively. The treated cells also showed a reduction in TNFa levels by 1.395 folds(P = 0.0013), 1.541 folds(P = 0.0005) and 1.550 folds(P = 0.0005) at 24, 48 and72 h, respectively. In addition, a 1.193-fold reduction(P = 0.0126) in COX-2 protein expression was found in C. carbonica-treated cells. The molecular docking showed interaction of C. carbonica with the phenylalanine 367 residue present in active site of ***: C. carbonica exhibited anti-inflammatory properties in lipopolysaccharide-stimulated cells by significantly reducing NO production and TNF-a level through downregulation of the COX-2 protein. This effect is probably mediated through interaction of C. carbonica with the phenylalanine

关键词： Inflammation Calcarea carbonica Cyclooxygenase-2 Nitric oxide Tumor necrosis factor-a Anti-inflammatory

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Stem cell therapy: A paradigm shift in breast cancer treatment

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World Journal of Stem Cells 2021年第7期13卷 841-860页

作者： Sabiha Khan Moushumi Suryavanshi Jasamrit Kaur Debadatta Nayak anil khurana Raj Kumar Manchanda Chanderdeep Tandon Simran Tandon Amity Institute of Molecular Medicine and Stem Cell Research Amity UniversityNoida 201313Uttar PradeshIndia Department of Pathology Rajiv Gandhi Cancer Institute and Research CentreNew Delhi 110085India Department of Chemistry Goswami Ganesh Dutta Sanatan Dharma CollegeChandigarh 160030India Central Council for Research in Homeopathy New Delhi 110058India Department of AYUSH Karol BaghNew Delhi 110011India Amity Institute of Biotechnology Amity UniversityNoida 201313Uttar PradeshIndia

As per the latest Globocan statistics,the high prevalence rate of breast cancer in low-and middle-income countries has led to it becoming the most common cancer to be diagnosed,hence posing a major public health *** per this data,more than 11.7%of the estimated new cancer cases in 2020 were due to breast cancer.A small but significant subpopulation of cells with self-renewing ability are present in the tumor stroma and have been given the nomenclature of cancer stem cells(CSCs).These cells display a high degree of plasticity owing to their ability to transition from the slowly cycling quiescent phase to the actively proliferating *** attribute of CSCs allows them to differentiate into various cell types having diverse *** CSCs have a pivotal role in development,metastasis,treatment resistance and relapse of breast *** review focuses on the pathways regulating breast CSC maintenance and the current strategies that are being explored for directing the development of novel,targeted,therapeutic approaches for limiting and eradicating this aberrant stem cell population.

关键词： Molecular genomics Breast cancer stem cells Tumor microenvironment Molecular pathways Targeted therapy Inhibitors

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高温有机超导体新进展

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世界科学 1991年第7期 7-8页

作者： anil khurana 刘兵

第一个有机超导体发现于1980年,当时,其临界温度还不到1K,1988年,有机材料的最高超导转变温度已达10K.最近,转变温度又有提高:美国阿贡国家实验室的研究人员报道合成了两类新型有机超导体.其中一类的临界温度在常压下达11.6K,另一类在0.... 详细信息

第一个有机超导体发现于1980年,当时,其临界温度还不到1K,1988年,有机材料的最高超导转变温度已达10K.最近,转变温度又有提高:美国阿贡国家实验室的研究人员报道合成了两类新型有机超导体.其中一类的临界温度在常压下达11.6K,另一类在0.3Kbar压力下,于12.8K成为超导体.这两类新型超导体如同许多其它有机超导体一样,当压力增加超过超导起始转变临界值时,其临界温

关键词：超导体第一个有机材料非金属材料导电性超导性

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高温超导究进展

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物理 1988年第3期 129-131页

作者： anil khurana ,阎守胜

一、同位素效应[1] 1950年以来,陆续发现在很多超导体中,当用质量大一些的同位素来取代其中的原子时,临界温度Tc降低,这意味着声子对超导相的出现起着重要的作用.这一发现导至 1957年***,***和***的理论的出现.理论认为,超导电性来源于... 详细信息

