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Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models

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Asian pacific Journal of Tropical Medicine 2012年第4期5卷 283-288页

作者： Ch V Rao AKS Rawat anil p singh Arpita singh Neeraj Verma pharmacognosy and Ethnopharmacology Division National Botanical Research Institute(Council of Scientific and Industrial Research)Rana Pratap MargP.O.Box No.436Lucknow 226001Uttar PradeshIndia Department of pharmacology Goel Institute of Pharmacy & SciencesFaizabad Road(Near Indira Canal) Lucknow 227105Uttar PradeshIndia

Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(***) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal ***:Five groups of six rats each were selected for the *** extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated *** serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGpT),alkaline phosphatase (SALp),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the ***:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of *** ***,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose *** addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver ***:The results of this study slrongly indicate that ethanolic extract of *** has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats.

关键词： Ziziphus oenoplia(Rhamnaceae) Rifampicin Isoniazid Hepatotoxicity

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Antihyperglycemic activity,antihyperlipedemic activity,haematological effects and histopathological analysis of Sapindus mukorossi Gaerten fruits in streptozotocin induced diabetic rats

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Asian pacific Journal of Tropical Medicine 2012年第7期5卷 518-522页

作者： Neeraj Verma G Amresh p K Sahu Neelam Mishra anil p singh Ch V Rao Department of pharmacology Goel Institute of Pharmacy & SciencesFaizabad Road(Near Indira Canal) Lucknow 227105Uttar PradeshIndia Department of pharmacology School of Pharmaceutical SciencesSiksha 'O' Anusandhan UniversityKalinga NagarGhatikiaBhubaneswar 751003 OrissaIndia Department of pharmacology Pharmacognosy and Ethnopharmacology DivisionNational Botanical Research Institute(Council of Scientific and Industrial Research)Rana Pratap MargP.O.Box No.436Lucknow 226001Uttar PradeshIndia

Objective:To investigate the antihyperglycemic and antihyperlipidemie properties of hydroalcoholic extract of fruits of Sapindus mukorossi Caerlen and its beneficial effect on haeniatological parameters with histopathological analysis in streptpzotocin induced diabetic ***:Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and standard drug glybenclamide(0.5 mg/kg body weight) were administered to diabetic *** of extract on hyperglycemia,hyperlipidemia and hematological parameters was studied in diabetic *** changes in diabetic rat pancreas were also observed after extract and glybenclamide ***:Daily oral administration of Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and glybenclamide for 20 days showed beneficial effects on blood glucose level(ppid *** extract has a favorable effect on the histopathological changes of the pancreas in streptozotocin induced ***: These findings reveal that the hydroalcoholic extract of Sapindus mukorossi fruits extract possesses antihyperglycemic and antihyperlipidemie *** *** extract can prevent various complications of diabetes and improve some haeniatological parameters.

关键词： Antihyperglycemic Antihyperlipidemic Streptozotocin Sapindus mukorossi

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prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

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World Journal of Virology 2025年第1期14卷 108-117页

作者： Sanjay K Thakur anil K Sinha Santosh K Sharma Aarzoo Jahan Dinesh K Negi Ruchika Gupta Sompal singh Regional Blood Transfusion Centre Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Zoology Veer Kunwar Singh UniversityAra 802301BiharIndia Regional Blood Transfusion Centre and pathology Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Cytopathology ICMR-National Institute of Cancer Prevention and ResearchNoida 201301Uttar PradeshIndia

BACKGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood *** India,screening for TTIs such as hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood ***,HCV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HCV and HIV/*** highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic ***,millions of blood donations take place annually,emphasizing the importance of maintaining blood *** To study the prevalence of TTIs,viz.,HBV,HCV,HIV I/II,syphilis,and malaria parasite(Mp),among different blood donor *** The study assessed the prevalence of TTIs among different blood donor groups in Delhi,*** included total donors,in-house donors,total camp donors,institutional camp donors,and community camp *** for HIV,HBV,and HCV were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and Mp rapid card *** prevalence of HBV,HCV,HIV,and syphilis,expressed as *** in infection rates between the groups were analyzed usingχ²tests and p-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in *** overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HCV,HIV-I/II,venereal disease research laboratory,and Mp were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,***-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the l