一、同位素效应[1] 1950年以来,陆续发现在很多超导体中,当用质量大一些的同位素来取代其中的原子时,临界温度Tc降低,这意味着声子对超导相的出现起着重要的作用.这一发现导至 1957年***,***和***的理论的出现.理论认为,超导电性来源于电子间通过声子作媒介所产生的吸弓湘互作用,当这种作用超过电子间的库仑排斥作用时,电子结合成对.这就是著名的BCS理论. 按照BCS理论,超导体的临界温度 A表征电子间有效的配对相互作用的大小,　,是通过交换声子产生的对吸引作用又和对中两电子间库仑排斥作用u之差.QD是一特征频率,通常称为德拜频率,大体可理解为晶体中最高的声子频率.由于晶格振动频率与离子质量M的平方根成反比,因此 TcCM,。一0.5.对很多超导体,实验得到的。值均为0.4到 0.5,与 BCS理论一致。如果在90K超导体中,用O“来代替O“,并假定。一｝,且与超导电性有关的所有的声子._一2模只涉及氧原子的振动,这时Tc将改变SK. 美国Bell实验室小组研究了YBa。Cu。O,-。和EuBa。Cu。O7-,样品,实验得到a—0士0·02,结论是同位素效应即...

关键词：氧化物超导体超导线超导陶瓷导线(电) 临界电流金属材料超导材料磁场临界场超导态同位素效应钉扎中心超导颗粒直流电压

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LaCu氧化物也具有超导电性

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物理 1988年第6期 321-323+336页

作者： anil khurana ,张宏 ,彭金林

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Colorectal cancer cell dormancy:An insight into pathways

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World Journal of Gastroenterology 2024年第33期30卷 3810-3817页

作者： anil Kumar Lekha Saha Department of Pharmacology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Cancer cell dormancy(CCD)in colorectal cancer(CRC)poses a significant challenge to effective *** CRC,CCD contributes to tumour recurrence,drug resistance,and amplifying the disease's *** molecular mechanisms governing CCD and strategies for eliminating dormant cancer cells remain largely ***,understanding the molecular mechanisms governing dormancy is crucial for improving patient outcomes and developing targeted *** editorial highlights the complex interplay of signalling pathways and factors involved in colorectal CCD,emphasizing the roles of Hippo/YAP,pluripotent transcription factors such as NANOG,HIF-1αsignalling,and Notch signalling ***,ERK/p38α/β/MAPK pathways,AKT signalling pathway,and Extracellular Matrix Metalloproteinase Inducer,along with some potential less explored pathways such as STAT/p53 switch and canonical and non-canonical Wnt and SMAD signalling,are also involved in promoting colorectal *** their clinical significance,these findings may offer the potential for identifying key dormancy regulator pathways,improving treatment strategies,surmounting drug resistance,and advancing personalized medicine ***,insights into dormancy mechanisms could lead to the development of predictive biomarkers for identifying patients at risk of recurrence and the tailoring of targeted therapies based on individual dormancy *** is essential to conduct further research into these pathways and their modulation to fully comprehend CRC dormancy mechanisms and enhance patient outcomes.

关键词： Colorectal cancer Colorectal cancer cell dormancy Cancer cell dormancy Pathways in colorectal cancer dormancy

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增长领先者制胜之道——以运营战略创造优势

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上海国资 2010年第7期 66-67页

作者： John S.Watts Charlie Hohenshelt Roger Wery anil khurana PRTM

绩效卓越的公司对其运营策略精雕细琢,积极地加以改进,并且通过聚焦于少数关键性的运营杠杆—尤其是对于客户生命周期的管理。

关键词：运营战略优势海市蜃楼持续增长业务战略持续性公司

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Offshore high-grade limemud resources of west coast of India:Economic potential and industrial applications

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Deep Underground Science and Engineering 2024年第2期3卷 163-170页