关键词： Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Malaria parasite Syphilis

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Evaluation of corrosion resistance, mechanical integrity loss and biocompatibility of pCL/HA/TiO_(2) hybrid coated biodegradable ZM21 Mg alloy

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Journal of Magnesium and Alloys 2022年第11期10卷 3179-3204页

作者： Navdeep singh Uma Batra Kamal Kumar anil Mahapatro Department of Metallurgical and Materials Engineering Punjab Engineering CollegeChandigarh 160012India Department of Mechanical Engineering Punjab Engineering CollegeChandigarh 160012India Department of Biomedical Engineering Wichita State UniversityWichitaKS 67260United States

A novel pCL/HA/TiO_(2)hybrid coating on ZM21 Mg alloy substrate has been investigated for corrosion resistance, biocompatibility and mechanical integrity loss in terms of bending, compressive and tensile strength in physiological media. The prepared hybrid coating was dip coated over ZM21 from HA/TiO_(2)and pCL solutions followed by creating a microporous pCL layer by utilizing Non-solvent Induced phase Separation(NIpS) technique. The electrochemical measurement and in-vitro degradation study in SBF after 28 days showed that the pCL/HA/TiO_(2) hybrid coating reduced H2 evolution rate, weight loss, and corrosion rate by 64, 116 and 118 times respectively, as compared to uncoated ZM21 samples. The surface studies carried out using SEM-EDX, FTIR and XRD revealed formation of highly stable 3d flower-like HA crystals with Ca/p ratio of 1.60 in the pCL micropores. This dense apatite growth effectively protected the pCL/HA/TiO_(2)hybrid coated samples to maintain the good mechanical integrity even after 28 days of immersion as compared to HA/TiO_(2)composite coated, As-polished(A/p) and As-machined(A/M) samples. The failure analysis of samples under mechanical loading were performed using *** in-vitro cellular viability of L929 fibroblast cells on pCL/HA/TiO_(2)hybrid coating was found 50.47% higher with respect to control group,whereas bacterial viability was supressed by 57.15 and 62.35% against gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacterial models. The comprehensive assessment indicates pCL/HA/TiO_(2)hybrid coating as a suitable candidate to delay early degradation and mechanical integrity loss of Mg-based alloys for devising biodegradable orthopaedic implant.

关键词： Magnesium alloy Surface modification Hybrid coating Mechanical integrity loss Degradation rate Biocompatibility

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Investigating TiO_(2)-HA-pCL hybrid coating as an efficient corrosion resistant barrier of ZM21 Mg alloy

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Journal of Magnesium and Alloys 2021年第2期9卷 627-646页

Surface modification for improving corrosion resistance of Mg alloys is highly demanded for degradable orthopedic and cardiovascular *** research reports the design and development of TiO_(2)–HA composite and novel TiO_(2)–HA–pCL hybrid coating belonging to the unique class of inorganic organic hybrid with striking features that are explored for the first time in the corrosion resistance of Mg ***–gel dip coating combined with non-solvent induced phase separation is used to create the hybrid ***_(2)–HA–pCL hybrid coating introduces strong hydrogen bonding between TiO_(2)–HA inorganic matrix and pCL organic layer in addition to the Vander wall electrostatic interaction of the later with the Mg substrate which in turn enhance adhesion strength to about 1.5 times of TiO_(2)–HA *** corrosion potentials for TiO_(2)–HA–pCL and TiO_(2)–HA were found to be-0.407 V and-1.017 V(vs Ag/Ag Cl),*** current densities of TiO_(2)–HA–pCL and TiO_(2)–HA were found to be 7.31×10^(-8)A/cm^(2)and 4.03×10^(-4)A/cm^(2)*** corrosion resistance of coatings was confirmed by immersion testing by weight loss,pH changes and H_(2)evolution measurements at interval of 7 days till 28 *** present TiO_(2)–HA–pCL coating in comparison to TiO_(2)–HA coating demonstrate nearly 6%less weight *** outcome of the present work was compared with the similar coatings in recent *** work done ingresses enhancing the corrosion resistance of Mg alloys,which fulfill the dreams of future degradable orthopedic and cardiovascular devices.

关键词： Corrosion resistance TiO_(2)-HA-pCL Contact angle Adhesion strength

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Utilization of alkali-activated copper slag as binder in concrete

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 773-780页

作者： Jagmeet singh S p singh Department of Civil Engineering Dr.B R Ambedkar National Institute of TechnologyJalandhar144011India

This study was focused on developing concrete using alkali-activated copper slag(AACS)as a *** properties of alkali-activated copper slag concrete(AACSC)were compared with portland cement concrete(pCC).Different AACSC mixes were prepared with varying Na_(2)O dosage(6%and 8%of the binder by weight)and curing *** products in AACSC were retrieved using Fourier-transform infrared spectroscopy(FTIR)and X-ray powder diffraction(XRD)*** test results indicate that the workability of AACSC was lesser than that of *** AACSC mix with 6%Na_(2)O dosage has exhibited similar mechanical properties as that of *** mechanical properties of AACSC were higher than pCC when 8%of Na_(2)O dosage was *** curing was effective to upgrade the strength properties of AACSC at an early age of curing,but at a later age mechanical properties of ambient cured and heat-cured AACSC were *** hydration products of AACSC were not identified in XRD patterns,whereas,in FTIR spectra of AACSC some alkali-activated reaction products were *** AACSC mixes were found to be more sustainable than *** has been concluded that AACSC can be produced similarly to that of pCC and ambient curing is sufficient.

关键词： binder concrete mechanical properties mineralogy workability

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Influence of peach(prunus persica Batsch)phenological stage on the short-term changes in oxidizable and labile pools of soil organic carbon and activities of carbon-cycle enzymes in the North-Western Himalayas

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pedosphere 2020年第5期30卷 638-650页

作者： Sovan DEBNATH Brij Lai ATTRI anil KUMAR Arun KISHOR Raj NARAYAN Kanchan SINHA Arpan BHOWMIK anil SHARMA Desh Beer singh Indian Council of Agricultural Research(lCAR)-Central Institute of Temperate Horticulture Regional StationMukteshwarNainitalUttarakhand 263138(India) Department of Agricultural Chemistry and Soil Science Faculty of AgricultureBidhan Chandra Krishi ViswavidyalayaMohanpurWest Bengal 741252(India) Indian Council of Agricultural Research(ICAR)-Directorate of Mushroom Research SolanHimachal Pradesh 173213(India) A Indian Council of Agricultural Research(ICAR)-Indian Agricultural Statistics Research Institute New Delhi 110012(India) Department of Agricultural Statistics Faculty of AgricultureBidhan Chandra Krishi ViswavidyalayaMohanpurWest Bengal 741252(India) Indian Council of Agricultural Research(ICAR)-Central Institute of Temperate Horticulture SrinagarJammu and Kashmir 190007(India)

The labile organic carbon(C)and C-related enzymes are sensitive indicators capturing alterations of soil organic matter(SOM),even in a short-time *** the effects of crop husbandry and land use change on these attributes have been well studied,there is no consensus about how plant phenology may impact *** study aimed to determine the short-term effect o f six distinct phenological stages(pS-1:full bloom;pS-2:fruit set;pS-3:pit hardening;pS-4:physiological maturity;pS-5:60 d after physiological maturity;and pS-6:fall)o f peach on the changes in soil organic carbon(SOC)fractions of different oxidizability,labile C pools,and C-cycle enzyme activities in soils,for two consecutive years(2015 and 2016)in the North-Western Himalayas(NWH).peach rhizosphere soils were sampled at the topsoil(0-15 cm)and subsoil(16-30 cm)layers,along with rhizosphere soils from adjacent perennial grasses,which served as a *** for most of the assessed parameters,including very labile C,labile C,microbial biomass C,permanganate oxidizable C,dissolved organic C,mineralizable C,amylase activity,and carboxymethyl-cellulase activity,were significantly(ppS-3 than at other phenological stages of ***,a sudden decline in these soil variables was recorded at pS-5,followed by a slight buildup at pS-6,particularly in the topsoil of the peach ***-term changes in organic C fractions of different oxidizability,influenced by peach phenological stage,significantly(ppool index,and lability *** the C management index and lability index showed their highest values at pS-3 and their lowest values at pS-5,clearly indicating short-term accretion and depletion of SOC,in tandem with the peach phenological *** component analysis suggested that a composite of soil indicators,including microbial biomass C,dissolved organic C,amylase,and invertase,could help detect short-term changes in SOC *** i