作者： anil Kumar Adukadukkam Rachna Pillai Mamatha Puthiyathara Kanakamma Marine&Coastal Survey Division Geological Survey of IndiaSalt LakeKolkataWest BengalIndia

Limestone is one of the essential raw materials in the cement,paint,steel,ceramic,glass,chemical,pharmaceutical,paper,and fertilizer *** India,only 8%of the limestone resources are placed under the reserve category,of which 97%is of cement ***,India depends on imports to bridge the demand‐supply gap of steel,blast furnace,and chemical‐grade *** of Geological Survey of India(GSI)to locate alternate sources for limestone led to the discovery of enormous quantities of carbonate minerals called limemud from the continental shelf margin of the west coast of *** carried out systematic studies to explore the nature of the disposition,quality,quantity,and suitability of the offshore limemud for various industrial applications.A preliminary estimate of resources using high‐resolution subbottom profiling and sediment core sample studies established the occurrence of more than 172 billion tonnes of high‐grade(The content of CaCO3 is greater than 80 wt%)limemud in 0.4–28.0m thick stratified sediment layers spread over an area of 18000 ***,physical,mineralogical,beneficiation,and agglomeration studies found the offshore limemud as a potential replacement for limestone in the cement,filler,blast furnace,steel melting shop,lime production,paint,and Grade‐I steel *** assessment of mining and transportation costs indicates that the offshore limemud(USD 5–6/ton)is more cost‐effective than that imported from other countries(USD16‐18/ton).With several advantageous factors like low impurity,mode of occurrence in overburden‐free stratified form,fine‐grained slurry nature,and shallow water depth,sustainable mining of offshore limemud could be a future reality with controllable technological,economic,and environmental challenges.

关键词： beneficiation industrial grade offshore limemud west coast of India

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Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

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Adoption of green finance and green innovation for achieving circularity:An exploratory review and future directions

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Geoscience Frontiers 2024年第4期15卷 333-346页

作者： Rohit Agrawal Shruti Agrawal Ashutosh Samadhiya anil Kumar Sunil Luthra Vranda Jain Operations Management and Quantitative Techniques Indian Institute of ManagementBodhgaya 824234BiharIndia Department of Humanities and Social Sciences Malaviya National Institute of Technology Jaipur RajasthanIndia Jindal Global Business School OP Jindal Global UniversitySonipatIndia Guildhall School of Business and Law London Metropolitan UniversityLondonUK AICTE Training and Learning(ATAL) All India Council for Technical EducationDelhiIndia Economics and International Business Jaipuria Institute of ManagementNoidaIndia

There is growing attention from governments and regulators towards crucial matters such as climate change and global warming,resulting in a pressing need to investigate the factors that make it possible for businesses to engage in green finance(GF).The externality of environmental pollution prioritizes the need of green innovation(GI)in public *** distributes financial resources to the research and development(R&D)of clean energy and environmentally friendly goods and processes;it is complementary to the GI process for environmental *** policies help to alleviate the impacts of financial constraints and GI impaired industries involving new products,processes,services and the global *** better understand how GF and GI have functioned as a catalyst for circular economy practices,this paper seeks to present a historical and contemporary overview of these *** research is thoroughly dissected by a systematic literature evaluation of articles from 2016 to 2023 that appear in peer-reviewed journals and are indexed in the SCOPUS *** attain supply chain circularity,this article encompasses four major research themes concerning the adoption of GF and green *** research also includes a network analysis of shortlisted articles to examine the overall citation *** is shown that several institutional theories are associated with the investigated *** a final step,a framework is provided to illustrate how GF and GIs might be used to achieve supply chain *** research findings provide a novel concept related to GF within the context of GI which are significant for environmentalists,policymakers,green investors,and *** its findings,the study provides a conceptual framework that promotes sustainable strategies to effectively balance financial considerations and environmental *** helps to leverage the potential of green research and practice to create value for businesses and to benefi

关键词： Green finance Green innovation Systematic literature review Environmental protection Climate change

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