关键词： carbon fractions fruit orchard Indian Himalaya plant phenology rhizosphere soil soil biological indicators

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Heat transfer and fluid flow analysis of an artificially roughened solar air heater： a CFD based investigation

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Frontiers in Energy 2014年第2期8卷 201-211页

作者： anil singh YADAV J. L. BHAGORIA Mechanical Engineering Department Technocrats Institute of Technology-Excellence Bhopal MP 462021 Mechanical Engineering Department Maulana Azad National Institute of Technology Bhopal MP 462051 India

In this paper, the effect of rib （circular sectioned） spacing on average Nusselt number and friction factor in an artificially roughened solar air heater （duct aspect ratio, AR= 5：1） is studied by adopting the computational fluid dynamics （CFD） approach. Numerical solutions are obtained using commercial software ANSYS FLUENT v12.1. The computations based on the finite volume method with the semi-implicit method for pressure-linked equations （SIMpLE） algorithm have been conducted. Circular sectioned transverse ribs are applied at the underside of the top of the duct, i.e., on the absorber plate. The rib-height-to-hydraulic diameter ratio （e/D） is 0.042. The rib-pitch-to-fib-height （p/e） ratios studied are 7.14, 10.71, 14.29 and 17.86. For each rib spacing simulations are executed at six different relevant Reynolds numbers from 3800 to 18000. The thermo-hydraulic performance parameter for p/e = 10.71 is found to be the best for the investigated range of parameters at a Reynolds number of 15000.

关键词： heat transfer pressure drop thermo-hydraulic performance parameter

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Reflection of three-dimensional plane waves at the free surface of a rotating triclinic half-space under the context of generalized thermoelasticity

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Applied Mathematics and Mechanics(English Edition) 2021年第9期42卷 1363-1378页

作者： p.singh A.K.singh A.CHATTOpADHYAY Department of Mathematics and Computing Indian Institute of Technology(ISM)Dhanbad-826004JharkhandIndia

The reflection of three-dimensional(3D) plane waves in a highly anisotropic(triclinic) medium under the context of generalized thermoelasticity is studied. The thermoelastic nature of the 3D plane waves in an anisotropic medium is investigated in the perspective of the three-phase-lag(TpL), dual-phase-lag(DpL), Green-Naghdi-III(GNIII), Lord-Shulman(LS), and classical coupled(CL) theories. The reflection coefficients and energy ratios for all the reflected waves are obtained in a mathematical form. The rotational effects on the reflection characteristics of the 3D waves are discussed under the context of generalized thermoelasticity. Comparative analyses for the reflection coefficients of the waves among these generalized thermoelastic theories are performed. The energy ratios for each of the reflected waves establish the energy conservation law in the reflection phenomena of the plane waves. The highly anisotropic materials along with the rotation may have a significant role in the phenomenon of the reflection behavior of the 3D waves. Numerical computations are performed for the graphical representation of the study.

关键词： reflection energy ratio triclinic thermoelasticity rotation three-dimensional(3D)wave

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Rayleigh-type wave propagation in incompressible visco-elastic media under initial stress

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Applied Mathematics and Mechanics(English Edition) 2018年第3期39卷 317-334页

作者： p.singh A.CHATTOpADHYAY A.K.singh Department of Applied Mathematics Indian Institute of Technology (ISM)

propagation of Rayleigh-type surface waves in an incompressible visco-elastic material over incompressible visco-elastic semi-infinite media under the effect of initial stresses is discussed. The dispersion equation is determined to study the effect of differ- ent types of parameters such as inhomogeneity, initial stress, wave number, phase velocity, damping factor, visco-elasticity, and incompressibility on the Rayleigh-type wave prop- agation. It is found that the affecting parameters have a significant effect on the wave propagation. Cardano＇s and Ferrari＇s methods are deployed to estimate the roots of dif- ferential equations associated with layer and semi-infinite media. The MATHEMATICA software is applied to explicate the effect of these parameters graphically.

关键词： Rayleigh-type wave inhomogeneity initial stress visco-elasticity incom-pressible

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